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  • 1.
    Andersson, Marie
    et al.
    Umeå University, Faculty of Medicine, Molecular Biology (Faculty of Medicine).
    Nordstrand, Annika
    Shamaei-Tousi, Alireza
    Jansson, Anna
    Bergström, Sven
    Umeå University, Faculty of Medicine, Molecular Biology (Faculty of Medicine).
    Guo, Betty P
    Umeå University, Faculty of Medicine, Molecular Biology (Faculty of Medicine).
    In situ immune response in brain and kidney during early relapsing fever borreliosis.2007In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 183, no 1-2, p. 26-32Article in journal (Refereed)
  • 2. Burman, Joachim
    et al.
    Svenningsson, Anders
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
    Cerebrospinal fluid concentration of Galectin-9 is increased in secondary progressive multiple sclerosis2016In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 292, p. 40-44Article in journal (Refereed)
    Abstract [en]

    Galectin-9 is produced by activated astrocytes, induces a pro -inflammatory response in microglia and maybe important to the pathogenesis of secondary progressive MS. In this study, Galectin-9 concentrations in CSF samples from healthy controls and two independent patient cohorts of MS patients were determined by ELISA. Patients from one of the cohorts underwent MRI as well. Galectin-9 concentrations in CSF were higher in SPMS patients than healthy controls and RRMS patients in both cohorts. Galectin-9 concentrations correlated with the number of lesions on Tl-weighted images, but not with gadolinium enhancing lesions, IgG index or CSF cell count.

  • 3. Burman, Joachim
    et al.
    Svensson, Emma
    Fransson, Moa
    Loskog, Angelica S. I.
    Zetterberg, Henrik
    Raininko, Raili
    Svenningsson, Anders
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
    Fagius, Jan
    Mangsbo, Sara M.
    The cerebrospinal fluid cytokine signature of multiple sclerosis: A homogenous response that does not conform to the Th1/Th2/Th17 convention2014In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 277, no 1-2, p. 153-159Article in journal (Refereed)
    Abstract [en]

    In this cross-sectional study, we wanted to identify key cytokines characteristic of different stages of multiple sclerosis (MS). To this end, cerebrospinal fluid from patients with MS was investigated with a multiplexed fluorescent bead-based immunoassay. In total 43 cytokines were assessed and related to clinical and imaging data. Increased levels of CCL22, CXCL10 and sCD40L characterized relapsing-remitting MS patients with the presence of gadolinium-enhancing lesions; decreased CCL2 and increased CXCL1 and CCL5 were typical of relapsing-remitting MS patients irrespectively of the presence of gadolinium-enhancing lesions. These homogenous patterns of cytokine activation do not conform to conventional Th1/Th2/Th17 responses. (C) 2014 Elsevier B.V. All rights reserved.

  • 4. Gruden, Marina A.
    et al.
    Sewell, Robert D. E.
    Yanamandra, Kiran
    Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
    Davidova, Tatyana V.
    Kucheryanu, Valery G.
    Bocharov, Evgeny V.
    Bocharova, Olga A.
    Poleschuk, Vsevolod V.
    Sherstnev, Vladimir V.
    Morozova-Roche, Ludmilla A.
    Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
    Immunoprotection against toxic biomarkers is retained during Parkinson's disease progression (vol 233, pg 221, 2011)2014In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 268, no 1-2, p. 99-99Article in journal (Refereed)
  • 5. Gruden, Marina A
    et al.
    Sewell, Robert D E
    Yanamandra, Kiran
    Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
    Davidova, Tatyana V
    Kucheryanu, Valery G
    Bocharov, Evgeny V
    Bocharova, Olga R
    Polyschuk, Vsevolod V
    Sherstnev, Vladimir V
    Morozova-Roche, Ludmilla A
    Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
    Immunoprotection against toxic biomarkers is retained during Parkinson's disease progression2011In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 233, no 1-2, p. 221-227Article in journal (Refereed)
    Abstract [en]

    The aim was to ascertain any possible linkage between humoral immune responses to principal biomarkers (α-synuclein monomers, its toxic oligomers or fibrils, dopamine and S100B) and cellular immunity in Parkinson's disease development. There were elevated autoantibody titers to α-synuclein monomers, oligomers plus fibrils in 72%, 56%, and 17% of Parkinsonian patients respectively with a 5-year disease duration. Additionally, there were increased titers to dopamine and S100B (96% and 89%) in the 5-year patient group. All of these values subsided in 10-year sufferers. Furthermore, CD3+, CD4+, CD8+ T-lymphocyte and B-lymphocyte subsets declined in the patient cohort during Parkinsonism indicating disease associated reductions in these lymphocyte subsets.

