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  • 1. Andersson, I-M
    et al.
    Lindahl, Roger
    Arbetsmiljöinstitutet.
    Nygren, Olle
    Arbetsmiljöinstitutet.
    Stor, H
    Sundström-Frisk, C
    Intermediärers roll2006In: Arbetsmiljöarbete i Sverige 2004: En kunskapssammanställning över strategier, metoder och arbetssätt för arbetsmiljöarbete / [ed] Andersson I-M, Hägg G, Rosén G, Stockholm: Arbetslivsinstitutet , 2006Chapter in book (Refereed)
  • 2.
    Bidleman, Terry
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Agosta, Kathleen
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Andersson, Agneta
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Brorström-Lundén, Eva
    Haglund, Peter
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Hansson, Katarina
    Laudon, Hjalmar
    Newton, Seth
    Nygren, Olle
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Ripszam, Matyas
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Tysklind, Mats
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Wiberg, Karin
    Atmospheric pathways of chlorinated pesticides and natural bromoanisoles in the northern Baltic Sea and its catchment2015In: Ambio, ISSN 0044-7447, E-ISSN 1654-7209, Vol. Suppl 3, no 44, p. 472-483Article in journal (Refereed)
    Abstract [en]

    Long-range atmospheric transport is a major pathway for delivering persistent organic pollutants to the oceans. Atmospheric deposition and volatilization of chlorinated pesticides and algae-produced bromoanisoles (BAs) were estimated for Bothnian Bay, northern Baltic Sea, based on air and water concentrations measured in 2011-2012. Pesticide fluxes were estimated using monthly air and water temperatures and assuming 4 months ice cover when no exchange occurs. Fluxes were predicted to increase by about 50 % under a 2069-2099 prediction scenario of higher temperatures and no ice. Total atmospheric loadings to Bothnian Bay and its catchment were derived from air-sea gas exchange and "bulk'' (precipitation ? dry particle) deposition, resulting in net gains of 53 and 46 kg year(-1) for endosulfans and hexachlorocyclohexanes, respectively, and net loss of 10 kg year(-1) for chlordanes. Volatilization of BAs releases bromine to the atmosphere and may limit their residence time in Bothnian Bay. This initial study provides baseline information for future investigations of climate change on biogeochemical cycles in the northern Baltic Sea and its catchment.

  • 3.
    Bidleman, Terry F.
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Agosta, Kathleen
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Andersson, Agneta
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Haglund, Peter
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Liljelind, Per
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Hegmans, Alyse
    Jantunen, Liisa M.
    Nygren, Olle
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Poole, Justen
    Ripszam, Matyas
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Tysklind, Mats
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Sea-air exchange of bromoanisoles and methoxylated bromodiphenylethers in the Northern Baltic2016In: Marine Pollution Bulletin, ISSN 0025-326X, E-ISSN 1879-3363, Vol. 112, no 1-2, p. 58-64Article in journal (Refereed)
    Abstract [en]

    Halogenated natural products in biota of the Baltic Sea include bromoanisoles (BAs) and methoxylated bromodiphenyl ethers (MeO-BDEs). We identified biogenic 6-MeO-BDE47 and 2'-MeO-BDE68 in Baltic water and air for the first time using gas chromatography - high resolution mass spectrometry. Partial pressures in air were related to temperature by: log p/Pa=m/T(K)+b. We determined Henry's law constants (HLCs) of 2,4-dibromoanisole (2,4-DiBA) and 2,4,6-tribromoanisole (2,4,6-TriBA) from 5 to 30°C and revised our assessment of gas exchange in the northern Baltic. The new water/air fugacity ratios (FRs) were lower, but still indicated net volatilization in May-June for 2,4-DiBA and May - September for 2,4,6-TriBA. The net flux (negative) of BAs from Bothnian Bay (38,000km2) between May - September was revised from -1319 to -532kg. FRs of MeO-BDEs were >1, suggesting volatilization, although this is tentative due to uncertainties in their HLCs and binding to dissolved organic carbon.

