The protein expression of Streptococcus pyogenes is significantly influenced by human plasma
2005 (English)In: Journal of Proteome Research, ISSN 1535-3893, E-ISSN 1535-3907, Vol. 4, no 6, 2302-2311 p.Article in journal (Refereed) PublishedText
During the courser of infection, the common human pathogen Streptococcus pyogenes encounters plasma. We show that plasma causes S. pyogenes to rapidly remodel its cellular metabolism and virulence pathways. We also identified a variant of the major virulence factor, M1 protein, lacking 13 amino acids at the NH2-terminus in bacteria grown with plasma. The pronounced effect of plasma on protein expression, suggests this is an important adaptive mechanism with implications for S. pyogenes pathogenicity.
Place, publisher, year, edition, pages
Washington: American Chemical Society (ACS), 2005. Vol. 4, no 6, 2302-2311 p.
Streptococcus pyogenes, 2D-PAGE, plasma, M protein, post-translational modifications
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:umu:diva-120396DOI: 10.1021/pr050217yISI: 000234007200046PubMedID: 16335979OAI: oai:DiVA.org:umu-120396DiVA: diva2:936213