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  • 601.
    Ahlgren, Per
    et al.
    Department of e-Resources, University Library, Stockholm University.
    Colliander, Cristian
    Högskolan i Jönköping, Högskolebiblioteket.
    Document-document similarity approaches and science mapping: experimental comparison of five approaches2009In: Journal of Informetrics, ISSN 1751-1577, E-ISSN 1875-5879, Vol. 3, no 1, p. 49-63Article in journal (Refereed)
    Abstract [en]

    This paper treats document-document similarity approaches in the context of science mapping. Five approaches, involving nine methods, are compared experimentally. We compare text-based approaches, the citation-based bibliographic coupling approach, and approaches that combine text-based approaches and bibliographic coupling. Forty-three articles, published in the journal Information Retrieval, are used as test documents. We investigate how well the approaches agree with a ground truth subject classification of the test documents, when the complete linkage method is used, and under two types of similarities, first-order and second-order. The results show that it is possible to achieve a very good approximation of the classification by means of automatic grouping of articles. One text-only method and one combination method, under second-order similarities in both cases, give rise to cluster solutions that to a large extent agree with the classification.

  • 602.
    Ahlgren, Per
    et al.
    Department of e-Resources, University Library, Stockholm University.
    Colliander, Cristian
    Umeå University, Faculty of Social Sciences, Department of Sociology.
    Persson, Olle
    Umeå University, Faculty of Social Sciences, Department of Sociology.
    Field normalized citation rates, field normalized journal impact and Norwegian weights for allocation of university research funds2012In: Scientometrics, ISSN 0138-9130, E-ISSN 1588-2861, Vol. 92, no 2, p. 767-780Article in journal (Refereed)
    Abstract [en]

    We compared three different bibliometric evaluation approaches: two citationbased approaches and one based on manual classification of publishing channels into quality levels. Publication data for two universities was used, and we worked with two levels of analysis: article and department. For the article level, we investigated the predictive power of field normalized citation rates and field normalized journal impact with respect to journal level. The results for the article level show that evaluation of journals based on citation impact correlate rather well with manual classification of journals into quality levels. However, the prediction from field normalized citation rates to journal level was only marginally better than random guessing. At the department level, we studied three different indicators in the context of research fund allocation within universities and the extent to which the three indicators produce different distributions of research funds. It turned out that the three distributions of relative indicator values were very similar, which in turn yields that the corresponding distributions of hypothetical research funds would be very similar.

  • 603.
    Ahlgren, Per
    et al.
    School of Education and Communication in Engineering Sciences (ECE), KTH Royal Institute of Technology, Sweden.
    Colliander, Cristian
    Umeå University, Faculty of Social Sciences, Department of Sociology. Umeå University, Umeå University Library.
    Sjögårde, Peter
    School of Education and Communication in Engineering Sciences (ECE), KTH Royal Institute of Technology, Sweden; Department of ALM, Uppsala University, Uppsala, Sweden.
    Exploring the Relation Between Referencing Practices and Citation Impact: A Large-Scale Study Based on Web of Science Data2018In: Journal of the Association for Information Science and Technology, ISSN 2330-1635, E-ISSN 2330-1643, Vol. 69, no 5, p. 728-743Article in journal (Refereed)
    Abstract [en]

    In this large-scale contribution, we deal with the relationship between properties of cited references of Web of Science articles and the field normalized citation rate of these articles. Using nearly 1 million articles, and three classification systems with different levels of granularity, we study the effects of number of cited references, share of references covered by Web of Science, mean age of references and mean citation rate of references on field normalized citation rate. To expose the relationship between the predictor variables and the response variable, we use quantile regression. We found that a higher number of references, a higher share of references to publications within Web of Science and references to more recent publications correlate with citation impact. A correlation was observed even when normalization was done with a finely grained classification system. The predictor variables affected citation impact to a larger extent at higher quantile levels. Regarding the relative importance of the predictor variables, citation impact of the cited references was in general the least important variable. Number of cited references carried most of the importance for both low and medium quantile levels, but this importance was lessened at the highest considered level.

