umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
ESPGHAN Committee on Nutrition Position Paper. Intravenous Lipid Emulsions and Risk of Hepatotoxicity in Infants and Children: a Systematic Review and Meta-analysis
Show others and affiliations
2016 (English)In: Journal of Pediatric Gastroenterology and Nutrition - JPGN, ISSN 0277-2116, E-ISSN 1536-4801, Vol. 62, no 5, 776-792 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

The aim of the present article was to perform a systematic review with meta-analysis of available scientific evidence regarding the role of different intravenous lipid emulsions (ILE) in the pathogenesis of cholestasis and parenteral nutrition-associated liver disease. A systematic review of the literature (up to March 2015) identified 23 randomized controlled trials (RCTs). Of these, 17 were performed in preterm infants or critically ill neonates with a short duration of intervention, 2 in older children with short-term use (following surgery or bone marrow transplantation), 1 in neonates with long-term use, and 3 in infants and children receiving long-term parenteral nutrition (PN). Meta-analysis showed no differences in the rate of cholestasis or bilirubin levels associated with short-term use of different ILEs. Because of high heterogeneity of the long-term studies no meta-analysis could be performed. Available studies found that the use of multicomponent fish oil (FO)-containing ILE compared with pure soya bean oil (SO), ILE-reduced liver enzymes, and bilirubin levels in noncholestatic children on long-term PN and one other RCT found that FO-based ILE-reversed cholestasis in a proportion of patients. The ESPGHAN Committee on Nutrition concludes that there is no evidence of a difference in rates of cholestasis or bilirubin levels between different ILE for short-term use in neonates. The use of multicomponent FO-containing ILE may contribute to a decrease in total bilirubin levels in children with IF on prolonged PN. Well-designed RCTs are, however, lacking and long-term effects have not been determined.

Place, publisher, year, edition, pages
2016. Vol. 62, no 5, 776-792 p.
Keyword [en]
children, fish oil, infants, lipids, medium-chain triglycerides, neonates, olive oil, soya bean oil
National Category
Pediatrics Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:umu:diva-121461DOI: 10.1097/MPG.0000000000001121ISI: 000374765900026OAI: oai:DiVA.org:umu-121461DiVA: diva2:938927
Available from: 2016-06-17 Created: 2016-06-02 Last updated: 2016-07-04Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Domellöf, Magnus
By organisation
Paediatrics
In the same journal
Journal of Pediatric Gastroenterology and Nutrition - JPGN
PediatricsNutrition and Dietetics

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 8 hits
ReferencesLink to record
Permanent link

Direct link