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A Review of Functional Motifs Utilized by Viruses
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
2016 (English)In: PROTEOMES, ISSN 2227-7382, Vol. 4, no 1, 3Article, review/survey (Refereed) PublishedText
Abstract [en]

Short linear motifs (SLiM) are short peptides that facilitate protein function and protein-protein interactions. Viruses utilize these motifs to enter into the host, interact with cellular proteins, or egress from host cells. Studying functional motifs may help to predict protein characteristics, interactions, or the putative cellular role of a protein. In virology, it may reveal aspects of the virus tropism and help find antiviral therapeutics. This review highlights the recent understanding of functional motifs utilized by viruses. Special attention was paid to the function of proteins harboring these motifs, and viruses encoding these proteins. The review highlights motifs involved in (i) immune response and post-translational modifications (e.g., ubiquitylation, SUMOylation or ISGylation); (ii) virus-host cell interactions, including virus attachment, entry, fusion, egress and nuclear trafficking; (iii) virulence and antiviral activities; (iv) virion structure; and (v) low-complexity regions (LCRs) or motifs enriched with residues (Xaa-rich motifs).

Place, publisher, year, edition, pages
2016. Vol. 4, no 1, 3
Keyword [en]
clathrin endocytosis, low-complexity repeats, ubiquitylation, agnoprotein, APOBEC, pentraxin, PDZ main, retinoblastoma, inhibitor of apoptosis (IAP), transposition
National Category
Cell and Molecular Biology
URN: urn:nbn:se:umu:diva-124204DOI: 10.3390/proteomes4010003ISI: 000378512300003OAI: diva2:950913
Available from: 2016-08-03 Created: 2016-07-28 Last updated: 2016-08-03Bibliographically approved

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Sobhy, Haitham
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