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• 201.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology. Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology. Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology. Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology.
Surface microdialysis sampling: a new approach described in a liver ischaemia model2012In: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 32, no 2, p. 99-105Article in journal (Refereed)

We recently have shown that samples from microdialysis (MD) probes placed on the surface of the heart reflect metabolic events in the myocardium. This new interesting observation challenges us to consider whether surface application of MD applies to other parenchymatous organs and their surfaces. In 13 anesthetized pigs, transient liver ischaemia was achieved by occlusion of arterial and venous inflow to the liver. Two probes on liver surface and two in parenchyma were perfused with a flow rate of 1 mu l per min (n = 13). An identical set-up was used for probes with a flow rate of 2 mu l per min (n = 9). Samples were collected for every 15-min period during 60 min of baseline, 45 min of ischaemia and 60 min of reperfusion. Lactate, glucose, pyruvate and glycerol were analysed in MD samples. We focused on relative changes in the present study. There was a strong agreement in relative lactate and glucose levels between probes placed on liver surface and those on parenchyma. No significant differences in relative changes in lactate and glucose levels were seen between samples from surface probes and probes in liver parenchyma during equilibration, baseline, ischaemia or reperfusion with a flow rate of 1 mu l per min. MD sampling applied on the liver surface is a new application area for the MD technique and may be used to monitor liver metabolism during both physiological and pathophysiological conditions.

• 202.
Umeå University, Faculty of Social Sciences, Department of Informatics.
Umeå University, Faculty of Social Sciences, Department of Informatics. Umeå University, Faculty of Social Sciences, Department of Informatics.
Digitala betalningar över Internet. Kan något system lyckas?1999Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
• 203.
Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics.
Ny lösning för uppvärmning av Nordanås provbana2016Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis

BAE Systems Hägglunds testbana är belägen i Nordanås nordväst om Örnsköldsvik. Detta projekt hade till avsikt att på BAE Systems förfrågan inventera testanläggningens nuvarande oljebaserade värmesystem för att finna ett mer ekonomiskt och miljövänligt alternativ. Utifrån en omfattande litteraturstudie samt kontakt med flera olika leverantörer, undersöktes vilka eventuella värmesystem som skulle kunna vara intressanta utifrån de krav som fanns i Nordanås.

De alternativa värmesystemen som ansågs vara tekniskt hållbara var följande; bergvärme med lätt biooljepanna, tung biooljepanna eller pelletspanna; pelletspanna, lätt biooljepanna och tung biooljepanna. Dessa alternativ är de som undersökts noggrant i studien och därefter jämförts med det nuvarande värmesystemet i form av ekonomi och miljöpåverkan.

I en ekonomisk kalkyl jämfördes de olika alternativens kapitalvärde och återbetalningstid. För att jämföra deras miljöpåverkan skapades en kalkyl som utifrån framtagna värden på olika bränslens utsläpp beräknade varje alternativs förväntade årliga utsläpp i form av koldioxidekvivalenter.

Slutligen konstaterades att om BAE Systems Hägglunds ska byta ut nuvarande systemet bör man antingen investera i ett bergvärmesystem med en lätt biooljepanna som spetspanna eller en konvertering till lätt biooljepanna. Med priser från den tid då rapporten skrevs skulle alternativet med bergvärme ha en beräknad återbetalningstid på ca 6,4 år och kapitalvärdet 1,0 Mkr. Motsvarande värden för alternativet med enbart en lätt biooljepanna uppgick till 1,0 års återbetalningstid samt 0,8 Mkr i kapitalvärde. Den stora skillnaden i återbetalningstid berodde på bergvärmesystemets höga investeringskostnad. Att investera i ett bergvärmesystem ansågs trots detta som ett bra alternativ på grund av den förväntade prisökningen av eldningsolja.

• 204.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Occupational Therapy.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Occupational Therapy.
Att möjliggöra delaktighet i behandlingen för personer med ätstörningsproblematik: En kvalitativ studie utifrån arbetsterapeuters erfarenheter2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis

Personer med ätstörningsproblematik kan ha en bristande insikt och ett kontrollbehov gentemot sin ätstörning. De kan även stundtals vara omotiverade till behandling och kan känna svårigheter i att förändra sitt beteende för att kunna bli fri från sin ätstörning. Detta kan försvåra för arbetsterapeuten att få dessa personer delaktiga i behandlingen, och därför blir syftet med studien att belysa arbetsterapeuters erfarenheter av vad som kan möjliggöra eller hindra delaktighet i behandlingen för personer med ätstörningsproblematik. Fem arbetsterapeuter intervjuades för att kunna besvara syftet och innehållet analyserades utifrån kvalitativ innehållsanalys. Resultatet presenterades i fyra kategorier; samarbete med patienten, klientcentrerad behandling, att medvetet använda sig själv och motivationens betydelse. Studiens slutsats är att om arbetsterapeuten lyckas skapa ett förtroende hos patienten, kan detta möjliggöra att patienten blir mer motiverad till att vilja bli fri från sin ätstörning. Detta kan uppnås genom att arbetsterapeuten bemöter patienten som en unik och kompetent person och tillsammans med denne reflekterar över personens livssituation och sätter upp mål i behandlingen, vilket leder till en ökad delaktighet i behandlingen.

• 205.
Umeå University, Faculty of Social Sciences, Department of Education.
Specialpedagogiska insatser för förskolebarn som behöver extra stöd i sin sociala kompetens: En kvalitativ studie av pedagogers uppfattningar om barns socialakompetens och betydelsen av anknytning och lek2015Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis

The aim of this study was to describe and analyse nine pedagogues understandings and experiences of preschools work with early childhood interventions and special education for children in need of extra support in their social skills, from a special educational approach. Data was collected by qualitative interviews and the collected material was analysed with the phenomenological approach.The result was analysed through systems theory and three perspectives on special education. The major result showed that attachment is a concept that all respondents seemed to think were important in preschool and the foundation of every child's development. Attachment should permeate the entire preschool environment. The definition of social skills in children was for example requirements of various abilities where components such as turn-taking, consideration,communication and empathy where important. Interaction and collaboration was also important.The play of the children was a good activity and a good opportunity to train social skills, as playsituations clearly demonstrates the abilities required and the unique needs of each child. It was important that educators were present and even participating, in play by introducing, guiding,explaining and interpreting rules in playsituations. Special education is about a systematic approach by including time for teachers to reflect and adapting communication, relationships and indoorenvironments in preschools.

• 206.
Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
Numerical analysis for random processes and fields and related design problems2011Doctoral thesis, comprehensive summary (Other academic)

In this thesis, we study numerical analysis for random processes and fields. We investigate the behavior of the approximation accuracy for specific linear methods based on a finite number of observations. Furthermore, we propose techniques for optimizing performance of the methods for particular classes of random functions. The thesis consists of an introductory survey of the subject and related theory and four papers (A-D).

