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Long-term dopamine transporter imaging in Parkinson's disease treated with zona incerta stimulation
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
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2016 (English)In: Nuclear medicine communications, ISSN 0143-3636, E-ISSN 1473-5628, Vol. 37, no 5, 499-508 p.Article in journal (Refereed) PublishedText
Abstract [en]

Objective: The caudal zona incerta (cZI) is a promising, clinically beneficial target for deep brain stimulation (DBS) in Parkinson’s disease (PD). To assess whether DBS of the cZI affects the rate of dopamine terminal dysfunction, PD patients with and without DBS were followed prospectively with 123I FP-Cit single photon emission tomography from the first diagnosis and up to 8 years.

Methods: Six patients underwent DBS of the cZI during the survey period. Twenty-two PD patients only on pharmacotherapy served as controls. 123I FP-Cit and clinical assessment were performed at baseline and after 1, 3 and 5 years in all patients. Ten patients also underwent a 123I FP-Cit after 8 years. Image data were evaluated semiquantitatively. Mixed-model analysis was used to assess the relative change in 123I FP-Cit uptake and comparison between surgically and conservatively treated PD patients.

Results: The relative decrease in 123I FP-Cit uptake was more pronounced in DBS-treated patients than in controls in the more affected caudate (P=0.037) and putamen (P=0.013). The annual decrease rates were higher in the less affected than the more affected putamen, and were slightly greater in DBS-treated patients (4.8%, 95%confidence interval: 8.5–2.2%) than in controls (4.0%, 95% confidence interval: 5.1–3.1%).

Conclusion: This long-term prospective study confirms that the underlying dopaminergic dysfunction continues despite clinical improvement in PD patients with DBS of the cZI. A slightly faster rate of decrease in 123I FP-Cit uptake in these patients compared with conservatively treated PD patients may reflect a more aggressive form of PD.

Place, publisher, year, edition, pages
2016. Vol. 37, no 5, 499-508 p.
Keyword [en]
deep brain stimulation, dopamine transporter, Parkinson disease, single photon emission computed tomography, zona incerta
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:umu:diva-121568DOI: 10.1097/MNM.0000000000000469ISI: 000374885400010PubMedID: 26716545OAI: oai:DiVA.org:umu-121568DiVA: diva2:944847
Available from: 2016-06-30 Created: 2016-06-03 Last updated: 2016-06-30Bibliographically approved

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Jakobson Mo, SusannaLinder, JanBlomstedt, PatricGranåsen, GabrielForsgren, LarsHariz, Marwan
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Diagnostic RadiologyDepartment of Pharmacology and Clinical NeuroscienceEpidemiology and Global Health
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Nuclear medicine communications
Radiology, Nuclear Medicine and Medical Imaging

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