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DNA Replication - A Matter of Fidelity
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics. Howard Hughes Medical Institute, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, NY 10016, USA.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
2016 (English)In: Molecular Cell, ISSN 1097-2765, E-ISSN 1097-4164, Vol. 62, no 5, 745-755 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

The fidelity of DNA replication is determined by many factors, here simplified as the contribution of the DNA polymerase (nucleotide selectivity and proofreading), mismatch repair, a balanced supply of nucleotides, and the condition of the DNA template (both in terms of sequence context and the presence of DNA lesions). This review discusses the contribution and interplay between these factors to the overall fidelity of DNA replication.

Place, publisher, year, edition, pages
2016. Vol. 62, no 5, 745-755 p.
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-122545DOI: 10.1016/j.molcel.2016.05.003ISI: 000377049500011PubMedID: 27259205OAI: oai:DiVA.org:umu-122545DiVA: diva2:949995
Available from: 2016-07-26 Created: 2016-06-20 Last updated: 2016-07-26Bibliographically approved

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Ganai, Rais AhmadJohansson, Erik
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