DNA Replication - A Matter of Fidelity
2016 (English)In: Molecular Cell, ISSN 1097-2765, E-ISSN 1097-4164, Vol. 62, no 5, 745-755 p.Article, review/survey (Refereed) PublishedText
The fidelity of DNA replication is determined by many factors, here simplified as the contribution of the DNA polymerase (nucleotide selectivity and proofreading), mismatch repair, a balanced supply of nucleotides, and the condition of the DNA template (both in terms of sequence context and the presence of DNA lesions). This review discusses the contribution and interplay between these factors to the overall fidelity of DNA replication.
Place, publisher, year, edition, pages
2016. Vol. 62, no 5, 745-755 p.
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:umu:diva-122545DOI: 10.1016/j.molcel.2016.05.003ISI: 000377049500011PubMedID: 27259205OAI: oai:DiVA.org:umu-122545DiVA: diva2:949995