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  • 1.
    Lundgren, Stefan
    et al.
    Umeå University, Faculty of Medicine, Department of Odontology, Oral and Maxillofacial Surgery. Umeå University, Faculty of Medicine, Department of Odontology.
    Nyström, Elisabeth
    Umeå University, Faculty of Medicine, Department of Odontology, Oral and Maxillofacial Surgery. Umeå University, Faculty of Medicine, Department of Odontology.
    Sennerby, Lars
    Sjöström, Mats
    Brechter, Magnus
    Umeå University, Faculty of Medicine, Department of Odontology, Oral and Maxillofacial Surgery.
    Nilson, Hans
    Öberg, Sven
    Lundqvist, Peter
    Jungner, Måns
    Umeå University, Faculty of Medicine, Department of Odontology, Oral and Maxillofacial Surgery.
    Tidehag, Per
    Gunne, Johan
    Umeå University, Faculty of Medicine, Department of Odontology, Prosthetic Dentistry.
    Rekonstruktiv käkkirurgi 2: Behandling av den tandlösa atrofiska maxillan2008In: Tandläkartidningen, ISSN 0039-6982, Vol. 100, no 5, p. 72-73Article in journal (Other (popular science, discussion, etc.))
  • 2.
    Öberg, Sven
    Umeå University, Faculty of Medicine, Department of Odontology.
    Bone Healing after implantation of bone substitute materials. Experimental studies in estrogen deficiency.2003Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Bone formation and bone healing were studied in the mandible, tibia and skull bones in adult, healthy and estrogen deficient rabbits implanted with different bone substitutes.

    In the first study an evaluation of the differences in bone regeneration in and around solid (Alveograf *) and porous hydroxyapatite (Interpore 200*) was undertaken. The implant material was placed into experimentally made bone defects and in half of the defects hydroxyapatite was mixed with a fibrin sealant (Tisseel *). The material alone or mixed with Tisseel was also placed subperiostally in the mandible. The observation time was six month. No difference in bone regeneration was found between solid or porous hydroxyapatite granulas and the addition of Tisseel* did not seem to disturb the bone healing process. The implant material placed subperiostally did not induce bone formation nor did it provoke any bone resorption. The addition of Tisseel made the implant material much easier to handle and retain in the tissue during surgery.

    Bone healing around hydroxyapatite implants was also evaluated in the second study. Experimental cavities in the mandible and tibia were filled with hydroxyapatite in granules or blocks (Interpore 200*) but now with or without autolyzed, antigen-extracted, allogeneic bone (AAA). Also in this study Tisseel* was used to facilitate the handling of the material. All cavities implanted with AAA-bone, regardless of the combination with hydroxyapatite or Tisseel, demonstrated excessive bone formation resembling exostosis formation. Thus, hydroxyapatite, both as granules and blocks, can be successfully combined with AAA bone utilizing the bone inductive capacity of AAA bone.

    The same model was used to study the healing in ovariectomized animals in the third study. Bone cavities were implanted with or without AAA bone and left to heal. The results indicate that the osteoinductive capacity of AAA bone is in operation also in animals deprived of a normal estrogen production.

    The effect of using AAA bone prior to implant insertion was studied in paper four. The bone-implant contact was significant higher when AAA bone had been used. The implant stability did not seem to be affected.

    In paper five defects were made in skull and tibial bone in estrogen deficient animals. The deficiency of estrogen was confirmed through blood analysis, the decrease in the weight of uterus and bone mineral density. The whole body scanning with DEXA showed that the ovariectomized animals developed osteopenia. Various degree of bone formation was seen in the defects due to the influence of the bone inductive substance AAA bone.

    The studies indicate that a conductive material like hydroxyapatite in granules or blocks could be useful in oral reconstructive surgery. The combination with AAA bone enhanced the bone formation in calvarial and tibial bone in healthy and estrogen deficient animals. Tisseel* could be used to facilitate handling and retention of the material in the intended position during the healing process without negative effects.

  • 3.
    Öberg, Sven
    et al.
    Umeå University, Faculty of Medicine, Department of Odontology.
    Kahnberg, Karl-Erik
    Combined use of hydroxy-apatite and Tisseel in experimental bone defects in the rabbit1993In: Swedish Dental Journal, ISSN 0347-9994, Vol. 17, no 3, p. 147-153Article in journal (Refereed)
  • 4.
    Öberg, Sven
    et al.
    Umeå University, Faculty of Medicine, Department of Odontology.
    Rosenquist, Jan
    Bone healing after implantation of hydroxyapatite granules and blocks (Interpore 200) combined with autolyzed antigen-extracted allogeneic bone and fibrin glue1994In: International Journal of Oral & Maxillofacial Surgery, ISSN 0901-5027, Vol. 23, no 4, p. 110-114Article in journal (Refereed)
  • 5.
    Öberg, Sven
    et al.
    Umeå University, Faculty of Medicine, Department of Odontology.
    Rosenquist, Jan
    Gordh, Monica
    Healing of bone defects in osteopenic rabbits.: Effect of autolyzed antigen-extracted allogeneic bone substitute on calvarial and tibial bone.Manuscript (Other academic)
  • 6.
    Öberg, Sven
    et al.
    Umeå University, Faculty of Medicine, Department of Odontology.
    Rosenquist, Jan
    Johansson, Carina
    Bone formation after implantation of autolyzed antigen-extracted allogeneic bone in ovariectomized rabbits.2003In: International Journal of Oral & Maxillofacial Surgery, ISSN 0901-5027, Vol. 32, no 6, p. 628-632Article in journal (Refereed)
  • 7.
    Öberg, Sven
    et al.
    Umeå University, Faculty of Medicine, Department of Odontology.
    Sennerby, Lars
    Integration of titanium implants in bone defects reconstructed with autolyzed antigen-extracted allogeneic (AAA) bone powder prior to implant placement: a histological and resonance frequency analysis study in the rabbitManuscript (preprint) (Other academic)
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