  • 604.
    Ahlgren, Per
    et al.
    School of Education and Communication in Engineering Sciences (ECE), KTH Royal Institute of Technology, 100 44 Stockholm, Sweden.
    Pagin, Peter
    Department of Philosophy, Stockholm University, 106 91 Stockholm, Sweden.
    Persson, Olle
    Umeå University, Faculty of Social Sciences, Department of Sociology.
    Svedberg, Maria
    Department of Philosophy, Stockholm University, 106 91 Stockholm, Sweden.
    Bibliometric analysis of two subdomains in philosophy: free will and sorites2015In: Scientometrics, ISSN 0138-9130, E-ISSN 1588-2861, Vol. 103, no 1, p. 47-73Article in journal (Refereed)
    Abstract [en]

    In this study we tested the fruitfulness of advanced bibliometric methods for mapping subdomains in philosophy. The development of the number of publications on free will and sorites, the two subdomains treated in the study, over time was studied. We applied the cocitation approach to map the most cited publications, authors and journals, and we mapped frequently occurring terms, using a term co-occurrence approach. Both subdomains show a strong increase of publications in Web of Science. When we decomposed the publications by faculty, we could see an increase of free will publications also in social sciences, medicine and natural sciences. The multidisciplinary character of free will research was reflected in the cocitation analysis and in the term co-occurrence analysis: we found clusters/groups of cocited publications, authors and journals, and of co-occurring terms, representing philosophy as well as non-philosophical fields, such as neuroscience and physics. The corresponding analyses of sorites publications displayed a structure consisting of research themes rather than fields. All in all, both philosophers involved in this study acknowledge the validity of the various networks presented. Bibliometric mapping appears to provide an interesting tool for describing the cognitive orientation of a research field, not only in the natural and life sciences but also in philosophy, which this study shows.

  • 605.
    Ahlgren, Per
    et al.
    Department of e-Resources, University Library, Stockholm University, SE-106 91 Stockholm, Sweden.
    Persson, Olle
    Umeå University, Faculty of Social Sciences, Department of Sociology.
    Globalization of citations and collaboration: a study of twelve journals2012In: Proceedings of 17th International Conference on Science and Technology Indicators / [ed] Éric Archambault, Yves Gingras and Vincent Larivière, 2012, p. 23-32Conference paper (Refereed)
    Abstract [en]

    We treated citations and collaboration from a spatial point of view with respect to twelve journals. Eleven of the journals are from the field of information science, the remaining one from the nanotechnology field. Publication data from Web of Science were used. The twelve journals were compared with respect to mean global impact (in terms of geographical citation distance), citation impact, share of foreign country citation links, degree of concentration of country citation links, and mean geographical collaboration distance. The information science journals oriented towards research evaluation tended to have lower global impact than the more general information science journals, whereas a reversed pattern was observed regarding share of foreign country citation links. For the relation between global impact and citation impact, there was a weak similarity between the global impact ordering and the citation impact ordering of the journals. Regarding the degree of concentration of country citation links, the links were found to be highly concentrated to certain countries, irrespective of if cited or citing countries were considered. For geographical collaboration distance, the nanotechnology journal in the study, Nature Nanotechnology, had the highest indicator value, which is in agreement with the outcome for global impact.

