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  • 1401.
    van Dijken, Jan W V
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    A prospective 8-year evaluation of a mild two-step self-etching adhesive and a heavily filled two-step etch-and-rinse system in non-carious cervical lesions.2010Inngår i: Dental Materials, ISSN 0109-5641, E-ISSN 1879-0097, Vol. 26, nr 9, s. 940-946Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVES: The aim of this study was to evaluate the long-term clinical retention to dentin of a two-step self-etching adhesive system Clearfil SE Bond and a two-step etch-and-rinse system PQ1. METHODS: A total of 119 Class V restorations were placed in non-carious cervical lesions without intentional involvement of the enamel incisal of the lesions. The restorations were evaluated yearly during an 8-year follow-up. Clinical dentin bonding efficiency was determined by the percentage of lost restorations at each of the recalls. RESULTS: At 8 years, 112 restorations could be evaluated. Both adhesives fulfilled the ADA 18-month full acceptance criteria for retention with a retention rate of 90.6% for PQ1 and 98.2% for Clearfil SE Bond. The loss rates increased then considerably after 2 and 3 years, respectively. The cumulative loss rates at 8 years were 25.5% for Clearfil SE and 39.3% for PQ1 (p=0.12). No significant differences were observed between lesions with sclerotic and non-sclerotic dentin. The size of the lesions did not influence the bonding effectiveness. A lower loss rate was found for the restorations placed in lesions slightly roughened before etching. CONCLUSION: Both adhesive systems showed acceptable short-term clinical retention to dentin, which decreased after long-time in vivo aging, especially for the simplified etch-and-rinse system.

  • 1402.
    van Dijken, Jan W. V.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    A randomized controlled 5-year prospective study of two HEMA-free adhesives, a 1-step self etching and a 3-step etch-and-rinse, in non-carious cervical lesions.2013Inngår i: Dental Materials, ISSN 0109-5641, E-ISSN 1879-0097, Vol. 29, nr 11, s. e271-e280Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVE: The aim of this study was to evaluate the 5 year clinical dentin bonding effectiveness of two HEMA-free adhesives in Class V non-carious cervical lesions.

    MATERIAL AND METHODS: A total of 169 Class V restorations were placed in 67 patients with a self-etching adhesive (G-Bond; 67), a 3-step HEMA and TEGDMA free etch-and-rinse (cfm; 51) and a control HEMA-containing etch-and-rinse adhesive (XP Bond; 51) in non-carious cervical lesions without intentional enamel involvement. The restorations were evaluated at baseline and yearly during a 5 year follow-up with modified USPHS criteria. Dentin bonding efficiency was determined by the percentage of lost restorations.

    RESULTS: During the 5 years, 159 restorations could be evaluated. Good short time dentin retention was observed for the three adhesives, there all adhesives fulfilled at 18 months the full acceptance ADA criteria. At 5 years a cumulative number of 22 lost restorations (13.8%) was observed. The HEMA-free adhesives showed significantly higher dentin retention compared to the HEMA-containing one. Loss of retention was observed for 5 G-Bond (7.9%), 4cfm (8.3%) and 13 XP Bond (27.1%) restorations (p<0.05). No post-operative sensitivity was reported by the participants. No secondary caries was observed.

    SIGNIFICANCE: The durability in non-carious cervical lesions of the HEMA-free adhesives was successful after 5 years. Despite concerns which have been raised, showed the 1-step SEA one of the best reported clinical dentin bonding effectiveness.

  • 1403.
    van Dijken, Jan W V
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Ceramic inlays cemented adhesively with glass-ionomer cement and resin composite luting agents2005Inngår i: Adhesive technology for restorative dentistry / [ed] Roulet, JF; Vanherle, G, Hanover Park: Quintessence publishing co inc , 2005, s. 135-151Konferansepaper (Fagfellevurdert)
    Abstract [en]

    This chapter reviews different ceramics and the influence of luting agents on the durability of ceramic inlays and onlays. The dental literature was reviewed for longitudinal, controlled clinical studies of ceramic inlays and onlays; luted with different luting agents. Longevity and annual failure were determined. Phosphate cements, light-cured resin composites, and conventional glass-ionomer cements showed unacceptable, high clinical failure rates and are not suitable for luting dental ceramic inlays. Dual-cured and chemically cured resin composites and a resin-modified glass-ionomer cement showed better durability. Inlays of pressed ceramics and computer-aided design/computer assisted manufacture (CAD/CAM)-produced ceramics showed better longevity than fired-ceramic inlays.

  • 1404.
    van Dijken, Jan W V
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Durability of resin composite restorations in high C-factor cavities: A 12-year follow-up2010Inngår i: Journal of Dentistry, ISSN 0300-5712, E-ISSN 1879-176X, Vol. 38, nr 6, s. 469-474Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVE: Polymerization shrinkage and shrinkage stress has been considered as one of the main disadvantages of resin composite restorations. Cavities with high C-factors increase the risk for interfacial failures. Several restorative techniques have been suggested to decrease the shrinkage stress. The purpose of this study was to evaluate the durability of techniques as oblique layering, indirect curing and/or a laminate with a poly-acid modified resin composite in direct Class I resin composite restorations in a 12-year follow-up. METHODS: Each of 29 patients received one or two pair(s) rather extensive Class I restorations. The first restoration was a poly-acid modified resin composite/resin composite sandwich restoration and the second a direct resin composite restoration. Both restorations, except for the laminate layer, were placed with oblique layering and two-step curing technique. 90 restorations were evaluated annually with slightly modified USPHS criteria during 12 years. RESULTS: At 12 years, 38 pairs were evaluated. Two cases of slight post-operative sensitivity were observed in one patient. A cumulative failure rate of 2.4% was observed for both the resin composite and the laminate restorations. One laminate restoration showed non-acceptable color match, but was not replaced and one resin composite restoration showed a chip fracture. Five restorations were replaced due to primary proximal caries. CONCLUSIONS: The high failure rate expected in the high C-factor Class I cavity, associated with polymerization shrinkage and shrinkage stress, were not observed. The techniques used resulted in an excellent durability for the Class I resin composite restorations.

  • 1405.
    van Dijken, Jan W V
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Koistinen, S
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Ramberg, Per
    A randomized controlled clinical study of the effect of daily intake of Ascophyllum nodosum alga on calculus, plaque, and gingivitis2015Inngår i: Clinical Oral Investigations, ISSN 1432-6981, E-ISSN 1436-3771, Vol. 19, nr 6, s. 1507-1518Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVE: The aim of this study is to evaluate, in a randomized controlled cross-over study, the effect of daily intake of the alga Ascophyllum nodosum on supragingival calculus, plaque formation, and gingival health over a 6-month period.

    MATERIAL AND METHODS: Sixty-one adults with moderate to heavy calculus formation since their last yearly recall visit participated. In a randomized order over two 6-month periods, they swallowed two capsules daily, comprising a total of 500 mg dried marine alga powder (Ascophyllum nodosum, ProDen PlaqueOff®) or two negative control tablets. During the study, the participants maintained their regular oral habits. Their teeth were professionally cleaned at the start of each period and after the 6-month registrations. A wash out period of 1 month separated the two 6-month periods. Supragingival calculus (Volpe Manhold), gingivitis (Löe and Silness), gingival bleeding (Ainamo and Bay), and plaque (Quigley-Hein) were registered at screening and at the end of the two periods. Differences in oral health between the test and control periods were analyzed using a paired t test and Wilcoxon signed rank test.

    RESULTS: Fifty-five participants completed the study. After the alga intake, the mean calculus reduction was 52 % compared to the control (p < 0.0001). Fifty-two participants showed less calculus formation in the alga group than in the control group. Plaque (p = 0.008) and gingival bleeding (p = 0.02) were also significantly less in the alga group. However, no significant difference was found between the groups for gingivitis (p = 0.13).

    CONCLUSIONS: The alga intake significantly reduced the formation of supragingival calculus and plaque and occurrence of gingival bleeding. The alga has a systemic effect on oral health.

    CLINICAL RELEVANCE: Daily intake of the alga Ascophyllum nodosum as an adjunct to customary oral hygiene showed a major reduction of supragingival calculus formation and reduced plaque formation. In addition, the calculus in the alga group was characterized by a more porous and less solid structure and was easier to remove than the calculus in the control group.

  • 1406.
    van Dijken, Jan W V
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandläkarutbildning.
    Lindberg, Anders
    A 15-year randomized controlled study of a reduced shrinkage stress resin composite2015Inngår i: Dental Materials, ISSN 0109-5641, E-ISSN 1879-0097, Vol. 31, nr 9, s. 1150-1158Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVES: The aim of this randomized controlled study was to evaluate the long term effectiveness of a reduced shrinkage stress resin composite in Class II restorations. The material was compared intra-individually with a microhybrid resin composite.

    MATERIALS AND METHODS: Each of 50 patients with at least one pair of two similar sized Class II cavities participated (22 female, 28 male, mean age 43 years, range 18-64). Each participant received in each pair, in a randomized way, one Class II restoration performed with a reduced shrinkage stress resin composite (InTen-S) and the other restoration with a microhybrid resin composite restoration (Point 4). Both restorations were placed with an etch-and-rinse bonding system and an oblique layering technique. A total of 106 restorations, 33 premolar and 73 molars, were placed. The restorations were evaluated blindly each year using modified USPHS criteria. The overall performance of the experimental restorations was tested after intra-individual comparison using the Friedmańs two-way analysis of variance test. The hypothesis was rejected at the 5% level.

    RESULTS: At 15 years, 91 restorations were evaluated. The drop out frequency was 15 restorations (5 male, 3 female participants; 2 premolar and 13 molar restorations). Except for 2 participants, who reported slight symptoms during a few weeks after placement, no post-operative sensitivity was observed at the recalls. The overall success rate at 15 years was 77%. Twenty-one non acceptable restorations were observed during the 15 years follow up, 10 InTen-S (21.7%) and 11 Point 4 (24.4%) restorations (p>0.05). Annual failure rates for the resin composites were 1.5% and 1.6%, respectively. The main reasons for failure were secondary caries (8) and resin composite fracture (7). The differences between premolar vs. molar restorations and between restorations in male vs. female participants were not significant. Significant differences were observed between 2-surface vs. 3-surface restorations.

    SIGNIFICANCE: During the 15-year follow up, the reduced shrinkage stress resin composite showed a good clinical durability in Class II cavities, but not significantly better than the control microhybrid resin composite. Secondary caries and material fracture were the main reasons of failure.

  • 1407.
    van Dijken, Jan W V
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Lindberg, Anders
    Clinical effectiveness of a low-shrinkage resin composite: a five-year evaluation2009Inngår i: The journal of adhesive dentistry, ISSN 1461-5185, Vol. 11, nr 2, s. 143-148Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    PURPOSE: To study the durability of a recently developed low-shrinkage resin composite, suggested to counter the stress formation in direct resin composite restorations. MATERIALS AND METHODS: Each of 50 patients received one or two pair(s) of Class II restorations. The first restoration in the pair was a low-shrinkage resin composite (InTen-S) and the second a hybrid resin composite restoration (Point 4). Both restorations were placed with an etch-and-rinse bonding system and an oblique layering technique. A total of 106 restorations, 33 premolar and 73 molars, were placed. The restorations were evaluated annually. RESULTS: At 5 years, 97 restorations were evaluated. Two participants reported slight postoperative sensitivity symptoms for a few weeks after placement. Twelve non acceptable restorations were observed during the 5 years, five InTen-S (10.4%) and 7 Point 4 (14.3%) (not significant). Secondary caries was the main reason for failure (8) followed by composite fracture (2) and tooth fracture (2). CONCLUSION: The low-shrinkage resin composite showed good durability, but not significantly better than the control resin composite in Class II cavities. Most failures occurred at the last part of the study. Secondary caries was the main reason for failure.

