umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
A Proton Water T1-NMRD Study of Ganglioside Micelles
Umeå University, Faculty of Science and Technology, Department of Chemistry.
2016 (English)In: Universal Journal of Chemistry, Vol. 4, no 2, 69-73 p.Article in journal (Refereed) Published
Abstract [en]

Ganglioside GM1 (GM1) micelles have been studied by means of water proton T1 NMRD experiment. The field dependent spin-lattice relaxation rates were measured for Larmor frequencies ranging from 0.1 to 40 MHz and for two micelle concentrations at three temperatures (T=10,15,20oC). The proton T1 NMRD-profiles are well described by assuming two proton pools are responsible for the dispersion curves. The proton pools are characterized by an effective correlation time and a proton fraction. The largest correlation time, τc,1 ≈ 130−160 ns, is determined by the low field part of the NMRD profile. The second correlation time, τc,2 ≈ 12 ns, is determined by the high fieldpartoftheNMRDprofile. Theradiusoftheganglioside micelles has previously been determined as about 54 using fluorescence experiments and with Stoke-Einstein relation the reorientation correlation time becomes τR= 120-165 ns depending on the temperature dependence of the water viscosity. It is thus plausible to identify one pool of waterprotons, characterized by the largest effective correlation time, as corresponding to waters residing in the headgroup withanorderparameterS6=0andτc,1 ≈ τR orcorresponding to labile protons with a τc,1as the mean life time. The proton NMRD profile reveal a second Lorenzian which also can eitherbelabileandexchangingGangliosideprotonsorwater moleculesresidingintheheadgroupwithameanlifetimeas approximately 12 ns. The proton NMRD experiment cannot discriminate between these two cases.

Place, publisher, year, edition, pages
2016. Vol. 4, no 2, 69-73 p.
Keyword [en]
Proton T1.NMRD Profiels, Proton Spin-lattice Relaxation, Ganglioside Micelles
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:umu:diva-124908DOI: 10.13189/ujc.2016.040204OAI: oai:DiVA.org:umu-124908DiVA: diva2:956454
Available from: 2016-08-30 Created: 2016-08-30 Last updated: 2016-08-30

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Westlund, Per-Olof
By organisation
Department of Chemistry
Chemical Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 44 hits
ReferencesLink to record
Permanent link

Direct link