Change search
ReferencesLink to record
Permanent link

Direct link
T-lymphocyte subsets, functional deficits, and morphology in sciatic nerves during experimental allergic neuritis
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
Show others and affiliations
1987 (English)In: Muscle and Nerve, ISSN 0148-639X, E-ISSN 1097-4598, Vol. 10, no 4, 329-337 p.Article in journal (Refereed) Published
Abstract [en]

Conduction velocities, demyelination, "macrophage/dendritic" cells, different sets of T-lymphocytes, and immunoglobulins were estimated in sciatic nerves during various phases of experimental allergic neuritis in Lewis rats. Demyelination was minimal day 15 postimmunization (p.i.) when conduction velocity already was reduced, somewhat more pronounced day 17 p.i. when nerve conduction was blocked, and most pronounced day 23 p.i. when nerve conduction partially had recovered. This suggests a dissociation between the degree of demyelination and the functional deficits. Decrease of sciatic nerve conduction velocities coincided with endoneurial appearance of T-lymphocytes and "macrophage/dendritic" cells, as well as endoneurial immunoglobulins, day 15 p.i. Later partial functional recovery occurred in parallel with the disappearance of T-cells. The degree of functional deficits thus correlated with the number of endoneurial T-lymphocytes. T-cells may, directly or indirectly, initiate several of the disease components in experimental allergic neuritis, including the nerve conduction deficit.

Place, publisher, year, edition, pages
New York: John Wiley & Sons, 1987. Vol. 10, no 4, 329-337 p.
Keyword [sv]
T-lymphocytes, immunoglobins, sciatic nerves
National Category
URN: urn:nbn:se:umu:diva-121689DOI: 10.1002/mus.880100409ISI: A1987G968500008PubMedID: 2438552OAI: diva2:947376
Available from: 2016-07-08 Created: 2016-06-07 Last updated: 2016-08-10Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Strigård, Karin
By organisation
In the same journal
Muscle and Nerve

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 1 hits
ReferencesLink to record
Permanent link

Direct link