Change search
ReferencesLink to record
Permanent link

Direct link
Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus
Show others and affiliations
2016 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 352, no 6289, 1105-1109 p.Article in journal (Refereed) PublishedText
Abstract [en]

Metal acquisition is a vital microbial process in metal-scarce environments, such as inside a host. Using metabolomic exploration, targeted mutagenesis, and biochemical analysis, we discovered an operon in Staphylococcus aureus that encodes the different functions required for the biosynthesis and trafficking of a broad-spectrum metallophore related to plant nicotianamine (here called staphylopine). The biosynthesis of staphylopine reveals the association of three enzyme activities: a histidine racemase, an enzyme distantly related to nicotianamine synthase, and a staphylopine dehydrogenase belonging to the DUF2338 family. Staphylopine is involved in nickel, cobalt, zinc, copper, and iron acquisition, depending on the growth conditions. This biosynthetic pathway is conserved across other pathogens, thus underscoring the importance of this metal acquisition strategy in infection.

Place, publisher, year, edition, pages
2016. Vol. 352, no 6289, 1105-1109 p.
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:umu:diva-123368DOI: 10.1126/science.aaf1018ISI: 000376480800040PubMedID: 27230378OAI: diva2:946304
Available from: 2016-07-05 Created: 2016-07-01 Last updated: 2016-07-05Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Espaillat, AkbarCava, Felipe
By organisation
Department of Molecular Biology (Faculty of Medicine)
In the same journal
Biochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 108 hits
ReferencesLink to record
Permanent link

Direct link