umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
Catechol O-methyltransferase Val(158)Met polymorphism is associated with cognitive performance in nondemented adults
Show others and affiliations
2005 (English)In: Journal of cognitive neuroscience, ISSN 0898-929X, E-ISSN 1530-8898, Vol. 17, no 7, 1018-1025 p.Article in journal (Refereed) PublishedText
Abstract [en]

The catechol O-methyltransferase ( COMT) gene is essential in the metabolic degradation of dopamine in the prefrontal cortex. In the present study, we examined the effect of a Val 158 Met polymorphism in the COMT gene on individual differences and changes in cognition ( executive functions and visuospatial ability) in adulthood and old age. The participants were 292 nondemented men ( initially aged 35-85 years) from a random sample of the population (i.e., the Betula study) tested at two occasions with a 5-year interval. Confirmatory factor analyses were used to test the underlying structure of three indicators of executive functions ( verbal fluency, working memory, and Tower of Hanoi). Associations between COMT, age, executive functioning, and visuospatial ( block design) tasks were examined using repeated-measures analyses of variance. Carriers of the Val allele ( with higher enzyme activity) compared with carriers of the Met/Met genotype ( with low enzyme activity) performed worse on executive functioning and visuospatial tasks. Individuals with the Val/Val genotype declined in executive functioning over the 5-year period, whereas carriers of the Met allele remained stable in performance. An Age x COMT interaction for visuospatial ability located the effect for middle-aged men only. This COMT polymorphism is a plausible candidate gene for executive functioning and fluid intelligence in nondemented middle-aged and older adults.

Place, publisher, year, edition, pages
Cambridge: MIT Press, 2005. Vol. 17, no 7, 1018-1025 p.
Keyword [en]
dopamine D1 receptors, prefrontal cortex, working memory, gene polymorphism, functional polymorphism, prospective cohort, divided attention, human brain, comt gene, age
National Category
Neurosciences Psychiatry
Identifiers
URN: urn:nbn:se:umu:diva-120414DOI: 10.1162/0898929054475136ISI: 000230933400004PubMedID: 16102234OAI: oai:DiVA.org:umu-120414DiVA: diva2:934376
Available from: 2016-06-08 Created: 2016-05-16 Last updated: 2016-06-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Adolfsson, Rolf
By organisation
Psychiatry
In the same journal
Journal of cognitive neuroscience
NeurosciencesPsychiatry

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 3 hits
ReferencesLink to record
Permanent link

Direct link