In paper A, we study a Hermite spline approximation of quadratic mean continuous and differentiable random processes with an isolated point singularity. We consider a piecewise polynomial approximation combining two different Hermite interpolation splines for the interval adjacent to the singularity point and for the remaining part. For locally stationary random processes, sequences of sampling designs eliminating asymptotically the effect of the singularity are constructed.

In Paper B, we focus on approximation of quadratic mean continuous real-valued random fields by a multivariate piecewise linear interpolator based on a finite number of observations placed on a hyperrectangular grid. We extend the concept of local stationarity to random fields and for the fields from this class, we provide an exact asymptotics for the approximation accuracy. Some asymptotic optimization results are also provided.

In Paper C, we investigate numerical approximation of integrals (quadrature) of random functions over the unit hypercube. We study the asymptotics of a stratified Monte Carlo quadrature based on a finite number of randomly chosen observations in strata generated by a hyperrectangular grid. For the locally stationary random fields (introduced in Paper B), we derive exact asymptotic results together with some optimization methods. Moreover, for a certain class of random functions with an isolated singularity, we construct a sequence of designs eliminating the effect of the singularity.

In Paper D, we consider a Monte Carlo pricing method for arithmetic Asian options. An estimator is constructed using a piecewise constant approximation of an underlying asset price process. For a wide class of Lévy market models, we provide upper bounds for the discretization error and the variance of the estimator. We construct an algorithm for accurate simulations with controlled discretization and Monte Carlo errors, andobtain the estimates of the option price with a predetermined accuracy at a given confidence level. Additionally, for the Black-Scholes model, we optimize the performance of the estimator by using a suitable variance reduction technique.

• 207.
Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics. Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
Was it snowing on lake Kassjön in January 4486 BC? Functional data analysis of sediment data2014Conference paper (Other academic)
• 208.
Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Physiotherapy. Swedish Winter Sports Research Centre Mid Sweden; University Department of Health Sciences, Östersund, Sweden. MOX – Department of Mathematics, Politecnico di Milano. Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Statistics. Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Physiotherapy. Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics. MOX – Department of Mathematics, Politecnico di Milano.
An inferential framework for domain selection in functional anova2014In: Contributions in infinite-dimensional statistics and related topics / [ed] Bongiorno, E.G., Salinelli, E., Goia, A., Vieu, P, Esculapio , 2014Conference paper (Refereed)

We present a procedure for performing an ANOVA test on functional data, including pairwise group comparisons. in a Scheff´e-like perspective. The test is based on the Interval Testing Procedure, and it selects intervals where the groups significantly differ. The procedure is applied on the 3D kinematic motion of the knee joint collected during a functional task (one leg hop) performed by three groups of individuals.

• 209.
Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Physiotherapy. Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Statistics. Department of Statistical Sciences, Università Cattolica del Sacro Cuore, Milan, Italy. Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation. Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Statistics. Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
Nonparametric inference for functional-on-scalar linear models applied to knee kinematic hop data after injury of the anterior cruciate ligament2018In: Scandinavian Journal of Statistics, Vol. 45, no 4, p. 1036-1061Article in journal (Refereed)

Motivated by the analysis of the dependence of knee movement patterns during functional tasks on subject-specific covariates, we introduce a distribution-free procedure for testing a functional-on-scalar linear model with fixed effects. The procedure does not only test the global hypothesis on the entire domain but also selects the intervals where statistically significant effects are detected. We prove that the proposed tests are provided with an asymptotic control of the intervalwise error rate, that is, the probability of falsely rejecting any interval of true null hypotheses. The procedure is applied to one-leg hop data from a study on anterior cruciate ligament injury. We compare knee kinematics of three groups of individuals (two injured groups with different treatments and one group of healthy controls), taking individual-specific covariates into account.

• 210.
Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
Multivariate piecewise linear interpolation of a random field2011Manuscript (preprint) (Other academic)

We consider a multivariate piecewise linear interpolation of a continuous random field on a-dimensional cube. The approximation performance is measured by the integrated mean square error. Multivariate piecewise linear interpolator is defined by N field observations on a locations grid (or design). We investigate the class of locally stationary random fields whose local behavior is like a fractional Brownian field in mean square sense and find the asymptotic approximation accuracy for a sequence of designs for large N. Moreover, for certain classes of continuous and continuously differentiable fields we provide the upper bound for the approximation accuracy in the uniform mean square norm.

• 211.
Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
On the error of the Monte Carlo pricing method for Asian option2008In: Journal of Numerical and Applied Mathematics, ISSN 0868-6912, Vol. 96, no 1, p. 1-10Article in journal (Refereed)

We consider a Monte Carlo method to price a continuous arithmetic Asian option with a given precision. Piecewise constant approximation and plain simulation are used for a wide class of models based on L\'{e}vy processes. We give bounds of the possible discretization and simulation errors. The sufficient numbers of discretization points and simulations to obtain requested accuracy are derived. To demonstrate the general approach, the Black-Scholes model is studied in more detail. We undertake the case of continuous averaging and starting time zero,  but the obtained results can be applied to the discrete case  and generalized for any time before an execution date. Some numerical experiments and comparison to the PDE based method are also presented.

• 212.
Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
Piecewise multilinear interpolation of a random field2013In: Advances in Applied Probability, ISSN 0001-8678, E-ISSN 1475-6064, Vol. 45, no 4, p. 945-959Article in journal (Refereed)

We consider a piecewise-multilinear interpolation of a continuous random field on a d-dimensional cube. The approximation performance is measured using the integrated mean square error. Piecewise-multilinear interpolator is defined by N-field observations on a locations grid (or design). We investigate the class of locally stationary random fields whose local behavior is like a fractional Brownian field, in the mean square sense, and find the asymptotic approximation accuracy for a sequence of designs for large N. Moreover, for certain classes of continuous and continuously differentiable fields, we provide the upper bound for the approximation accuracy in the uniform mean square norm.

• 213.
Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
Spline approximation of a random process with singularity2011In: Journal of Statistical Planning and Inference, ISSN 0378-3758, E-ISSN 1873-1171, Vol. 141, no 3, p. 1333-1342Article in journal (Refereed)

Let a continuous random process X defined on [0,1] be (m+β)-smooth, 0m, 0<β$\leq$1, in quadratic mean for all t>0 and have an isolated singularity point at t=0. In addition, let X be locally like a m-fold integrated β-fractional Brownian motion for all nonsingular points. We consider approximation of X by piecewise Hermite interpolation splines with n free knots (i.e., a sampling design, a mesh). The approximation performance is measured by mean errors (e.g., integrated or maximal quadratic mean errors). We construct a sequence of sampling designs with asymptotic approximation rate n^(m+β) for the whole interval.

