umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
Systemic Aggregatibacter Actinomycetemccomitans Leukotoxin-Neutralizing Antibodies in Periodontitis.
Umeå University, Faculty of Medicine, Department of Odontology. (Aa-gruppen)ORCID iD: 0000-0002-8069-8263
2016 (English)In: Journal of Periodontology, ISSN 0022-3492, E-ISSN 1943-3670Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND: The leukotoxin expressed by Aggregatibacter actinomycetemcomitans is a powerful exotoxin, which can cause imbalance in the host response. Immunoreactivity to the leukotoxin is a marker for the presence of leukotoxic A. actinomycetemcomitan, a presence that may modify the disease pattern of the colonized individuals. The aim of the present study was to examine the presence of systemic immunoreactivity to A. actionmycetemcomitans leukotoxin in relation to clinical and inflammatory findings in individuals with or without periodontitis (n = 88).

METHODS: The periodontal status was examined in a population of cases (n = 49) and controls (n = 39), and the cases received periodontal treatment. Systemic biomarkers associated with inflammation and infections, as well as the clinical parameters, were analyzed at baseline, three months after treatment and six months after.

RESULTS: The presence of immunoreactivity against leukotoxin was associated with impaired remission of the disease after periodontal treatment. This immunoreactivity was also significantly associated with increased systemic levels of A. actinomycetemcomtans-specific immunoglobulins and increasing age.

CONCLUSION: The presence and levels of systemic immunoreactivity against A. actinomycetemcomitans leukotoxin are associated with a decreased remission after otherwise successful periodontal treatment.

Place, publisher, year, edition, pages
2016.
Keyword [en]
Parodontit, Aggregatibacter actinomycetemcomitans, leukotoxin, Immunologi
National Category
Medical and Health Sciences
Research subject
Clinical Immunology
Identifiers
URN: urn:nbn:se:umu:diva-124619DOI: 10.1902/jop.2016.160193PubMedID: 27523521OAI: oai:DiVA.org:umu-124619DiVA: diva2:953507
Projects
Aa-projektet
Available from: 2016-08-17 Created: 2016-08-17 Last updated: 2016-09-08

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Johansson, Anders
By organisation
Department of Odontology
In the same journal
Journal of Periodontology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 1 hits
ReferencesLink to record
Permanent link

Direct link