Change search
ReferencesLink to record
Permanent link

Direct link
Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.
Show others and affiliations
2016 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 7, 10979Article in journal (Refereed) Published
Abstract [en]

Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa.

Place, publisher, year, edition, pages
2016. Vol. 7, 10979
National Category
Cancer and Oncology
URN: urn:nbn:se:umu:diva-122103DOI: 10.1038/ncomms10979ISI: 000373804700001PubMedID: 27052111OAI: diva2:937255
Available from: 2016-06-15 Created: 2016-06-15 Last updated: 2016-08-17Bibliographically approved

Open Access in DiVA

fulltext(792 kB)19 downloads
File information
File name FULLTEXT01.pdfFile size 792 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Johansson, Mattias
By organisation
Department of Biobank ResearchUrology and Andrology
In the same journal
Nature Communications
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 19 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 14 hits
ReferencesLink to record
Permanent link

Direct link