• 214.
Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
Stratified Monte Carlo quadrature for continuous random fields2015In: Methodology and Computing in Applied Probability, ISSN 1387-5841, E-ISSN 1573-7713, Vol. 17, no 1, p. 59-72Article in journal (Refereed)

We consider the problem of numerical approximation of integrals of random fields over a unit hypercube. We use a stratified Monte Carlo quadrature and measure the approximation performance by the mean squared error. The quadrature is defined by a finite number of stratified randomly chosen observations with the partition generated by a rectangular grid (or design). We study the class of locally stationary random fields whose local behavior is like a fractional Brownian field in the mean square sense and find the asymptotic approximation accuracy for a sequence of designs for large number of the observations. For the H¨older class of random functions, we provide an upper bound for the approximation error. Additionally, for a certain class of isotropic random functions with an isolated singularity at the origin, we construct a sequence of designs eliminating the effect of the singularity point.

• 215.
Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics. Politecnico di Milano, Italy. Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics. Politecnico di Milano, Italy. Oslo University, Norway.
Clustering misaligned dependent curves applied to varved lake sediment for climate reconstruction2017In: Stochastic environmental research and risk assessment (Print), ISSN 1436-3240, E-ISSN 1436-3259, Vol. 31, no 1, p. 71-85Article in journal (Refereed)

In this paper we introduce a novel functional clustering method, the Bagging Voronoi K-Medoid Aligment (BVKMA) algorithm, which simultaneously clusters and aligns spatially dependent curves. It is a nonparametric statistical method that does not rely on distributional or dependency structure assumptions. The method is motivated by and applied to varved (annually laminated) sediment data from lake Kassjön in northern Sweden, aiming to infer on past environmental and climate changes. The resulting clusters and their time dynamics show great potential for seasonal climate interpretation, in particular for winter climate changes.

• 216.
Umeå University, Faculty of Science and Technology, Department of Science and Mathematics Education.
Umeå University, Faculty of Science and Technology, Department of Science and Mathematics Education.
Pojkar som skriver: En kvalitativ studie om vad som utmärker mer avancerade skrivare2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis

• 217.
Umeå University, Faculty of Social Sciences, Department of Informatics.
Umeå University, Faculty of Social Sciences, Department of Informatics. Umeå University, Faculty of Social Sciences, Department of Informatics.
Systemutveckling som designarbete – En studie av en systemutvecklingsprocess 2003Independent thesis Basic level (degree of Bachelor), 15 credits / 22,5 HE creditsStudent thesis
• 218.
Umeå University, Faculty of Social Sciences, Department of Informatics.
Umeå University, Faculty of Social Sciences, Department of Informatics.
Överlever Internet? En granskning av hoten mot Internets infrastruktur2004Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
• 219.
Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Statistics.
Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Statistics.
Skattning av kausala effekter med matchat fall-kontroll data2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
• 220.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Pharmacology.
Följsamhet till behandling med bisfosfonater: En intervjustudie på ortopedavdelningen vid Norrlands Universitetssjukhus, Umeå2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
• 221.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Pharmacology.
PREVALENCE OF DRUG RELATED PROBLEMS STOPP/START in elderly people with dementia2019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
• 222.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Pharmacology.
Adherence to Bisphosphonates among People Admitted to an Orthopaedic and Geriatric Ward at a University Hospital in Sweden2018In: Pharmacy, ISSN 2226-4787, E-ISSN 1913-4711, Vol. 6, no 1, article id 20Article in journal (Refereed)

• 223.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Pharmacology.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Pharmacology.
Prevalence of drug-related problems using STOPP/START and medication reviews in elderly patients with dementia2019In: Research in Social and Administrative Pharmacy, ISSN 1551-7411, E-ISSN 1934-8150Article in journal (Refereed)

Background: Drug-related problems (DRPs) are common among elderly patients with dementia. STOPP/START is an explicit tool that has been used to detect DRPs among elderly patients.

Objectives: The objective of this study was to compare prevalence and type of DRPs identified by STOPP/START with DRPs identified by clinical pharmacists among the same population. Secondary objectives were to investigate factors associated with the use of DRPs using the two methods.

Method: Extracts from medical records were used to identify DRPs in 212 patients by using STOPP/START. The patients were ≥65 years of age with dementia or cognitive impairment. An earlier study was performed in the same study population in 2012–2014, where DRPs were identified by clinical pharmacists in order to decrease the number of rehospitalizations.

Results: STOPP/START identified DRPs in 72.2% of the patients compared with 66.0% identified by the clinical pharmacists. The numbers of DRPs identified by the different methods were 326 and 310, respectively. Different types of DRPs were identified with the different tools. STOPP/START mainly identified DRPs in the categories “ineffective/inappropriate drug” and “needs additional drug therapy”, whereas the clinical pharmacists identified DRPs in several categories.

Conclusion: Even though STOPP/START was able to identify a similar number of DRPs compared with DRPs identified by clinical pharmacists, STOPP/START failed to identify DRPs in several important categories. To cover all DRPs, STOPP/START might be used as a complement to implicit criteria.

• 224.
Umeå University, Faculty of Social Sciences, Social and Economic Geography.
Housing Careers in a Changing Welfare State2003Doctoral thesis, monograph (Other academic)

The departure point of this thesis was changes to the welfare state. These changes began during the recession in the 1970s and were emphasised in the beginning of the 1990s. The housing market was particularly affected, as the state almost completely withdrew its engagement. Questions were raised as to how the development of the welfare state and the subsequent changes have affected different sectors of the housing market (social housing) and the housing careers of different groups.

Besides the introduction the thesis consists of five papers, beginning with a review article on the effect of welfare state changes on the social housing stock in some western countries. The social housing sector (housing the lowest income groups) became more residualised as the concentration of low-income households in this sector increased in most countries. At the same time, government interest in this sector decreased.

The second, third and fourth papers follow the housing careers of different groups in three Swedish municipalities during the period 1985–1995. Nest-leaving and choice of tenure of the young population, aged 16–24, in the Gävle municipality were studied. A study of two cohorts showed that nest-leaving was postponed during the recession of the early 1990s when unemployment rates were high among young people. A slight increase in moves to co-operative housing was seen during this period. Immigrants in Jönköping, Gävle and Västerås were studied. Results show that the structure of the local housing market as well as time spent in Sweden are important factors in the housing careers of immigrants. In areas with a large share of owner-occupation, immigrants live in this type of housing to a larger extent. A housing career similar to that of the Swedish population is more common among immigrants who have spent a longer time in Sweden. Residential mobility of seniors towards the city centres in the same municipalities showed only a marginal increase in this type of move. However, the characteristics of those moving were those that, to a large extent, characterise the baby boom generation born in the 1940s. As a result, this type of move can be expected to increase as this group retires.