  • 606.
    Ahlgren, Per
    et al.
    Department of e-Resources, University Library, Stockholm University.
    Persson, Olle
    Umeå University, Faculty of Social Sciences, Department of Sociology.
    Tijssen, Robert
    Centre for Science and Technology Studies (CWTS), Leiden University, PO Box 905, 2300 AX Leiden, The Netherlands.
    Geographical distance in bibliometric relations within epistemic communities2013In: Scientometrics, ISSN 0138-9130, E-ISSN 1588-2861, Vol. 95, no 2, p. 771-784Article in journal (Refereed)
    Abstract [en]

    Scientists collaborate increasingly on a global scale. Does this trend also hold for other bibliometric relations such as direct citations, cocitations and shared references? This study examines citation-based relations in publications published in the journal Scientometrics from 1981 to 2010. Different measures of Mean Geographical Distance (MGD) are tested. If we take all citation links into consideration, there is no indication of MGD increase, but when we look at maximum distances of each relation, a weak tendency of increasing MGD could be observed. One major factor behind the lack of growth of mean distances is the form of the distribution of citation links over distances. Our data suggest that the interactions might grow simultaneously for both short and long distances.

  • 607.
    Ahlgren, Roger
    et al.
    Umeå University, Faculty of Social Sciences, Department of Food and Nutrition.
    Bergh, Kurt
    Umeå University, Faculty of Social Sciences, Department of Food and Nutrition.
    Hauer, Cecilia
    Umeå University, Faculty of Social Sciences, Department of Food and Nutrition.
    Jonsson, Mona
    Umeå University, Faculty of Social Sciences, Department of Food and Nutrition.
    Lindberg, Kerstin
    Umeå University, Faculty of Social Sciences, Department of Food and Nutrition.
    Nygren, Charlotte
    Umeå University, Faculty of Social Sciences, Department of Food and Nutrition.
    Reivell, Gun-Britt
    Umeå University, Faculty of Social Sciences, Department of Food and Nutrition.
    Rönnlund, Ulla
    Umeå University, Faculty of Social Sciences, Department of Food and Nutrition.
    Sandahl, Carla
    Umeå University, Faculty of Social Sciences, Department of Food and Nutrition.
    Dahlgren, Lars
    Umeå University, Faculty of Social Sciences, Department of Food and Nutrition.
    Kostvetenskaplig kompetens: belyst med kvalitativ metod1996Report (Other academic)
  • 608.
    Ahlgren, Roger
    et al.
    Umeå University, Faculty of Social Sciences, Department of Food and Nutrition.
    Malmros, Bengt
    Umeå University, Umeå University Library, Centre for teaching and learning (UPL).
    Sjödin, Anna
    Umeå University, Faculty of Social Sciences, Department of Food and Nutrition.
    Tieva, Åse
    Umeå University, Faculty of Social Sciences, Department of Food and Nutrition.
    Att bryta en trend och förändra en tradition2015In: Universitetspedagogiska konferensen 2015: Gränslös kunskap, Umeå: Umeå universitet , 2015, p. 6-7Conference paper (Other academic)
  • 609.
    Ahlgren, Stefan
    et al.
    Umeå University, Faculty of Social Sciences, Education.
    Nestander, Tomas
    Umeå University, Faculty of Social Sciences, Education.
    Redo! Alltid redo!: Lärare och lärarstudenters åsikter om bemötande av barn i kris2007Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Förr eller senare kommer vi som lärare att ställas inför det faktum att vi måste hantera krissituationer där en eller flera elever behöver omsorg. Vårt syfte med detta examensarbete har varit att försöka beskriva och jämföra erfarna lärares och lärarstudenters åsikter och erfarenheter om bemötande av barn i kris. Vi ville genom vår undersökning ta reda på vad lärare har för beredskap för att möta barn som drabbats av en kris och hur lärare bemöter dessa barn på bästa sätt. Vi har använt oss av kvalitativa intervjuer där vi intervjuat sex lärare med minst fem års yrkeserfarenhet och sex lärarstudenter i slutskedet av sin utbildning. Intervjuerna har tillsammans med den litteratur vi läst gett oss följande resultat: Skilsmässa är den krisorsak för barn som enligt resultatet är den vanligaste. Upplevelser av kriser kan variera mycket för barn beroende på vilken ålder de är i. Signalerna kan ibland vara svaga och svåra att tolka men ofta förändrar barnet sitt sätt att vara på ett märkbart sätt. Ingen kris är den andra lik, därför är det svårt att vara förberedd på att hantera en krissituation då de ser så olika ut från gång till gång. Den viktigaste känslan läraren kan förmedla är trygghet till den som är drabbad. Få av de intervjuade kände sig beredda att möta barn i kris, men lärarna tillade att de inte var rädda för det. Samtliga informanter ansåg att de fått för lite eller ingen kunskap om krishantering under sin utbildning. Alla var överens om att det skulle behövas.

