umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
Neutrophil-derived heparin binding protein--a mediator of increased vascular permeability after burns?
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology. Department of Perioperative Medicine, Faculty of Health Sciences, Linköping University Hospital, Linköping, Sweden.
2009 (English)In: Burns, ISSN 0305-4179, E-ISSN 1879-1409, Vol. 35, no 8Article in journal (Refereed) Published
Abstract [en]

Increased vascular permeability and oedema formation constitute a major clinical challenge following burns. Several clinical studies show that leukocytes are systemically activated following burns. Neutrophils have the capability to increase vascular permeability via mechanisms thought to involve the release of heparin binding protein (HBP). We hypothesised that HBP is elevated in plasma after major burns due to a systemic inflammatory response and investigated plasma-HBP concentrations in 10 severely burned patients daily for 1 week following the burn. Five-fold higher levels in plasma-HBP concentration compared to a control group were detected on the first day after injury, followed by a steep reduction in the time-period that corresponds to the last part of the hyperpermeability phase. These data are in accordance with the hypothesis that HBP may function as a mediator of the early burn-induced increase in vascular permeability, and call for further studies to confirm a possible cause-and-effect relationship between HBP and oedema formation following burns.

Place, publisher, year, edition, pages
2009. Vol. 35, no 8
National Category
Anesthesiology and Intensive Care
Identifiers
URN: urn:nbn:se:umu:diva-124888DOI: 10.1016/j.burns.2009.02.021PubMedID: 19477593OAI: oai:DiVA.org:umu-124888DiVA: diva2:956237
Available from: 2016-08-29 Created: 2016-08-29 Last updated: 2016-08-29

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Johansson, Joakim
By organisation
Anaesthesiology
In the same journal
Burns
Anesthesiology and Intensive Care

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

ReferencesLink to record
Permanent link

Direct link