Change search
ReferencesLink to record
Permanent link

Direct link
Quantification of the smoking-associated cancer risk with rate advancement periods: meta-analysis of individual participant data from cohorts of the CHANCES consortium
Show others and affiliations
2016 (English)In: BMC Medicine, ISSN 1741-7015, E-ISSN 1741-7015, Vol. 14, 62Article in journal (Refereed) PublishedText
Abstract [en]

Background: Smoking is the most important individual risk factor for many cancer sites but its association with breast and prostate cancer is not entirely clear. Rate advancement periods (RAPs) may enhance communication of smoking related risk to the general population. Thus, we estimated RAPs for the association of smoking exposure (smoking status, time since smoking cessation, smoking intensity, and duration) with total and site-specific (lung, breast, colorectal, prostate, gastric, head and neck, and pancreatic) cancer incidence and mortality.

Methods: This is a meta-analysis of 19 population-based prospective cohort studies with individual participant data for 897,021 European and American adults. For each cohort we calculated hazard ratios (HRs) for the association of smoking exposure with cancer outcomes using Cox regression adjusted for a common set of the most important potential confounding variables. RAPs (in years) were calculated as the ratio of the logarithms of the HRs for a given smoking exposure variable and age. Meta-analyses were employed to summarize cohort-specific HRs and RAPs.

Results: Overall, 140,205 subjects had a first incident cancer, and 53,164 died from cancer, during an average follow-up of 12 years. Current smoking advanced the overall risk of developing and dying from cancer by eight and ten years, respectively, compared with never smokers. The greatest advancements in cancer risk and mortality were seen for lung cancer and the least for breast cancer. Smoking cessation was statistically significantly associated with delays in the risk of cancer development and mortality compared with continued smoking.

Conclusions: This investigation shows that smoking, even among older adults, considerably advances, and cessation delays, the risk of developing and dying from cancer. These findings may be helpful in more effectively communicating the harmful effects of smoking and the beneficial effect of smoking cessation.

Place, publisher, year, edition, pages
2016. Vol. 14, 62
Keyword [en]
Smoking, Cancer, Incidence, Mortality, Cohort, Meta-analysis
National Category
Public Health, Global Health, Social Medicine and Epidemiology Cancer and Oncology
URN: urn:nbn:se:umu:diva-120629DOI: 10.1186/s12916-016-0607-5ISI: 000373438100001PubMedID: 27044418OAI: diva2:953226
Available from: 2016-08-17 Created: 2016-05-18 Last updated: 2016-09-12Bibliographically approved

Open Access in DiVA

fulltext(4111 kB)21 downloads
File information
File name FULLTEXT01.pdfFile size 4111 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Söderberg, StefanNilsson, Lena Maria
By organisation
CardiologyNutritional ResearchArctic Research Centre at Umeå University
In the same journal
BMC Medicine
Public Health, Global Health, Social Medicine and EpidemiologyCancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 21 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 23 hits
ReferencesLink to record
Permanent link

Direct link