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Design and Synthesis of 2,2'-Diindolylmethanes to Selectively Target Certain G-Quadruplex DNA Structures
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
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2016 (English)In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 22, no 37, 13004-13009 p.Article in journal (Refereed) Published
Abstract [en]

G-quadruplex (G4) structures carry vital biological functions, and compounds that selectively target certain G4 structures have both therapeutic potential and value as research tools. Along this line, 2,2'-diindolylmethanes have been designed and synthesized in this work based on the condensation of 3,6- or 3,7-disubstituted indoles with aldehydes. The developed class of compounds efficiently stabilizes G4 structures without inducing conformational changes in such structures. Furthermore, the 2,2'-diindolylmethanes target certain G4 structures more efficiently than others and this G4 selectivity can be altered by chemical modifications of the compounds.

Place, publisher, year, edition, pages
2016. Vol. 22, no 37, 13004-13009 p.
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:umu:diva-124638DOI: 10.1002/chem.201602416ISI: 000383763200005PubMedID: 27431593OAI: oai:DiVA.org:umu-124638DiVA: diva2:953819
Available from: 2016-08-18 Created: 2016-08-18 Last updated: 2016-10-19Bibliographically approved

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Livendahl, MadeleineJamroskovic, JanIvanova, SvetlanaDemirel, PeterSabouri, NasimChorell, Erik
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Department of ChemistryDepartment of Medical Biochemistry and Biophysics
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