Finally, the fifth paper follows the housing career of four cohorts during the development of the welfare state after 1945. The cohorts were born in 1925, 1942, 1955 and 1970, respectively. They were interviewed about the meaning attached to the terms size, tenure and location, important factors in the development of Swedish housing policy. Despite differences in the housing market at the start of their housing careers, with time the cohorts developed similar demands on size, standard and location. Tenure was not cohort-specific but was instead discussed as degrees of freedom found in owner occupation or rental tenure.

• 225.
Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC). Umeå University, Faculty of Science and Technology, Department of Plant Physiology.
Umeå University, Faculty of Science and Technology, Department of Plant Physiology. Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC).
UHPLC-ESI/TOFMS Determination of Salicylate-like Phenolic Gycosides in Populus tremula Leaves2011In: Journal of Chemical Ecology, ISSN 0098-0331, E-ISSN 1573-1561, Vol. 37, no 8, p. 857-70Article in journal (Refereed)

Associations of salicylate-like phenolic glycosides (PGs) with biological activity have been reported in Salix and Populus trees, but only for a few compounds, and in relation to a limited number of herbivores. By considering the full diversity of PGs, we may improve our ability to recognize genotypes or chemotype groups and enhance our understanding of their ecological function. Here, we present a fast and efficient general method for salicylate determination in leaves of Eurasian aspen that uses ultra-high performance liquid chromatography-electrospray ionization/time-of-flight mass spectrometry (UHPLC-ESI/TOFMS). The time required for the liquid chromatography separations was 13.5 min per sample, compared to around 60 min per sample for most HPLC protocols. In leaf samples from identical P. tremula genotypes with diverse propagation and treatment histories, we identified nine PGs. We found the compound-specific mass chromatograms to be more informative than the UV-visible chromatograms for compound identification and when quantitating samples with large variability in PG content. Signature compounds previously reported for P. tremoloides (tremulacin, tremuloidin, salicin, and salicortin) always were present, and five PGs (2'-O-cinnamoyl-salicortin, 2'-O-acetyl-salicortin, 2'-O-acetyl-salicin, acetyl-tremulacin, and salicyloyl-salicin) were detected for the first time in P. tremula. By using information about the formic acid adduct that appeared for PGs in the LTQ-Orbitrap MS environment, novel compounds like acetyl-tremulacin could be tentatively identified without the use of standards. The novel PGs were consistently either present in genotypes regardless of propagation and damage treatment or were not detectable. In some genotypes, concentrations of 2'-O-acetyl-salicortin and 2'-O-cinnamoyl-salicortin were similar to levels of biologically active PGs in other Salicaceous trees. Our study suggests that we may expect a wide variation in PG content in aspen populations which is of interest both for studies of interactions with herbivores and for mapping population structure.

• 226.
Umeå University, Faculty of Science and Technology, Department of Physics.
Effectof Growth Time, Growth Temperature and Light  on Growth Mechanism of C60 nanorods2013Independent thesis Advanced level (degree of Master (Two Years)), 10 credits / 15 HE creditsStudent thesis

In this thesis work C60 nanorods were produced by Liquid-Liquid Interfacial Precipitation method (LLIP) assisted with 10 s of weak sonication. Ethanol and m-dichlorobenzene were used as poor and good solvents of C60, respectively. Five different temperatures, 4, 10, 20, 30, 40 and 50                         , were chosen as growth temperatures of different samples to investigate the effect of temperature on the grown structures. Different samples were prepared in the dark and under the light with various growth time to determine the effect of light and growth time on growth of C60 nanorods. The characterization of the grown C60 nanorods were conducted by transmission electron microscopy (TEM) and x-ray diffraction (XRD). The result of characterization indicated that the sonication introduced smaller C60 nanostructures; light irradiation and temperature increase (till 40 C0) during the growth time resulted in nanorods with smaller diameter, whereas the long growth time lead to the increase of the diameter of C60 nanorods. The as-grown C60 nanorods synthesized at different conditions possess an hcp crystal structure.

• 227.
Umeå University, Faculty of Science and Technology, Department of Physics.
Measuring the efficiency and charge carrier mobility of organic solar cells2012Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis

P3HT single layer, P3HT/PCBM bilayer and P3HT/PCBM inverted bilayer devices were produced by spin coating organic layers onto ITO patterned glass in air, and clamping it with an Au coated silicon wafer, as top electrode, at the end (Figure13). Normal and inverted bilayer devices were also fabricated with and without PEDOT:PSS. All devices were divided into two groups by changing concentration of P3HT solution. The first group of devices contained 1.0 wt. % P3HT solution (P3HT in dichlorobenzene); the second group 0.56wt %. Power conversion efficiency, short circuit current, open circuit voltage, fill factor and maximum extracted power were measured on all produced devices.

In contrast, all devices with 1.0wt % P3HT concentration showed better result than the devices with 0.56wt %. The highest result was obtained for P3HT single layer devices in both cases with short circuit current 56uA/cm2, open circuit voltage 0.94mV, maximum power 11.4uW/cm2 and power conversion efficiency of 0.11%. Inverted bilayer devices performed better than the non-inverted one. The devices with PEDOT:PSS got slightly better performance than the non-PEDOT:PSS used one.

Charge carrier mobility measurement was done for all fabricated devices with charge extraction by linearly increasing voltage (CELIV) and dark injected space charge limited current (DI-SCLC) methods. All devices showed same magnitude of charge carrier mobility 10-5 cm2/V.s, the highest value still belongs to P3HT single layer device. The charge carrier mobility in all devices observed by DI-SCLC technique is one order of magnitude higher than by CELIV technique. This may be due to DI-SCLC method`s restriction on ohmic contacts between material and electrode.

• 228. Abu-Elyazeed, R R
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
Safety and immunogenicity of a glycoprotein D genital herpes vaccine in healthy girls 10-17 years of age: results from a randomised, controlled, double-blind trial2013In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 31, no 51, p. 6136-6143Article in journal (Refereed)

OBJECTIVE: The investigational AS04-adjuvanted herpes simplex virus type 2 (HSV-2) glycoprotein D (gD2) subunit prophylactic vaccine ('HSV vaccine'; GlaxoSmithKline Vaccines) has been shown to be well tolerated in adults, but limited data exist for pre-teen and adolescent girls, a likely target population. The primary objective of this study was to compare the occurrence of serious adverse events (SAEs) over 12 months between HSV vaccine recipients and saline recipients (placebo control group) in pre-teen and adolescent girls. The immunogenicity of the HSV vaccine was also assessed.

