Change search
ReferencesLink to record
Permanent link

Direct link
Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells
Show others and affiliations
2016 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 7, 12175Article in journal (Refereed) Published
Abstract [en]

Wiskott-Aldrich syndrome (WAS) is caused by loss-of-function mutations in the WASp gene. Decreased cellular responses in WASp-deficient cells have been interpreted to mean that WASp directly regulates these responses in WASp-sufficient cells. Here, we identify an exception to this concept and show that WASp-deficient dendritic cells have increased activation of Rac2 that support cross-presentation to CD8(+) T cells. Using two different skin pathology models, WASp-deficient mice show an accumulation of dendritic cells in the skin and increased expansion of IFN gamma-producing CD8(+) T cells in the draining lymph node and spleen. Specific deletion of WASp in dendritic cells leads to marked expansion of CD8(+) T cells at the expense of CD4(+) T cells. WASp-deficient dendritic cells induce increased cross-presentation to CD8(+) T cells by activating Rac2 that maintains a near neutral pH of phagosomes. Our data reveals an intricate balance between activation of WASp and Rac2 signalling pathways in dendritic cells.

Place, publisher, year, edition, pages
2016. Vol. 7, 12175
National Category
Cell and Molecular Biology
URN: urn:nbn:se:umu:diva-125592DOI: 10.1038/ncomms12175ISI: 000380810700001PubMedID: 27425374OAI: diva2:971768
Available from: 2016-09-19 Created: 2016-09-13 Last updated: 2016-09-19Bibliographically approved

Open Access in DiVA

fulltext(2852 kB)14 downloads
File information
File name FULLTEXT01.pdfFile size 2852 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Forsell, Mattias N. E.
By organisation
In the same journal
Nature Communications
Cell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 14 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 44 hits
ReferencesLink to record
Permanent link

Direct link