umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
Alterations in Factors Involved in Differentiation and Barrier Function in the Epithelium in Oral and Genital Lichen Planus.
Umeå University, Faculty of Medicine, Department of Odontology, Endodontics. Umeå University, Faculty of Medicine, Department of Odontology, Oral Diagnostics. (Lichen gruppen Umeå)
2016 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057Article in journal, Editorial material (Refereed) Published
Abstract [en]

Lichen planus is a chronic recurrent inflammatory disease affecting both skin and mucosa, mainly in oral and/or genital regions. Keratinocytes go through a well-regulated process of proliferation and differentiation, alterations in which may result in defects in the protective epithelial barrier. Long-term barrier impairment might lead to chronic inflammation. In order to broaden our understanding of the differentiation process in mucosal lichen planus, we mapped the expression of 4 factors known to be involved in differentiation. Biopsies were collected from oral and genital lichen planus lesions and normal controls. Altered expression of all 4 factors in epithelium from lichen planus lesions was found, clearly indicating disturbed epithelial differentiation in lichen planus lesions.

Place, publisher, year, edition, pages
2016.
National Category
Medical and Health Sciences
Research subject
Medical Cell Biology; Pathology
Identifiers
URN: urn:nbn:se:umu:diva-125780DOI: 10.2340/00015555-2533OAI: oai:DiVA.org:umu-125780DiVA: diva2:971404
Available from: 2016-09-16 Created: 2016-09-16 Last updated: 2016-09-16

Open Access in DiVA

No full text

Other links

Publisher's full texthttp://www.medicaljournals.se/acta/content/?doi=10.2340/00015555-2533

Search in DiVA

By author/editor
Ebrahimi, Majid
By organisation
EndodonticsOral Diagnostics
In the same journal
Acta Dermato-Venereologica
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 4 hits
ReferencesLink to record
Permanent link

Direct link