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  • 1. Akesson, K
    et al.
    Nyström, Lennarth
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Färnkvist, L
    Östman, J
    Lernmark, A
    Kockum, I
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Increased risk of diabetes among relatives of female insulin-treated patients diagnosed at 15-34 years of age.2005In: Diabetic medicine, ISSN 0742-3071, Vol. 22, no 11, p. 1551-7Article in journal (Refereed)
  • 2. Bakhtadze, E
    et al.
    Borg, H
    Stenström, G
    Fernlund, P
    Arnqvist, H J
    Ekbom-Schnell, A
    Bolinder, J
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Gudbjörnsdottir, S
    Nyström, Lennarth
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Public Health Sciences.
    Groop, L C
    Sundkvist, G
    HLA-DQB1 genotypes, islet antibodies and beta cell function in the classification of recent-onset diabetes among young adults in the nationwide Diabetes Incidence Study in Sweden.2006In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 49, no 8, p. 1785-1794Article in journal (Refereed)
  • 3.
    Bergfors, M
    et al.
    Umeå University, Faculty of Science and Technology, Studies in Biology and Environmental Sciences. Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Barnekow-Bergkvist, M
    Kalezic, N
    Umeå University, Faculty of Medicine, Surgical and Perioperative Sciences, Sports Medicine.
    Lyskov, E
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Short-term effects of repetitive arm work and dynamic exercise on glucose metabolism and insulin sensitivity.2005In: Acta Physiologica Scandinavica, ISSN 0001-6772, E-ISSN 1365-201X, Vol. 183, no 4, p. 345-356Article in journal (Refereed)
  • 4. Berne, C
    et al.
    Yki-Järvinen, H
    Taskinen, M-R
    Fritz, T
    Ekstrand, A
    Eliasson, B
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Rekommendationer för vård och behandling vid typ 2 diabetes.2004In: Recallmedicin Publication Helsinki, 2004, p. 1-32Chapter in book (Other (popular science, discussion, etc.))
  • 5. Bolinder, J
    et al.
    Fernlund, P
    Borg, H
    Arnqvist, H J
    Björk, E
    Blohmé, G
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Nyström, Lennarth
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Public Health Sciences.
    Östman, J
    Sundkvist, G
    Hyperproinsulinemia segregates young adult patients with newly diagnosed autoimmune (type 1) and non-autoimmune (type 2) diabetes.2005In: Scand J Clin Lab Invest, ISSN 0036-5513, Vol. 65, no 7, p. 585-94Article in journal (Refereed)
  • 6.
    Burén, Jonas
    et al.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Is insulin resistance caused by defects in insulin's target cells or by a stressed mind?2005In: Diabetes/Metabolism Research Reviews, ISSN 1520-7552, E-ISSN 1520-7560, Vol. 21, no 6, p. 487-494Article in journal (Other academic)
    Abstract [en]

    The importance of understanding insulin action is emphasized by the increasing prevalence of insulin resistance in various populations and by the fact that it plays an important pathophysiological role in many common disorders, for example, diabetes, obesity, hypertension and dyslipidemia. The primary factors responsible for the development of insulin resistance are so far unknown, although both genetic and environmental factors are involved. The genetic defects responsible for the common forms of insulin resistance, for example, in type 2 diabetes, are largely unidentified. Some studies from our group as well as by other investigators suggest that cellular insulin resistance is reversible and that it may be secondary to factors in the in vivo environment. These may include insulin-antagonistic action of hormones like catecholamines, glucocorticoids, sex steroids and adipokines as well as dysregulation of autonomic nervous activity and they could contribute to the early development of insulin resistance. Some of these factors can directly impair glucose uptake capacity and this might be due to alterations in key proteins involved in insulin's intracellular signaling pathways. This article briefly summarizes proposed mechanisms behind cellular and whole-body insulin resistance. In particular, we question the role of intrinsic defects in insulin's target cells as primary mechanisms in the development of insulin resistance in type 2 diabetes and we suggest that metabolic and neurohormonal factors instead are the main culprits.

