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Seasonal affective disorder and the G-protein beta-3-subunit C825T polymorphism
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
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2004 (English)In: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 55, no 3, 317-319 p.Article in journal (Refereed) PublishedText
Abstract [en]

Background: Guanine nucleotide-binding proteins (G-proteins) have been implicated in affective disorders, with reports of altered signal transduction and G-protein levels. Association with seasonal affective disorder (SAD) has been found for the higher activity T-allele of the G-protein beta-3-subunit C825T polymorphism.

Methods. European SAD patients (n = 159) and matched controls (n = 159) were genotyped for the C825T. Seasonality and diurnal preference were investigated in subsets of the material (n = 177 and 92, respectively).

Results. We found no association between C825T and SAD (chi(2) = .09, p = .96) or seasonality (F = 1.76, p = .18). There was some evidence for an effect on diurnal preference but only in the control group (n = 46, t = - 2.8, Bonferroni corrected p = .045).

Conclusions: These results suggest that the G-protein beta-3-subunit 825 T-allele does not play a major role in susceptibility to seasonal affective disorder in the population studied.

Place, publisher, year, edition, pages
New York: Elsevier, 2004. Vol. 55, no 3, 317-319 p.
Keyword [en]
depression, seasonality, morningness-eveningness, G beta 3, signal transduction, association study
National Category
Neurology Neurosciences Psychiatry
URN: urn:nbn:se:umu:diva-122178DOI: 10.1016/S0006-3223(03)00640-1ISI: 000188434000017PubMedID: 14744475OAI: diva2:938886
Available from: 2016-06-17 Created: 2016-06-15 Last updated: 2016-06-17Bibliographically approved

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Smedh, ChristinaAdolfsson, RolfPartonen, Timo
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