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Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease
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2005 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 26, no 8, 1145-1151 p.Article in journal (Refereed) PublishedText
Abstract [en]

Malfunctioning of cyclin-dependent kinase 5 (CDK5) through aberrant proteolytic cleavage of its neuronal activators p35 and p39 is involved in neurodegeneration in Alzheimer's disease (AD) and other neurodegenerative brain diseases. By extensive genetic analysis of the genes encoding CDK5 (CDK5), p35 (CDK5RI) and p39 (CDK5R2), we excluded causal mutations in 70 familial early-onset AD patients. We performed an association study with five informative SNPs in CDK5 in two independent samples of early-onset AD patients and matched control individuals from The Netherlands and northern Sweden. Association was observed with g.149800G > C in intron 5 of CDK5, and a two times increased risk was observed in both patient samples for carriers of the C-allele. Our data are indicative for a role of the CDK5 molecular complex in the genetic etiology of early-onset AD, and suggest that a yet unknown functional variant in CDK5 or in a nearby gene might lead to increased susceptibility for early-onset AD.

Place, publisher, year, edition, pages
New York: Elsevier, 2005. Vol. 26, no 8, 1145-1151 p.
Keyword [en]
Alzheimer dementia, neurodegeneration, cyclin-dependent kinase, mutation analysis, association analysis
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Geriatrics Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-120410DOI: 10.1016/j.neurobiolaging.2004.10.003ISI: 000229816900002PubMedID: 15917097OAI: oai:DiVA.org:umu-120410DiVA: diva2:934870
Available from: 2016-06-09 Created: 2016-05-16 Last updated: 2016-06-09Bibliographically approved

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Adolfsson, RolfCruts, M
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