A randomized controlled cross-over study of the effect of alcohol-free chlorhexidine and essential oils on interleukin-1 levels in crevicular fluid
2016 (English)In: Swedish Dental Journal, ISSN 0347-9994, Vol. 40, no 2, 143-152 p.Article in journal (Refereed) Published
Aim of the study was to determine the effect of an alcohol-free chlorhexidine mouth rinse and an essential oils containing mouth rinse on pro-inflammatory cytokine levels in gingival crevicular fluid in participa nts who continue to perform their regula r mechanical oral hygiene regimes and normal dietary practice.
Twenty adult volunteers (mean age: 59 yea rs) participated in the double-blind randomised controlled cross-over study. Three mouth rinses were used during 16-day periods as an adjuncti ve to regular mecha nical oral hygiene:a solution with alcohol-free chlorhexidine (CHX; Paroex®), a solution with essentialoils (EO; Listerine®), and water (negative control). The mouth rinse periods were separated by 3-month washout periods.
At days o (baseline) and 17 (end) of each mouth rinse period, gingiva lcrevicular fluid (GCF)
was collected at different tooth sites and analyzed with ELISA technique for IL-1a,IL-115 and IL-ira leveIs.
No significant correlations between clinical parameters (QHI and GI) and cytokine concentra tions were observed, regardless of mouth rinse regimen.The generalized linear modeIs revealed that none of the mouth rinses had a statistically significant impact on IL-1 concentrations in GCF. Large inter-individual variations were observed for the levels of IL-1a, IL-115 and IL-1ra. Also the changes in concentrations between day o and day 17 for the mouthrinses showed Iarge intra-individual variations.
It can be concluded that neither the alcohol-free chlorhexidine nor the mouth rinse contain ing essential oils reduced the levels of IL-ia, IL-115 and IL-ira in GCF.
Place, publisher, year, edition, pages
2016. Vol. 40, no 2, 143-152 p.
Clinical, chlorhexidine, crevicu/arfluid, cytokines, essential oi/s, mouth rinse
IdentifiersURN: urn:nbn:se:umu:diva-125067OAI: oai:DiVA.org:umu-125067DiVA: diva2:957826