  • 4.
    Bidleman, Terry F.
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Agosta, Kathleen
    Andersson, Agneta
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Haglund, Peter
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Nygren, Olle
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Ripszam, Matyas
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Tysklind, Mats
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Air-water exchange of brominated anisoles in the northern baltic sea2014In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 48, no 11, p. 6124-6132Article in journal (Refereed)
    Abstract [en]

    Bromophenols produced by marine algae undergo O-methylation to form bromoanisoles (BAs), which are exchanged between water and air. BAs were determined in surface water of the northern Baltic Sea (Gulf of Bothnia, consisting of Bothnian Bay and Bothnian Sea) during 2011-2013 and on a transect of the entire Baltic in September 2013. The abundance decreased in the following order: 2,4,6-tribromoanisole (2,4,6-TBA) > 2,4-dibromoanisole (2,4-DBA) ≫ 2,6-dibromoanisole (2,6-DBA). Concentrations of 2,4-DBA and 2,4,6-TBA in September were higher in the southern than in the northern Baltic and correlated well with the higher salinity in the south. This suggests south-to-north advection and dilution with fresh riverine water enroute, and/or lower production in the north. The abundance in air over the northern Baltic also decreased in the following order: 2,4,6-TBA > 2,4-DBA. However, 2,6-DBA was estimated as a lower limit due to breakthrough from polyurethane foam traps used for sampling. Water/air fugacity ratios ranged from 3.4 to 7.6 for 2,4-DBA and from 18 to 94 for 2,4,6-TBA, indicating net volatilization. Flux estimates using the two-film model suggested that volatilization removes 980-1360 kg of total BAs from Bothnian Bay (38000 km(2)) between May and September. The release of bromine from outgassing of BAs could be up to 4-6% of bromine fluxes from previously reported volatilization of bromomethanes and bromochloromethanes.

  • 5.
    Bidleman, Terry F.
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Brorström-Lundén, Eva
    Hansson, Katarina
    Laudon, Hjalmar
    Nygren, Olle
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Tysklind, Mats
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Atmospheric transport and deposition of bromoanisoles along a temperate to arctic gradient2017In: Environmental Science and Technology, ISSN 1086-931X, E-ISSN 1520-6912, Vol. 51, no 19, p. 10974-10982Article in journal (Refereed)
    Abstract [en]

    Bromoanisoles (BAs) arise from O-methylation of bromophenols, produced by marine algae and invertebrates. BAs undergo sea-air exchange and are transported over the oceans. Here we report 2,4-DiBA and 2,4,6-TriBA in air and deposition on the Swedish west coast (Råö) and the interior of arctic Finland (Pallas). Results are discussed in perspective with previous measurements in the northern Baltic region in 2011−2013. BAs in air decreased from south to north in the order Råö > northern Baltic > Pallas. Geometric mean concentrations at Pallas increased significantly (p < 0.05) between 2002 and 2015 for 2,4-DiBA but not for 2,4,6-TriBA. The logarithm of BA partial pressures correlated significantly to reciprocal air temperature at the coastal station Råö and over the Baltic, but only weakly (2,4-DiBA) or not significantly (2,4,6-TriBA) at inland Pallas. Deposition fluxes of BAs were similar at both sites despite lower air concentrations at Pallas, due to greater precipitation scavenging at lower temperatures. Proportions of the two BAs in air and deposition were related to Henry’s law partitioning and source regions. Precipitation concentrations were 10−40% of those in surface water of Bothnian Bay, northern Baltic Sea. BAs deposited in the bay catchment likely enter rivers and provide an unexpected source to northern estuaries. BAs may be precursors to higher molecular weight compounds identified by others in Swedish inland lakes.

  • 6.
    Bidleman, Terry F.
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Laudon, Hjalmar
    Nygren, Olle
    Lokalförsörjningsenheten, Umeå universitet.
    Svanberg, Staffan
    Tysklind, Mats
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Chlorinated pesticides and natural brominated anisoles in air at three northern Baltic stations2017In: Environmental Pollution, ISSN 0269-7491, E-ISSN 1873-6424, Vol. 225, p. 381-389Article in journal (Refereed)
    Abstract [en]