  • 1408.
    van Dijken, Jan W V
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Pallesen, Ulla
    A 7-year randomized prospective study of a one-step self-etching adhesive in non-carious cervical lesions. The effect of curing modes and restorative material.2012Inngår i: Journal of Dentistry, ISSN 0300-5712, E-ISSN 1879-176X, Vol. 40, nr 12, s. 1060-7Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVE: The aim of this study was to evaluate the clinical retention of a one-step self-etching adhesive system (Xeno III) in Class V non-carious cervical lesions and the effect of restorative material and curing techniques on longevity of the restorations.

    MATERIALS AND METHODS: A total of 139 Class V restorations were placed with the self-etching primer Xeno III and a resin composite (Tetric Ceram) or a poly-acid modified resin composite (Dyract AP) in non-carious cervical lesions without intentional enamel involvement. The materials were cured with a conventional continuous light, a soft-start or a pulse-delay curing mode. The restorations were evaluated at baseline, 6, 12, 18 and 24 months and then yearly during a 7 year follow-up with modified USPHS criteria. Dentine bonding efficiency was determined by the percentage of lost restorations.

    RESULTS: During the 7 years, 135 restorations could be evaluated. No post-operative sensitivity was reported by the participants. Overall relative cumulative loss rate frequencies for the adhesive system at 6 and 18 months and 7 years, independent of curing technique and restorative material, were 0.8%, 6.9% and 23.0%, respectively. The self-etching adhesive fulfilled at 18 months the full acceptance ADA criteria. Tetric Ceram showed at 7 years a 20.9% loss of retention and Dyract AP a 25.0% loss rate (Log rank p=0.48). The loss rates for the 3 curing techniques: continuous, soft start and pulse delay were 17%, 27.9% and 24.4%, respectively (Log rank p=0.52). No secondary caries was observed.

    SIGNIFICANCE: The single-step self-etching adhesive showed acceptable clinical long-time retention rates to dentine surfaces independent of restorative material and curing technique used.

  • 1409.
    van Dijken, Jan W. V.
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandhygienistutbildning.
    Pallesen, Ulla
    A Randomized 10-year Prospective Follow-up of Class II Nanohybrid and Conventional Hybrid Resin Composite Restorations2014Inngår i: Journal of Adhesive Dentistry, ISSN 1461-5185, Vol. 16, nr 6, s. 585-592Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Purpose: To evaluate the 10-year durability of a nanohybrid resin composite in Class II restorations in a randomized controlled intraindividual comparison with its conventional hybrid resin composite predecessor. Materials and Methods: Each of 52 participants received at least two Class II restorations that were as similar as possible. The cavities were chosen at random to be restored with a nanohybrid resin composite (Excite/Tetric EvoCeram (TEC); n = 61) and a conventional hybrid (Excite/Tetric Ceram (TC); n = 61). The restorations were evaluated with slightly modified USPHS criteria at baseline and then annually for 10 years. The overall performance of the experimental restorations was tested after intra-individual comparison and their ranking was tested using Friedman's two-way ANOVA. The level of significance was set at 5%. Results: Four patient drop-outs with 8 restorations (4TEC, 4TC) were registered during the follow-up. A prediction of the caries risk showed that 16 of the evaluated 52 patients were considered as high risk patients. In total, 22 restorations, 11 TEC (3 premolars, 8 molars) and 11 TC (3 premolars, 8 molars) restorations failed during the 10 years. The main reason for failure was secondary caries (50%). 63% of the recurrent caries lesions were found in high caries risk participants. The overall success rate at 10 years was 80.7%, with an annual failure rate of 1.9%. No statistically significant difference was found in the overall survival rate between the two investigated resin composites. Conclusion: The nanohybrid and the conventional hybrid resin composite showed good clinical effectiveness in extensive Class II restorations during the 10-year study.

  • 1410.
    van Dijken, Jan W. V.
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandhygienistutbildning.
    Pallesen, Ulla
    Univ Copenhagen, Fac Hlth Sci, Inst Odontol, DK-1168 Copenhagen, Denmark.
    A randomized controlled three year evaluation of "bulk-filled" posterior resin restorations based onstress decreasing resin technology2014Inngår i: Dental Materials, ISSN 0109-5641, E-ISSN 1879-0097, Vol. 30, nr 9, s. E245-E251Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective. The objective of this randomized controlled prospective clinical trial was to evaluate the efficacy of a flowable resin composite (SDR) bulk fill technique in posterior restorations and to compare it intraindividually with a conventional 2 mm resin composite curing technique in a 3-year follow up. Materials and methods. Thirty-eight pairs Class II and 15 pairs Class I restorations were placed in 38 patients with a mean age of 55.3 years (range 32-87). Each patient received at random at least two, as similar as possible, Class II or Class I restorations of two restorative techniques. In all cavities a single step self-etch adhesive (Xeno V) was applied. In one of the cavities of each pair, a flowable resin composite (SDR) was placed, in bulk increments up to 4 mm as needed to fill the cavity 2 mm short of the occlusal cavosurface. The occlusal part was completed with a nano-hybrid resin composite (Ceram X mono) layer. In the second cavity, the hybrid resin composite was placed in 2 mm increments. The restorations were evaluated using slightly modified USPHS criteria at baseline and then yearly during 3 years. Caries risk and parafunctional habits of the participants were estimated. Results. After three years, 76 Class II and 28 Class I restorations could be observed. One molar resin composite-only tooth showed post-operative sensitivity during 3 weeks for temperature changes and occlusal forces. Two failed Class II molar restorations in the resin composite-only group were observed during the first year, one cusp fracture and one resin composite fracture. An annual failure rate of 1.3% was found for the resin composite only restorations and of 0% in the bulk-filled restorations (n.s.). Ten participants were estimated as having high caries risk and eleven showed active bruxing habits. Significance. The 4 mm bulk-fill technique with the flowable resin composite SDR showed highly clinical effectiveness, which was comparable during the 3-year follow-up with the 2 mm resin composite layering technique. 

  • 1411.
    van Dijken, Jan W V
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Pallesen, Ulla
    University of Copenhagen.
    A six-year prospective randomized study of a nano-hybrid and a conventional hybrid resin composite in Class II restorations2013Inngår i: Dental Materials, ISSN 0109-5641, E-ISSN 1879-0097, Vol. 29, nr 2, s. 191-198Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: The objective of this 6 year prospective randomized equivalence trial was to evaluate the long-term clinical performance of a new nano-hybrid resin composite (RC) in Class II restorations in an intraindividual comparison with its well-established conventional hybrid RC predecessor. Methods: Each of 52 participants received at least two, as similar as possible, Class II restorations. The cavities were chosen at random to be restored with an experimental nano-hybrid RC (Exite/Tetric EvoCeram (TEC); n = 61) and a conventional hybrid RC (Exite/Tetric Ceram (TC); n = 61). The restorations were evaluated with slightly modified USPHS criteria at baseline and then annually during 6 years. Results: Two patient drop outs with 4 restorations (2TEC, 2TC) were registered during the follow-up. A prediction of the caries risk showed that 16 of the evaluated 52 patients were considered as high risk patients. Eight TEC (2 P, 6M) and 6 TC (2P, 4M) restorations failed during the 6 years. The main reason of failure was secondary caries (43%; including the failure fracture + secondary caries it increases to 57.1%). 63% of the recurrent caries lesions were found in high caries risk participants. The overall success rate at six years was 88.1%. No statistical significant difference was found in the overall survival rate between the two investigated RC.Significance: The nano-hybrid RC showed good clinical performance during the 6 year evaluation, comparable to the well-established conventional hybrid RC.

  • 1412.
    van Dijken, Jan W V
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Pallesen, Ulla
    Bulk-filled posterior resin restorations based on stress-decreasing resin technology: a randomized, controlled 6-year evaluation2017Inngår i: European Journal of Oral Sciences, ISSN 0909-8836, E-ISSN 1600-0722, Vol. 125, nr 4, s. 303-309Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This randomized study evaluated a flowable resin composite bulk-fill technique in posterior restorations and compared it intraindividually with a conventional 2-mm resin composite layering technique over a 6-yr follow-up period. Thirty-eight pairs of Class II restorations and 15 pairs of Class I restorations were placed in 38 adults. In all cavities a single-step self-etch adhesive (Xeno V) was applied. In the first cavity of each pair, the flowable resin composite (SDR) was placed, in bulk increments of up to 4 mm. The occlusal part was completed with a layer of nanohybrid resin composite (Ceram X mono). In the second cavity of each pair, the hybrid resin composite was placed in 2-mm increments. The restorations were evaluated using slightly modified US Public Health Service (USPHS) criteria at baseline and then annually for a time period of 6 yr. After 6 yr, 72 Class II restorations and 26 Class I restorations could be evaluated. Six failed Class II molar restorations, three in each group, were observed, resulting in a success rate of 93.9% for all restorations and an annual failure rate (AFR) of 1.0% for both groups. The AFR for Class II and Class I restorations in both groups was 1.4% and 0%, respectively. The main reason for failure was resin composite fracture.

  • 1413.
    van Dijken, Jan W V
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Pallesen, Ulla
    School of Dentistry, Faculty of Health Science, University of Copenhagen, Denmark.
    Clinical performance of a hybrid resin composite with and without an intermediate layer of flowable resin composite: a 7-year evaluation2011Inngår i: Dental Materials, ISSN 0109-5641, E-ISSN 1879-0097, Vol. 27, nr 2, s. 150-156Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVE: The objective of this prospective clinical follow up was to evaluate the long term clinical performance of a hybrid resin composite in Class II restorations with and without intermediate layer of flowable resin composite.

    METHODS: Each participant received at least two, as similar as possible, Class II restorations of the hybrid resin composite. One resin composite restoration of each pair (59) was chosen at random to be restored with an intermediary layer with flowable resin composite. The other was restored without. The 118 restorations were evaluated using slightly modified USPHS criteria at baseline and then yearly during 7 years.

    RESULTS: Four drop outs were registered during the 7-year follow up (2 with and 2 without flowable) restorations. A prediction of the caries risk showed that 18 of the evaluated 46 patients were considered as high risk patients. Seventeen failures were observed, 8 in restorations with and 9 in restorations without an intermediate layer of flowable resin composite, resulting in a 14.9% failure rate after 7 years. The main reasons for failure were: fracture of resin composite (8), secondary caries (4) and cusp fracture (3). No statistical difference was seen between restorations restored with and without flowable layer.

    CONCLUSION: The hybrid resin composite showed a good clinical performance during the 7-year evaluation. The use of flowable resin composite as an intermediate layer did not result in improved effectiveness of the Class II restorations.

  • 1414.
    van Dijken, Jan W V
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Pallesen, Ulla
    Durability of a low shrinkage TEGDMA/HEMA-free resin composite system in Class II restorations: A 6-year follow up2017Inngår i: Dental Materials, ISSN 0109-5641, E-ISSN 1879-0097, Vol. 33, nr 8, s. 944-953Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVE: The objective of this randomized controlled prospective trial was to evaluate the durability of a low shrinkage and TEGDMA/HEMA-free resin composite system in posterior restorations in a 6-year follow up.

