The effects of physical activity on muscle atrophy in cancer cachexia
Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Physical activity is, among other things, characterized by an increased quality of life and several physiological positive results such as hypertrophy and counteracting atrophy. Cachexia has been proven to degradate muscle proteins and is a contributing factor to death in cancer. Cachectic muscles are resistant to anabolic effects, and this knowledge combined with the many proven positive outcomes on muscle hypertrophy by exercise led this study to investigate the previous studies conducted on this subject further. The design was a descriptive review study and information was collected through 51 articles. The ubiquitin- proteasome system (UPS) plays a significant role in protein degradation, more specifically the E3 ubiquitin ligases MuRF-1 (muscle RING finger protein-1) and MaFbx (muscle atrophy F-box), which are FoxO (forkhead box-O) transcription factors. The UPS can be inhibited by substrates upregulated by physical activity, such as IGF-1 (Insulin-like Growth Factor-1) and PGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha). In conclusion, there are a lot of pathways in both cancer cachexia and physical activity that border on each other, but the molecular mechanisms are complex and not always clear.
Place, publisher, year, edition, pages
2016. , 22 p.
Cachexia, cancer, physical activity, muscle atrophy, protein degradation
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-122031OAI: oai:DiVA.org:umu-122031DiVA: diva2:936689
Physical Trainer Pogramme
Universitetsadjunkt, Apostolos, Theos
ProjectsCOMMIT projekt. "The development of a Critical Muscle Mass Index for the early diagnosis and prevention of morbidity and disability"