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Innate biology versus lifestyle behaviour in the aetiology of obesity and type 2 diabetes: the GLACIER Study
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2016 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 59, no 3, 462-471 p.Article in journal (Refereed) PublishedText
Abstract [en]

Aims/hypothesis We compared the ability of genetic (established type 2 diabetes, fasting glucose, 2 h glucose and obesity variants) and modifiable lifestyle (diet, physical activity, smoking, alcohol and education) risk factors to predict incident type 2 diabetes and obesity in a population-based prospective cohort of 3,444 Swedish adults studied sequentially at baseline and 10 years later. Methods Multivariable logistic regression analyses were used to assess the predictive ability of genetic and lifestyle risk factors on incident obesity and type 2 diabetes by calculating the AUC. Results The predictive accuracy of lifestyle risk factors was similar to that yielded by genetic information for incident type 2 diabetes (AUC 75% and 74%, respectively) and obesity (AUC 68% and 73%, respectively) in models adjusted for age, age2 and sex. The addition of genetic information to the lifestyle model significantly improved the prediction of type 2 diabetes (AUC 80%; p = 0.0003) and obesity (AUC 79%; p < 0.0001) and resulted in a net reclassification improvement of 58% for type 2 diabetes and 64% for obesity. Conclusions/interpretation These findings illustrate that lifestyle and genetic information separately provide a similarly high degree of long-range predictive accuracy for obesity and type 2 diabetes.

Place, publisher, year, edition, pages
2016. Vol. 59, no 3, 462-471 p.
Keyword [en]
Environment, Genes, Obesity, Predictors, Type 2 diabetes, LONG ER, 1988, BIOMETRICS, V44, P837 lmud Philippa J., 2015, DIABETES, V64, P1830 llmans Gï¿œran, 2003, Scandinavian journal of public health. Supplement, V61, P18 Development Core Team, 2008, R: A language and environment for statistical computing, hansson I, 2002, PUBLIC HEALTH NUTRITION, V5, P487 zaffarian Dariush, 2008, CIRCULATION, V117, P3031 pert Committee on the Diagnosis and Classification of Diabetes Mellitus, 2003, Diabetes Care, V26, PS5 ntaine-Bisson B., 2010, DIABETOLOGIA, V53, P2155
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Endocrinology and Diabetes
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URN: urn:nbn:se:umu:diva-123081DOI: 10.1007/s00125-015-3818-yISI: 000377302900009PubMedID: 26625858OAI: oai:DiVA.org:umu-123081DiVA: diva2:943037
Available from: 2016-06-27 Created: 2016-06-27 Last updated: 2016-06-27Bibliographically approved

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Hallmans, GöranJohansson, IngegerdRenstrom, FridaFranks, Paul W.
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Department of Biobank ResearchDepartment of OdontologyMedicine
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Diabetologia
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