    METHODS: 139 Class II restorations were placed in 67 patients with a mean age of 53 years (range 29-82). Each participant received at random two, as similar as possible, Class II restorations. In the first cavity of each pair the TEGDMA/HEMA-free resin composite system was placed with its 3-step etch-and-rinse adhesive (cmf-els). In the second cavity a 1-step HEMA-free self-etch adhesive was used (AdheSe One F). The restorations were evaluated using slightly modified USPHS criteria at baseline and then yearly during 6 years. Caries risk and parafunctional habits of the participants were estimated.

    RESULTS: Three molar teeth showed mild post-operative sensitivity during 3 weeks for temperature changes and occlusal forces. After 6 years, 134 Class II restorations were evaluated. Twenty-one restorations, 8 cmf-els (11.4%) and 13 ASE-els (20%) failed during the 6 years (p<0.0001). The annual failure rates were 1.9% and 3.3%, respectively. The main reasons for failure were fracture followed by recurrent caries. Most fractures and all caries lesions were found in high risk participants.

    SIGNIFICANCE: The Class II resin composite restorations performed with the new TEGDMA/HEMA-free low shrinkage resin composite system showed good durability over six years.

  • 1415.
    van Dijken, Jan W V
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Pallesen, Ulla
    Eight-year randomized clinical evaluation of Class II nanohybrid resin composite restorations bonded with a one-step self-etch or a two-step etch-and-rinse adhesive2015Inngår i: Clinical Oral Investigations, ISSN 1432-6981, E-ISSN 1436-3771, Vol. 19, nr 6, s. 1371-1379Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVES: The aim of this study is to observe the durability of Class II nanohybrid resin composite restorations, placed with two different adhesive systems, in an 8-year follow-up.

    METHODS: Seventy-eight participants received at random at least two Class II restorations of the ormocer-based nanohybrid resin composite (Ceram X) bonded with either a one-step self-etch adhesive (Xeno III) or a control two-step etch-and-rinse adhesive (Excite). The 165 restorations were evaluated using slightly modified United States Public Health Services (USPHS) criteria at baseline and then yearly during 8 years.

    RESULTS: One hundred and fifty-eight restorations were evaluated after 8 years. Three participants with five restorations (three Xeno III, two Excite) were registered as dropouts. Twenty-one failed restorations (13.3 %) were observed during the follow-up. Twelve in the one-step self-etch adhesive group (13.5 %) and nine in the two-step etch-and-rinse group (13.0 %). This resulted in nonsignificant different annual failure rates of 1.69 and 1.63 %, respectively. Fracture of restoration was the main reason for failure.

    CONCLUSION: Good clinical performance was shown during the 8-year evaluation and no significant difference in overall clinical performance between the two adhesives. Fracture was the main reason for failure.

    CLINICAL RELEVANCE: The one-step self-etch adhesive showed a good long-term clinical effectiveness in combination with the nanohybrid resin composite in Class II restorations.

  • 1416.
    van Dijken, Jan W V
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Pallesen, Ulla
    Institute of Odontology, Faculty of Health Science, University of Copenhagen, Denmark.
    Four-year clinical evaluation of Class II nano-hybrid resin composite restorations bonded with a one-step self-etch and a two-step etch-and-rinse adhesive2011Inngår i: Journal of Dentistry, ISSN 0300-5712, E-ISSN 1879-176X, Vol. 39, nr 1, s. 16-25Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVE: The objective of this prospective clinical trial was to evaluate the 4-year clinical performance of an ormocer-based nano-hybrid resin composite (Ceram X; Dentsply/DeTrey) in Class II restorations placed with a one-step self-etch (Xeno III; Dentsply/DeTrey) and two-step etch-and-rinse adhesive (Ivoclar Vivadent).

    METHODS: Seventy-eight participants received at random at least two, as similar as possible, Class II restorations of the nano-hybrid resin composite bonded with either a single step self-etch adhesive or a control 2-step etch-and-rinse adhesive. The 165 restorations were evaluated using slightly modified USPHS criteria at baseline and then yearly during 4 years.

    RESULTS: 162 restorations were evaluated at 4 years. Postoperative sensitivity was observed in 6 patients (3 Xeno III, 3 Exite) between 1-3 weeks. Eleven failed restorations (6.8%) were observed during the follow up. Seven in the one-step self-etch adhesive group (7.7%) and four in the 2-step etch-and-rinse group (5.6%). This resulted in non-significant different annual failure rates of 1.9% and 1.4%, respectively. Fracture of restoration was the main reason for failure.

    CONCLUSION: The ormocer-based nano-hybrid resin composite showed a good clinical performance in Class II cavities during the 4 year evaluation. No significant difference was seen in overall clinical effectiveness between the two adhesives.

  • 1417.
    van Dijken, Jan W V
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Pallesen, Ulla
    Posterior bulk-filled resin composite restorations: a 5-year randomized controlled clinical study2016Inngår i: Journal of Dentistry, ISSN 0300-5712, E-ISSN 1879-176X, Vol. 51, s. 29-35Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVE: To evaluate in a randomized controlled study the 5-year clinical durability of a flowable resin composite bulk-fill technique in Class I and Class II restorations.

    MATERIAL AND METHODS: 38 pairs Class I and 62 pairs Class II restorations were placed in 44 male and 42 female (mean age 52.4 years). Each patient received at least two, as similar as possible, extended Class I or Class II restorations. In all cavities, a 1-step self-etch adhesive (Xeno V+) was applied. Randomized, one of the cavities of each pair received the flowable bulk-filled resin composite (SDR), in increments up to 4mm as needed to fill the cavity 2mm short of the occlusal cavosurface. The occlusal part was completed with the nano-hybrid resin composite (Ceram X mono+). In the other cavity, the resin composite-only (Ceram X mono+) was placed in 2mm increments. The restorations were evaluated using slightly modified USPHS criteria at baseline and then yearly during 5 years. Caries risk and bruxing habits of the participants were estimated.

    RESULTS: No post-operative sensitivity was reported. At 5-year 183, 68 Class I and 115 Class II, restorations were evaluated. Ten restorations failed (5.5%), all Class II, 4 SDR-CeramX mono+ and 6 CeramX mono+-only restorations. The main reasons for failure were tooth fracture (6) and secondary caries (4). The annual failure rate (AFR) for all restorations (Class I and II) was for the bulk-filled-1.1% and for the resin composite-only restorations 1.3% (p=0.12). For the Class II restorations, the AFR was 1.4% and 2.1%, respectively.

    CONCLUSION: The stress decreasing flowable bulk-fill resin composite technique showed good durability during the 5-year follow-up.

    CLINICAL SIGNIFICANCE: The use of a 4mm incremental technique with the flowable bulk-fill resin composite showed during the 5-year follow up slightly better, but not statistical significant, durability compared to the conventional 2mm layering technique in posterior resin composite restorations.

  • 1418.
    van Dijken, Jan W. V.
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandhygienistutbildning.
    Pallesen, Ulla
    Randomized 3-year Clinical Evaluation of Class I and II Posterior Resin Restorations Placed with a Bulk-fill Resin Composite and a One-step Self-etching Adhesive2015Inngår i: The Journal of Adhesive Dentistry, ISSN 1461-5185, Vol. 17, nr 1, s. 81-88Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Purpose: To evaluate the 3-year clinical durability of the flowable bulk-fill resin composite SDR in Class I and Class II restorations. Materials and Methods: Thirty-eight pairs of Class I and 62 pairs of Class II restorations were placed in 44 male and 42 female patients (mean age 52.4 years). Each patient received at least two extended Class I or Class II restorations that were as similar as possible. In all cavities, a one-step self-etching adhesive (XenoV+) was applied. One of the cavities of each pair was randomly assigned to receive the flowable bulk-fill resin composite SDR in increments up to 4 mm as needed to fill the cavity 2 mm short of the occlusal cavosurface. The occlusal part was completed with an ormocer-based nanohybrid resin composite (Ceram X mono+). In the other cavity, only the resin composite CeramX mono+ was placed in 2 mm increments. The restorations were evaluated using slightly modified USPHS criteria at baseline and then annually for 3 years. Caries risk and bruxing habits of the participants were estimated.

    Results: No post-operative sensitivity was reported. At the 3-year follow-up, 196 restorations - 74 Class I and 122 Class II - were evaluated. Seven restorations failed (3.6%), 4 SDR-CeramX mono+ and 3 CeramX mono+ only restorations, all of which were Class II. The main reason for failure was tooth fracture, followed by resin composite fracture. The annual failure rate (AFR) for all restorations (Class I and II) was 1.2% for the bulk filled restorations and 1.0% for the resin composite-only restorations (p > 0.05). For the Class II restorations, the AFR was 2.2% and 1.6%, respectively. Conclusion: The 4-mm bulk-fill technique showed good clinical effectiveness during the 3-year follow-up.

  • 1419.
    van Dijken, Jan W. V.
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Pallesen, Ulla
    Three-year randomized clinical study of a one-step universal adhesive and a two-step self-etch adhesive in class II composite restorations2017Inngår i: Journal of Adhesive Dentistry, ISSN 1461-5185, Vol. 19, nr 4, s. 287-294Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Purpose: To evaluate in a randomized clinical evaluation the 3-year clinical durability of a one-step universal adhesive and compare it intraindividually with a 2-step self-etch adhesive in Class II restorations.

    Materials and Methods: Each of 57 participants (mean age 58.3 years) received at least two extended Class II restorations that were as similar as possible. The cavities in each of the 60 individual pairs of cavities were randomly distributed to the 1-step universal adhesive (All-Bond Universal: AU) and the control 2-step self-etch adhesive (Optibond XTR: OX). A low shrinkage composite (Aelite LS) was used for all restorations, which were evaluated using slightly modified USPHS criteria at baseline and 1, 2, and 3 years.

    Results: 114 Class II restorations were evaluated at three years. Eight restorations, 3 AU and 5 OX, failed during the follow-up, resulting in 94.7% (AU) and 91.2% (OX) success rates (p > 0.05). Annual failure rates were 1.8% and 2.9%, respectively. The main reason for failure was composite fracture.

    Conclusion: Class II composite restorations placed with a 1-step universal adhesive showed good short-term efficacy.

  • 1420. van Dijken, Jan Wv
    et al.
    Sunnegårdh-Grönberg, Karin
    Umeå universitet, Medicinsk fakultet, Odontologi. Umeå universitet, Medicinsk fakultet, Odontologi, Tandhygienistutbildning.
    A calcium aluminate cement as restorative material in Class V cavities.2004Inngår i: Swedish Dental Journal, ISSN 0347-9994, Vol. 28, nr 3, s. 111-8Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Recently a calcium aluminate cement (Doxa Certex, Uppsala, Sweden) has been developed intended to be used as direct restorative filling material.The aim of this study was to evaluate intra-individually the experimental calcium aluminate cement (CAC) and a resin composite (RC;Tetric Ceram) in Class V restorations. Each of 46 participants received at least one pair of restorations of the same size, one CAC and one RC.The 119 restorations were evaluated clinically, according to slightly modified USPHS criteria, at baseline, after 6 mths, 1, 2 and 3 yrs. None of the patients reported post-operative sensitivity. At 3 yrs, 111 restorations were evaluated. Significantly better clinical durability was shown for RC.Two non-acceptable CAC restorations were observed at 6 months, 3 CAC and 1 RC at 12 months, 5 CAC and 2 RC at 24 months, and 8 CAC at 36 months.This resulted in a cumulative failure frequency of 32% for the CAC material and 5% for the RC material. Main reason for failure for the CAC was total or partial lost restorations, and for the RC lost restorations. It can be concluded that the CAC showed a non-acceptable clinical failure rate for Class V restorations.

