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Oestrogen treatment reduces duration of experimental allergic neuritis in rats and suppresses T cell responses to myelin.
Division of Surgery, CLINTEC, Karolinska Institutet, Department of Surgical Gastroenterology, Karolinska University Hospital, Huddinge, Sweden.
1990 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 81, no 5, 436-442 p.Article in journal (Refereed) Published
Abstract [en]

The effects of oestrogen and pregnancy on the disease course of experimental allergic neuritis (EAN) in rats were investigated. Pregnant rats were totally protected from EAN and long term 17-beta-oestradiol treatment significantly shortened the disease duration. Lymph node cells from oestrogen treated rats had a suppressed proliferative response when stimulated with myelin or PPD, both when the response was measured immediately after cell preparation and after 72 h cell culture in vitro. Serum levels of IgG antibodies against myelin, P2 or PPD did not differ between treated and non-treated rats although oestrogen treated rats had significantly higher levels of total IgG. Immunohistochemical stainings of nerve roots showed less intensive invasion of T lymphocytes in the oestrogen treated group while immunoreactivity to both class I and II major histocompatibility complex antigens did not differ in between the groups. These findings show that oestrogen ameliorates EAN and suggest that this effect is mediated by suppression of T cell dependent immunity. Factors in addition to oestrogen may be operative during pregnancy when a total protection from EAN is obtained.

Place, publisher, year, edition, pages
1990. Vol. 81, no 5, 436-442 p.
Keyword [en]
17-β-oestradiol, pregnancy, T cell response, autoimmune disease, Lewis rats, antibodies
National Category
Neurology
Identifiers
URN: urn:nbn:se:umu:diva-124049PubMedID: 2115722OAI: oai:DiVA.org:umu-124049DiVA: diva2:947440
Available from: 2016-07-08 Created: 2016-07-08 Last updated: 2016-10-18

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