Persisters - as elusive as ever
2016 (English)In: Applied Microbiology and Biotechnology, ISSN 0175-7598, E-ISSN 1432-0614, Vol. 100, no 15, 6545-6553 p.Article, review/survey (Refereed) PublishedText
Persisters-a drug-tolerant sub-population in an isogenic bacterial culture-have been featured throughout the last decade due to their important role in recurrent bacterial infections. Numerous investigations detail the mechanisms responsible for the formation of persisters and suggest exciting strategies for their eradication. In this review, we argue that the very term "persistence" is currently used to describe a large and heterogeneous set of physiological phenomena that are functions of bacterial species, strains, growth conditions, and antibiotics used in the experiments. We caution against the oversimplification of the mechanisms of persistence and urge for a more rigorous validation of the applicability of these mechanisms in each case.
Place, publisher, year, edition, pages
2016. Vol. 100, no 15, 6545-6553 p.
Antibiotic tolerance, Antibiotic resistance, Persisters, Bet hedging, Antibiotic development, Bacterial infections
Microbiology in the medical area
IdentifiersURN: urn:nbn:se:umu:diva-124313DOI: 10.1007/s00253-016-7648-8ISI: 000379317300003PubMedID: 27262568OAI: oai:DiVA.org:umu-124313DiVA: diva2:958157