  • 1421.
    van Geelen, Marco
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    The Influence of Powder on Accuracy of Digital Imprint Techniques: Varying Spraying Duration2016Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
  • 1422.
    Van Guelpen, Bethany
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
    Dahlin, Anna M
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
    Hultdin, Johan
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Klinisk kemi.
    Eklöf, Vincy
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
    Johansson, Ingegerd
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Henriksson, Maria L
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
    Cullman, Inger
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
    Hallmans, Göran
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Näringsforskning.
    Palmqvist, Richard
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
    One-carbon metabolism and CpG island methylator phenotype status in incident colorectal cancer: a nested case-referent study2010Inngår i: Cancer Causes and Control, ISSN 0957-5243, E-ISSN 1573-7225, Vol. 21, nr 4, s. 557-566Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVE: We related prediagnostic plasma folate, vitamin B12, and total homocysteine concentrations, and the MTHFR 677C>T and 1298A>C polymorphisms, to the risk of colorectal cancer with and without the CpG island methylator phenotype (CIMP).

    METHODS: This was a nested case-referent study of 190 cases and double, matched referents from the large, population-based Northern Sweden Health and Disease Study. Using archival tumor tissue, promoter methylation in an eight-gene panel was analyzed by MethyLight.

    RESULTS: A reduced risk of CIMP-low/CIMP-high CRC (>/=1 gene methylated) was observed in subjects with very low plasma folate concentrations [multivariate odds ratio 2.96 (95% CI 1.24-7.08) for quintiles two to five versus one (lowest)]. With the exception of a reduced risk in MTHFR 677 TT-homozygotes, none of the other one-carbon variables were associated with the risk of CIMP-low/CIMP-high CRC. For CIMP-negative CRC, only the MTHFR polymorphisms were statistically significantly related to risk, inversely for 677C>T and positively for 1298A>C, but a tendency toward a reduced risk was observed in subjects with an adequate methyl availability, combining the plasma variables [multivariate odds ratio 0.61 (95% CI 0.32-1.15)].

    CONCLUSION: Though limited by low power, these findings suggest the possibility of different roles for one-carbon metabolism in different pathways of colorectal tumorigenesis.

  • 1423.
    Van Guelpen, Bethany
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
    Hultdin, Johan
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Klinisk kemi.
    Johansson, Ingegerd
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Kariologi.
    Hallmans, Göran
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Näringsforskning.
    Stenling, Roger
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
    Riboli, E
    Winkvist, A
    Palmqvist, Richard
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
    Low folate levels may protect against colorectal cancer2006Inngår i: Gut, ISSN 0017-5749, E-ISSN 1468-3288, Vol. 55, nr 10, s. 1461-1466Artikkel i tidsskrift (Annet vitenskapelig)
    Abstract [en]

    BACKGROUND AND AIMS: Dietary folate is believed to protect against colorectal cancer (CRC). However, few studies have addressed the role of circulating levels of folate. The aim of this study was to relate prediagnostic plasma folate and homocysteine concentrations and the methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C polymorphisms to the risk of developing CRC.

    SUBJECTS: Subjects were 226 cases and 437 matched referents from the population based Northern Sweden Health and Disease Cohort.

    RESULTS: We observed a bell-shaped association between plasma folate concentrations and CRC risk; multivariate odds ratio for middle versus lowest quintile 2.00 (95% confidence interval (CI) 1.13-3.56). In subjects with follow up times greater than the median of 4.2 years however, plasma folate concentrations were strongly positively related to CRC risk; multivariate odds ratio for highest versus lowest quintile 3.87 (95% CI 1.52-9.87; p trend = 0.007). Homocysteine was not associated with CRC risk. Multivariate odds ratios for the MTHFR polymorphisms were, for 677 TT versus CC, 0.41 (95% CI 0.19-0.85; p trend = 0.062), and for 1298 CC versus AA, 1.62 (95% CI 0.94-2.81; p trend = 0.028). Interaction analysis suggested that the result for 1298A>C may have been largely due to linkage disequilibrium with 677C>T. The reduced CRC risk in 677 TT homozygotes was independent of plasma folate status.

    CONCLUSIONS: Our findings suggest a decreased CRC risk in subjects with low folate status. This possibility of a detrimental component to the role of folate in carcinogenesis could have implications in the ongoing debate in Europe concerning mandatory folate fortification of foods.

  • 1424.
    Van Guelpen, Bethany
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
    Hultdin, Johan
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Klinisk kemi.
    Johansson, Ingegerd
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Kariologi.
    Stegmayr, Birgitta
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
    Hallmans, Göran
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Näringsforskning.
    Nilsson, Torbjörn K
    Weinehall, Lars
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och folkhälsovetenskap.
    Witthoft, Cornelia
    Palmqvist, Richard
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
    Winkvist, Anna
    Folate, vitamin B12, and risk of ischemic and hemorrhagic stroke: a prospective, nested case-referent study of plasma concentrations and dietary intake.2005Inngår i: Stroke, ISSN 0039-2499, E-ISSN 1524-4628, Vol. 36, nr 7, s. 1426-1431Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND AND PURPOSE: Folate metabolism has been implicated in stroke. However, the possibility of a role for folate and vitamin B12, independent of their effects on homocysteine status, remains to be explored. The aim of this prospective, nested case-referent study was to relate plasma and dietary intake levels of folate and vitamin B12 to risk of stroke, taking into consideration plasma homocysteine concentrations and methylenetetrahydrofolate reductase polymorphisms. METHODS: Subjects were 334 ischemic and 62 hemorrhagic stroke cases and matched double referents from the population-based Northern Sweden Health and Disease Cohort. RESULTS: Plasma folate was statistically significantly associated with risk of hemorrhagic stroke in an inverse linear manner, both in univariate analysis and after adjustment for conventional risk factors including hypertension (odds ratio [OR] for highest versus lowest quartile 0.21 (95% confidence interval [CI], 0.06 to 0.71; P for trend=0.008)). Risk estimates were attenuated by inclusion of homocysteine in the model (OR, 0.34; 95% CI, 0.08 to 1.40; P for trend=0.088). A similar pattern was observed for increasing folate intake (multivariate OR, 0.07; 95% CI, 0.01 to 0.55; P for trend=0.031 without homocysteine, and OR, 0.16, 95% CI, 0.02 to 1.23; P for trend=0.118 with homocysteine in the analysis). We found little evidence of an association between plasma or dietary folate and risk of ischemic stroke. Neither plasma nor dietary vitamin B12 was associated with risk of either stroke subtype. CONCLUSIONS: The results of this study suggest a protective role for folate, possibly in addition to its effects on homocysteine status, in hemorrhagic but not ischemic stroke.

  • 1425.
    Van Guelpen, Bethany
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
    Hultdin, Johan
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Klinisk kemi.
    Johansson, Ingegerd
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Kariologi.
    Witthöft, C
    Weinehall, Lars
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och folkhälsovetenskap.
    Eliasson, Mats
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin.
    Hallmans, Göran
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Näringsforskning.
    Palmqvist, Richard
    Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi.
    Jansson, Jan-Håkan
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin.
    Winkvist, A
    Plasma folate and total homocysteine levels are associated with the risk of myocardial infarction, independently of each other and of renal function2009Inngår i: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 266, nr 2, s. 182-195Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVES: To investigate the relationship between plasma folate, vitamin B12 and total homocysteine concentrations, dietary intake of folate and vitamins B12, B6 and B2, and the risk of first acute myocardial infarction (MI). DESIGN: Nested case-referent study with up to 13 years of follow-up. SETTING: The population-based Northern Sweden Health and Disease Study, with 73 879 participants at the time of case ascertainment. SUBJECTS: A total of 571 MI cases (406 men) and 1569 matched referents. Of the cases, 530 had plasma samples available, and 247 had dietary B-vitamin intake data. RESULTS: Plasma concentrations of folate were inversely associated, and total homocysteine positively associated, with the risk of MI, independently of each other and of a number of established and novel cardiovascular risk factors, including renal function [multivariate odds ratio for highest vs. lowest quintile of folate 0.52 (95% CI 0.31-0.84), P for trend = 0.036, and homocysteine 1.92 (95% CI 1.20-3.09), P for trend = 0.006]. For plasma vitamin B12 concentrations, and vitamin B12, B6 and B2 intake, no clear risk relationship was apparent. Though not statistically significant, the results for folate intake were consistent with those for plasma concentrations. CONCLUSIONS: In this large prospective study of a population without mandatory folic acid fortification, both folate and homocysteine were strongly associated with the risk of myocardial infarction, independently of each other and of renal function. Although randomized trials of folic acid supplementation are needed to determine causality, our findings highlight the potential importance of folate, or sources of folate, in incident cardiovascular disease.

  • 1426. van Heumen, Céleste C M
    et al.
    Tanner, Johanna
    van Dijken, Jan W V
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Pikaar, Ronald
    Lassila, Lippo V J
    Creugers, Nico H J
    Vallittu, Pekka K
    Kreulen, Cees M
    Five-year survival of 3-unit fiber-reinforced composite fixed partial dentures in the posterior area.2010Inngår i: Dental Materials, ISSN 0109-5641, E-ISSN 1879-0097, Vol. 26, nr 10, s. 954-960Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives: The purpose of this clinical study was to evaluate the long-term outcome of three-unit posterior fixed partial dentures (FPDs) made of fiber-reinforced resin composite (FRC), and to identify design factors influencing the survival rate.

    Methods: 77 patients (52 females, 25 males) received 96 indirectly made FRC FPDs, using pre-impregnated unidirectional glass-fibers, requiring manual wetting, as framework material. FPDs were surface (n = 31) inlay (n = 45) or hybrid (n = 20) retained and mainly located in the upper jaw. Hybrid FPDs consisted of a wing retainer at canine and an inlay retainer at distal abutment tooth. Surface FPDs consisted of uplay and wing combinations. Follow-up period was at minimum 4.5 years, with checkups at every 1–2 years. The study was carried out by six operators in three centers in the Netherlands, Finland and Sweden. Survival rates, including reparable defects of FPDs, and success rates were determined.

    Results: Kaplan–Meier survival rate at 5 years was 71.2% (SE 4.8%) for success and 77.5% (SE 4.4%) for survival. Differences were not significantly different. Main failure modes were delamination and fracture of the FPD. Only FPDs with surface retainers showed debonding.

    Conclusions: A success rate of 71% and a survival rate of 78% after 5 years was found. Survival rates of inlay, hybrid and surface retained FPDs did not significantly differ.

  • 1427. van Heumen, Céleste C M
    et al.
    van Dijken, Jan W V
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Tanner, Johanna
    Pikaar, Ronald
    Lassila, Lippo V J
    Creugers, Nico H J
    Vallittu, Pekka K
    Kreulen, Cees M
    Five-year survival of 3-unit fiber-reinforced composite fixed partial dentures in the anterior area2009Inngår i: Dental Materials, ISSN 0109-5641, E-ISSN 1879-0097, Vol. 25, nr 6, s. 820-827Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives: The purpose of this clinical study was to evaluate the long-term outcome of 3-unit anterior fixed partial dentures (FPDs) made of fiber-reinforced resin composite (FRC), and to identify design factors influencing the survival rate.

