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Expanded RED products and loci containing CAG/CTG repeats on chromosome 17 (ERDA1) and chromosome 18 (CTG18.1) in trans-generational pairs with bipolar affective disorder
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2004 (English)In: American Journal of Medical Genetics, ISSN 0148-7299, E-ISSN 1096-8628, Vol. 128B, no 1, 71-75 p.Article in journal (Refereed) PublishedText
Abstract [en]

The purpose of the present study was to further test if expanded CAG repeats detected by the repeat expansion detection (RED) method in bipolar affective disorder (BPAD) are correlated with ERDA1 (17q21.3) and/or CTG18.1 (18q21.1) loci expansions, and changes of phenotype severity in successive generations (anticipation). The sample was designed to analyze ERDA1 and CTG18.1 expansions in trans-generational pairs of affected individuals (parent-offspring pairs: G1 and G2). Clinical and genetic information was available on 95 two-generations pairs. We found in our sample no one patient.

Place, publisher, year, edition, pages
Hoboken: John Wiley & Sons, 2004. Vol. 128B, no 1, 71-75 p.
Keyword [en]
bipolar affective disorder, unipolar affective disorder, anticipation, CAG repeats, repeat expansion detection, method, ERDA1, CTG18.1
National Category
Psychiatry Medical Genetics
URN: urn:nbn:se:umu:diva-122163DOI: 10.1002/ajmg.b.20006ISI: 000222423700016PubMedID: 15211635OAI: diva2:941234
Available from: 2016-06-22 Created: 2016-06-15 Last updated: 2016-06-22Bibliographically approved

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Massat, IsabelleEngström, ChristerAdolfsson, Rolf
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