  • 610.
    Ahlgren, Ulf
    Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
    Exploring the pancreas with optical projection tomography2012In: Imaging in Medicine, ISSN 1755-5191, Vol. 4, no 1, p. 5-7Article in journal (Refereed)
  • 611.
    Ahlgren, Ulf
    Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
    Imaging shows insulin-producing cells in diabetes2013In: TrAC. Trends in analytical chemistry, ISSN 0165-9936, E-ISSN 1879-3142, Vol. 44, p. III-IIIArticle in journal (Other (popular science, discussion, etc.))
  • 612.
    Ahlgren, Ulf
    et al.
    Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
    Gotthardt, Martin
    Department of Nuclear Medicine, Nijmegen, Netherlands.
    Approaches for imaging islets2010In: Advances in Experimental Medicine and Biology, ISSN 0065-2598, E-ISSN 2214-8019, Vol. 654, p. 39-57Article in journal (Refereed)
    Abstract [en]

    The establishment of improved technologies for imaging of the pancreas is a key element in addressing several aspects of diabetes pathogenesis. In this respect, the development of a protocol that allows for non-invasive scoring of human islets, or islet beta-cells, is of particular importance. The development of such a technology would have profound impact on both clinical and experimental medicine, ranging from early diagnosis of diabetes to the evaluation of therapeutic regimes. Another important task is the development of modalities for high-resolution imaging of experimental animal models for diabetes. Rodent models for diabetes research have for decades been instrumental to the diabetes research community. The ability to image, and to accurately quantify, key players of diabetogenic processes with molecular specificity will be of great importance for elucidating mechanistic aspects of the disease. This chapter aims to overview current progress within these research areas.

  • 613.
    Ahlgren, Ulf
    et al.
    Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
    Hörnblad, Andreas
    Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
    Optical imaging of islets: new possibilities by the development of infrared fluorescent proteins2009In: Islets, ISSN 1938-2022, Vol. 1, no 2, p. 163-164Article in journal (Refereed)
    Abstract [en]

    The capacity to record the spatial and quantitative distribution of cellular subtypes involved in diabetogenic processes is a key element in experimental diabetes research. A non-invasive technique to accurately monitor parameters such as pancreatic β-cell mass (BCM) and its distribution would provide a stepping stone in understanding different aspects of diabetes pathogenesis. It would also assist in the development of therapeutic regimes by providing a tool for the evaluation of anti-diabetic drugs or other curative or diagnostic measures. At present, a range of imaging modalities are being explored for this purpose. Whereas nuclear imaging techniques, characterised by their high tissue penetration depth but relatively low spatial resolution, appear most promising for the study of humans and large animals, optical imaging enables a route to cost-effective, high sensitivity, high resolution imaging in rodent models for disease. In this commentary, the potential impact of infrared fluorescent proteins (IFPs), as recently reported by Shu et al in Science, for imaging of the pancreas in small animals will be discussed.