    Methods: 52 patients (26 females, 26 males) received 60 indirectly made FRC FPDs, using pre-impregnated unidirectional glass fibers, requiring manual wetting, as framework material. FPDs were surface (n = 48) or hybrid (n = 12) retained and mainly located in the upper jaw. Hybrid FPDs had a combination of retainers; i.e. crown at one and surface retention at the other abutment tooth. Surface FPDs were either purely adhesively retained (n = 29) or with additional mechanical retention (n = 19). Follow-up period was at minimum 5 years, with check-ups every 1–2 years. Six operators were involved, in three centers in the Netherlands, Finland and Sweden. Survival rates, including repairable defects of FPDs, and success rates were determined.

    Results: Kaplan–Meier survival rate at 5 years was 64% (SE 7%). For the level of success, values were 45% (SE 7%) and the estimated median survival time 58 (SE 10.1) months. For surface FPDs, additional mechanical retention did not improve survival significantly. There was a trend towards better survival of surface FPDs over hybrid FPDs, but differences were not significant. Main failure modes were fracture of the FPD and delamination of veneering composite.

    Significance: A success rate of 45% and a survival rate of 64% after 5 years was found. Fracture of the framework and delamination are the most prevalent failure modes, especially for surface FPDs.

  • 1428. van Noort, R
    et al.
    Gjerdet, NR
    Schedle, A
    Björkman, L
    Berglund, Anders
    Umeå universitet, Medicinsk fakultet, Odontologi, Tandteknikerprogrammet.
    An overview of the current status of national reporting systems for adverse reactions to dental materials.2004Inngår i: Journal of Dentistry, ISSN 0300-5712, E-ISSN 1879-176X, Vol. 32, nr 5, s. 351-358Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVES: Since all dental materials pose a potential risk to patients and members of the dental team, the post-market monitoring of adverse reactions caused by dental materials should be considered essential. This article reviews the current status of post-market monitoring of adverse reactions to dental materials and highlights some of the issues that arise in trying to establish an evidence base on the characteristics of adverse reactions to dental materials. METHODS: Norway, Sweden and more recently the UK have sought to monitor adverse reactions to dental materials systematically and proactively in an effort to add to the evidence base on the safety of dental materials. Their experiences in undertaking post-market surveillance have been combined in preparing this article. RESULTS: To date the Norwegian, Swedish and the UK projects has received 1268 reports over 11 years, 848 reports over 5.5 years and 1117 reports over 3 years, respectively, relating to adverse reactions seen or experienced by dental personnel and patients. Presently, there are no harmonized criteria for what can be classified as an adverse reaction related to dental materials. Under reporting is a recognised problem and lack of awareness and lack of clarity as to what constitutes an adverse reaction may be contributory factors. A pro-active reporting system takes a considerable time to become established, but can generate a lot of potentially useful information. CONCLUSIONS: There is a need to raise the awareness among dental professionals of the potential for adverse reactions due to dental materials and to develop an internationally accepted system of data gathering that can produce the evidence that reflect the extent, severity and incidence of adverse reactions to dental materials.

  • 1429. Vanderveken, Olivier M
    et al.
    Devolder, Annick
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Ortodonti.
    Marklund, Marie
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Boudewyns, An N
    Braem, Marc J
    Okkerse, Walter
    Verbraecken, Johan A
    Franklin, Karl
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Lungmedicin. Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Kirurgi.
    De Backer, Wilfried A
    Van de Heyning, Paul H
    Comparison of a custom-made and a thermoplastic oral appliance for the treatment of mild sleep apnea2008Inngår i: American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, E-ISSN 1535-4970, Vol. 178, nr 2, s. 197-202Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Rationale: The efficacy of immediate adaptation of mandibular advancement devices made of thermoplastic material as a treatment option for sleep-disordered breathing (SDB) has been demonstrated in clinical studies. To date, there have been no studies comparing the efficacy of such prefabricated devices with custom-made devices.

    Objectives: Our purpose was to compare the efficacy of both types of devices in patients with SDB.

    Methods: A randomized controlled cross-over trial, comprising 4 months of treatment with a thermoplastic and a custom-made device, with a 1-month washout interval.

    Measurements and Main Results: A total of 35 patients (29 males; age, 49 ± 9 yr; apnea–hypopnea index [AHI], 13 ± 11 events/h; body mass index, 28 ± 4 kg/m2) completed the protocol. AHI was only reduced with the custom-madedevice (P = 0.005). In addition, this device reduced snoring to a greater extent than the thermoplastic device. The success rate was higher with the custom-made device (60 vs. 31%; P = 0.02). One-third of the patients demonstrated compliance failure with the thermoplastic device, mainly because of insufficient overnight retention. Total failure rate with the thermoplastic device was 69%, whereas the majority (63%) of these were successfully treated with the custom-made device. At the end of the study, 82% of the patients preferred the custom-made device, and 9% had no preference (P < 0.0001).

    Conclusions: In this study, a custom-made device turned out to be more effective than a thermoplastic device in the treatment of SDB. Our results suggest that the thermoplastic device cannot be recommended as a therapeutic option nor can it be used as a screening tool to find good candidates for mandibular advancement therapy.

  • 1430. Vandevoorde, S
    et al.
    Jonsson, K-O
    Labar, G
    Persson, Emma
    Umeå universitet, Medicinsk fakultet, Odontologi, Oral cellbiologi.
    Lambert, D M
    Fowler, C J
    Umeå universitet, Medicinsk fakultet, Farmakologi och klinisk neurovetenskap, Farmakologi.
    Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro.2007Inngår i: Br J Pharmacol, ISSN 0007-1188, Vol. 150, nr 2, s. 186-91Artikkel i tidsskrift (Fagfellevurdert)
  • 1431. Varga, Tibor V.
    et al.
    Kurbasic, Azra
    Aine, Mattias
    Eriksson, Pontus
    Ali, Ashfaq
    Hindy, George
    Gustafsson, Stefan
    Luan, Jian'an
    Shungin, Dmitry
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi. Lund Univ, Skane Univ Hosp, Malmo, Sweden.
    Chen, Yan
    Schulz, Christina-Alexandra
    Nilsson, Peter M.
    Hallmans, Goran
    Barroso, Ines
    Deloukas, Panos
    Langenberg, Claudia
    Scott, Robert A.
    Wareham, Nicholas J.
    Lind, Lars
    Ingelsson, Erik
    Melander, Olle
    Orho-Melander, Marju
    Renström, Frida
    Umeå universitet, Medicinska fakulteten, Enheten för biobanksforskning. Lund Univ, Skane Univ Hosp, Malmo, Sweden.
    Franks, Paul W.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin. Lund Univ, Skane Univ Hosp, Malmo, Sweden ; Harvard, Boston, MA USA.
    Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults2017Inngår i: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 46, nr 4, s. 1211-1222Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Cross-sectional genome-wide association studies have identified hundreds of loci associated with blood lipids and related cardiovascular traits, but few genetic association studies have focused on long-term changes in blood lipids. Methods: Participants from the GLACIER Study (N-max = 3492) were genotyped with the MetaboChip array, from which 29 387 SNPs (single nucleotide polymorphisms;replication, fine-mapping regions and wildcard SNPs for lipid traits) were extracted for association tests with 10-year change in total cholesterol (Delta TC) and triglycerides (Delta TG). Four additional prospective cohort studies (MDC, PIVUS, ULSAM, MRC Ely; N-max = 8263 participants) were used for replication. We conducted an in silico look-up for association with coronary artery disease (CAD) in the Coronary ARtery DIsease Genome-wide Replication and Meta-analysis (CARDIoGRAMplusC4D) Consortium (N similar to 190 000) and functional annotation for the top ranking variants. Results: In total, 956 variants were associated (P < 0.01) with either Delta TC or Delta TG in GLACIER. In GLACIER, chr19:50121999 at APOE was associated with Delta TG and multiple SNPs in the APOA1/A4/C3/A5 region at genome-wide significance (P < 5 x 10(-8)), whereas variants in four loci, DOCK7, BRE, SYNE1 and KCNIP1, reached study-wide significance (P < 1.7 x 10(-6)). The rs7412 variant at APOE was associated with DTC in GLACIER (P < 1.7 x 10(-6)). In pooled analyses of all cohorts, 139 SNPs at six and five loci were associated with Delta TC and for Delta TG, respectively (P < 10(-3)). Of these, a variant at CAPN3 (P = 1.2 x 10(-4)), multiple variants at HPR (P-min = 1.5 x 10(-6)) and a variant at SIX5 (P = 1.9 x 10(-4)) showed evidence for association with CAD. Conclusions: We identified seven novel genomic regions associated with long-term changes in blood lipids, of which three also raise CAD risk.

  • 1432. Varga, Tibor V.
    et al.
    Sonestedt, Emily
    Shungin, Dmitry
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi. Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin. Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
    Koivula, Robert W.
    Hallmans, Göran
    Umeå universitet, Medicinska fakulteten, Enheten för biobanksforskning. Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Näringsforskning.
    Andersson Escher, Stefan
    Barroso, Ines
    Nilsson, Peter
    Melander, Olle
    Orho-Melander, Marju
    Renström, Frida
    Umeå universitet, Medicinska fakulteten, Enheten för biobanksforskning. Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
    Franks, Paul W.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin. Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden ; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
    Genetic determinants of long-term changes in blood lipid concentrations: 10-year follow-up of the GLACIER study2014Inngår i: PLOS Genetics, ISSN 1553-7390, E-ISSN 1553-7404, Vol. 10, nr 6, s. e1004388-Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Recent genome-wide meta-analyses identified 157 loci associated with cross-sectional lipid traits. Here we tested whether these loci associate (singly and in trait-specific genetic risk scores [GRS]) with longitudinal changes in total cholesterol (TC) and triglyceride (TG) levels in a population-based prospective cohort from Northern Sweden (the GLACIER Study). We sought replication in a southern Swedish cohort (the MDC Study; N = 2,943). GLACIER Study participants (N = 6,064) were genotyped with the MetaboChip array. Up to 3,495 participants had 10-yr follow-up data available in the GLACIER Study. The TC- and TG-specific GRSs were strongly associated with change in lipid levels (beta = 0.02 mmol/l per effect allele per decade follow-up, P = 2.0x10(-11) for TC; beta = 0.02 mmol/l per effect allele per decade follow-up, P = 5.0x10(-5) for TG). In individual SNP analysis, one TC locus, apolipoprotein E (APOE) rs4420638 (beta = 0.12 mmol/l per effect allele per decade follow-up, P = 2.0x10(-5)), and two TG loci, tribbles pseudokinase 1 (TRIB1) rs2954029 (beta = 0.09 mmol/l per effect allele per decade follow-up, P = 5.1x10(-4)) and apolipoprotein A-I (APOA1) rs6589564 (beta = 0.31 mmol/l per effect allele per decade follow-up, P = 1.4x10(-8)), remained significantly associated with longitudinal changes for the respective traits after correction for multiple testing. An additional 12 loci were nominally associated with TC or TG changes. In replication analyses, the APOE rs4420638, TRIB1 rs2954029, and APOA1 rs6589564 associations were confirmed (P <= 0.001). In summary, trait-specific GRSs are robustly associated with 10-yr changes in lipid levels and three individual SNPs were strongly associated with 10-yr changes in lipid levels.

