Change search
ReferencesLink to record
Permanent link

Direct link
No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities
Show others and affiliations
2005 (English)In: Leukemia, ISSN 0887-6924, E-ISSN 1476-5551, Vol. 19, no 4, 557-563 p.Article in journal (Refereed) PublishedText
Abstract [en]

This study characterized the additional chromosomal abnormalities (ACA) associated with 11q23 rearrangements in 450 infants and children with acute lymphoblastic leukemia ( ALL) and examined the impact of these ACA on survival. Overall, 213 (47%) cases had ACA but the incidence varied according to patient age and 11q23 subgroup. Infants and patients with t(4; 11)(q21; q23) had the lowest incidence of ACA (50/182 (27%) and 57/216 (26%) respectively), whereas patients with del( 11)( q23) had the highest incidence (66/93 (71%)). Del( 11)( q23) abnormalities were heterogeneous and occasionally secondary to t( 9; 22)(q34; q11.2). Thus, patients with del( 11)( q23) comprised a separate biological entity, which was clearly distinct from those with an 11q23 translocation. The most frequent specific ACA were trisomy X ( n = 38), abnormal 12p ( n = 32), abnormal 9p ( n = 28) and del( 6q) ( n = 19). The presence of ACA did not change the 5 year event-free survival estimates among children (56% (95% CI 46 - 65%) vs 62% (54 - 69%)) or infants (22% ( 15 - 29%) vs 18% ( 9 - 29%)), nor when the different 11q23 subgroups were analyzed separately. This study has conclusively demonstrated that there is no prognostic effect of secondary chromosomal changes in association with 11q23 abnormalities in childhood ALL. However, characterization of these ACA is important to determine their potential role in initiation of MLL driven leukemogenesis.

Place, publisher, year, edition, pages
London: Nature Publishing Group, 2005. Vol. 19, no 4, 557-563 p.
Keyword [en]
acute lymphoblastic leukemia, childhood, infant, cytogenetics, 11q23, MLL
National Category
Cancer and Oncology Hematology
URN: urn:nbn:se:umu:diva-120431DOI: 10.1038/sj.leu.2403695ISI: 000227860300012PubMedID: 15744345OAI: diva2:932876
Available from: 2016-06-02 Created: 2016-05-16 Last updated: 2016-06-02Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Forestier, Erik
By organisation
Medical and Clinical Genetics
In the same journal
Cancer and OncologyHematology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 5 hits
ReferencesLink to record
Permanent link

Direct link