  • 7.
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    [Exciting findings can change the view on the pathogenesis of type 2 diabetes. Impaired mitochondrial function can explain metabolic disorders in several organs]2004In: Läkartidningen, ISSN 0023-7205, Vol. 101, no 39, p. 2992-3Article in journal (Refereed)
  • 8. Giorgino, F
    et al.
    Laviola, L
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies.2005In: Acta Physiol Scand, ISSN 0001-6772, Vol. 183, no 1, p. 13-30Article in journal (Refereed)
  • 9. Hu, Gang
    et al.
    Qiao, Qing
    Tuomilehto, Jaakko
    Balkau, Beverley
    Borch-Johnsen, Knut
    Pyorala, Kalevi
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine.
    Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in nondiabetic European men and women.2004In: Arch Intern Med, ISSN 0003-9926, Vol. 164, no 10, p. 1066-76Article in journal (Refereed)
  • 10.
    Lindmark, Stina
    et al.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Burén, Jonas
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Eriksson, Jan W
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Insulin resistance, endocrine function and adipokines in type 2 diabetes patients at different glycaemic levels: potential impact for glucotoxicity in vivo2006In: Clinical Endocrinology, ISSN 0300-0664, E-ISSN 1365-2265, Vol. 65, no 3, p. 301-309Article in journal (Refereed)
    Abstract [en]

    Objective To evaluate the interplay between hyperglycaemia, insulin resistance, hormones and adipokines in patients with type 2 diabetes mellitus (T2DM). Design and methods Ten patients with T2DM with good glycaemic control (G), 10 with poor control (P) and 10 nondiabetic control subjects (C) were matched for sex (M/F 6/4), age and body mass index. A hyperinsulinaemic, euglycaemic clamp was performed and cytokines and endocrine functions, including cortisol axis activity were assessed. Results Patients with diabetes were more insulin resistant than group C, and group P exhibited the highest degree of insulin resistance ( P = 0·01, P vs C). Tumour necrosis factor (TNF)-alpha levels were elevated in patients with diabetes ( P = 0·05) and group P had the highest levels of fasting serum cortisol ( P = 0·05), nonesterified fatty acids (NEFA; P = 0·06) and C-reactive protein (CRP; P = 0·01). Adiponectin levels were lower in the P group. In partial correlation analyses, significant associations were found: glycaemic level (HbA1c) with insulin resistance, TNF-alpha, CRP and basal and ACTH-stimulated cortisol levels, insulin resistance with plasma NEFA, TNF-alpha and stimulated cortisol levels. Conclusion Poor glycaemic control in patients with T2DM was associated with insulin resistance and with elevated TNF-alpha, CRP and basal as well as stimulated cortisol levels. Inflammatory mediators, e.g. TNF-alpha, may contribute to insulin resistance in hyperglycaemic patients with T2DM and this might be a partial explanation for glucotoxicity.

