Catechol O-methyltransferase Val(158)Met polymorphism is associated with cognitive performance in nondemented adults
2005 (English)In: Journal of cognitive neuroscience, ISSN 0898-929X, E-ISSN 1530-8898, Vol. 17, no 7, 1018-1025 p.Article in journal (Refereed) PublishedText
The catechol O-methyltransferase ( COMT) gene is essential in the metabolic degradation of dopamine in the prefrontal cortex. In the present study, we examined the effect of a Val 158 Met polymorphism in the COMT gene on individual differences and changes in cognition ( executive functions and visuospatial ability) in adulthood and old age. The participants were 292 nondemented men ( initially aged 35-85 years) from a random sample of the population (i.e., the Betula study) tested at two occasions with a 5-year interval. Confirmatory factor analyses were used to test the underlying structure of three indicators of executive functions ( verbal fluency, working memory, and Tower of Hanoi). Associations between COMT, age, executive functioning, and visuospatial ( block design) tasks were examined using repeated-measures analyses of variance. Carriers of the Val allele ( with higher enzyme activity) compared with carriers of the Met/Met genotype ( with low enzyme activity) performed worse on executive functioning and visuospatial tasks. Individuals with the Val/Val genotype declined in executive functioning over the 5-year period, whereas carriers of the Met allele remained stable in performance. An Age x COMT interaction for visuospatial ability located the effect for middle-aged men only. This COMT polymorphism is a plausible candidate gene for executive functioning and fluid intelligence in nondemented middle-aged and older adults.
Place, publisher, year, edition, pages
Cambridge: MIT Press, 2005. Vol. 17, no 7, 1018-1025 p.
dopamine D1 receptors, prefrontal cortex, working memory, gene polymorphism, functional polymorphism, prospective cohort, divided attention, human brain, comt gene, age
IdentifiersURN: urn:nbn:se:umu:diva-120414DOI: 10.1162/0898929054475136ISI: 000230933400004PubMedID: 16102234OAI: oai:DiVA.org:umu-120414DiVA: diva2:934376