  • 614.
    Ahlgren, Ulf
    et al.
    Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
    Kostromina, Elena
    Umeå University, Faculty of Medicine, Umeå Centre for Molecular Medicine (UCMM).
    Imaging the pancreatic beta cell: chapter 132011In: Type 1 diabetes: pathogenesis, genetics and immunotherapy / [ed] David Wagner, InTech, 2011Chapter in book (Refereed)
    Abstract [en]

    This book is a compilation of reviews about the pathogenesis of Type 1 Diabetes. T1D is a classic autoimmune disease. Genetic factors are clearly determinant but cannot explain the rapid, even overwhelming expanse of this disease. Understanding etiology and pathogenesis of this disease is essential. A number of experts in the field have covered a range of topics for consideration that are applicable to researcher and clinician alike. This book provides apt descriptions of cutting edge technologies and applications in the ever going search for treatments and cure for diabetes. Areas including T cell development, innate immune responses, imaging of pancreata, potential viral initiators, etc. are considered.

  • 615. Ahlin, Cecilia
    et al.
    Fernö, Mårten
    Amini, Rose-Marie
    Tolockiene, Egle
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
    Blomqvist, Carl
    Bergh, Jonas
    Fjällskog, Marie-Louise
    [Ki-67 and cyclin A: prognostic factors in breast cancer. Time to introduce proliferation markers in clinical routine].2010In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 107, no 10, p. 672-675Article in journal (Refereed)
  • 616.
    Ahlin, Ida
    Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Economics.
    En paneldatastudie av Beveridgekurvan: Fokus på ungdomsarbetslöshet2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 617.
    Ahlin, Ida
    Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Economics.
    Hur påverkas hälsan av konjunkturförändringar i Sverige?2017Independent thesis Advanced level (degree of Master (Two Years)), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna studie avser analysera hur hälsan i den svenska befolkningen varierar med konjunkturcykeln. Relationen mellan hälsa och konjunkturcykeln studeras genom att undersöka hur mortalitet och utnyttjandet av sjukvård påverkas av förändringar i arbetslöshet. Relationen mellan mortalitet och arbetslöshet är välstuderad utomlands och i Sverige men denna studie tar analysen ett steg vidare genom att även använda utnyttjandet av sluten respektive öppen vård som mått på hälsa. Den ekonometriska metoden som tillämpats är regression med fixa effekter som estimerats med paneldata som avser Sveriges 21 län. Överlag kan resultaten i denna studie inte visa på ett tydligt samband mellan arbetslöshet och de studerade hälsovariablerna. Med viss försiktighet i tolkningarna kan resultaten visa tecken på att en ökad arbetslöshet leder till lägre mortalitet och högre sjukvårdsutnyttjande momentant. Den dynamiska analysen i studien visar tecken på att arbetslöshet har en större effekt på mortalitet ett och två år senare, liknande resultat finns i relationen mellan arbetslöshet och utnyttjandet av öppen vård. Utnyttjandet av sluten vård ökar momentant men effekten av stigande arbetslöshet minskar efter ett och två år.

  • 618.
    Ahlin, Ida
    Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Economics.
    Kan ekonomiska styrmedel riktade mot livsmedel förbättra folkhälsan?2016Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna studie utvärderar ekonomiska styrmedels effekt på konsumtionen av livsmedel samt ifall skatter och subventioner kan vara en metod som styr matkonsumtionen mot hälsosamma livsmedelsval. Sex livsmedelsgrupper analyseras i studien och dessa är sötsaker och glass, kött, grönsaker, mejerivaror, bröd och spannmålsprodukter samt frukt och bär. Fyra scenarier som representerar olika skatte- och/eller subventionsreformer simuleras för att analysera vilken effekt ekonomiska styrmedel kan ha på matkonsumtion och hälsa. Responsen som de ekonomiska styrmedlen har på matkonsumtionen beräknas med elasticiteter som tagits fram från parameterestimat i AIDS-modellen. Den data som ligger till grund för den ekonometriska modellen är aggregerad konsumtionsdata, konsumentprisindex och livsmedelsförsäljning. Resultatet från studien visar att det går att styra konsumtionen av livsmedel men att substitution mellan varor kan leda till att de hälsomål som reformen är menad att nå inte uppfylls.

