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Long-term efficacy of an oral appliance in early treated patients with obstructive sleep apnea
Umeå University, Faculty of Medicine, Department of Odontology.
2016 (English)In: Sleep and Breathing, ISSN 1520-9512, E-ISSN 1522-1709, Vol. 20, no 2, 689-694 p.Article in journal (Refereed) PublishedText
Abstract [en]

The purpose of the present study was to evaluate the long-term efficacy of oral appliances (OAs) in early treated patients with obstructive sleep apnea (OSA). Polysomnographic sleep recordings without and with an OA were performed at treatment start and in patients who had been continuously treated with OAs for at least 15 years. Nine patients (eight men) with a median age of 68.1 years (interquartile range (IQR) 60.0 to 76.3 years) and a median treatment time of 16.5 years (IQR 16.3 to 18.0 years) were included. The apnea-hypopnea index decreased from a median of 17.3 (IQR 9.7 to 26.5) to 7.2 (IQR 4.0 to 9.6; p = 0.03) at the short-term follow-up. After long-term use, the apnea-hypopnea index was 32.4 (IQR 22.2 to 58.8) without the device and 35.1 (IQR 13.6 to 46.2) with it (p = 0.08). There were increases in the apnea-hypopnea index, both without the device (p = 0.02) and with it (p = 0.008). The degree of mandibular advancement did not differ between the two study occasions (p = 1.0). Patients treated with oral appliances may experience deteriorations in disease severity and treatment efficacy during continuous long-term OA treatment. Regular follow-up schedules with renewed sleep apnea recordings should be considered for these patients in order to avoid suboptimal or a total loss of effects on sleep apneas.

Place, publisher, year, edition, pages
Springer, 2016. Vol. 20, no 2, 689-694 p.
Keyword [en]
Obstructive sleep apnea, Mandibular advancement device, Oral appliance, Long-term
National Category
Neurology Respiratory Medicine and Allergy
URN: urn:nbn:se:umu:diva-121467DOI: 10.1007/s11325-015-1280-1ISI: 000375434400030PubMedID: 26527204OAI: diva2:940049
Available from: 2016-06-20 Created: 2016-06-02 Last updated: 2016-06-20Bibliographically approved

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Marklund, Marie
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