  • 11. Littorin, B
    et al.
    Blom, P
    Schölin, A
    Arnqvist, H J
    Blohmé, G
    Bolinder, J
    Ekbom-Schnell, A
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Gudbjörnsdottir, S
    Nyström, Lennarth
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Public Health Sciences.
    Ostman, J
    Sundkvist, G
    Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide Diabetes Incidence Study in Sweden (DISS).2006In: Diabetologia, ISSN 0012-186X, Vol. 49, no 12, p. 2847-52Article in journal (Refereed)
  • 12.
    Lundgren, Magdalena
    et al.
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Buren, Jonas
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Ruge, Toralph
    Umeå University, Faculty of Medicine, Surgical and Perioperative Sciences, Surgery.
    Myrnäs, Torbjörn
    Umeå University, Faculty of Medicine, Surgical and Perioperative Sciences, Surgery.
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Glucocorticoids down-regulate glucose uptake capacity and insulin-signaling proteins in omental but not subcutaneous human adipocytes.2004In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 89, no 6, p. 2989-2997Article in journal (Refereed)
  • 13.
    Lundgren, Magdalena
    et al.
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    No in vitro effects of fatty acids on glucose uptake, lipolysis or insulin signaling in rat adipocytes.2004In: Hormone and Metabolic Research, ISSN 0018-5043, E-ISSN 1439-4286, Vol. 36, no 4, p. 203-209Article in journal (Refereed)
  • 14.
    Lundgren, Magdalena
    et al.
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Svensson, Maria
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Lindmark, Stina
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Renström, Frida
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Ruge, Toralph
    Umeå University, Faculty of Medicine, Surgical and Perioperative Sciences, Surgery.
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Fat cell enlargement is an independent marker of insulin resistance and 'hyperleptinaemia'.2007In: Diabetologia, ISSN 0012-186X, Vol. 50, no 3, p. 625-33Article in journal (Refereed)
  • 15.
    Norberg, Margareta
    et al.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Public Health Sciences.
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Lindahl, B
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine.
    Andersson, Christer
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.
    Rolandsson, Olov
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.
    Stenlund, Hans
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Public Health Sciences.
    Weinehall, Lars
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Public Health Sciences.
    A combination of HbA1c, fasting glucose and BMI is effective in screening for individuals at risk of future type 2 diabetes: OGTT is not needed.2006In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 260, no 3, p. 263-71Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: To identify a screening model that predicts high risk of future type 2 diabetes and is useful in clinical practice. DESIGN AND METHODS: Incident case-referent study nested within a population-based health survey. We compared screening models with three risk criteria and calculated sensitivity, specificity, positive (PPV) and negative (NPV) predictive values and attributable proportion. We used fasting plasma glucose (FPG) alone or with an oral glucose tolerance test (OGTT), glycosylated haemoglobin A (HbA1c) (normal range 3.6-5.3%), body mass index (BMI), triglycerides and family history of diabetes (FHD). SETTING: Participants in a health survey at all primary care centres (n=33,336) and subjects with diagnosed type 2 diabetes in primary and hospital care (n=6088) in Umeå during 1989-2001. SUBJECTS: Each of the 164 subjects who developed clinically diagnosed type 2 diabetes (median time to diagnosis of 5.4 years) and 304 sex- and age-matched referents without diabetes diagnosis. RESULTS: Screening models with at least one criterion present had sensitivities of 0.90-0.96, specificities of 0.43-0.57 and PPVs of 8-9%. Combinations of the criteria, FPG>or=6.1 mmol L-1 (capillary plasma), HbA1c>or=4.7% and BMI>or=27 in men and BMI>or=30 in women, had sensitivities, specificities and PPVs of 0.66%, 0.93% and 32%, and 0.52%, 0.97% and 46% respectively. Using FHD as one of three risk criteria showed comparable results. Addition of triglycerides or OGTT did not improve the prediction. CONCLUSIONS: The combination of HbA1c, FPG and BMI are effective in screening for individuals at risk of future clinical diagnosis of type 2 diabetes. OGTT or FHD is not necessary.

  • 16.
    Norberg, Margareta
    et al.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Public Health Sciences.
    Stenlund, Hans
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Public Health Sciences.
    Lindahl, B
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine.
    Andersson, Christer
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Weinehall, Lars
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Public Health Sciences.
    Work stress and low emotional support is associated with increased risk of future type 2 diabetes in women2007In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 76, no 3, p. 368-377Article in journal (Refereed)
    Abstract [en]

    A case-referent study nested within a population-based health survey investigated the associations between psychosocial stress, such as work stress and low emotional support, and future development of type 2 diabetes among occupationally working middle-aged men and women. All participants in a health survey conducted during 1989-2000 (n=33,336) in Umeå in northern Sweden, were included. We identified 191 cases, who were not diabetic initially but were diagnosed with type 2 diabetes after 5.4+/-2.6 years. Two age- and sex-matched referents were selected for each case. Multivariate logistic regression analyses and interaction effects between variables were evaluated.