  • 619.
    Ahlin, Karin
    Umeå University, Faculty of Social Sciences, Department of Education.
    Dansundervisning och genus: Danslärare inom fritidsverksamhetens uppfattning, behandling och förväntningar på sina elever utifrån ett genusperspektivIndependent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Den nutida forskningen i Sverige visade att könsklyftorna i skolan mellan killar och tjejer

    fortfarande var stora. Baserat på dessa ojämlikheter mellan pojkar och flickor i skolan

    triggades mitt intresse för om, och i så fall hur, detta även är fallet under danslektioner. Syftet

    med studien var att undersöka utifrån danslärarens perspektiv, om och i så fall hur läraren

    behandlade eleverna olika baserat på kön, samt ifall lärarens förväntningar på sina elever

    skiljde sig mellan tjejer och killar. Studien utgick från frågeställningarna: hur dansläraren

    behandlar sina elever beroende på om de är tjej eller kille, samt om läraren förväntar sig olika

    saker från dem baserat på kön. Observationer genomfördes, vid fyra olika dansskolor. Dessa

    besök, uppföljdes med fyra forskningsintervjuer, med danslärarna från de observerade

    lektionerna. Studien begränsades till fyra dansskolor inom Västra Götalandsregionen.

    Skillnader i hur danslärare behandlade elever baserat på kön observerades, både genom

    initiativ från läraren, men även genom situationer som skapades av eleverna under

    danslektionen. Danslärarna uttryckte att de hade samma förväntningar på eleverna, oavsett

    kön, men erkände att samhällets struktur och kultur påverkade även vad som skedde under på

    lektionstid.

  • 620.
    Ahlin, Karin
    et al.
    Mid Sweden University.
    Saarikko, Ted
    Umeå University, Faculty of Social Sciences, Department of Informatics.
    Exploiting Information: Seeking Long-term Preservation of organisational knowledge2013Conference paper (Other academic)
    Abstract [en]

    Long-term preservation of organisational knowledge gives the business opportunities to reusestored knowledge. This preservation of knowledge is present both in the organisation as such,found explicitly in the organisational stock, and also in the individual workers, implicit intheir flow of action. Theoretically have the reuse of knowledge been named organisationalmemory and also been addressed in knowledge management. In a single case-study of amanufacturing company, the authors study the utilisation of product configuration information(PCI) and its role in meeting requirements on long-time preservation of product-relatedknowledge. This structured and standardised information is used throughout the organisation,serving as a base for both organisational and individual knowledge for the entire company.Since the information has been used in the same way for decades it is a part of theorganisation´s culture and influences structures and procedures connected to the informationbase. The result of the study implies that usage of PCI grants the individual worker a highdegree of task-related freedom as well as intra-organisational mobility. The downside for theindividuals is the long time period it takes to get familiar with PCI due to its complexity. Forthe organisation as such, PCI provides a stable stock of knowledge which is available overextended periods of time, drastically reducing dependence upon individual workers.

  • 621.
    Ahlin, Mikael
    et al.
    Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
    Ranby, Felix
    Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
    Predicting Marketing Churn Using Machine Learning Models2019Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    For any organisation that engages in marketing actions there is a need to understand how people react to communication messages that are sent. Since the introduction of General Data Protection Regulation, the requirements for personal data usage have increased and people are able to effect the way their personal information is used by companies. For instance people have the possibility to unsubscribe from communication that is sent, this is called Opt-Out and can be viewed as churning from communication channels. When a customer Opt-Out the organisation loses the opportunity to send personalised marketing to that individual which in turn result in lost revenue. 

