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Redox regulation of the MED28 and MED32 mediator subunits is important for development and senescence
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics. Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC).
2016 (English)In: Protoplasma, ISSN 0033-183X, E-ISSN 1615-6102, Vol. 253, no 3, 957-963 p.Article in journal (Refereed) Published
Abstract [en]

Mediator is a conserved multi-protein complex that acts as a bridge between promoter-bound transcriptional regulators and RNA polymerase II. While redox signaling is important in adjusting plant metabolism and development, the involvement of Mediator in redox homeostasis and regulation only recently started to emerge. Our previous results show that the MED10a, MED28, and MED32 Mediator subunits form various types of covalent oligomers linked by intermolecular disulfide bonds in vitro. To link that with biological significance we have characterized Arabidopsis med32 and med28 mutants and found that they are affected in root development and senescence, phenotypes possibly associated to redox changes.

Place, publisher, year, edition, pages
2016. Vol. 253, no 3, 957-963 p.
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Biochemistry and Molecular Biology
URN: urn:nbn:se:umu:diva-121313DOI: 10.1007/s00709-015-0853-yISI: 000373578500029PubMedID: 26195288OAI: diva2:931951

Special Issue on Cell Biology in Agricultural and Food Science

Available from: 2016-05-31 Created: 2016-05-31 Last updated: 2016-08-15Bibliographically approved

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Björklund, Stefan
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Department of Medical Biochemistry and BiophysicsUmeå Plant Science Centre (UPSC)
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