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  • 1.
    Börschel, Christin S.
    et al.
    Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany.
    Geelhoed, Bastiaan
    Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany.
    Niiranen, Teemu
    Finnish Institute for Health and Welfare, Helsinki, Finland; Deparment of Internal Medicine, University of Turku, Turku, Finland; Division of Medicine, Turku University Hospital, Turku, Finland.
    Camen, Stephan
    Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany.
    Donati, Maria Benedetta
    Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy.
    Havulinna, Aki S.
    Finnish Institute for Health and Welfare, Helsinki, Finland; Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland.
    Gianfagna, Francesco
    Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy; Mediterranea Cardiocentro, Naples, Italy.
    Palosaari, Tarja
    Finnish Institute for Health and Welfare, Helsinki, Finland.
    Jousilahti, Pekka
    Finnish Institute for Health and Welfare, Helsinki, Finland.
    Kontto, Jukka
    Finnish Institute for Health and Welfare, Helsinki, Finland.
    Vartiainen, Erkki
    Finnish Institute for Health and Welfare, Helsinki, Finland.
    Ojeda, Francisco M.
    Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany.
    den Ruijter, Hester M.
    Laboratory for Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
    Costanzo, Simona
    Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy.
    de Gaetano, Giovanni
    Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy.
    Di Castelnuovo, Augusto
    Mediterranea Cardiocentro, Naples, Italy.
    Linneberg, Allan
    Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Centre for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark.
    Vishram-Nielsen, Julie K.
    Centre for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark; Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
    Løchen, Maja-Lisa
    Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
    Koenig, Wolfgang
    German Heart Centre Munich, Technical University of Munich, Munich, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance Munich, Munich, Germany; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany.
    Jørgensen, Torben
    Centre for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
    Kuulasmaa, Kari
    Finnish Institute for Health and Welfare, Helsinki, Finland.
    Blankenberg, Stefan
    Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany.
    Iacoviello, Licia
    Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy; Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy.
    Zeller, Tanja
    Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany; University Center of Cardiovascular Science, University Heart and Vascular Center Hamburg-Eppendorf, Hamburg, Germany.
    Söderberg, Stefan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Salomaa, Veikko
    Finnish Institute for Health and Welfare, Helsinki, Finland.
    Schnabel, Renate B.
    Department of Cardiology, University Heart and Vascular Centre Hamburg-Eppendorf, Hamburg, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany.
    Risk prediction of atrial fibrillation and its complications in the community using hs troponin I2023In: European Journal of Clinical Investigation, ISSN 0014-2972, E-ISSN 1365-2362, Vol. 53, no 5, article id e13950Article in journal (Refereed)
    Abstract [en]

    Aims: Atrial fibrillation (AF) is becoming increasingly common. Traditional cardiovascular risk factors (CVRF) do not explain all AF cases. Blood-based biomarkers reflecting cardiac injury such as high-sensitivity troponin I (hsTnI) may help close this gap.

    Methods: We investigated the predictive ability of hsTnI for incident AF in 45,298 participants (median age 51.4 years, 45.0% men) across European community cohorts in comparison to CVRF and established biomarkers (C-reactive protein, N-terminal pro B-type natriuretic peptide).

    Results: During a median follow-up of 7.7 years, 1734 (3.8%) participants developed AF. Those in the highest hsTnI quarter (≥4.2 ng/L) had a 3.91-fold (95% confidence interval (CI) 3.30, 4.63; p <.01) risk for developing AF compared to the lowest quarter (<1.4 ng/L). In multivariable-adjusted Cox proportional hazards models a statistically significant association was seen between hsTnI and AF (hazard ratio (HR) per 1 standard deviation (SD) increase in log10(hsTnI) 1.08; 95% CI 1.01, 1.16; p =.03). Inclusion of hsTnI did improve model discrimination (C-index CVRF 0.811 vs. C-index CVRF and hsTnI 0.813; p <.01). Higher hsTnI concentrations were associated with heart failure (HR per SD 1.37; 95% CI 1.12, 1.68; p <.01) and overall mortality (HR per SD 1.24; 95% CI 1.09, 1.41; p <.01).

