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Elimination of CD8+ T cells in vivo does not break induced immunospecific tolerance to experimental allergic neuritis in rats.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
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1988 (English)In: Scandinavian Journal of Immunology, ISSN 0300-9475, E-ISSN 1365-3083, Vol. 28, no 3Article in journal (Refereed) Published
Abstract [en]

The role of CD8+ T 'cytotoxic/suppressor' T cells in induced immunospecific tolerance and during recovery after actively induced disease was examined by means of elimination of CD8+ cells from Lewis rats using in vivo treatment by Ox8 monoclonal antibodies, in experimental allergic neuritis (EAN). Animals depleted of CD8+ T cells after recovery from EAN did not show any clinical signs of relapse. Other animals were pretreated with the peripheral nerve basic protein P2 and thereby rendered resistant to disease induction with a potentially neuritogenic emulsion. The elimination of CD8+ T cells did not result in EAN here either. Thus, the CD8+ T-cell population does not seem to participate in the suppression of this autoimmune disease under these experimental conditions.

Place, publisher, year, edition, pages
1988. Vol. 28, no 3
Keyword [en]
CD8+, T cells, Lewis rats. monoclonal antibodies, EAN, autoimmune disease
National Category
Neurology
Identifiers
URN: urn:nbn:se:umu:diva-124041PubMedID: 2461582OAI: oai:DiVA.org:umu-124041DiVA: diva2:947389
Available from: 2016-07-08 Created: 2016-07-08 Last updated: 2016-07-08

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