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Longitudinal Evidence for Smaller Hippocampus Volume as a Vulnerability Factor for Perceived Stress
Umeå University, Faculty of Medicine, Department of Nursing. Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
Umeå University, Faculty of Social Sciences, Department of Psychology. Department of Clinical Dentistry, Faculty of Health Sciences, UIT - The Arctic University of Norway, Tromsø, Norway.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Department of Radiation Sciences. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
2016 (English)In: Cerebral Cortex, ISSN 1047-3211, E-ISSN 1460-2199, Vol. 26, no 8, 3527-3533 p.Article in journal (Refereed) Published
Abstract [en]

Hippocampal volume has been found to be smaller in individuals with stress-related disorders, but it remains unclear whether smaller volume is a consequence of stress or rather a vulnerability factor. Here, we examined this issue by relating stress levels to hippocampal volumes in healthy participants examined every 5 years in a longitudinal population-based study. Based on scores of 25- to 60-year-old participants on the perceived stress questionnaire, we defined moderately to high (n = 35) and low (n = 76) stress groups. The groups were re-examined after 5 years (at the 6th study wave). Historical data on subjective stress were available up to 10 years prior to Wave 5. At the first MRI session, the moderately to high stress group had a significantly smaller hippocampal volume, as measured by FreeSurfer (version 5.3), compared with the low-stress group. At follow-up, group differences in stress levels and hippocampal volume remained unchanged. In retrospective analyses of subjective stress, the observed group difference in stress was found to be stable. The long-term stability of group differences in perceived stress and hippocampal volume suggests that a small hippocampal volume may be a vulnerability factor for stress-related disorders.

Place, publisher, year, edition, pages
2016. Vol. 26, no 8, 3527-3533 p.
Keyword [en]
healthy individuals, hippocampal volume, magnetic resonance imaging, stress, susceptibility
National Category
Nursing Applied Psychology
Identifiers
URN: urn:nbn:se:umu:diva-124464DOI: 10.1093/cercor/bhw154PubMedID: 27230217OAI: oai:DiVA.org:umu-124464DiVA: diva2:952410
Available from: 2016-08-12 Created: 2016-08-12 Last updated: 2016-09-14Bibliographically approved

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Lindgren, LenitaBergdahl, JanNyberg, Lars
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Department of NursingDepartment of Surgical and Perioperative SciencesUmeå Centre for Functional Brain Imaging (UFBI)Department of PsychologyDepartment of Integrative Medical Biology (IMB)Department of Radiation Sciences
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Cerebral Cortex
NursingApplied Psychology

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