METHODS: Healthy girls aged 10-17 years, stratified by age (10-15 years; 16-17 years), were randomised 2:1:1 to receive the HSV vaccine, a hepatitis A vaccine (Havrix™; HAV control) or placebo (saline) according to a 0-, 1-, 6-month schedule. Participants and study personnel not involved in the preparation or administration of vaccines were blinded to treatment. Safety and immunogenicity analyses were performed overall and by age (10-15 years; 16-17 years) and HSV serostatus.

RESULTS: No statistically significant difference in the percentage of subjects with SAEs was observed between the HSV and saline group, or between the HSV and pooled control (HAV and saline) groups. The HSV vaccine was well tolerated, although a higher incidence of solicited local symptoms was observed in the HSV group than in the control group. Neither age nor HSV serostatus at the time of study entry had an impact on the safety profile of this vaccine. The HSV vaccine was immunogenic regardless of pre-vaccination HSV serostatus. Higher anti-gD geometric mean concentrations were observed in HSV-1 seropositive participants than in HSV-1 seronegative participants.

CONCLUSION: The HSV vaccine had an acceptable safety profile, and was well tolerated and immunogenic when administered to girls aged 10-17 years regardless of age or HSV pre-vaccination serostatus.

• 229.
Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics.
Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics. Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics.
Understanding Web Users Behaviour From A Web Video Camera2003Report (Other academic)

To develop a Real-Time system, which can capture and track the web user’s head motion. Based on the head motion information, the system should be able to identify whether the user is interested in the current homepage or not. A future system property would be to find out in which area of the homepage the user’s interest is moving.

• 230. Abul-Kasim, Kasim
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Hand Surgery.
Advanced radiological work-up as an adjunct to decision in early reconstructive surgery in brachial plexus injuries2010In: Journal of Brachial Plexus and Peripheral Nerve Injury, ISSN 1749-7221, E-ISSN 1749-7221, Vol. 5, p. 14-Article in journal (Refereed)

Background

As neurophysiologic tests may not reveal the extent of brachial plexus injury at the early stage, the role of early radiological work-up has become increasingly important. The aim of the study was to evaluate the concordance between the radiological and clinical findings with the intraoperative findings in adult patients with brachial plexus injuries.

Methods

Seven consecutive male patients (median age 33; range 15-61) with brachial plexus injuries, caused by motor cycle accidents in 5/7 patients, who underwent extensive radiological work-up with magnetic resonance imaging (MRI), computed tomography myelography (CT-M) or both were included in this retrospective study. A total of 34 spinal nerve roots were evaluated by neuroradiologists at two different occasions. The degree of agreement between the radiological findings of every individual nerve root and the intraoperative findings was estimated by calculation of kappa coefficient (К-value). Using the operative findings as a gold standard, the accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the clinical findings and the radiological findings were estimated.

Results

The diagnostic accuracy of radiological findings was 88% compared with 65% for the clinical findings. The concordance between the radiological findings and the intraoperative findings was substantial (К = 0.76) compared with only fair (К = 0.34) for the clinical findings. There were two false positive and two false negative radiological findings (sensitivity and PPV of 0.90; specificity and NPV of 0.87).

Conclusions

The advanced optimized radiological work-up used showed high reliability and substantial agreement with the intraoperative findings in adult patients with brachial plexus injury.

• 231.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Pharmacology.
Biverkningar avsolskyddsprodukter: Retrospektiv analys av allvarliga biverkningarinrapporterade till Läkemedelsverket underperioden 2013–20172019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
• 232.
Network Governance: The Role of Power and Trust in Mandated Collaboration Network2014Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis

Mandated collaboration networks are an overly studied topic in the field of public administration and management, with the emphasis on these studies however focused on the failures to accomplish its collaborative aims. The role that mandated collaboration networks play today in enabling societies and governments alike,  to realize insurmountable challenges through their  collaborative efforts is however not being paid as much attention as it should be, yet through it, huge socio and economic benefits are derived.

This study recognizes the part mandated collaboration network plays by seeking to further investigate the role, power and trust play in influencing managers towards attaining efficiency. Data was collected from 7 managers from the public sector, with some public managers, tasked with the responsibility of playing oversight role and disbursing funds and other public managers tasked with implementing the services, all working towards achieving a regional goal within Västerbotten region. By conducting semi-structured interviews with them, the aim was to find out the daily encounters they faced in implementing their activities and achieving their goals.

In order to analyze this study adequately, theories were derived from governance, principal agency, structuration theory, Long & Sitkin integrated trust and control framework  that enabled me to come up with a conceptual framework. The findings of this framework were particularly insightful in regards to how managers in mandated collaboration network can use trust in ensuring that they achieve their desired efficiency goals. The findings show both power and trust in mandated collaboration network play a coordinative and regulative role in ensuring that the goals are realized. Calculative trust alongside formal controls can be used to address challenges that managers encounter in realizing their goals. Relational trust can also be nurtured, however at an interpersonal level or with peers that perform the same activities but not at an institutional level such as the mandated collaboration network. Attaining efficiency in the mandated collaboration network is however also further compounded by contextual matters both internal and external that hamper its attainment.

• 233.
Istanbul Kemerburgaz University.
Umeå University, Faculty of Social Sciences, Department of Economic History.
Convergence of CO2 emissions and economic growth in the OECD countries: did the type of fuel matter?2017In: Energy Sources, Part B: Economics, Planning, and Policy, ISSN 1556-7249, Vol. 12, no 7, p. 618-627Article in journal (Refereed)

This study analyzes convergence in CO2 emissions in the OECD countries with respect to the source of emissions (oil versus coal). The investigated period 1973-2010 is divided into two sub-periods, 1973-1991 and 1992-2010. The first period covers the OPEC oil price shocks, where the OECD oil policy was to a high extent governed by energy security concerns and cold war strategic considerations. The second period corresponds to the end of the cold war and the rise of climate policy in several OECD countries. Due to such contextual differences, oil and coal behave differently in the two sub-periods. The generally stronger convergence with respect to oil-related emissions until 1991 conditional on GDP per capita is compatible with a situation where the rising oil prices led to a strong transformation in the countries of interest. Besides, we evidence decoupling of economic growth from oil-related emissions in the post-cold war period.

• 234.
Istanbul Kemerburgaz University, Turkey.
Umeå University, Faculty of Social Sciences, Department of Economic History.
Periods of converging carbon dioxide emissions from oil combustion in a pre-Kyoto context2016In: Environmental Development, ISSN 2211-4645, Vol. 19, p. 1-9Article in journal (Refereed)

This paper examines convergence of carbon dioxide (CO2) emissions caused by oil combustion for a panel of 86 countries considering the importance of analyzing sub-periods separately. The investigation also points at the necessity of choosing a restricted global sample, which takes into account, for instance, that Eastern Bloc countries reacted differently to increasing world crude oil prices than the rest of the world. The analysis builds on examining the β-convergence hypothesis in a neoclassical growth model setting with additional control variables such as emissions from combustion of solid fuels. The results reveal evidence in support of unconditional β-convergence of CO2 emissions intensity due to oil combustion in the restricted sample for the sub-periods 1973–1979 and 1979–1991, while no evidence for convergence was found for the post-1991, pre-Kyoto period. We could not find support for coal substituting technologies.

