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  • 1. Bittles, Alan H
    et al.
    Egerbladh, Inez
    Umeå University, Faculty of Social Sciences, Demographic Data Base.
    The influence of past endogamy and consanguinity on genetics disorders in northern Sweden2005In: Annals of Human Genetics, no 69, p. 1-10Article in journal (Refereed)
  • 2.
    Egerbladh, Inez
    Umeå University, Faculty of Social Sciences, Demographic Data Base (DDB).
    Agrara bebyggelseprocesser: Utvecklingen i Norrbottens kustland fram till 1900-talet1987Doctoral thesis, monograph (Other academic)
  • 3.
    Egerbladh, Inez
    et al.
    Umeå University, Faculty of Social Sciences, Demographic Data Base.
    Bittles, AH
    Socioeconomic, demographic and legal influences on consanguinity and kinship in northern coastal Sweden 1780-18992011In: Journal of Biosocial Science, ISSN 0021-9320, E-ISSN 1469-7599, Vol. 43, no 4, p. 413-435Article in journal (Refereed)
    Abstract [en]

    Most studies on consanguinity have been conducted on contemporary populations and have focused on the prevalence and types of preferred intra-familial marriage. With its comprehensive birth, marriage and deaths records dating back to the late 17th century, and the legal bar on first cousin marriage removed in the mid-19th century, Sweden offers unique opportunities to examine the factors that determine by whom, where and why consanguineous marriages were contracted. The present study covers the period 1780-1899 and presents a detailed portrait of cousin and sibling exchange marriages in the Skelleftea region of northern coastal Sweden. The combined prevalence of first, second and third cousin marriage increased from 2.3% in 1790-1810 to 8.8% in 1880-1899, and multi-generation consanguinity also increased significantly over the study period. The distribution and prevalence of first cousin marriages was strikingly non-random, with a significantly greater propensity for consanguinity among land-owning families, especially involving first-born sons, within specific pedigrees, and in a number of more remote inland communities. Additional factors associated with a greater likelihood of consanguineous marriage included physical or mental disability among males, and among females the prior birth of an illegitimate child. Besides the inherent interest in the social and demographic structure of this region of northern Sweden during the course of the 19th century, in future studies it will be important to determine the degree to which the observed patterns of consanguineous and sibling exchange marriages in these past generations could have influenced present-day genetic structure.

  • 4.
    Egerbladh, Inez
    et al.
    Umeå University, Faculty of Social Sciences, Centre for Population Studies (CPS).
    Bittles, Alan
    The influence of consanguineous marriage on reproductive behavior and early mortality in Northern Coastal Sweden, 1780-18992008In: Kinship and demographic behavior in the past, Springer, 2008, p. 205-224Conference paper (Refereed)
    Abstract [en]

    Remarkably few studies have been conducted into the prevalence and possible influence of close kin marriage on fertility and mortality in northern European populations. The Demographic DataBase at Umea University offers a unique opportunity to correct this situation, with data on births, deaths, and marriages in the Skelleftea region of Sweden for the period 1720-1899 collected by the State Lutheran Church. The data are made more interesting by the fact that until 1680 first cousin unions were prohibited in Sweden; and from 1680 until 1844 a royal dispensation was needed before such unions could proceed. Of the 14,639 marriages initially studied, 20.8 percent were between couples related as sixth cousins or closer, with a significant increase in first cousin marriages post-1844. Using logistic regression, two subsets of marriages contracted from 1780 to 1899 were investigated with respect to fertility and mortality. First cousin marriages were strongly favored by freeholders and peasant landowning families; and in some families they had been preferentially contracted across successive generations. Consanguinity appeared to exert no influence on fertility. However, first cousin couples had higher rates of stillbirths and more deaths in infancy and early childhood among their progeny. This excess mortality was probably associated with the expression of detrimental recessive genes, although nongenetic factors may also have been involved. There was evidence of the clustering of multiple deaths within first cousin families, which likewise would be consistent with a genetic aetiology. Overall, the data confirm the significance of close consanguinity as an important demographic variable in this European population.

  • 5.
    Einarsdottir, Elisabet
    et al.
    Umeå University, Faculty of Medicine, Department of Medical Biosciences.
    Andersson Escher, Stefan
    Egerbladh, Inez
    Beckman, Lars
    Sandgren, Ola
    Golovleva, Irina
    Holmberg, Dan
    The population structure of northern Sweden and its implications for mapping genetic diseasesManuscript (Other academic)
  • 6.
    Einarsdottir, Elisabet
    et al.
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics.
    Egerbladh, Inez
    Beckman, Lars
    Holmberg, Dan
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics.
    Andersson Escher, Stefan
    The genetic population structure of northern Sweden and its implications for mapping genetic diseases.2007In: Hereditas, ISSN 1601-5223, Vol. 144, no 5, p. 171-180Article in journal (Refereed)
    Abstract [en]

    The northern Swedish population has a history of admixture of three ethnic groups and a dramatic population growth from a relatively small founder population. This has resulted in founder effects that together with unique resources for genealogical analyses provide excellent conditions for genetic mapping of monogenic diseases. Several recent examples of successful mapping of genetic factors underlying susceptibility to complex diseases have suggested that the population of northern Sweden may also be an important tool for efficient mapping of more complex phenotypes. A potential factor contributing to these effects may be population sub-isolates within the large river valleys, constituting a central geographic characteristic of this region. We here provide evidence that marriage patterns as well as the distribution of gene frequencies in a set of marker loci are compatible with this notion. The possible implications of this population structure on linkage- and association based strategies for identifying genes contributing risk to complex diseases are discussed.

  • 7.
    Inez, Egerbladh
    Umeå University, Faculty of Social Sciences, Demographic Data Base.
    Agrara bebyggelseprocesser: Utvecklingen i Norrbottens kustland fram till 1900-talet1987Licentiate thesis, monograph (Other academic)
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