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The source of MHC class I presented peptides and its implications
Umeå University, Faculty of Medicine, Department of Medical Biosciences. Equipe Labellisée la Ligue Contre le Cancer, Inserm UMR1162, Université Paris, France ; RECAMO, Masaryk Memorial Cancer Institute, Czech Republic.
2016 (English)In: Current Opinion in Immunology, ISSN 0952-7915, E-ISSN 1879-0372, Vol. 40, 117-122 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

The source of peptides that enter the major histocompatibility class I (MHCI) pathway has been intensively debated over the last two decades. The initial assumption that peptides are derived from degradation of full length proteins was challenged by a model in which alternative translation products are a source of peptides. This model has been tested and supported by scientific data. We now need new hypotheses on the physiological implications of different sources of peptides for the MHCI pathway. The aim of this overview is to give an up-todate account of the source of antigenic peptide material for the MHCI pathway and to incorporate the more recent observations of alternative mRNA translation products into existing models of the direct and cross-presentation pathways.

Place, publisher, year, edition, pages
2016. Vol. 40, 117-122 p.
National Category
Immunology in the medical area
URN: urn:nbn:se:umu:diva-123980DOI: 10.1016/j.coi.2016.04.002ISI: 000377836700017PubMedID: 27105144OAI: diva2:953771
Available from: 2016-08-18 Created: 2016-07-07 Last updated: 2016-08-18Bibliographically approved

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