    Abstract Polyurethane foam (PUF) disk passive samplers were deployed at one inland and two island locations in the Bothnian Bay region of the northern Baltic Sea. Uptake was linear over 81–147 d and a temperature range of −2.6 to 14.2 °C for organochlorine pesticides (OCPs) and current-use pesticides (CUPs) having log KOA ≥9 at ambient temperatures. Partial saturation of the PUF disks occurred for the more volatile OCPs hexachlorocyclohexanes (HCHs) and hexachlorobenzene (HCB), and for bromoanisoles (BAs), which are products of bromophenols released by natural and anthropogenic sources. Correction for nonlinear uptake of these was made using experimentally measured PUF-air partition coefficients. Passive-derived air concentrations of pesticides were uniform over the bay and agreed within a factor of 2 or better with levels determined by active (pumped) sampling at one of the island stations. Levels of OCPs were similar to those reported at background sites in the European and Canadian Arctic and at monitoring stations in the central Baltic and southern Scandinavia, indicating long-range transport. The insecticide chlorpyrifos was 10 times lower at bay stations than in the Canadian Arctic. Insight to sources and processes was gained by examining compound profiles. Fractions Falpha = α-HCH/(α-HCH + γ-HCH) and FTC = trans-chlordane/(trans-chlordane + cis-chlordane) at bay stations were higher than in the Norwegian and Finnish Arctic and similar to those at the southern monitoring stations. Volatilization of chlordanes from Baltic seawater may also modify FTC. Higher FTriBA = 2,4,6-TriBA/(2,4,6-TriBA + 2,4-DiBA) distinguished local volatilization from the Baltic Sea versus lower FTriBA found at the inland site and reported in air on the Norwegian coast, suggesting westerly transport from the Atlantic across Norway and Sweden.

  • 7.
    Bidleman, Terry F.
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Nygren, Olle
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Tysklind, Mats
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Field estimates of polyurethane foam: air partition coefficients for hexachlorobenzene, alpha-hexachlorocyclohexane and bromoanisoles2016In: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 159, p. 126-131Article in journal (Refereed)
    Abstract [en]

    Partition coefficients of gaseous semivolatile organic compounds (SVOCs) between polyurethane foam (PUF) and air (KPA) are needed in the estimation of sampling rates for PUF disk passive air samplers. We determined KPA in field experiments by conducting long-term (24-48 h) air sampling to saturate PUF traps and shorter runs (2-4 h) to measure air concentrations. Sampling events were done at daily mean temperatures ranging from 1.9 to 17.5 °C. Target compounds were hexachlorobenzene (HCB), alpha-hexachlorocyclohexane (α-HCH), 2,4-dibromoanisole (2,4-DiBA) and 2,4,6-tribromoanisole (2,4,6-TriBA). KPA (mL g(-1)) was calculated from quantities on the PUF traps at saturation (ng g(-1)) divided by air concentrations (ng mL(-1)). Enthalpies of PUF-to-air transfer (ΔHPA, kJ mol(-1)) were determined from the slopes of log KPA/mL g(-1) versus 1/T(K) for HCB and the bromoanisoles, KPA of α-HCH was measured only at 14.3 to 17.5 °C and ΔHPA was not determined. Experimental log KPA/mL g(-1) at 15 °C were HCB = 7.37; α-HCH = 8.08; 2,4-DiBA = 7.26 and 2,4,6-TriBA = 7.26. Experimental log KPA/mL g(-1) were compared with predictions based on an octanol-air partition coefficient (log KOA) model (Shoeib and Harner, 2002a) and a polyparameter linear free relationship (pp-LFER) model (Kamprad and Goss, 2007) using different sets of solute parameters. Predicted KP values varied by factors of 3 to over 30, depending on the compound and the model. Such discrepancies provide incentive for experimental measurements of KPA for other SVOCs.

  • 8.
    Nygren, Olle
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Development of a method for screening spill and leakage of antibiotics on surfaces based on wipe sampling and HPLC-MS/MS analysis2010Conference paper (Other academic)
  • 9.
    Nygren, Olle
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Development of a method for screening spill and leakage of antibiotics on surfaces based on wipe sampling and HPLC-MS/MS analysis2010Conference paper (Other academic)
  • 10.
    Nygren, Olle
    Arbetslivsinstitutet.
    Development of measuring methods based on wipe sampling for assessment of emission and distribution of cytotoxic drugs in indoor environments2005Conference proceedings (editor) (Refereed)
  • 11.
    Nygren, Olle
    Arbetslivsinstitutet.
    Exposure to hazardous drugs2006In: Hospital Pharmacy Europe, Vol. 4, no 27, p. 66-68Article in journal (Refereed)
    Abstract [en]