• 235. Acar, Sevil
Umeå University, Faculty of Social Sciences, Center for Environmental and Resource Economics (CERE). Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE).
Convergence of per capita carbon dioxide emissions: implications and meta-analysis2018In: Climate Policy, ISSN 1469-3062, E-ISSN 1752-7457, Vol. 18, no 4, p. 512-525Article in journal (Refereed)

There is a rich empirical literature testing whether per capita carbon dioxide emissions tend to converge over time and across countries. This article provides a meta-analysis of the results from this research, and discusses how carbon emissions convergence may be understood in, for instance, the presence of international knowledge spillovers and policy convergence. The results display evidence of either divergence or persistent gaps at the global level, but convergence of per capita carbon dioxide emissions between richer industrialized countries. However, the results appear sensitive to the choice of data sample and choice of convergence concept, e.g. stochastic convergence versus β-convergence. Moreover, peer-reviewed studies have a higher likelihood of reporting convergence in carbon dioxide emissions compared to non-refereed work.

• 236. Accinelli, Cesare
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Removal of oseltamivir (Tamiflu) and other selected pharmaceuticals from wastewater using a granular bioplastic formulation entrapping propagules of Phanerochaete chrysosporium2010In: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 81, no 3, p. 436-43Article in journal (Refereed)

The capacity of the ligninolytic fungus Phanerochaete chrysosporium to degrade a wide variety of environmentally persistent xenobiotics has been largely reported in the literature. Beside other factors, one barrier to a wider use of this bioremediation fungus is the availability of effective formulations that ensure easy preparation, handling and application. In this series of laboratory experiments, we evaluated the efficiency of a granular bioplastic formulation entrapping propagules of P. chrysosporium for removal of four selected pharmaceuticals from wastewater samples. Addition of inoculated granules to samples of the wastewater treatment plant of Bologna significantly increased the removal of the antiviral drug oseltamivir (Tamiflu), and the antibiotics, erythromycin, sulfamethoxazol, and ciprofloxacin. Similar effects were also observed in effluent water. Oseltamivir was the most persistent of the four active substances. After 30d of incubation, approximately two times more oseltamivir was removed in bioremediated wastewater than controls. The highest removal efficiency of the bioplastic formulation was observed with the antibiotic ciprofloxacin. Microbiological DNA-based analysis showed that the bioplastic matrix supported the growth of P. chrysosporium, thus facilitating its adaptation to unusual environment such as wastewater.

• 237. Accinelli, Cesare
Umeå University, Faculty of Science and Technology, Department of Chemistry. Umeå University, Faculty of Science and Technology, Department of Chemistry.
Dissipation and removal of oseltamivir (Tamiflu) in different aquatic environments2010In: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 79, no 8, p. 891-897Article in journal (Refereed)

The antiviral drug oseltamivir (Tamiflu) has received recent attention due to the potential use as a first-line defense against H5N1 and H1N1 influenza viruses. Research has shown that oseltamivir is not removed during conventional wastewater treatments, thus having the potential to enter surface water bodies. A series of laboratory experiments investigated the fate and the removal of oseltamivir in two surface water ecosystems of Japan and in a municipal wastewater treatment plant located in Northern Italy. Persistence of oseltamivir in surface water ranged from non-detectable degradation to a half-life of 53d. After 40d, <3% of radiolabeled oseltamivir evolved as (14)CO(2). The presence of sediments (5%) led to a significant increase of oseltamivir degradation and mineralization rates. A more intense mineralization was observed in samples of the wastewater treatment plant when applying a long incubation period (40d). More precisely, 76% and 37% of the initial radioactivity applied as (14)C-oseltamivir was recovered as (14)CO(2) from samples of the biological tank and effluent water, respectively. Two bacterial strains growing on oseltamivir as sole carbon source were isolated and used for its removal from synthetic medium and environmental samples, including surface water and wastewater. Inoculation of water and wastewater samples with the two oseltamivir-degrading strains showed that mineralization of oseltamivir was significantly higher in both inoculated water and wastewater, than in uninoculated controls. Denaturing gradient gel electrophoresis and quantitative PCR analysis showed that Tamiflu would not affect the microbial population of surface water and wastewater.

• 238. Accordini, Simone
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine. Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine.
A three-generation study on the association of tobacco smoking with asthma2018In: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 47, no 4, p. 1106-1117Article in journal (Refereed)

Background: Mothers' smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers' smoking may have a similar effect, and biological plausibility that fathers' smoking during adolescence may influence offspring's health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma.

Methods: Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents' (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines.

Results: Fathers' smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01-2.01] and mothers' smoking during pregnancy (RRR = 1.27, 95% CI: 1.01-1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers' smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17-2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02-1.55).

Conclusions: Fathers' smoking during early adolescence and grandmothers' and mothers' smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception.

• 239. Acharya, Shravan S.
Umeå University, Faculty of Science and Technology, Department of Chemistry. School of Chemistry, Monash University, Clayton, Australia.
Diverse composites of metal-complexes and PEDOT facilitated by metal-free vapour phase polymerization2017In: Reactive & functional polymers, ISSN 1381-5148, E-ISSN 1873-166X, Vol. 116, p. 101-106Article in journal (Refereed)

Abstract Oxidative polymerization for the manufacture of conducting polymers such as poly(3,4-ethylenedioxy-thiophene) has traditionally employed iron(III) salts. Demonstrated in this study is vapour phase polymerization of 3,4-ethylenedio- xythiophene using a metal-free oxidant, ammonium persulfate, leading to films with an estimated conductivity of 75 S/cm. Additionally, a route for embedding active transition metal complexes into these poly(3,4-ethylenedioxythiophene)/-poly(styrene-4-sulfonate) (PEDOT/PSS) films via vapour assisted complexation is outlined. Here, the vapour pressure of solid ligands around their melting temperatures was exploited to ensure complexation to metal ions added into the oxidant mixture prior to polymerization of PEDOT. Four composite systems are discussed, viz. PEDOT/PSS embedded with tris(8-hydroxyquinolinato)cobalt(III), tris(2,2-bipyridine)cobalt(II), tris(1,10- phenanthroline)cobalt(II) and tris(8-hyd-roxyquinolinato)aluminium(III). Using these composites, electrochemical reduction of nitrite to ammonia with a faradaic efficiency of 61% was reported.

