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Women with PTSD have a changed sensitivity to GABA-A receptor active substances
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynaecology.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynaecology.
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2016 (English)In: Psychopharmacology, ISSN 0033-3158, E-ISSN 1432-2072, Vol. 233, no 11, 2025-2033 p.Article in journal (Refereed) PublishedText
Abstract [en]

The use of benzodiazepines in treating anxiety symptoms in patients with posttraumatic stress disorder (PTSD) has been debated. Studies on other anxiety disorders have indicated changed sensitivity to GABA-A receptor active substances. In the present study, we investigated the GABA receptor sensitivity in PTSD patients. Injections of allopreganolone, diazepam, and flumazenil were carried out, each on separate occasions, in 10 drug na < ve patients with PTSD compared to 10 healthy controls. Effects were measured in saccadic eye velocity (SEV) and in subjective ratings of sedation. The PTSD patients were less sensitive to allopregnanolone compared with healthy controls. This was seen as a significant difference in SEV between the groups (p = 0.047). Further, the patients were less sensitive to diazepam, with a significant less increase in sedation compared to controls (p = 0.027). After flumazenil injection, both patients and controls had a significant agonistic effect on SEV, leading to decreased SEV after injection. The patients also responded with an increase in sedation after flumazenil injection, while this was not seen in the controls. Patients with PTSD have a changed sensitivity to GABA-A receptor active substances. As a consequence of this, benzodiazepines and other GABA-A receptor active compounds such as sleeping pills will be less useful for this group of patients.

Place, publisher, year, edition, pages
2016. Vol. 233, no 11, 2025-2033 p.
Keyword [en]
Allopregnanolone, Benzodiazepines, Diazepam, Flumazenil, Saccadic eye velocity, Sedation
National Category
Neurology Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:umu:diva-123365DOI: 10.1007/s00213-014-3776-yISI: 000376102100002PubMedID: 25345735OAI: oai:DiVA.org:umu-123365DiVA: diva2:946323
Available from: 2016-07-05 Created: 2016-07-01 Last updated: 2016-07-05Bibliographically approved

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Bäckström, TorbjörnNyberg, Sigrid
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