  • 1433. Vergnaud, Anne-Claire
    et al.
    Norat, Teresa
    Mouw, Traci
    Romaguera, Dora
    May, Anne M.
    Bueno-de-Mesquita, H. Bas
    van der Daphne, A.
    Agudo, Antonio
    Wareham, Nicholas
    Khaw, Kay-Tee
    Romieu, Isabelle
    Freisling, Heinz
    Slimani, Nadia
    Perquier, Florence
    Boutron-Ruault, Marie-Christine
    Clavel-Chapelon, Francoise
    Palli, Domenico
    Berrino, Franco
    Mattiello, Amalia
    Tumino, Rosario
    Ricceri, Fulvio
    Rodriguez, Laudina
    Molina-Montes, Esther
    Amiano, Pilar
    Barricarte, Aurelio
    Chirlaque, Maria-Dolores
    Crowe, Francesca L.
    Orfanos, Philippos
    Naska, Androniki
    Trichopoulou, Antonia
    Teucher, Birgit
    Kaaks, Rudolf
    Boeing, Heiner
    Buijsse, Brian
    Johansson, Ingegerd
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Hallmans, Göran
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Näringsforskning. Umeå universitet, Medicinska fakulteten, Enheten för biobanksforskning.
    Drake, Isabel
    Sonestedt, Emily
    Jakobsen, Marianne Uhre
    Overvad, Kim
    Tjonneland, Anne
    Halkjaer, Jytte
    Skeie, Guri
    Braaten, Tonje
    Lund, Eiliv
    Riboli, Elio
    Peeters, Petra H. M.
    Macronutrient Composition of the Diet and Prospective Weight Change in Participants of the EPIC-PANACEA Study2013Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 8, nr 3, s. e57300-Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The effect of the macronutrient composition of the usual diet on long term weight maintenance remains controversial.

    Methods: 373,803 subjects aged 25-70 years were recruited in 10 European countries (1992-2000) in the PANACEA project of the EPIC cohort. Diet was assessed at baseline using country-specific validated questionnaires and weight and height were measured at baseline and self-reported at follow-up in most centers. The association between weight change after 5 years of follow-up and the iso-energetic replacement of 5% of energy from one macronutrient by 5% of energy from another macronutrient was assessed using multivariate linear mixed-models. The risk of becoming overweight or obese after 5 years was investigated using multivariate Poisson regressions stratified according to initial Body Mass Index.

    Results: A higher proportion of energy from fat at the expense of carbohydrates was not significantly associated with weight change after 5 years. However, a higher proportion of energy from protein at the expense of fat was positively associated with weight gain. A higher proportion of energy from protein at the expense of carbohydrates was also positively associated with weight gain, especially when carbohydrates were rich in fibre. The association between percentage of energy from protein and weight change was slightly stronger in overweight participants, former smokers, participants >= 60 years old, participants underreporting their energy intake and participants with a prudent dietary pattern. Compared to diets with no more than 14% of energy from protein, diets with more than 22% of energy from protein were associated with a 23-24% higher risk of becoming overweight or obese in normal weight and overweight subjects at baseline.

    Conclusion: Our results show that participants consuming an amount of protein above the protein intake recommended by the American Diabetes Association may experience a higher risk of becoming overweight or obese during adult life.

  • 1434. Vergnaud, Anne-Claire
    et al.
    Norat, Teresa
    Romaguera, Dora
    Mouw, Traci
    May, Anne M
    Romieu, Isabelle
    Freisling, Heinz
    Slimani, Nadia
    Boutron-Ruault, Marie-Christine
    Clavel-Chapelon, Francoise
    Morois, Sophie
    Kaaks, Rudolf
    Teucher, Birgit
    Boeing, Heiner
    Buijsse, Brian
    Tjønneland, Anne
    Halkjaer, Jytte
    Overvad, Kim
    Jakobsen, Marianne Uhre
    Rodriguez, Laudina
    Agudo, Antonio
    Sanchez, Maria-Jose
    Amiano, Pilar
    Maria Huerta, Jose
    Barricarte Gurrea, Aurelio
    Wareham, Nick
    Khaw, Kay-Tee
    Crowe, Francesca
    Orfanos, Philippos
    Naska, Androniki
    Trichopoulou, Antonia
    Masala, Giovanna
    Pala, Valeria
    Tumino, Rosario
    Sacerdote, Carlotta
    Mattiello, Amalia
    Bueno-de-Mesquita, H Bas
    van Duijnhoven, Franzel JB
    Drake, Isabel
    Wirfalt, Elisabet
    Johansson, Ingegerd
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Kariologi.
    Hallmans, Göran
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Näringsforskning.
    Engeset, Dagrun
    Braaten, Tonje
    Parr, Christine L
    Odysseos, Andreani
    Riboli, Elio
    Peeters, Petra HM
    Fruit and vegetable consumption and prospective weight change in participants of the European prospective investigation into cancer and nutrition - physical activity, nutrition, alcohol, cessation of smoking, eating out of home, and obesity study2012Inngår i: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 95, nr 1, s. 184-193Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Fruit and vegetable consumption might prevent weight gain through their low energy density and high dietary fiber content.

    Objective: We assessed the association between the baseline consumption of fruit and vegetables and weight change in participants from 10 European countries participating in the European Prospective Investigation into Cancer and Nutrition study.

    Design: Diet was assessed at baseline in 373,803 participants by using country-specific validated questionnaires. Weight was measured at baseline and self-reported at follow-up in most centers. Associations between baseline fruit and vegetable intakes (per 100 g/d) and weight change (g/y) after a mean follow-up of 5 y were assessed by using linear mixed-models, with age, sex, total energy intake, and other potential confounders controlled for.

    Results: After exclusion of subjects with chronic diseases at baseline and subjects who were likely to misreport energy intakes, baseline fruit and vegetable intakes were not associated with weight change overall. However, baseline fruit and vegetable intakes were inversely associated with weight change in men and women who quit smoking during follow-up. We observed weak positive associations between vegetable intake and weight change in women who were overweight, were former smokers, or had high prudent dietary pattern scores and weak inverse associations between fruit intake and weight change in women who were >50 y of age, were of normal weight, were never smokers, or had low prudent dietary pattern scores.

    Conclusions: In this large study, higher baseline fruit and vegetable intakes, while maintaining total energy intakes constant, did not substantially influence midterm weight change overall but could help to reduce risk of weight gain in persons who stop smoking. The interactions observed in women deserve additional attention. Am J Clin Nutr 2012;95:184-93.

  • 1435. Vergnaud, Anne-Claire
    et al.
    Norat, Teresa
    Romaguera, Dora
    Mouw, Traci
    May, Anne M
    Travier, Noemie
    Luan, Jian'an
    Wareham, Nick
    Slimani, Nadia
    Rinaldi, Sabina
    Couto, Elisabeth
    Clavel-Chapelon, Françoise
    Boutron-Ruault, Marie-Christine
    Cottet, Vanessa
    Palli, Domenico
    Agnoli, Claudia
    Panico, Salvatore
    Tumino, Rosario
    Vineis, Paolo
    Agudo, Antonio
    Rodriguez, Laudina
    Sanchez, Maria Jose
    Amiano, Pilar
    Barricarte, Aurelio
    Huerta, Jose Maria
    Key, Timothy J
    Spencer, Elisabeth A
    Bueno-de-Mesquita, Bas
    Büchner, Frederike L
    Orfanos, Philippos
    Naska, Androniki
    Trichopoulou, Antonia
    Rohrmann, Sabine
    Hermann, Silke
    Boeing, Heiner
    Buijsse, Brian
    Johansson, Ingegerd
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Kariologi.
    Hellström, Veronica
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Näringsforskning.
    Manjer, Jonas
    Wirfält, Elisabet
    Jakobsen, Marianne Uhre
    Overvad, Kim
    Tjonneland, Anne
    Halkjaer, Jytte
    Lund, Eiliv
    Braaten, Tonje
    Engeset, Dagrun
    Odysseos, Andreani
    Riboli, Elio
    Peeters, Petra HM
    Meat consumption and prospective weight change in participants of the EPIC-PANACEA study2010Inngår i: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 92, nr 2, s. 398-407Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Meat intake may be related to weight gain because of its high energy and fat content. Some observational studies have shown that meat consumption is positively associated with weight gain, but intervention studies have shown mixed results.

    OBJECTIVE: Our objective was to assess the association between consumption of total meat, red meat, poultry, and processed meat and weight gain after 5 y of follow-up, on average, in the large European population who participated in the European Prospective Investigation into Cancer and Nutrition-Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating Out of Home and Obesity (EPIC-PANACEA) project.

    DESIGN: A total of 103,455 men and 270,348 women aged 25-70 y were recruited between 1992 and 2000 in 10 European countries. Diet was assessed at baseline with the use of country-specific validated questionnaires. A dietary calibration study was conducted in a representative subsample of the cohort. Weight and height were measured at baseline and self-reported at follow-up in most centers. Associations between energy from meat (kcal/d) and annual weight change (g/y) were assessed with the use of linear mixed models, controlled for age, sex, total energy intake, physical activity, dietary patterns, and other potential confounders.

    RESULTS: Total meat consumption was positively associated with weight gain in men and women, in normal-weight and overweight subjects, and in smokers and nonsmokers. With adjustment for estimated energy intake, an increase in meat intake of 250 g/d (eg, one steak at approximately 450 kcal) would lead to a 2-kg higher weight gain after 5 y (95% CI: 1.5, 2.7 kg). Positive associations were observed for red meat, poultry, and processed meat.

    CONCLUSION: Our results suggest that a decrease in meat consumption may improve weight management.

  • 1436. Vergnaud, Anne-Claire
    et al.
    Romaguera, Dora
    Peeters, Petra H.
    van Gils, Carla H.
    Chan, Doris S. M.
    Romieu, Isabelle
    Freisling, Heinz
    Ferrari, Pietro
    Clavel-Chapelon, Francoise
    Fagherazzi, Guy
    Dartois, Laureen
    Li, Kuanrong
    Tikk, Kaja
    Bergmann, Manuela M.
    Boeing, Heiner
    Tjonneland, Anne
    Olsen, Anja
    Overvad, Kim
    Dahm, Christina C.
    Luisa Redondo, Maria
    Agudo, Antonio
    Sanchez, Maria-Jose
    Amiano, Pilar
    Chirlaque, Maria-Dolores
    Ardanaz, Eva
    Khaw, Kay-Tee
    Wareham, Nick J.
    Crowe, Francesca
    Trichopoulou, Antonia
    Orfanos, Philippos
    Trichopoulos, Dimitrios
    Masala, Giovanna
    Sieri, Sabina
    Tumino, Rosario
    Vineis, Paolo
    Panico, Salvatore
    Bueno-de-Mesquita, H. Bas
    Ros, Martine M.
    May, Anne
    Wirfalt, Elisabet
    Sonestedt, Emily
    Johansson, Ingegerd
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandläkarutbildning.
    Hallmans, Goran
    Umeå universitet, Medicinska fakulteten, Enheten för biobanksforskning. Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Näringsforskning.
    Lund, Eiliv
    Weiderpass, Elisabete
    Parr, Christine L.
    Riboli, Elio
    Norat, Teresa
    Adherence to the World Cancer Research Fund/American Institute for Cancer Research guidelines and risk of death in Europe: results from the European Prospective Investigation into Nutrition and Cancer cohort study2013Inngår i: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 97, nr 5, s. 1107-1120Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: In 2007, the World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) issued recommendations on diet, physical activity, and weight management for cancer prevention on the basis of the most comprehensive collection of available evidence. Objective: We investigated whether concordance with WCRF/AICR recommendations is related to risk of death. Design: The current study included 378,864 participants from 9 European countries enrolled in the European Prospective Investigation into Cancer and Nutrition study. At recruitment (1992-1998), dietary, anthropometric, and lifestyle information was collected. A WCRF/AICR score, which incorporated 6 of the WCRF/AICR recommendations for men [regarding body fatness, physical activity, foods and drinks that promote weight gain, plant foods, animal foods, and alcoholic drinks (score range: 0-6)] and 7 WCRF/AICR recommendations for women [plus breastfeeding (score range: 0-7)], was constructed. Higher scores indicated greater concordance with WCRF/AICR recommendations. Associations between the WCRF/AICR score and risks of total and cause-specific death were estimated by using Cox regression analysis. Results: After a median follow-up time of 12.8 y, 23,828 deaths were identified. Participants within the highest category of the WCRF/AICR score (5-6 points in men; 6-7 points in women) had a 34% lower hazard of death (95% CI: 0.59, 0.75) compared with participants within the lowest category of the WCRF/AICR score (0-2 points in men; 0-3 points in women). Significant inverse associations were observed in all countries. The WCRF/AICR score was also significantly associated with a lower hazard of dying from cancer, circulatory disease, and respiratory disease. Conclusion: Results of this study suggest that following WCRF/AICR recommendations could significantly increase longevity.