    In women, passive or tense working situations were associated with future type 2 diabetes with odds ratios 3.6 (95% confidence interval 1.1-11.7) and 3.6 (1.0-13.3), respectively, and also low emotional support 3.0 (1.3-7.0). These associations were not seen in men. In women, they remained after adjustment for BMI, civil status and educational level, and there were also tendencies for interactions between work stress and low emotional support.

    In conclusion, work stress and low emotional support may increase the risk of type 2 diabetes in women, but not in men. These findings contribute to our understanding of psychosocial stress as potential risk factors for type 2 diabetes in a Swedish population.

  • 17.
    Norberg, Margareta
    et al.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    Stenlund, Hans
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    Lindahl, Bernt
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine.
    Andersson, Christer
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.
    Weinehall, Lars
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Public Health Sciences.
    Hallmans, Göran
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research.
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Components of metabolic syndrome predicting diabetes: no role of inflammation or dyslipidemia.2007In: Obesity (Silver Spring), ISSN 1930-7381, Vol. 15, no 7, p. 1875-1885Article in journal (Refereed)
  • 18. Petrauskiene, V
    et al.
    Falk, M
    Waernbaum, Ingeborg
    Umeå University, Faculty of Social Sciences, Department of Statistics.
    Norberg, Margareta
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Public Health Sciences.
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    The risk of venous thromboembolism is markedly elevated in patients with diabetes2005In: Diabetologia, Vol. 48, p. 1017–1021-Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: To survey unnatural deaths among teenagers in northern Sweden and to suggest preventive measures. SETTING: The four northernmost counties (908,000 inhabitants, 1991), forming 55% of the area of Sweden. MATERIAL AND METHODS: All unnatural teenager deaths from 1981 through 2000 were identified in the databases of the Department of Forensic Medicine in Umea, National Board of Forensic Medicine. Police reports and autopsy findings were always studied, social and hospital records if present. RESULTS: Three hundred and fifty-five deaths were found, of which 267 (75%) were males and 88 (25%) females. Ninety out of 327 (28%) tested positive for alcohol. Two hundred and forty-eight (70%) were unintentional and 102 (30%) were intentional deaths, and five (1%) were categorized as undetermined manner of death. Unintentional deaths decreased while the incidence of intentional deaths remained unaffected by time. CONCLUSIONS: Injury-reducing measures have been effective concerning unintentional deaths and the fall in young licensed drivers due to the economical recess have probably also contributed to the decrease. However, there were no signs of decreasing numbers of suicides during the study period, which calls for resources to be allocated to suicide prevention.

