umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
Prevention of Vitamin K Deficiency Bleeding in Newborn Infants: A Position Paper by the ESPGHAN Committee on Nutrition
Show others and affiliations
2016 (English)In: Journal of Pediatric Gastroenterology and Nutrition - JPGN, ISSN 0277-2116, E-ISSN 1536-4801, Vol. 63, no 1, 123-129 p.Article in journal (Refereed) PublishedText
Abstract [en]

Vitamin K deficiency bleeding (VKDB) due to physiologically low vitamin K plasma concentrations is a serious risk for newborn and young infants and can be largely prevented by adequate vitamin K supplementation. The aim of this position paper is to define the condition, describe the prevalence, discuss current prophylaxis practices and outcomes, and to provide recommendations for the prevention of VKDB in healthy term newborns and infants. All newborn infants should receive vitamin K prophylaxis and the date, dose, and mode of administration should be documented. Parental refusal of vitamin K prophylaxis after adequate information is provided should be recorded especially because of the risk of late VKDB. Healthy newborn infants should either receive 1 mg of vitamin K-1 by intramuscular injection at birth; or 3 x 2 mg vitamin K-1 orally at birth, at 4 to 6 days and at 4 to 6 weeks; or 2 mg vitamin K-1 orally at birth, and a weekly dose of 1 mg orally for 3 months. Intramuscular application is the preferred route for efficiency and reliability of administration. The success of an oral policy depends on compliance with the protocol and this may vary between populations and healthcare settings. If the infant vomits or regurgitates the formulation within 1 hour of administration, repeating the oral dose may be appropriate. The oral route is not appropriate for preterm infants and for newborns who have cholestasis or impaired intestinal absorption or are too unwell to take oral vitamin K-1, or those whose mothers have taken medications that interfere with vitamin K metabolism. Parents who receive prenatal education about the importance of vitamin K prophylaxis may be more likely to comply with local procedures.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2016. Vol. 63, no 1, 123-129 p.
Keyword [en]
newborn infant, vitamin K, vitamin K deficiency bleeding
National Category
Gastroenterology and Hepatology Nutrition and Dietetics Pediatrics
Identifiers
URN: urn:nbn:se:umu:diva-124255DOI: 10.1097/MPG.0000000000001232ISI: 000378692400035PubMedID: 27050049OAI: oai:DiVA.org:umu-124255DiVA: diva2:950652
Available from: 2016-08-01 Created: 2016-07-29 Last updated: 2016-08-01Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Domellöf, Magnus
By organisation
Paediatrics
In the same journal
Journal of Pediatric Gastroenterology and Nutrition - JPGN
Gastroenterology and HepatologyNutrition and DieteticsPediatrics

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 11 hits
ReferencesLink to record
Permanent link

Direct link