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Zebrafish sex determination and differentiation: involvement of FTZ-F1 genes
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).ORCID iD: 0000-0003-3730-1790
2005 (English)In: Reproductive Biology and Endocrinology, ISSN 1477-7827, E-ISSN 1477-7827, Vol. 3, 63Article, review/survey (Refereed) PublishedText
Abstract [en]

Sex determination is the process deciding the sex of a developing embryo. This is usually determined genetically; however it is a delicate process, which in many cases can be influenced by environmental factors. The mechanisms controlling zebrafish sex determination and differentiation are not known. To date no sex linked genes have been identified in zebrafish and no sex chromosomes have been identified. However, a number of genes, as presented here, have been linked to the process of sex determination or differentiation in zebrafish. The zebrafish FTZ-F1 genes are of central interest as they are involved in regulating interrenal development and thereby steroid biosynthesis, as well as that they show expression patterns congruent with reproductive tissue differentiation and function. Zebrafish can be sex reversed by exposure to estrogens, suggesting that the estrogen levels are crucial during sex differentiation. The Cyp19 gene product aromatase converts testosterone into 17 beta-estradiol, and when inhibited leads to male to female sex reversal. FTZ-F1 genes are strongly linked to steroid biosynthesis and the regulatory region of Cyp19 contains binding sites for FTZ-F1 genes, further linking FTZ-F1 to this process. The role of FTZ-1 and other candidates for zebrafish sex determination and differentiation is in focus of this review.

Place, publisher, year, edition, pages
London: BioMed Central, 2005. Vol. 3, 63
Keyword [en]
steroidogenic factor-1, anti-mullerian hormone, char salvelinus-alpinus, sry-related gene, tarazu factor-1, rice-field eel, fushi tarazu, rainbow trout, molecular cloning, nuclear receptor
National Category
Genetics Developmental Biology
URN: urn:nbn:se:umu:diva-120392DOI: 10.1186/1477-7827-3-63ISI: 000233653200001PubMedID: 16281973OAI: diva2:937524
Available from: 2016-06-15 Created: 2016-05-16 Last updated: 2016-06-15Bibliographically approved

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von Hofsten, Jonas
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