• 240. Acharya, Shravan
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Rates of water exchange in 2,2'-bipyridine and 1,10-phenanthroline complexes of CoII and MnII2017In: Australian journal of chemistry (Print), ISSN 0004-9425, E-ISSN 1445-0038, Vol. 70, no 6, p. 751-754Article in journal (Refereed)

The rates and activation parameters of water exchange at pH 3.0 have been determined using variable temperature 17O NMR spectroscopy for four CoII complexes and one MnII complex: [Co(bpy)(H2O)4]2+, [Co(bpy)2 (H2O)2]2+, [Co(phen)-(H2O)4]2+, [Co(phen)2 (H2O)2]2+, and [Mn(bpy)(H2O)4]2+ (bpy = 2,2′-bipyridyl and phen = 1,10-phenanthroline). Substitution of aquo ligands with 1,10-phenanthroline or 2,2′-bipyridyl leads to an increase in the rate of exchange in the manganese complexes, from k298 (1.8 ± 0.1) × 107 s-1 for [Mn(H2O)6]2+ to (7.2 ± 0.3) × 107 s-1 for [Mn(phen)2 (H2O)2]2+, whereas the trends are more complex for the cobalt complexes. We have used the new data in conjunction with literature data for similar complexes to analyse the effect of M–OH2 distance and degree of substitution.

• 241.
Umeå University, Faculty of Science and Technology, Umeå School of Architecture.
Sequence Lane: De-centralization of the social arena in the modern city plan2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis

Reconstruction and densification of Gamla storgatan in Holmsund.

• 242. Achouiti, A.
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
Myeloid related protein (mrp) 8/14 contributes to an antibacterial host response against klebsiella (k.) pneumoniae2012In: Shock, ISSN 1073-2322, E-ISSN 1540-0514, Vol. 37, no S1, p. 56-56Article in journal (Other academic)
• 243. Achouiti, Ahmed
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Clinical Bacteriology. Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Clinical Bacteriology.
Myeloid-related protein-14 contributes to protective immunity in gram-negative pneumonia derived sepsis2012In: PLoS Pathogens, ISSN 1553-7374, Vol. 8, no 10, p. e1002987-Article in journal (Refereed)

Klebsiella (K.) pneumoniae is a common cause of pneumonia-derived sepsis. Myeloid related protein 8 (MRP8, S100A8) and MRP14 (S100A9) are the most abundant cytoplasmic proteins in neutrophils. They can form MRP8/14 heterodimers that are released upon cell stress stimuli. MRP8/14 reportedly exerts antimicrobial activity, but in acute fulminant sepsis models MRP8/14 has been found to contribute to organ damage and death. We here determined the role of MRP8/14 in K. pneumoniae sepsis originating from the lungs, using an established model characterized by gradual growth of bacteria with subsequent dissemination. Infection resulted in gradually increasing MRP8/14 levels in lungs and plasma. Mrp14 deficient (mrp14(-/-)) mice, unable to form MRP8/14 heterodimers, showed enhanced bacterial dissemination accompanied by increased organ damage and a reduced survival. Mrp14(-/-) macrophages were reduced in their capacity to phagocytose Klebsiella. In addition, recombinant MRP8/14 heterodimers, but not MRP8 or MRP14 alone, prevented growth of Klebsiella in vitro through chelation of divalent cations. Neutrophil extracellular traps (NETs) prepared from wildtype but not from mrp14(-/-) neutrophils inhibited Klebsiella growth; in accordance, the capacity of human NETs to kill Klebsiella was strongly impaired by an anti-MRP14 antibody or the addition of zinc. These results identify MRP8/14 as key player in protective innate immunity during Klebsiella pneumonia.

• 244.
Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Wallenberg Centre for Molecular Medicine at Umeå University (WCMM). Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Long non-coding RNA and Polycomb: an intricate partnership in cancer biology2018In: Frontiers in Bioscience, ISSN 1093-9946, E-ISSN 1093-4715, Vol. 23, p. 2106-2132Article in journal (Refereed)

High-throughput analyses have revealed that the vast majority of the transcriptome does not code for proteins. These non-translated transcripts, when larger than 200 nucleotides, are termed long non-coding RNAs (lncRNAs), and play fundamental roles in diverse cellular processes. LncRNAs are subject to dynamic chemical modification, adding another layer of complexity to our understanding of the potential roles that lncRNAs play in health and disease. Many lncRNAs regulate transcriptional programs by influencing the epigenetic state through direct interactions with chromatin-modifying proteins. Among these proteins, Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) have been shown to be recruited by lncRNAs to silence target genes. Aberrant expression, deficiency or mutation of both lncRNA and Polycomb have been associated with numerous human diseases, including cancer. In this review, we have highlighted recent findings regarding the concerted mechanism of action of Polycomb group proteins (PcG), acting together with some classically defined lncRNAs including X-inactive specific transcript (XIST), antisense non-coding RNA in the INK4 locus (ANRIL), metastasis associated lung adenocarcinoma transcript 1 (MALAT1), and HOX transcript antisense RNA (HOTAIR).

• 245.
Umeå University, Faculty of Medicine, Department of Odontology.
Umeå University, Faculty of Medicine, Department of Odontology.
Anti-Tumor Necrosis Factor-α Treatment in Periodontal Disease – a literature review2016Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis

The aim of this literature review was to summarize human studies on the effects of tumor necrosis factor-α (TNF-α) inhibitors on periodontal status. Today TNF-α inhibitors is an established treatment method with positive effects in Rheumatoid arthritis (RA) a disease similar to periodontitis. TNF-α inhibitors have in animal studies demonstrated positive results in experimental periodontitis.

Literature search was made in PubMed. Included articles were clinical human studies examining the effects on bleeding on probing (BOP), gingival index (GI) or modified gingival index (MGI), clinical attachment level (CAL) and periodontal probing depth (PPD) in patients with autoimmune diseases and treated with TNF-α inhibitors. Animal studies and studies in languages other than English were excluded. The guidelines of The Swedish Council on Technology Assessment in Health Care (SBU) were used to evaluate the level of evidence in the included articles and they were graded according to the GRADE system.

The search rendered 264 articles of which 17 were selected for abstract reading. Eight of these were read in full-text; one randomized clinical trial (RCT) of moderate quality, two cross-sectional studies and five longitudinal studies of low evidence.  Patients treated with anti-TNF-α compared to the untreated reference groups in the two cross-sectional studies demonstrated lower BOP and GI, while diverging results on attachment loss were shown. The longitudinal studies demonstrated diverging effects of anti-TNF-α treatment on all periodontal parameters. The RCT showed that anti-TNF-α as a complement to conventional periodontal treatment had positive effects on CAL, PPD, BOP and GI while anti-TNF-α treatment alone lacked significant effects on these parameters. There are limited publications within the field and the studies show heterogeneity in terms of study design. Anti-TNF-α treatment showed small significant positive effects on the periodontal parameters in some studies but diverging results were noted. Studies of sufficient scientific quality specifically addressing the effect of anti-TNF-α treatment on periodontitis are needed to elucidate the effects of anti-TNF-α treatment in periodontitis.