  • 1437. Vermeulen, Esther
    et al.
    Zamora-Ros, Raul
    Duell, Eric J
    Lujan-Barroso, Leila
    Boeing, Heiner
    Aleksandrova, Krasimira
    Bueno-de-Mesquita, H Bas
    Scalbert, Augustin
    Romieu, Isabelle
    Fedirko, Veronika
    Touillaud, Marina
    Fagherazzi, Guy
    Perquier, Florence
    Molina-Montes, Esther
    Chirlaque, Maria-Dolores
    Argueelles, Marcial Vicente
    Amiano, Pilar
    Barricarte, Aurelio
    Pala, Valeria
    Mattiello, Amalia
    Saieva, Calogero
    Tumino, Rosario
    Ricceri, Fulvio
    Trichopoulou, Antonia
    Vasilopoulou, Effie
    Ziara, Gianna
    Crowe, Francesca L
    Khaw, Kay-Thee
    Wareham, Nicholas J
    Lukanova, Annekatrin
    Grote, Verena A
    Tjonneland, Anne
    Halkjaer, Jytte
    Bredsdorff, Lea
    Overvad, Kim
    Siersema, Peter D
    Peeters, Petra HM
    May, Anne M
    Weiderpass, Elisabete
    Skeie, Guri
    Hjartaker, Anette
    Landberg, Rikard
    Johansson, Ingegerd
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandläkarutbildning.
    Sonestedt, Emily
    Ericson, Ulrika
    Riboli, Elio
    Gonzalez, Carlos A
    Dietary flavonoid intake and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition Cohort2013Inngår i: American Journal of Epidemiology, ISSN 0002-9262, E-ISSN 1476-6256, Vol. 178, nr 4, s. 570-581Artikkel i tidsskrift (Fagfellevurdert)
  • 1438. Vesper, Hubert W
    et al.
    Slimani, Nadia
    Hallmans, Göran
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Näringsforskning.
    Tjønneland, Anne
    Agudo, Antonio
    Benetou, Vassiliki
    Bingham, Sheila
    Boeing, Heiner
    Boutron-Ruault, Marie-Christine
    Bueno-de-Mesquita, H Bas
    Chirlaque, Dolores
    Clavel-Chapelon, Françoise
    Crowe, Francesca
    Drogan, Dagmar
    Ferrari, Pietro
    Johansson, Ingegerd
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi. Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Kaaks, Rudolf
    Linseisen, Jakob
    Lund, Eiliv
    Manjer, Jonas
    Mattiello, Amalia
    Palli, Domenico
    Peeters, Petra H M
    Rinaldi, Sabina
    Skeie, Guri
    Trichopoulou, Antonia
    Vineis, Paolo
    Wirfält, Elisabet
    Overvad, Kim
    Strömberg, Ulf
    Cross-sectional study on acrylamide hemoglobin adducts in subpopulations from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.2008Inngår i: J Agric Food Chem, ISSN 1520-5118, Vol. 56, nr 15, s. 6046-53Artikkel i tidsskrift (Fagfellevurdert)
  • 1439. Vestman, Nelly Romani
    et al.
    Chen, Tsute
    Lif Holgerson, Pernilla
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Öhman, Carina
    Johansson, Ingegerd
    Oral Microbiota Shift after 12-Week Supplementation with Lactobacillus reuteri DSM 17938 and PTA 5289; A Randomized Control Trial2015Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 10, nr 5, s. e0125812-Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Lactobacillus spp. potentially contribute to health by modulating bacterial biofilm formation, but their effects on the overall oral microbiota remain unclear.

    METHODS AND FINDINGS: Oral microbiota was characterized via 454-pyrosequencing of the 16S rDNA hypervariable region V3-V4 after 12 weeks of daily Lactobacillus reuteri DSM 17938 and PTA 5289 consumption. Forty-four adults were assigned to a test group (n = 22) that received lactobacilli lozenges (108 CFU of each strain/lozenge) or a control group that received placebo (n = 22). Presence of L. reuteri was confirmed by cultivation and species specific PCR. Tooth biofilm samples from 16 adults before, during, and after exposure were analyzed by pyrosequencing. A total of 1,310,292 sequences were quality filtered. After removing single reads, 257 species or phylotypes were identified at 98.5% identity in the Human Oral Microbiome Database. Firmicutes, Bacteroidetes, Fusobacteria, Proteobacteria, and Actinobacteria were the most abundant phyla. Streptococcus was the most common genus and the S. oralis/S. mitis/S. mitis bv2/S. infantis group comprised the dominant species. The number of observed species was unaffected by L. reuteri exposure. However, subjects who had consumed L. reuteri were clustered in a principal coordinates analysis relative to scattering at baseline, and multivariate modeling of pyrosequencing microbiota, and culture and PCR detected L. reuteri separated baseline from 12-week samples in test subjects. L. reuteri intake correlated with increased S. oralis/S. mitis/S. mitis bv2/S. infantis group and Campylobacter concisus, Granulicatella adiacens, Bergeyella sp. HOT322, Neisseria subflava, and SR1 [G-1] sp. HOT874 detection and reduced S. mutans, S. anginosus, N. mucosa, Fusobacterium periodicum, F. nucleatum ss vincentii, and Prevotella maculosa detection. This effect had disappeared 1 month after exposure was terminated.

    CONCLUSIONS: L. reuteri consumption did not affect species richness but induced a shift in the oral microbiota composition. The biological relevance of this remains to be elucidated.

    TRIAL REGISTRATION: ClinicalTrials.gov NCT02311218.

  • 1440.
    Vestman, Nelly Romani
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandläkarutbildning.
    Hasslöf, Pamela
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandläkarutbildning.
    Keller, Mette K
    Granström, Elisabeth
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandläkarutbildning.
    Roos, Stefan
    Twetman, Svante
    Stecksen-Blicks, Christina
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandläkarutbildning.
    Lactobacillus reuteri influences regrowth of mutans streptococci after full-mouth disinfection: a double-blind, randomised controlled trial2013Inngår i: Caries Research, ISSN 0008-6568, E-ISSN 1421-976X, Vol. 47, nr 4, s. 338-345Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This study assessed whether the persistence of Lactobacillus reuteri DSM 17938 and ATCC PTA 5289 in saliva could delay the regrowth of mutans streptococci (MS) after a full-mouth disinfection with chlorhexidine (CHX). A randomised, double-blind, placebo-controlled study with a 6-week intervention period and 3- and 6-month follow-up was performed. 62 healthy subjects with moderate to high counts of MS were randomly assigned to a test group (n = 32) or a placebo group (n = 30). Before onset of the intervention, subjects received two sessions of professional cleaning, flossing, and application of CHX varnish and rinsed their mouth with a CHX solution between the sessions (2 days). Thereafter, the test group used probiotic lozenges (2/day) containing L. reuteri (DSM 17938 and ATCC PTA 5289; 1 × 108 CFU of each strain), and the placebo group used identical lozenges lacking the lactobacilli. Saliva samples were collected and cultured onto selective media, and isolates of L. reuteri as well as DNA directly extracted from saliva were tested by polymerase chain reaction (PCR) with specific primers. Presence of salivary MS was analysed with a chair-side test. L. reuteri was frequently detected by culture during the intervention period but in only 3 test group subjects at follow-ups. Regrowth of MS statistically significantly differed depending on the presence or absence of L. reuteri DSM 17938 detected by PCR. We conclude that cultivable L. reuteri strains may only sporadically be confirmed after termination of the intervention, but subjects with PCR-detected L. reuteridemonstrated slower regrowth of MS.

  • 1441.
    Vestman, Nelly Romani
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Timby, Niklas
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
    Holgerson, Pernilla Lif
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Kressirer, Christine A
    Claesson, Rolf
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Domellöf, Magnus
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
    Öhman, Carina
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandläkarutbildning.
    Tanner, Anne CR
    Hernell, Olle
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk vetenskap, Pediatrik.
    Johansson, Ingegerd
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Tandläkarutbildning.
    Characterization and in vitro properties of oral lactobacilli in breastfed infants2013Inngår i: BMC Microbiology, ISSN 1471-2180, E-ISSN 1471-2180, Vol. 13, s. 193-Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Lactobacillus species can contribute positively to general and oral health and are frequently acquired by breastfeeding in infancy. The present study aimed to identify oral lactobacilli in breast and formula-fed 4 month-old infants and to evaluate potential probiotic properties of the dominant Lactobacillus species detected. Saliva and oral swab samples were collected from 133 infants who were enrolled in a longitudinal study (n=240) examining the effect of a new infant formula on child growth and development. Saliva was cultured and Lactobacillus isolates were identified from 16S rRNA gene sequences. Five L. gasseri isolates that differed in 16S rRNA sequence were tested for their ability to inhibit growth of selected oral bacteria and for adhesion to oral tissues. Oral swab samples were analyzed by qPCR for Lactobacillus gasseri.

    Results: 43 (32.3%) infants were breastfed and 90 (67.7%) were formula-fed with either a standard formula (43 out of 90) or formula supplemented with a milk fat globule membrane (MFGM) fraction (47 out of 90). Lactobacilli were cultured from saliva of 34.1% breastfed infants, but only in 4.7% of the standard and 9.3% of the MFGM supplemented formula-fed infants. L. gasseri was the most prevalent (88% of Lactobacillus positive infants) of six Lactobacillus species detected. L. gasseri isolates inhibited Streptococcus mutans binding to saliva-coated hydroxyapatite, and inhibited growth of S. mutans, Streptococcus sobrinus, Actinomyces naeslundii, Actinomyces oris, Candida albicans and Fusobacterium nucleatum in a concentration dependent fashion. L. gasseri isolates bound to parotid and submandibular saliva, salivary gp340 and MUC7, and purified MFGM, and adhered to epithelial cells. L. gasseri was detected by qPCR in 29.7% of the oral swabs. Breastfed infants had significantly higher mean DNA levels of L. gasseri (2.14 pg/uL) than infants fed the standard (0.363 pg/uL) or MFGM (0.697 pg/uL) formula.

    Conclusions: Lactobacilli colonized the oral cavity of breastfed infants significantly more frequently than formulafed infants. The dominant Lactobacillus was L. gasseri, which was detected at higher levels in breastfed than formula-fed infants and displayed probiotic traits in vitro.