  • 6. Khademi, Mohsen
    et al.
    Dring, Ann
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
    Gilthorpe, Jonathan
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
    Wuolikainen, Anna
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Al Nimer, Faiez
    Harris, Robert
    Andersson, Magnus
    Brundin, Lou
    Piehl, Fredrik
    Olsson, Tomas
    Svenningsson, Anders
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
    Multivariate analysis of inflammatory and neuronal injury markers in cerebrospinal fluid of multiple sclerosis: higher levels are associated with younger age2012In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 253, no 1-2, p. 100-100Article in journal (Other academic)
  • 7.
    Nilsson, Olov
    et al.
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Pharmacology.
    Hellqvist, Hedvig
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Pharmacology.
    Investigation of brain endothelial cell lines as models of the blood-brain barrier2012In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 253, no 1-2, p. 39-39Article in journal (Other academic)
  • 8. Ojala, Johanna O
    et al.
    Timonen, Anne
    Sutinen, Elina M
    Suuronen, Tiina
    Pirttila, Tuula
    Anderson, George
    Salminen, Antero
    Kangas, Lauri
    Thornell, Anders
    Umeå University.
    Neuroprotective potential of estrogens and estrogenic compounds against amyloid-beta and oxidative stress2012In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 253, no 1-2, p. 110-110Article in journal (Other academic)
  • 9.
    Strigård, Karin
    et al.
    Division of Surgery, CLINTEC, Karolinska Institutet, Department of Surgical Gastroenterology, Karolinska University Hospital, Huddinge, Sweden.
    Larsson, Per
    Holmdahl, Rikard
    Klareskog, Lars
    Olsson, Tomas
    In vivo monoclonal antibody treatment with Ox19 (anti-rat CD5) causes disease relapse and terminates P2-induced immunospecific tolerance in experimental allergic neuritis.1989In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 23, no 1, p. 11-18Article in journal (Refereed)
    Abstract [en]

    The role of CD5+ lymphocytes in the recovery phase and on immunospecific protection against experimental allergic neuritis (EAN) was examined in Lewis rats by in vivo treatment with Ox19, a mouse anti-rat CD5 monoclonal antibody. Animals pretreated with the peripheral nerve basic protein P2 and thereby rendered resistant to the disease showed clinical signs of EAN after intraperitoneal (i.p.) Ox19 injection given at the same time as the rechallenge with neuritogenic doses of myelin in Freund's complete adjuvant. Non-pretreated rats recovered from signs of EAN developed a clinical relapse after i.p. Ox19 injections. Taken together, these data suggest an important regulatory role of the CD5 receptor in the immune response.

  • 10. Sundqvist, Emilie
    et al.
    Bergström, Tomas
    Daialhosein, Hadi
    Sundström, Peter
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
    Hillert, Jan
    Alfredsson, Lars
    Kockum, Ingrid
    Olsson, Tomas
    Varicella zoster virus IgG titers correlate with multiple sclerosis2012In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 253, no 1-2, p. 138-139Article in journal (Other academic)
  • 11.
    Sundström, Peter
    et al.
    Umeå University, Faculty of Medicine, Pharmacology and Clinical Neuroscience, Neurology.
    Nyström, Maria
    Umeå University, Faculty of Medicine, Molecular Biology (Faculty of Medicine).
    Ruuth, Kristina
    Umeå University, Faculty of Medicine, Molecular Biology (Faculty of Medicine).
    Lundgren, Erik
    Umeå University, Faculty of Medicine, Molecular Biology (Faculty of Medicine).
    Antibodies to specific EBNA-1 domains and HLA DRB1*1501 interact as risk factors for multiple sclerosis.2009In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 215, no 1-2, p. 102-107Article in journal (Refereed)
    Abstract [en]

    Epitope reactivity of multiple sclerosis (MS) plasma antibodies against the Epstein-Barr virus protein EBNA-1 and its association with HLA DRB1*1501 status was investigated in a case-referent study. Based on EBNA-1 fragment reactivity and the effect of peptide blocking, four 29-36 amino acid long EBNA-1 fragments were selected for detailed studies. MS cases had increased antibody reactivity against several EBNA-1 domains, of which antibodies against EBNA-1 (amino acid 385-420) in HLA DRB1*1501 positive individuals were associated with a 24-fold risk increase for MS. The data need confirmation in a larger sample but suggest a role for this epitope in the autoimmune pathogenesis of MS.

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