Seasonal affective disorder and the G-protein beta-3-subunit C825T polymorphism
2004 (English)In: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 55, no 3, 317-319 p.Article in journal (Refereed) PublishedText
Background: Guanine nucleotide-binding proteins (G-proteins) have been implicated in affective disorders, with reports of altered signal transduction and G-protein levels. Association with seasonal affective disorder (SAD) has been found for the higher activity T-allele of the G-protein beta-3-subunit C825T polymorphism.
Methods. European SAD patients (n = 159) and matched controls (n = 159) were genotyped for the C825T. Seasonality and diurnal preference were investigated in subsets of the material (n = 177 and 92, respectively).
Results. We found no association between C825T and SAD (chi(2) = .09, p = .96) or seasonality (F = 1.76, p = .18). There was some evidence for an effect on diurnal preference but only in the control group (n = 46, t = - 2.8, Bonferroni corrected p = .045).
Conclusions: These results suggest that the G-protein beta-3-subunit 825 T-allele does not play a major role in susceptibility to seasonal affective disorder in the population studied.
Place, publisher, year, edition, pages
New York: Elsevier, 2004. Vol. 55, no 3, 317-319 p.
depression, seasonality, morningness-eveningness, G beta 3, signal transduction, association study
Neurology Neurosciences Psychiatry
IdentifiersURN: urn:nbn:se:umu:diva-122178DOI: 10.1016/S0006-3223(03)00640-1ISI: 000188434000017PubMedID: 14744475OAI: oai:DiVA.org:umu-122178DiVA: diva2:938886