  • 1442.
    Viblom, Jonathan
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Emauelsson, Jonas
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Mandibular Reconstruction after Head and Neck Tumor Treatment, a Systematic Review2014Independent thesis Advanced level (degree of Master (Two Years)), 20 poäng / 30 hpOppgave
    Abstract [en]

    Objectives

    This systematic literature review examined the literature about mandibular reconstruction after cancer treatment with segmental resection, with focus on  success rate for the reconstruction, patient survival rate, dental rehabilitation and how this effect the patients QOL, oral function and aesthetics.

     

    Material and methods

    A search was performed in Pubmed, a database of scientific articles, based on four keywords (Mandibular, Reconstruction, Cancer, Segmental). After screening using our inclusion and exclusion criteria’s, 89 articles were chosen. A data base in excel was established to sort the information we needed for our study.  

     

    Results

    Sixty out of the 89 included articles were in full text and 29 were abstracts. The median year of publication was 2006 (range 1977 to 2013). A total of 5629 patients were included in the literature review. Of these, 3783 patients were included in articles that had categorized by gender and we found that 65.4% were males and 34.6% were females.

    The total success rate for reconstruction therapies including plate, vascularized- and non-vascularized bone transplant was 86.4% in 3219 patients (range from 70.4% in the plate group to 92.3% in the non-vascular group). The mean follow up time were 46.9 mounts (range 0.2 – 216 months).

     

    Conclusion

    This literature review indicates a focus on success rates for different kinds of reconstruction techniques. The overall success rate for non- and vascularized bone reconstruction techniques were very high compared to plate reconstruction only. To evaluate patient-related factors such as function, aesthetics and quality of life, further prospective randomized studies is required.

  • 1443.
    Vikdahl, M.
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Allmänmedicin.
    Backman, L.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Allmänmedicin.
    Johansson, Ingegerd
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Forsgren, Lars
    Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
    Håglin, Lena
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Allmänmedicin.
    Cardiovascular risk factors and the risk of Parkinson's disease2015Inngår i: European Journal of Clinical Nutrition, ISSN 0954-3007, E-ISSN 1476-5640, Vol. 69, nr 6, s. 729-733Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND/OBJECTIVES: The objective of this study was to investigate whether serum triglycerides (S-TG), cholesterol, blood pressure and waist/height ratio are risk factors for Parkinson's disease (PD).

    SUBJECTS AND METHODS: A population-based sample within the Northern Sweden Health and Disease Study (NSHDS) was used in this study (n = 101 790 subjects). Cases with PD were identified prospectively in a community-based study of idiopathic Parkinsonism in the period 2004-2009 in the county of Vasterbotten in northern Sweden. The case database obtained was crosslinked to the NSHDS. Eighty-four of 147 patients with PD had visited the primary health care 2-8 years before diagnosis for participation in the NSHDS. For each case, four referents from the NSHDS population were selected, matched for sex, age, year of health survey, subcohort and geographic area.

    RESULTS: Cases had lower mean S-TG levels (P = 0.007). After stratification for sex, the lower S-TG remained significant for men (P = 0.006) but not for women (P = 0.450), and these were confirmed by the conditional logistic regression for all cases, none adjusted (hazard ratio (HR): 0.65; 95% confidence interval (CI): 0.42, 0.99) and after adjusting for age, body mass index (BMI) and physical activity (HR: 0.61; 95% CI: 0.39, 0.96). Systolic blood pressure (SBP) was negatively associated with PD risk after adjustments for age, BMI and physical activity (HR: 0.98; 95% CI: 0.97-0.99). Smoking and former smoking were associated with a reduced risk for PD.

    CONCLUSIONS: We found lower S-TG and SBP 2-8 years before a diagnosis of PD. Smoking was confirmed to be negatively associated with PD, whereas recreational activity indicates a risk for women.

  • 1444.
    Vikström, Joel
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Larsson, Johan
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Prevalence of cagE in Aggregatibacter actinomycetemcomitans2016Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
  • 1445. Vilkuna-Rautiainen, T
    et al.
    Pussinen, PJ
    Roivainen, M
    Petäys, T
    Jousilahti, P
    Hovi, T
    Vartiainen, E
    Asikainen, Sirkka
    Umeå universitet, Medicinsk fakultet, Odontologi, Oral mikrobiologi.
    Serum antibody response to periodontal pathogens and herpes simplex virus in relation to classic risk factors of cardiovascular disease.2006Inngår i: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 35, nr 6, s. 1486-1494Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Increasing evidence links chronic infections, especially burden of several infections, with increased risk for cardiovascular diseases (CVD). We studied joint immune response against two major periodontal pathogens and herpes simplex virus (HSV) in relation to established risk factors of CVD. METHODS: Serum antibody levels to HSV, Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis were determined by ELISA. The study included 1107 subjects, 734 from Finland and 373 from Russia. RESULTS: Combined antibody response to periodontal pathogens was associated inversely (OR, 95% CI) with high-density lipoprotein (HDL) cholesterol concentration (beta = 0.35; 0.20, 0.60; P < 0.001) and directly with HSV antibody quartiles: compared with the first quartile, ORs (95% CI) for quartiles 2-4 were 1.43 (0.88-2.32), 1.74 (1.07-2.82), and 1.89 (1.18-3.02), respectively (P for trend <0.001), after adjusting for age, gender, area, education, smoking, BMI, alcohol, triglycerides, and number of teeth. In linear regression analysis, the 3-pathogen antibody score (comprising antibody levels against periodontal pathogens and HSV) was inversely associated with HDL cholesterol concentration (beta = -0.067/1 mmol/l; -0.235, -0.018; P < 0.05). CONCLUSIONS: HSV infection may promote infection by periodontal pathogens. Furthermore, the infectious burden comprising HSV and periodontitis may increase the risk for CVD by clearly decreasing HDL cholesterol concentrations.

  • 1446.
    Välimaa, Sofia
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    A Suggested Prediction Model for Fixed- and Removable Partial Dentures2015Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
    Abstract [en]

    When replacing lost teeth, as well as other oral tissues, with artificial prostheses, the dentist often rely solely on clinical experience to determine the prognosis for a particular prosthesis. Even though there are numerous reports on success- and failure rates for different types of prostheses, today there is still no report of a model that can provide guidance on whether the prognosis for a given treatment is good or poor. This may be particularly troublesome for professionals with limited experience in the field of oral prosthetics.

    In an attempt to alleviate this lack of a guiding tool in clinical prosthetic dentistry, a model was constructed based upon possible risk indicators and risk factors that were considered relevant, and that could prove to be important for the long-term outcome of the treatment, i.e. a prosthetic prognosis. By using this model together with acquired clinical skills, contrary to rely on experience alone, the aim was to increase the probability of making more accurate predictions on prosthetic treatments.

    After an initial interview with a specialist in oral prosthetics, an electronic literature search was conducted on PubMed for articles on possible risk indicators and risk factors for prosthetic treatments. With the information retrieved, a prediction-model was constructed.

    In this model; caries, periodontitis, endodontic treatment, prosthetic material, anatomical conditions, prosthetic design, patient adaption/cooperation, patient motivation, as well as general health were considered to be factors with a possible impact on prosthetic treatment outcome and prognosis.

     

     

  • 1447.
    Wadelius, Philip
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Salomonsson, Lars
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Early Detection of Malignancies and Potential Malignancies in the Oral Cavity - a systematic review2017Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
    Abstract [en]

    Oral cancer is a major health problem, with over 500000 patients diagnosed each year. Although progress has been made in regards to both diagnosis and treatment, the overall 5-year survival rate has not changed much in the last 30 years and still relatively static at around 50 %. This high mortality rate is related to late diagnosis of oral malignancies. At stages III and IV the 5-year survival rate is as low as 30 %, however if diagnosed at stage I the survival rate increases substantially to approximately 80 %. Research in to viable methods for early detection of oral malignancies and potential malignancies has the potential to save lives and reduce suffering for many people word wide. The purpose of this systematic review is to find an effective and practical diagnostic test for early detection of malignancies and potential malignancies in the oral cavity. Electronic database searches were conducted in English on the 4th of February 2017, using PubMed medical database, publication date 2005 or later. Inclusion criteria: Diagnostic Test Accuracy studies for oral malignancies and potential malignancies in human patients with gold standard reference test. Search yielded 166 records, titles and abstracts was screened and evaluated, 19 records was included. Included studies were assessed in detail regarding methodological quality and diagnostic accuracy. 19 studies with a total of 11575 participants were included. The studies were subdivided in to groups based on the specific index test assessed in each study. Diagnostic accuracy results: 4 records assessed Tissue autofluorescence; sensitivity ranging from 65.5 % to 100 % and specificity ranging from 41.7 % to 97.4 %. 10 records assessed Brush biopsy sampling; sensitivity ranging from 45 % to 100 % and specificity ranging from 90 % to 100 %. 1 record assessed Blood sampling; sensitivity 64 % and specificity 80 %. 2 records assessed saliva sampling Saliva sampling; sensitivity 100 % and specificity 96.7 %. 1 record assessed Metachromatic dye staining; detection rate of experimental group was 5 % higher than control group. 1 record assessed Narrow-band imaging; sensitivity 95 % and specificity 97 %. The Brush biopsy sampling diagnostic test methods has a body of evidence that far exceeds any other category presented in this review. As for methodological quality, diagnostic accuracy and risk of bias, we deemed the category as a whole to be at an acceptable level. 

  • 1448.
    Wahlgren, Frida
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Jakobsson, Emma
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Dental Rehabilitation through Implant-supported Prosthetics after Fibula Free Flap2018Independent thesis Advanced level (professional degree), 20 poäng / 30 hpOppgave
    Abstract [en]

    Objectives

    To retrospectively follow up patients rehabilitated with implant supported constructions after partial mandibular resection and reconstruction through free fibula flap in Umeå university hospital and to compare the results with the literature.

    Material and methods

    Data were collected from 44 patients between January 2000 and November 2017. A systematic review was performed in PubMed by combining following keywords; Fibula flap, Mandibular reconstruction, Tumour. 46 articles met our inclusion criteria. The information was analysed and summarized in Excel.

    Results

    44 patients (31 men/13 women) with a mean age of 62 years (range 35-80) were identified. Main treatment indication was malignant tumours (84,1%). Failure occurred in 5 cases. Four patients (10,3%) received four implants each with implant installation 20-30 months after mandibular reconstruction.The literature review contained 1680 patients with a mean age of 47,1 years (range 8-88). 1422 patients were categorized by gender (997 men/425 women). Malignant tumours were the dominant reason for the free fibula flap (65,2%). Benign tumours were the most common diagnosis among patients receiving implants after free fibula flap (40,4%). 473 implants were placed in 156 patients, (average 3,3/patient).

    Discussion/Conclusion

    Both the literature review and our retrospective follow up showed a male dominance with malignant tumours among patients reconstructed with free fibula flap. The indication for implant rehabilitation differs between our follow up (malignant tumours) and the literature (benign tumours). A minority of the reconstructed patients are rehabilitated with implants in a separate procedure 20 – 30 months later.

  • 1449.
    Wahlin, Ylva Britt
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Konradsson, Katarina
    Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Antibiotikaprofylax är sällan indicerat i tandhygienistens arbete2010Inngår i: Tandhygienisttidningen, ISSN 1102-6146, Vol. 30, nr 5, s. 16-18Artikkel i tidsskrift (Annet vitenskapelig)
  • 1450.
    Walther, Emelie
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Biomedicinsk laboratorievetenskap. Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
    Serumresistens och biofilmbildning hos Aggregatibacter aphrophilus: Betydelsen av H-NS2018Independent thesis Basic level (professional degree), 10 poäng / 15 hpOppgave
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