    The aim with this thesis is to investigate the Opt-Out phenomena and build a model that is able to predict the risk of losing a customer from the communication channels. The risk of losing a customer is measured as the estimated probability that a specic individual will Opt-Out in the near future. To predict future Opt-Outs the project uses machine learning algorithms on aggregated communication and customer data. Of the algorithms that were tested the best and most stable performance was achieved by an Extreme Gradient Boosting algorithm that used simulated variables. The performance of the model is best described by an AUC score of 0.71 and a lift score of 2.21, with an adjusted threshold on data two months into the future from when the model was trained. With a model that uses simulated variables the computational cost goes up. However, the increase in performance is signicant and it can be concluded that the choice to include information about specic communications is considered relevant for the outcome of the predictions. A boosted method such as the Extreme Gradient Boosting algorithm generates stable results which lead to a longer time between model retraining sessions.

  • 622.
    Ahlin, Terese
    Umeå University, Faculty of Social Sciences, Department of Political Science.
    Den kommunala självstyrelsen: En kvalitativ idéanalys om riksdagspartiers syn på skolan och kommunens mottagande av nyanlända2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 623.
    Ahlinder, Annie
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Speech and Language Therapy.
    Labba, Julia
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Speech and Language Therapy.
    SIV-Speech clarity, Intelligibility & Voice: Development of a speech assessment tool for use by healthprofessionals who work with patients treated with DeepBrain Stimulation2013Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Background: Patients with Parkinson’s disease (PD) and Essential tremor (ET) who havebeen treated with Deep Brain Stimulation (DBS) generally experience a positive effect,particularly regarding the motor symptoms. However, the patients’ communication skillsare often negatively affected and the assessment instrument currently used withinneurological clinical care is not sufficiently sensitive to assess these patients’ speechclarity, voice and intelligibility satisfactorily.Aim: This study’s purpose was to develop a prototype assessment tool for speech clarity,intelligibility and voice, with speech and language pathology (SLP) validity, that isadaptable to a neurological clinical care setting.Method: The assessment tool was designed using general design methodology. Aprototype was constructed and tested on speech samples of read text for reliability. ThreeSLP’s, three DBS nurses and three naive listeners (NL) were represented in the test group.Levels of agreement were calculated using Percent Close Agreement, PCA.Results: The results indicate a relatively high level of agreement between the groups, inparticular the SLP group and the DBS group (μ: 0.82, 0.79, and 0.74).Conclusion: The results demonstrate the need for an assessment tool with SLPcompetence to assess speech clarity, intelligibility and voice within neurological clinicalcare. The assessment tool was shown to be a useful and adequate prototype that can easilyevolve into a truly useful and versatile perceptual speech assessment tool. The results ofthis study should be treated cautiously, considering the test groups’ modest size.

  • 624.
    Ahlinder, Isak
    Umeå University, Faculty of Social Sciences, Department of Sociology.
    The impact of labor market insecurity on mental health among immigrants in Europe2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The impact of labor market insecurity on immigrants’ mental health is understudied. This current study investigated whether labor market insecurity, as measured by different employment arrangements, has detrimental impact on immigrants’ depression, and if so, how it compares to the role of unemployment. Furthermore, this study investigated whether labor market insecurity had more detrimental impact on immigrants than non-immigrants. To do so, data from seventh wave of European Social Survey (2014/2015) was divided into three separate immigrant groups; first-generation immigrants, second-generation immigrants and non-immigrants. The results shows that labor market insecurity among immigrants had detrimental impact on mental health. The effects were not restricted to the first- generation immigrants’ mental health, they could also be observed in the second-generation immigrants and among non-immigrants. The results presented in this thesis show that not only unemployment, but also insecure employment arrangement have negative impact on mental health, both among immigrants and non-immigrants.