  • 19.
    Renström, Frida
    et al.
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine.
    Buren, Jonas
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine.
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine.
    Insulin receptor substrates-1 and -2 are both depleted but via different mechanisms after down-regulation of glucose transport in rat adipocytes.2005In: Endocrinology, ISSN 0013-7227, E-ISSN 1945-7170, Vol. 146, no 7, p. 3044-3051Article in journal (Refereed)
  • 20.
    Renström, Frida
    et al.
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine. Medicin.
    Buren, Jonas
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine. Medicin.
    Svensson, Maria
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine. Medicin.
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine. Medicin.
    Insulin resistance induced by high glucose and high insulin precedes insulin receptor substrate 1 protein depletion in human adipocytes.2007In: Metabolism: Clinical and Experimental, ISSN 0026-0495, E-ISSN 1532-8600, Vol. 56, no 2, p. 190-198Article in journal (Refereed)
  • 21.
    Ruge, Toralph
    et al.
    Umeå University, Faculty of Medicine, Surgical and Perioperative Sciences, Surgery.
    Sukonina, V
    Umeå University, Faculty of Medicine, Medical Biosciences, Physiological chemistry.
    Myrnäs, Torbjörn
    Umeå University, Faculty of Medicine, Surgical and Perioperative Sciences, Surgery.
    Lundgren, Magdalena
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Olivecrona, G
    Umeå University, Faculty of Medicine, Medical Biosciences, Physiological chemistry.
    Lipoprotein lipase activity/mass ratio is higher in omental than in subcutaneous adipose tissue.2006In: European Journal of Clinical Investigation, ISSN 0014-2972, E-ISSN 1365-2362, Vol. 36, no 1, p. 16-21Article in journal (Refereed)
  • 22.
    Ruge, Toralph
    et al.
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Physiological chemistry.
    Svensson, Maria
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
    Olivecrona, Gunilla
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Physiological chemistry.
    Tissue-specific regulation of lipoprotein lipase in humans: effects of fasting.2005In: Eur J Clin Invest, ISSN 0014-2972, Vol. 35, no 3, p. 194-200Article in journal (Refereed)
  • 23.
    Sahli, David
    et al.
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Eliasson, Björn
    Svensson, Maria
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Blohmé, Göran
    Eliasson, Mats
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Samuelsson, Pär
    Öjbrandt, Kristina
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine.
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Assessment of toe blood pressure is an effective screening method to identify diabetes patients with lower extremity arterial disease2004In: Angiology, ISSN 0003-3197, E-ISSN 1940-1574, Vol. 55, no 6, p. 641-651Article in journal (Refereed)
  • 24. Schölin, A
    et al.
    Björklund, L
    Borg, H
    Arnqvist, H
    Björk, E
    Blohmé, G
    Bolinder, J
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Gudbjörnsdottir, S
    Nyström, Lennarth
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Public Health Sciences.
    Östman, J
    Karlsson, A F
    Sundkvist, G
    Islet antibodies and remaining beta-cell function 8 years after diagnosis of diabetes in young adults: a prospective follow-up of the nationwide Diabetes Incidence Study in Sweden.2004In: J Intern Med, ISSN 0954-6820, Vol. 255, no 3, p. 384-91Article in journal (Refereed)
  • 25. Schölin, A
    et al.
    Törn, C
    Nyström, Lennarth
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Public Health Sciences.
    Berne, C
    Arnqvist, H
    Blohmé, G
    Bolinder, J
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Kockum, I
    Landin-Olsson, M
    Östman, J
    Karlsson, F A
    Sundkvist, G
    Björk, E
    Normal weight promotes remission and low number of islet antibodies prolong the duration of remission in Type 1 diabetes.2004In: Diabet Med, ISSN 0742-3071, Vol. 21, no 5, p. 447-55Article in journal (Refereed)
  • 26. Schölin, Anna
    et al.
    Siegbahn, Agneta
    Lind, Lars
    Berne, Christian
    Sundkvist, Göran
    Björk, Elisabeth
    Karlsson, F Anders
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    CRP and IL-6 concentrations are associated with poor glycemic control despite preserved beta-cell function during the first year after diagnosis of type 1 diabetes.2004In: Diabetes Metab Res Rev, ISSN 1520-7552, Vol. 20, no 3, p. 205-10Article in journal (Refereed)
  • 27. Sjöholm, Å
    et al.
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Lönnqvist, F
    Eliasson, B
    Insulinresistens - kardiovaskulära risker och nya behandlingsstrategier2004In: Medikament, no 5-03Article in journal (Other (popular science, discussion, etc.))
  • 28. Sun, Chengjun
    et al.
    Sedimbi, Saikiran K
    Ashok, Ayyappa K
    Sanjeevi, Carani B
    Landin-Olsson, Mona
    Arnqvist, Hans
    Björck, Elisabeth
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Nyström, Lennarth
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health.
    Ohlson, Lars Olof
    Scherstén, Bengt
    Östman, Jan
    Aili, M
    Bååth, LE
    Carlsson, E
    Edenwall, H
    Forsander, G
    Granström, BW
    Gustavsson, I
    Hanås, R
    Hellenberg, L
    Hellgren, H
    Holmberg, E
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
    Hörnell, H
    Ivarsson, S-A
    Johansson, C
    Jonsell, G
    Kockum, K
    Lindblad, B
    Lindh, A
    Ludvigsson, J
    Myrdal, U
    Neiderud, J
    Segnestam, K
    Sjöblad, S
    Skogsberg, L
    Strömberg, L
    Ståhle, U
    Thalme, B
    Tullus, K
    Tuvemo, T
    Wallensteen, M
    Westphal, O
    Dahlquist, Gisela
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
    Åman, J
    CRYAB-650 C>G (rs2234702) affects susceptibility to type 1 diabetes and IAA-positivity in Swedish population2012In: Human Immunology, ISSN 0198-8859, E-ISSN 1879-1166, Vol. 73, no 7, p. 759-766Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Single nucleotide polymorphisms (SNPs) in the promoter region of CRYAB gene have been associated with in multiple sclerosis. CRYAB gene, which encodes alpha B-crystallin (a member of small heat shock protein), was reported as a potential autoimmune target. In this study we investigated whether SNPs in the promoter region of CRYAB gene were also important in the etiology of Type 1 diabetes (T1D).