    Conclusion: hsTnI as a biomarker of myocardial injury does not improve prediction of AF incidence beyond classical CVRF and NT-proBNP. However, it is associated with the AF-related disease heart failure and mortality likely reflecting underlying subclinical cardiovascular impairment.

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  • 2. Jansson, PA
    et al.
    Eliasson, B
    Lindmark, Stina
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Eriksson, JW
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Endocrine abnormalities in healthy first-degree relatives of type 2 diabetes patients: potential role of steroid hormones and leptin in the development of insulin resistance2002In: European Journal of Clinical Investigation, ISSN 0014-2972, E-ISSN 1365-2362, Vol. 32, no 3, p. 172-178Article in journal (Refereed)
    Abstract [en]

    BackgroundFirst-degree relatives of type 2 diabetes patients are at risk of developing diabetes and they display several metabolic and hormonal perturbations. The interplay between insulin resistance, steroid hormones and circulating leptin is, however, still not fully explored in this group.

    DesignThirty-three healthy first-degree relatives of type 2 diabetic patients (relatives; M/F 19/14) were compared to 33 healthy subjects without a family history of diabetes (controls) and the groups were matched for gender, age and body mass index (BMI). We performed euglycaemic hyperinsulinaemic clamps and blood was sampled for hormone analyses.

    ResultsRelatives exhibited decreased insulin sensitivity (index of metabolic clearance rate of glucose; MCRI) but when genders were analysed separately, this difference was significant only in males (11·3 ± 1·3 vs. 15·0 ± 1·5 units, means ± SEM, P = 0·030). In male relatives morning cortisol and testosterone levels were lower, whereas leptin was higher than in male controls (P = 0·018, 0·008 and 0·063, respectively). In male relatives plasma testosterone levels were significantly associated with insulin sensitivity (r = 0·48, P = 0·040). Circulating leptin levels were inversely correlated with insulin sensitivity in all subject groups (r-values –0·49 to –0·66; P < 0·05, except in female control subjects P = 0·063). These associations were present also when age and BMI or waist : hip ratio were included in stepwise multiple regression analyses.

    ConclusionMale subjects genetically predisposed for type 2 diabetes display several endocrine abnormalities including leptin, cortisol and testosterone levels. Dysregulation of these hormones may be important in the development of insulin resistance and type 2 diabetes.

  • 3. Meinderts, S. M.
    et al.
    Oldenborg, Per-Arne
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
    Beuger, B.
    Kuijpers, T. W.
    van den Berg, T. K.
    van Bruggen, R.
    Antibody-mediated phagocytosis of red blood cells by neutrophils in the human spleen2016In: European Journal of Clinical Investigation, ISSN 0014-2972, E-ISSN 1365-2362, Vol. 46, p. 77-77Article in journal (Other academic)
  • 4.
    Ruge, Toralph
    et al.
    Umeå University, Faculty of Medicine, Surgical and Perioperative Sciences, Surgery.
    Sukonina, V
    Umeå University, Faculty of Medicine, Medical Biosciences, Physiological chemistry.
    Myrnäs, Torbjörn
    Umeå University, Faculty of Medicine, Surgical and Perioperative Sciences, Surgery.
    Lundgren, Magdalena
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Olivecrona, G
    Umeå University, Faculty of Medicine, Medical Biosciences, Physiological chemistry.
    Lipoprotein lipase activity/mass ratio is higher in omental than in subcutaneous adipose tissue.2006In: European Journal of Clinical Investigation, ISSN 0014-2972, E-ISSN 1365-2362, Vol. 36, no 1, p. 16-21Article in journal (Refereed)
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