umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
The Role of microRNAs in Animal Cell Reprogramming
Show others and affiliations
2016 (English)In: Stem Cells and Development, ISSN 1547-3287, E-ISSN 1557-8534, Vol. 25, no 14, 1035-1049 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

Our concept of cell reprogramming and cell plasticity has evolved since John Gurdon transferred the nucleus of a completely differentiated cell into an enucleated Xenopus laevis egg, thereby generating embryos that developed into tadpoles. More recently, induced expression of transcription factors, oct4, sox2, klf4, and c-myc has evidenced the plasticity of the genome to change the expression program and cell phenotype by driving differentiated cells to the pluripotent state. Beyond these milestone achievements, research in artificial cell reprogramming has been focused on other molecules that are different than transcription factors. Among the candidate molecules, microRNAs (miRNAs) stand out due to their potential to control the levels of proteins that are involved in cellular processes such as self-renewal, proliferation, and differentiation. Here, we review the role of miRNAs in the maintenance and differentiation of mesenchymal stem cells, epimorphic regeneration, and somatic cell reprogramming to induced pluripotent stem cells.

Place, publisher, year, edition, pages
2016. Vol. 25, no 14, 1035-1049 p.
National Category
Cell Biology
Identifiers
URN: urn:nbn:se:umu:diva-124325DOI: 10.1089/scd.2015.0359ISI: 000379611100001PubMedID: 27224014OAI: oai:DiVA.org:umu-124325DiVA: diva2:963016
Available from: 2016-09-07 Created: 2016-08-04 Last updated: 2016-09-07Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Bako, Laszlo
By organisation
Department of Plant Physiology
In the same journal
Stem Cells and Development
Cell Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

ReferencesLink to record
Permanent link

Direct link