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  • 1.
    Asplund, Kjell
    et al.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Axelsen, Mette
    Berglund, Göran
    Berne, Christian
    Karlström, Brita
    Lindahl, Bernt
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine.
    Lindblom, Jonas
    Norlund, Anders
    Rosén, Måns
    Ränzlöv, Ewalotte
    Toft, Eva
    Täljedal, Inge-Bert
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Histology and Cell Biology.
    Wolk, Alicja
    Mat vid diabetes. En systematisk litteraturöversikt.2010Report (Other academic)
  • 2.
    Persson-Sjögren, S
    et al.
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Histology and Cell Biology.
    Forsgren, S
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
    Shi, C L
    Täljedal, I B
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Histology and Cell Biology.
    Mouse islets cultured with vasoactive intestinal polypeptide: effects on insulin release and immunoreactivity for tyrosine hydroxylase.2001In: Pancreas, ISSN 0885-3177, E-ISSN 1536-4828, Vol. 22, no 1, p. 84-90Article in journal (Refereed)
    Abstract [en]

    Mouse islets cultured for 1 or 4 days with or without 10 nM vasoactive intestinal polypeptide (VIP) were stained for tyrosine hydroxylase (TH) and examined for insulin secretion during culture and in a postculture perifusion system. Exposure to exogenous VIP for 4 days increased the frequency of islet cells expressing TH-like immunoreactivity. Regardless of the culturing conditions, the islets exhibited significant insulin secretory responses to 16.7 mM glucose, the effect being potentiated by 10 nM VIP in the perifusion medium. The insulin-releasing action of glucose and the potentiating effect of VIP were less pronounced in islets cultured for 1 day with VIP than in islets cultured without this neuropeptide. The following conclusions are suggested: (a) VIP stimulates the expression of TH in mouse islet cells; (b) the latency of the VIP-induced TH is a postreceptor phenomenon; (c) islet cultures exposed to VIP represent a new instance of the association between increased functional demands on beta cells and enhanced expression of TH and a new instance of VIP having trophic effects.

  • 3.
    Persson-Sjögren, S
    et al.
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Histology and Cell Biology.
    Forsgren, S
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
    Täljedal, I B
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Histology and Cell Biology.
    Tyrosine hydroxylase in mouse pancreatic islet cells, in situ and after syngeneic transplantation to kidney.2002In: Histology and Histopathology, ISSN 0213-3911, E-ISSN 1699-5848, Vol. 17, no 1, p. 113-21Article in journal (Refereed)
    Abstract [en]

    Tyrosine hydroxylase (TH) is co-expressed with islet hormones in the fetal mouse pancreas. In the adult animal, the enzyme has been considered as a marker of ageing beta-cells. By immunohistochemical staining, we analyzed the expression of TH-like immunoreactivity (TH-LI), insulin-LI (INS-LI) and somatostatin-LI (SOM-LI) in adult mouse islets, in situ and after isolation and transplantation to kidney. In pancreas in situ, most TH-LI cells expressed INS-LI while less than 5% expressed SOM-LI. The total number of TH-LI cells/mm2 was significantly increased directly after isolation and in 0-day, 12-week and 52-week old grafts, but not in 3-day grafts. The proportion of TH-LI cells expressing SOM-LI increased after transplantation, amounting to about one-third by 52 weeks. As expressed per unit islet area, the frequencies of both TH/INS and TH/SOM cells increased significantly in the transplants. The results demonstrate that TH occurs in both beta-cells and D-cells of adult islets. In both cell types the enzyme appears to be responsive to the microenvironmental changes inherent in transplantation. This cellular phenotype plasticity might contribute to the altered insulin secretory dynamics in islet grafts.

  • 4.
    Täljedal, Inge-Bert
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Histology and Cell Biology.
    Esse est percpi and percept identity in C. J. Boström's philosophy2013In: Idealistic Studies, ISSN 0046-8541, E-ISSN 2153-8239, Vol. 43, no 1-2, p. 63-70Article in journal (Refereed)
    Abstract [en]

    Berkeley's 'esse is percipi' has been criticized for implying epistemological solipsism, the main argument being that different minds cannot harbor numerically one and the same idea. Similarly, C. J. Boström, the dominating Swedish philosopher in the 19th century, was early scorned because his principle of esse est percipi allegedly contradicts the simultaneous claim that two spirits (God and a human, or two humans) can perceive the same thing under qualitatively different appearances. Whereas the criticism against Berkeley is here regarded as valid, it is argued that Boström successfully defended himself by employing a dual concept of meaning, resembling Frege's Sinn and Bedeutung some thirty years later, and by postulating an ontology that permits human minds to share in the divine ideas that constitute reality.

