umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
COMT gene polymorphism is associated with declarative memory in adulthood and old age
Show others and affiliations
2004 (English)In: Behavior Genetics, ISSN 0001-8244, E-ISSN 1573-3297, Vol. 34, no 5, 533-539 p.Article in journal (Refereed) PublishedText
Abstract [en]

Variation in memory performance is to a large extent explained by genes. In the prefrontal cortex, the catechol O-methyltransferase (COMT) gene is essential in the metabolic degradation of dopamine, a neurotransmitter implicated in cognitive functions. The present study examined the effect of a polymorphism in the COMT gene on individual differences and changes in memory in adulthood and old age. Tests assessing episodic and semantic memory were administered to 286 men (initially aged 35-85 years) from a random sample of the population (i.e., the Betula prospective cohort study) at two occasions followed over a 5-year period. Carriers of the Met/Met genotype (with low enzyme activity) performed better on episodic and semantic memory, as compared to carriers of the Val allele (with higher enzyme activity). Division of episodic memory into its recall and recognition components showed that the difference was specific to episodic recall, not recognition tasks; an effect that was observed across three age groups (middle-age, young-old, and old-old adults) and over a 5-year period. The COMT gene is a plausible candidate gene for memory functioning in adulthood and old age.

Place, publisher, year, edition, pages
New York: Kluwer Academic Publishers, 2004. Vol. 34, no 5, 533-539 p.
Keyword [en]
adulthood, aging, COMT, genetics, memory
National Category
Psychology Medical Genetics
Identifiers
URN: urn:nbn:se:umu:diva-122155DOI: 10.1023/B:BEGE.0000038491.06972.8cISI: 000223403200006PubMedID: 15319576OAI: oai:DiVA.org:umu-122155DiVA: diva2:941391
Available from: 2016-06-22 Created: 2016-06-15 Last updated: 2016-06-22Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Adolfsson, Rolf
By organisation
Psychiatry
In the same journal
Behavior Genetics
PsychologyMedical Genetics

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 2 hits
ReferencesLink to record
Permanent link

Direct link