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Alterations in factors involved in differentiation and barrier function in the epithelium in oral and genital lichen planus
Umeå University, Faculty of Medicine, Department of Odontology. (OLP GRUPPEN)
Umeå University, Faculty of Medicine, Department of Odontology. (OLP gruppen)
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Dermatology and Venerology. (OLP gruppen)
Umeå University, Faculty of Medicine, Department of Odontology. (OLP gruppen)
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2017 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 97, no 2, 214-218 p.Article in journal, Editorial material (Refereed) Published
Abstract [en]

Lichen planus is a chronic recurrent inflammatory disease affecting both skin and mucosa, mainly in oral and/or genital regions. Keratinocytes go through a well-regulated process of proliferation and differentiation, alterations in which may result in defects in the protective epithelial barrier. Long-term barrier impairment might lead to chronic inflammation. In order to broaden our understanding of the differentiation process in mucosal lichen planus, we mapped the expression of 4 factors known to be involved in differentiation. Biopsies were collected from oral and genital lichen planus lesions and normal controls. Altered expression of all 4 factors in epithelium from lichen planus lesions was found, clearly indicating disturbed epithelial differentiation in lichen planus lesions.

Place, publisher, year, edition, pages
2017. Vol. 97, no 2, 214-218 p.
Keyword [en]
lichen planus, differentiation, epithelial barrier
National Category
Dentistry Dermatology and Venereal Diseases
Research subject
Medical Cell Biology; Pathology
Identifiers
URN: urn:nbn:se:umu:diva-125780DOI: 10.2340/00015555-2533ISI: 000393895500009PubMedID: 27599552OAI: oai:DiVA.org:umu-125780DiVA: diva2:971404
Available from: 2016-09-16 Created: 2016-09-16 Last updated: 2017-04-21Bibliographically approved

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Danielsson, KarinEbrahimi, MajidNylander, ElisabetWahlin, Ylva BrittNylander, Karin
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