    METHODS: Genotyping of SNPs in the promoter region of CRYAB gene was performed in a Swedish cohort containing 444 T1D patients and 350 healthy controls. Three SNPs were included in this study: CRYAB-652 A>G (rs762550), -650 C>G (rs2234702) and -249 C > G (rs14133). Two SNPs (CRYAB-652 and -650) were not included in previous genome wide association studies.

    RESULTS: CRYAB-650 (rs2234702)*C allele was significantly more frequent in patients than in controls (OR = 1.48, Pc = 0.03). CRYAB-650*C allele was associated with IAA positivity (OR = 8.17, Pc < 0.0001) and IA-2A positivity (OR = 2.14, Pc = 0.005) in T1D patients. This association with IAA was amplified by high-risk HLA carrier state (OR = 10.6, P < 0.0001). No association was found between CRYAB-650 and other autoantibody positivity (GADA and ICA). CRYAB haplotypes were also associated with IAA and IA-2A positivity (highest OR = 2.07 and 2.11, respectively), these associations remain in high HLA-risk T1D patients.

    CONCLUSIONS: CRYAB-650 was associated with T1D in the Swedish cohort we studied. CRYAB-650*C allele might confers susceptibility to the development of T1D. CRYAB-650 was also associated with the development of IAA-positivity in T1D patients, especially in those carrying T1D high-risk HLA haplotypes.

  • 29.
    Svensson, Maria
    et al.
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Insulin resistance in diabetic nephropathy--cause or consequence?2006In: Diabetes Metab Res Rev, ISSN 1520-7552, Vol. 22, no 5, p. 401-10Article in journal (Refereed)
  • 30.
    Svensson, Maria
    et al.
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Dahlquist, Gisela
    Umeå University, Faculty of Medicine, Clinical Sciences, Paediatrics.
    Early glycemic control, age at onset, and development of microvascular complications in childhood-onset type 1 diabetes: a population-based study in northern Sweden.2004In: Diabetes Care, ISSN 0149-5992, Vol. 27, no 4, p. 955-62Article in journal (Refereed)
  • 31. Tan, M H
    et al.
    Johns, D
    Strand, J
    Halse, J
    Madsbad, S
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Clausen, J
    Konkoy, C S
    Herz, M
    Sustained effects of pioglitazone vs. glibenclamide on insulin sensitivity, glycaemic control, and lipid profiles in patients with Type 2 diabetes.2004In: Diabet Med, ISSN 0742-3071, Vol. 21, no 8, p. 859-66Article in journal (Refereed)
  • 32. Valdes, AM
    et al.
    Thomson, G
    Graham, J
    Zarghami, M
    McNeney, B
    Eriksson, Jan
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine.
    D6S265*15 mars a DRB1*15, DQB1*002 haplotype associated with attenuated protection from type 1 diabetes mellitus.2005In: Diabetologia, ISSN 0012-186X, Vol. 48, no 12, p. 2540-3Article in journal (Refereed)
1 - 32 of 32
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