Change search
ReferencesLink to record
Permanent link

Direct link
Modulation of experimental allergic neuritis in rats by in vivo treatment with monoclonal anti T cell antibodies.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
Show others and affiliations
1988 (English)In: Journal of the Neurological Sciences, ISSN 0022-510X, E-ISSN 1878-5883, Vol. 83, no 2-3Article in journal (Refereed) Published
Abstract [en]

Monoclonal antibodies (MCA) to different T lymphocyte cell surface antigens have been used to treat rats during different phases of the development of experimental allergic neuritis (EAN). The effects of this treatment were followed by clinical evaluation and in some instances by immunohistochemical analysis of lymphoid organs and affected nerves of the antibody-treated rats. Several MCA, W3/13 (pan T cell reactive), W3/25 (anti-rat CD4), Ox 8 (anti-rat CD8) as well as Ox 6 (anti-Ia) partly prevented clinical signs of EAN when given shortly before expected onset of disease, whereas W3/13 and Ox 8 given at the height of disease did not further affect disease development. However, Ox 19 (anti-rat CD5) given at the same time as immunization partly prevented clinical signs of EAN, while Ox 19 given shortly before expected onset of disease or during height of disease drastically exaggerated disease symptoms. Immunohistochemical studies after Ox 8 or Ox 19 treatment showed a complete absence of staining for the respective antibodies, while staining was preserved with the other MCA. It is concluded that: (1) Ox 8 positive "suppressor/cytotoxic" T lymphocytes do not exert any suppressive effects on EAN during the now investigated phases of disease, and that (2) anti T lymphocyte antibodies (here Ox 19) may exert opposite effects on autoimmune disease when given at different phases of disease development. This may have implications for potential therapeutic trials of MCA therapy for putative autoimmune demyelinating diseases in man.

Place, publisher, year, edition, pages
1988. Vol. 83, no 2-3
Keyword [en]
Monoclonal antibodies, Experimental allergic neuritis, Autoimmune diseases, T cell subsets, Lewis rats
National Category
Research subject
URN: urn:nbn:se:umu:diva-124040PubMedID: 3258628OAI: diva2:947384
Available from: 2016-07-08 Created: 2016-07-08 Last updated: 2016-07-08

Open Access in DiVA

No full text


Search in DiVA

By author/editor
Strigård, Karin
By organisation
In the same journal
Journal of the Neurological Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 2 hits
ReferencesLink to record
Permanent link

Direct link