    Methods to control spill and leakage as well as monitoring exposure are needed to be able to study how antibiotics are released and spread, thus causing ­exposure. Development of more closed and safe handling systems is also desirable

  • 12.
    Nygren, Olle
    Umeå University, Faculty of Science and Technology, Chemistry.
    Monitoring exposure to antineoplastic drugs in Sweden2008In: International Colloquium Antineoplastic Drug Monitoring 2008 April 30, Hennef, Germany, 2008Conference paper (Other academic)
  • 13.
    Nygren, Olle
    Umeå University, Faculty of Science and Technology, Chemistry.
    Occupational exposure during preparation of Cytotoxic drugs from a Swedish perspective2007In: 10th GERPAC conference 2007 October 3-5, Mol, Belgium, 2007Conference paper (Other academic)
  • 14.
    Nygren, Olle
    Arbetslivsinstitutet.
    Occupational exposure to palladium in various work environments2005In: Palladium Emissions in the Environment: Analytic, Environmental Assessment and Health Effects / [ed] Zereini F and Alt F, Springer Verlag , 2005Chapter in book (Refereed)
  • 15.
    Nygren, Olle
    Arbetslivsinstitutet.
    Platinum element and gold: Occupational exposure2005In: Speciation analysis of platinum group elements and gold / [ed] Cornelis R, London: Wiley & Son , 2005Chapter in book (Refereed)
  • 16.
    Nygren, Olle
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Screening of spill and leakage of antibiotics in hospital wards2010Conference paper (Other academic)
  • 17.
    Nygren, Olle
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Spill and leakage during drug handling at pharmacies and hospitals in Sweden2009In: Teva Nordic Autumn Meeting, Torekov, Sweden 2009-08-26--27, 2009Conference paper (Refereed)
  • 18.
    Nygren, Olle
    Umeå University, Faculty of Science and Technology, Chemistry.
    Spill and leakage from various closed and open systems2008In: Tevadaptor Spring Meeting 2008, May 12-15, Tel-Aviv, Israel, 2008Conference paper (Other academic)
  • 19.
    Nygren, Olle
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Spill, exponering och läckage av läkemedel vid hantering2010Conference paper (Other academic)
  • 20.
    Nygren, Olle
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Ultrafina partiklar - förekomst, effekter och mätning2009In: Temadagar om aerosoler, Fenix Environmental och Scantec Lab, Göteborg 2009-09-21--22, 2009Conference paper (Refereed)
  • 21.
    Nygren, Olle
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Varför storleksselektiv partikelprovtagning?2009In: Temadagar om aerosoler, Fenix Environmental och Scantec Lab, Göteborg 2009-09-21--22, 2009Conference paper (Other academic)
  • 22.
    Nygren, Olle
    National Institute for Working Life, Department of Work and the Physical Environment.
    Wipe sampling as a tool for monitoring aerosol deposition in workplaces2006In: Journal of Environmental Monitoring, ISSN 1464-0325, E-ISSN 1464-0333, Vol. 8, no 1, p. 49-52Article in journal (Refereed)
    Abstract [en]

    As a complement to traditional exposure assessment, monitoring deposition of aerosols can be a simple and quick screening method for identifying deposited aerosols. In this presentation examples of screening studies, based on wipe sampling in combination with adequate analytical techniques, are described. These screening methods are rapid, simple and easy to carry out. The examples given in this presentation show a broad applicability and the methods are proven useful for assessing aerosol distribution in the workplace as well as to identify target spots for more extensive assessment of a worker's exposure situation.

  • 23.
    Nygren, Olle
    et al.
    National Institute for Working Life, Department of Work and the Physical Environment.
    Gustavsson, Bengt
    Eriksson, Robert
    A test method for assessment of spill and leakage from drug preparation systems2005In: Annals of Occupational Hygiene, ISSN 0003-4878, E-ISSN 1475-3162, Vol. 49, no 8, p. 711-718Article in journal (Refereed)
    Abstract [en]

    Anti-cancer drugs are reactive compounds with known adverse health effects. To prevent occupational exposure to these drugs, there are, in most countries, regulations for handling anti-cancer drugs. Many preparation systems are available, e.g. isolators, biological safety cabinets (BSCs), filter spikes (venting spikes with micro-pore filter) and closed systems (e.g. PhaSeal). Although these systems are used, there are reports of exposure. This causes concern over how efficient these systems are to prevent spill and leakage that may cause undesired exposure when handling cytotoxic drugs. Today, this knowledge is lacking. This paper presents a method (Tc-method) for testing drug preparation systems for spill and leakage. The Tc-method is based on 99Tc(m) as a tracer, with which drug vials used for test preparations are spiked. Wipe samples are then collected around the working area to measure spill and leakage. The Tc-method has been validated using an independent method, showing good agreement between the methods. Spills down to 1 nl cm(-2) can be determined. In an appendix, the Tc-method is described in a detailed step-by-step procedure.