  • 5.
    Täljedal, Inge-Bert
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Histology and Cell Biology.
    Linnaeus' Questions to the Sami Herdsman: The ID-versus-Science Issue in a Nut-ShellManuscript (preprint) (Other academic)
    Abstract [en]

    According to a United States court ruling, Intelligent Design (ID) theory is religious in nature, not scientific, and must not be taught in schools. In opposition, Fuller argues for a closer rapport between science and religion. Here it is emphasized that any allegedly scientific conclusion from design in Nature to the existence of God is a hypothesis subject to the same quality norms as empirical hypotheses in general. By quotations from his Iter Lapponicum, Linnæus is summoned in support of a strictly immanent conception of science, against Fuller’s suggestion that Linnæus’ personal piety could be reason for considering ID scientific.

  • 6.
    Täljedal, Inge-Bert
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
    Linnaeus's Questions to the Sami Herdsman: The ID-versus-Science Issue in a Nutshell2010In: Philosophy of the social sciences, ISSN 0048-3931, E-ISSN 1552-7441, Vol. 40, no 3, p. 456-466Article in journal (Refereed)
    Abstract [en]

    According to a U.S. court ruling, intelligent design (ID) theory is religious in nature, not scientific, and must not be taught in schools. In opposition, Fuller argues for a closer rapport between science and religion. Here it is emphasized that any allegedly scientific conclusion from design in nature to the existence of God is a hypothesis subject to the same quality norms as empirical hypotheses in general. By quotations from his Iter Lapponicum, Linnaeus is summoned in support of a strictly immanent conception of science, against Fuller's suggestion that Linnaeus' personal piety could be a reason for considering ID scientific.

  • 7.
    Täljedal, Inge-Bert
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Histology and Cell Biology.
    Quantitative studies on phosphatases in isolated pancreatic islets of mammals1967Doctoral thesis, comprehensive summary (Other academic)
  • 8.
    Täljedal, Inge-Bert
    Umeå University, Faculty of Medicine, Integrative Medical Biology, Histology and Cell Biology.
    Strong holism, weak holism, and health.2004In: Med Health Care Philos, ISSN 1386-7423, Vol. 7, no 2, p. 143-8; discussion 149Article in journal (Other academic)
    Abstract [en]

    The health theories of Nordenfelt and Boorse are compared. Critical attention is focused on Nordenfelt's description of his theory as one of holistic welfare, contrasting with Boorse's analytical and statistical approach. Neither theory is found to give an entirely satisfactory account of 'health' in scientific medicine or common usage. Because Nordenfelt attenuates the ontological significance of organs and organ parts and simplifies the role of statistics, his theory is regarded as weakly holistic. Boorse underrates the importance of non-statistical evaluation. A mediating position, termed 'strong holism' is suggested as a way of integrating normative and statistical elements in a more adequate health concept.

  • 9.
    Täljedal, Inge-Bert
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Histology and Cell Biology.
    The idea of being is not uniquely innate2016In: Principia: an International Journal of Epistemology, ISSN 1414-4247, E-ISSN 1808-1711, Vol. 20, no 3, p. 343-359Article, review/survey (Refereed)
    Abstract [en]

    According to the Italian philosopher Antonio Rosmini (1797-1855), being is an innate idea that is requisite for contemplating anything. He emphatically claims that it is the one and only innate idea. Rosmini makes a sharp distinction between sensations and perceptions. Perceptions are thought to arise when the undetermined idea of being (tantamount to possibility) is combined with sensations, universals when being is combined with perceptions. It is argued here that Rosmini’s explanation of the origin of universals does not work. If the idea of being is regarded as innate, then several others should be similarly regarded, notably the idea of qualitative identity which is an idea necessary for deriving universals.  Although Rosmini holds that certain properties are necessarily present in real objects and therefore implicit in the idea of being, the property of being qualitatively identical with something else is not among those properties. Theological motives may have encouraged  Rosmini to emphasize being as a peculiarly fundamental idea. However, if the idea of being is more fundamental than other universals, it may be regarded so in virtue of its generality,  not because it has a uniquely innate character.

  • 10.
    Täljedal, Inge-Bert
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Histology and Cell Biology.
    The vulnerability of university culture and individual integrity2013In: Trust and confidence in scientific research / [ed] Göran Hermeren, Kerstin Sahlin, Nils-Eric Sahlin & Kungl. Vitterhets historie och antikvitets akademien, Stockholm: Kungl. Vitterhetsakademien (The Royal Swedish Academy of Letters, History and Antiquities) , 2013, p. 52-58Chapter in book (Other (popular science, discussion, etc.))
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