• 246.
Umeå University, Faculty of Social Sciences, Department of Psychology.
Motivation och engagemang hos innebandytränare: - Ur ett Self-determination Theory-perspektiv2016Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis

According to Self-determination Theory, people perform better when they experience inner motivation, rather than motivation sprung from external factors. This study aims to examine motivation in floorball coaches. Especially, reasons for starting to work as a coach are examined, as well as relationships between those reasons and the coaches experienced type of motivation. A web-survey was sent to 1059 floorball coaches in Sweden, wich were answered by 355 coaches. The results show 12 reasons why the coaches chose to commit themselves: Their own children, Sports interest, Contribute, Lack of coaches, Enjoyment, Their own development, A general interest, Leadership interest, Social connections, Asked to, Possessed expertise and A good cause. The results also showed that the coaches experienced inner motivation to the largest extent. Several relationships were shown between eight of the categories and the different types of motivation. Of those, the most distinct was the relationship between Contribute and self-determined motivation. This may be due to that the will to contribute can be related to the psychological need for relatedness. The study contributes to the knowledge of factors that may affect inner motivation in athletic coaches.

• 247.
Umeå University, Faculty of Social Sciences, Basic training programme for Police Officers.
Umeå University, Faculty of Social Sciences, Basic training programme for Police Officers.
Mobbing och kränkande behandling: Hur agerar skolan2003Independent thesis Basic level (professional degree), 5 credits / 7,5 HE creditsStudent thesis

Många svenska skolor har problem med våld, mobbing, skadegörelse och stölder. Enligt skolverkets attitydundersökning uppgav fyra procent av eleverna att de kände sig mobbare av andra elever medan sex procent kände sig mobbade av lärare. Mobbningen kan få svåra följder som t.ex. låg självkänsla. Skolans agerande mot mobbning och kränkande behandling regleras i ett antal styrdokument, främst Skollagen och Läroplanen, som anger de mål och riktlinjer skolan ska följa. Skolan har skyldighet att upprätta en handlingsplan som beskriver de åtgärder som skall vidtas för att förebygga och motverka mobbing och annan kränkande behandling. Ett problem som uppmärksammats är att många av skolans handlingsplaner uppvisar brister när det gäller de förebyggande åtgärderna samt uppföljningen av programmen. Alla som arbetar i skolan har skyldighet att aktivt motverka trakasserier och förtryck. Det är viktigt att kartlägga innebörden i begreppen mobbing och kränkande behandling för att veta vart gränsen går och vilka förebyggande åtgärder som är möjliga. I arbetet belyser vi frågeställningar så som; Vad är mobbing och kränkande behandling? Upplevs mobbing som ett problem i skolorna? Förekommer samverkan med andra myndigheter? Idet förebyggande arbetet är samverkan en förutsättning för att på ett effektivt sätt kunna motverka mobbing och kränkande behandling…

• 248.
How do SMEs engage in Green Public Procurement?: An exploratory study of SMEs' barriers and enablers for Green Public Procurement in Scotland.2015Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
• 249.
National University of Colombia. Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health. National University of Colombia.
Equidad en el desarrollo de guias de practica clinica: [The concept of equity when developing clinical practice guidelines]2011In: Revista de Salud Pública, ISSN 0124-0064, Vol. 13, no 2, p. 327-38Article in journal (Refereed)

This systematic literature review sought to identify methodologies and technical strategies emphasising healthcare services and outcomes when incorporating the concept of equity into Clinical Practice Guidelines (CPG). 940 references were identified, of which 20 fulfilling the inclusion criteria were selected. While no reports were found describing or evaluating an explicit methodology for incorporating considerations of equity into CPG, some studies revealed related strategies or processes, summarised as follows: 1. Target population involvement during all phases of designing, implementing and evaluating CPG; 2. "Cultural capacity" seen as being necessary in CPGs' "cultural translation" for interventions to have less disparity regarding their application and results; 3. Considering psycho-social factors which could affect implementing CPG, and; 4. Considering system inequities so that any health intervention would also confront risks and obstacles to health care due to socioeconomic status. It was concluded that CPGs could be a potential route for promoting more equitable healthcare effects by standardising health interventions if, by incorporating some of the processes described above, they actively seek to avoid unjust differences in access to and/or the quality of the interventions that they prescribe.

• 250.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Occupational Therapy.
Arbetsterapeutiska interventioner vid depression – en systematisk litteraturöversikt: Occupational therapy interventions for depression - a systematic literature review2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis

Depression kan drabba personer i alla åldrar och är en av de vanligaste psykiska sjukdomarna i Sverige och i världen. I Sverige drabbas ca 4-10% av befolkningen av depression och symtom kan återkomma flera gånger under en livstid, vilket beskrivs som depressiva episoder. Sjukdomstillståndet kan leda till nedsatt livskvalitet som orsakas av depressiva symtom som nedstämdhet, minskat intresse, aptitförändring, sömnsvårigheter, energilöshet, pessimistiska tankar, koncentrationssvårigheter och självmordstankar. Studiens syfte var att identifiera och beskriva effekten av arbetsterapeutiska interventioner vid diagnostiserad depression samt att belysa upplevelsen av dessa interventioner.  Nio vetenskapliga artiklar granskades och analyserades i en litteraturöversikt. Endast vuxna deltagare med egentlig depression som primär diagnos inkluderades i sökning i databaserna PsycINFO, Academic Search Elite, PubMed, - OT-Seeker och CINAHL. Resultatet presenterar aktivitetsbaserade interventioner för att hantera vardagen så som arbetsinriktade interventioner, skapande aktiviteter och programbaserade interventioner. Effekter av dessa arbetsterapeutiska interventioner beskrivs förbättra klientens livskvalitet, minska depressions symtom, öka känsla av delaktighet och tillfredställelse i vardagliga aktiviteter, samt främja klientens återgång till arbete utan att uppleva ökad stress. Författaren i den här studien anser att det kan vara av stor betydelse för yrkesverksamma arbetsterapeuter att använda sig av aktivitetsbaserade interventioner som känns meningsfulla och tillfredställande för klienten. Ytterligare forskning behövs dock, då det finns för få studier som undersöker effekten av arbetsterapeutiska interventioner för personer med depression och upplevelse av att leva med depression.

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