  • 24.
    Nygren, Olle
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Lindahl, Roger
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Development of a method for screening spill and leakage of antibiotics on surfaces based on wipe sampling and HPLC-MS/MS analysis2011In: Journal of ASTM International, ISSN 1546-962X, E-ISSN 1546-962X, Vol. 8, no 6, p. 10-Article in journal (Refereed)
    Abstract [en]

    A screening method for determination of spill and leakage of 12 different antibiotic substances has been developed. The method is based on wipe sampling where the sampling procedure has been simplified for screening purposes. After sample processing, the antibiotic substances are determined by liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS). Twelve antibiotic substances can be determined in the screening method: Cefadroxil, Cefalexin, Ciprofloxacin, Demeclocyklin HCl, Diaveridin, Doxycyklin, Enrofloxacin, Flukonazol, Metronidazol, Norfloxacin, Ofloxacin, and Trimetoprim. These substances are active components in antibiotic drugs frequently used in Sweden. For screening investigations using collection of wipe samples, good or acceptable performance was obtained for ten substances on three or more surface materials. Although not fully acceptable, useful performance for screening purposes was also obtained on the other surface materials and for the other substances, except Demeclocyklin HCl, on all surface materials. By employing a classification procedure, where the samples are divided into groups according to increasing contamination of the sample surfaces, screening samples and the contamination level can simply be compared. This classification procedure will also help to circumvent any deficiency in recovery performance for some substances and surface materials.

     

  • 25.
    Nygren, Olle
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Lindahl, Roger
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Screening of spill and leakage of antibiotics in hospital wards2011In: Journal of ASTM International, ISSN 1546-962X, E-ISSN 1546-962X, Vol. 8, no 6, p. 24-Article in journal (Refereed)
    Abstract [en]

    This paper presents a two-phase study of spill and leakage of antibiotics in hospitals. The first phase was a screening of spill and leakage at 21 hospital wards in 16 hospitals. Phase two was an extended investigation, where different measures to reduce spill and leakage were implemented and a follow-up screening was made to evaluate the effect of the measures. At the screening, 206 samples were collected. The result was used to classify the wards into four classes: Low, Mean, High, and Very high. Spatial distribution patterns and the effect of compounding systems were also investigated. The screening showed that spill and leakage occur at all wards. Eleven of the 21 wards had High or Very high contamination level. This result also showed that the substances were distributed according to three possible patterns. The compounding systems also had an impact on the spill and leakage. All four wards that used a closed system were found among the six wards with the lowest spill and leakage, while all three wards that used open venting systems were found among the six wards with the highest spill and leakage. The result also showed that it is possible to handle antibiotics with only insignificant spill and leakage, i.e., by using closed systems. Three wards, classified as Very high, were included in the second phase. Measures to decrease spill and leakage and reduce the distribution the substances were implemented. After two month, a follow-up screening was carried out. The result showed lower contamination levels at all three wards and the implemented measures had some effect. Simple and easy-to-do measures can contribute to reduce the spill and leakage that occur. There is still, however, a need to discuss how to handle antibiotics in a safe way to reduce possible spill and leakage and to prevent the distribution of this spill and leakage.

