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A randomized controlled cross-over study of the effect of alcohol-free chlorhexidine and essential oils on interleukin-1 levels in crevicular fluid
Umeå University, Faculty of Medicine, Department of Odontology.
Umeå University, Faculty of Medicine, Department of Odontology.
2016 (English)In: Swedish Dental Journal, ISSN 0347-9994, Vol. 40, no 2, 143-152 p.Article in journal (Refereed) Published
Abstract [en]

Aim of the study was to determine the effect of an alcohol-free chlorhexidine mouth rinse and an essential oils containing mouth rinse on pro-inflammatory cytokine levels in gingival crevicular fluid in participa nts who continue to perform their regula r mechanical oral hygiene regimes and normal dietary practice.

Twenty adult volunteers (mean age: 59 yea rs) participated in the double-blind randomised controlled cross-over study. Three mouth rinses were used during 16-day periods as an adjuncti­ ve to regular mecha nical oral hygiene:a solution with alcohol-free chlorhexidine (CHX; Paroex®), a solution with essentialoils (EO; Listerine®), and water (negative control). The mouth rinse periods were separated by 3-month washout periods.

At days o (baseline) and 17 (end) of each mouth rinse period, gingiva lcrevicular fluid (GCF)

was collected at different tooth sites and analyzed with ELISA technique for IL-1a,IL-115 and IL-ira leveIs.

No significant correlations between clinical parameters (QHI and GI) and cytokine concentra­ tions were observed, regardless of mouth rinse regimen.The generalized linear modeIs revealed that none of the mouth rinses had a statistically significant impact on IL-1 concentrations in GCF. Large inter-individual variations were observed for the levels of IL-1a, IL-115 and IL-1ra. Also the changes in concentrations between day o and day 17 for the mouthrinses showed Iarge intra-individual  variations.

It can  be concluded that  neither the alcohol-free  chlorhexidine  nor the  mouth  rinse contain­ ing essential oils reduced the levels of IL-ia, IL-115 and IL-ira in GCF.

Place, publisher, year, edition, pages
2016. Vol. 40, no 2, 143-152 p.
Keyword [en]
Clinical, chlorhexidine, crevicu/arfluid, cytokines, essential oi/s, mouth rinse
National Category
URN: urn:nbn:se:umu:diva-125067OAI: diva2:957826
Available from: 2016-09-05 Created: 2016-09-05 Last updated: 2016-09-06

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Wikén Albertsson, KatarinaVan Dijken, Jan
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