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Regulation of twin of eyeless during Drosophila development
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
2016 (English)In: Gene Expression Patterns, ISSN 1567-133X, E-ISSN 1872-7298, Vol. 20, no 2, 120-129 p.Article in journal (Refereed) PublishedText
Abstract [en]

The Pax-6 protein is vital for eye development in all seeing animals, from sea urchins to humans. Either of the Pax6 genes in Drosophila (twin of eyeless and eyeless) can induce a gene cascade leading to formation of entire eyes when expressed ectopically. The twin of eyeless (toy) gene in Drosophila is expressed in the anterior region of the early fly embryo. At later stages it is expressed in the brain, ventral nerve cord and (eventually) the visual primordium that gives rise to the eye-antennal imaginal discs of the larvae. These discs subsequently form the major part of the adult head, including compound eyes. We have searched for genes that are required for normal toy expression in the early embryo to elucidate initiating events of eye organogenesis. Candidate genes identified by mutation analyses were subjected to further knock-out and miss-expression tests to investigate their interactions with toy. Our results indicate that the head-specific gap gene empty spiracles can act as a repressor of Toy, while ocelliless (oc) and spalt major (salm) appear to act as positive regulators of toy gene expression. (C) 2016 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
2016. Vol. 20, no 2, 120-129 p.
Keyword [en]
Drosophila melanogaster, Eye development, Pax6, twin of eyeless
National Category
Genetics
Identifiers
URN: urn:nbn:se:umu:diva-121601DOI: 10.1016/j.gep.2016.03.002ISI: 000375160800006OAI: oai:DiVA.org:umu-121601DiVA: diva2:940694
Available from: 2016-06-21 Created: 2016-06-03 Last updated: 2016-06-21Bibliographically approved

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Skottheim Honn, JohnJohansson, LinnRasmuson Lestander, Asa
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Department of Molecular Biology (Faculty of Science and Technology)
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Gene Expression Patterns
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