  • 26.
    Nygren, Olle
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Lindahl, Roger
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Slutrapport AFA-projekt 07-0043: undersökning av spill och läckage vid hantering av antibiotika inom sjukvården2010Report (Other academic)
  • 27.
    Nygren, Olle
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Lindahl, Roger
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Undersökning av spill och läckage vid hantering av antibiotika inom sjukvården: en populärvetenskaplig sammanfattning av AFA-projekt 07-00432010Report (Other (popular science, discussion, etc.))
  • 28.
    Nygren, Olle
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Olofsson, Eva
    University Hospital Pharmacy, Apoteket AB, Umeå, Sweden.
    Johannson, Lennart
    Department of Radiophysiology, Umeå University Hospital, Umeå Sweden.
    NIOSH definition of closed-system drug-transfer devices: Letter to the Editor2009In: Annals of Occupational Hygiene, ISSN 0003-4878, E-ISSN 1475-3162, Vol. 53, no 5, p. 549-Article in journal (Other academic)
  • 29.
    Nygren, Olle
    et al.
    Umeå University, Faculty of Science and Technology, Chemistry.
    Olofsson, Eva
    Johansson, Lennart
    Spill and Leakage Using a Drug Preparation System Based on Double-Filter Technology2008In: Annals of Occupational Hygiene, Vol. 52, no 2, p. 95-8Article in journal (Refereed)
    Abstract [en]

    Occupational exposure to cytotoxic drugs has frequently been reported during recent years. Various drug-handling systems have been applied to reduce the spill and leakage that cause this exposure. Some of these systems have also been tested for spill and leakage using independent test methods. In this paper, a new drug-handling system has been tested for spill and leakage during drug preparation. The handling system, TevadaptorTM, was tested using a modification of an independent test method, the Technetium test method, based on the use of Technetium m-99 as tracer substance. The test results showed that the spill was <100 nl for all 75 preparations and was <1 nl for 70 of the preparations. This is comparable with other tested drug-handling system, e.g. isolators, PhaSealTM. The test shows that the Tevadaptor drug-handling system has similar performance as drug-handling systems regarded as closed systems.

  • 30.
    Nygren, Olle
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Söderström, Hanna
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Wipe sampling: ­a tool for assessing drug aerosol deposition in hospitals2008In: AIRMON 2008, Geilo, Norway 2008-01-29--31: Sixth International Symposium on Modern Principles of Air Monitoring and Biomonitoring, 2008, p. 45-45Conference paper (Other academic)
  • 31.
    Schneider, Thomas
    et al.
    National Research Centre for the Working Environment, Copenhagen, Denmark.
    Jansson, Anders
    Department of Applied Environmental Science, Stockholm University, Sweden.
    Alstrup Jensen, Keld
    National Research Centre for the Working Environment, Copenhagen, Denmark.
    Kristjansson, Vidir
    Administration of Occupational Safety and Health, Reykjavik, Island.
    Luotamo, Marita
    Finnish Institute of Occupational Health, Helsinki, Suomi.
    Nygren, Olle
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Savolainen, Kai
    Finnish Institute of Occupational Health, Helsinki, Suomi.
    Skaug, Vidar
    National Institute of Occupational health, Oslo, Norway.
    Thomassen, Yngvar
    National Institute of Occupational health, Oslo, Norway.
    Tossavainen, Antti
    Finnish Institute of Occupational Health, Helsinki, Suomi.
    Tuomi, Timo
    Finnish Institute of Occupational Health, Helsinki, Suomi.
    Wallin, Håkan
    National Research Centre for the Working Environment, Copenhagen, Denmark.
    Evaluation and control of occupational health risks from nanoparticles2007Report (Refereed)
    Abstract [en]

    Rapid growth in the nanoparticle industry is anticipated in the Nordic countries owing to highly focused national research and investment initiatives. Knowledge on consequences for occupational exposures to engineered nanoparticles and appropriate technical control levels is still limited. This report explores existing knowledge on exposure risks and technical control approaches. The report concludes that data are too limited to allow general conclusions to be drawn regarding risks of exposure to engineered nanoparticles.Engineering techniques for controlling nanoparticle exposure can build on the current knowledge and approaches to control exposure to e.g. welding fume and carbon black. There is a need for improving the quality of information provided in Material Safety Data Sheets.

  • 32. Åteg, M
    et al.
    Andersson, I-M
    Neely, Gregory
    Rosén, G
    Laring, J
    Nygren, Olle
    Arbetslivsinstitutet.
    Arbetsmiljöarbete och motivation: Teoretisk översikt och konstruktion av ett frågeformulär2007Report (Other academic)
  • 33. Åteg, M
    et al.
    Nygren, Olle
    Arbetslivsinstitutet.
    Andersson, I-M
    Laring, J
    Neely, Gregory
    Rosén, G
    Metoder och verktyg för motivation och integration av arbetsmiljöarbete2006Report (Other academic)
1 - 33 of 33
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