  • 625.
    Ahlinder, Jon
    et al.
    Division of CBRN Defence and Security, FOI, Swedish Defence Research Agency, Umeå, Sweden.
    Mathisen, Peter
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Sjödin, Andreas
    Umeå University, Faculty of Science and Technology, Department of Chemistry. Division of CBRN Defence and Security, FOI, Swedish Defence Research Agency, Umeå, Sweden.
    Nilsson, Elin
    Division of CBRN Defence and Security, FOI, Swedish Defence Research Agency, Umeå, Sweden.
    Forsman, Mats
    Division of CBRN Defence and Security, FOI, Swedish Defence Research Agency, Umeå, Sweden.
    Andersson, Agneta
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Thelaus, Johanna
    Division of CBRN Defence and Security, FOI, Swedish Defence Research Agency, Umeå, Sweden.
    Oligotyping reveals divergent responses of predation resistant bacteria to aquatic productivity and plankton compositionManuscript (preprint) (Other academic)
    Abstract [en]

    Predation-resistance has been suggested to be a key for persistence of pathogenic bacteria in aquatic environments. Little is known about driving factors for different types of protozoa resistant bacteria (PRB). We studied if presence of PRB is linked to specific plankton taxa, the aquatic nutrient state, or predation pressure on bacteria. Nineteen freshwater systems were sampled and analyzed for PRB, plankton composition and physicochemical variables. Three PRB genera were identified; Pseudomonas, Mycobacterium and Rickettsia. Use of minimum entropy decomposition algorithm and phylogenetic analysis showed that different nodes (representing OTUs of high taxonomic resolution) matched to environmental isolates of the three genera. Links between the PRB genera and specific plankton taxa were found, but showed different relationships depending on if 18S rRNA OTU or microscopy data were used in the analysis. Mycobacterium spp. was negatively correlated to aquatic nutrient state, while Pseudomonas showed the opposite pattern. Rickettsia spp. was positively related to predation pressure on bacteria. Both Mycobacterium and Rickettsia were more abundant in systems with high eukaryotic diversity, while Pseudomonas occurred abundantly in waters with low prokaryotic diversity. The different drivers may be explained by varying ecological strategies, where Mycobacterium and Rickettsia are slow growing and have an intracellular life style, while Pseudomonas is fast growing and opportunistic. Here we give an insight to the possibilities of newly advanced methods such as sequencing and oligotyping to link potential pathogens with biomarkers. This as a tool to assist predictions of the occurrence and persistence of environmental pathogens.

  • 626. Ahlinder, Jon
    et al.
    Ohrman, Caroline
    Svensson, Kerstin
    Lindgren, Petter
    Johansson, Anders
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Forsman, Mats
    Larsson, Pär
    Sjödin, Andreas
    Increased knowledge of Francisella genus diversity highlights the benefits of optimised DNA-based assays2012In: BMC Microbiology, ISSN 1471-2180, E-ISSN 1471-2180, Vol. 12, p. 220-Article in journal (Refereed)
    Abstract [en]

    Background: Recent advances in sequencing technologies offer promising tools for generating large numbers of genomes, larger typing databases and improved mapping of environmental bacterial diversity. However, DNA-based methods for the detection of Francisella were developed with limited knowledge about genetic diversity. This, together with the high sequence identity between several Francisella species, means there is a high risk of false identification and detection of the highly virulent pathogen Francisella tularensis. Moreover, phylogenetic reconstructions using single or limited numbers of marker sequences often result in incorrect tree topologies and inferred evolutionary distances. The recent growth in publicly accessible whole-genome sequences now allows evaluation of published genetic markers to determine optimal combinations of markers that minimise both time and laboratory costs. Results: In the present study, we evaluated 38 previously published DNA markers and the corresponding PCR primers against 42 genomes representing the currently known diversity of the genus Francisella. The results highlight that PCR assays for Francisella tularensis are often complicated by low specificity, resulting in a high probability of false positives. A method to select a set of one to seven markers for obtaining optimal phylogenetic resolution or diagnostic accuracy is presented. Conclusions: Current multiple-locus sequence-typing systems and detection assays of Francisella, could be improved by redesigning some of the primers and reselecting typing markers. The use of only a few optimally selected sequence-typing markers allows construction of phylogenetic topologies with almost the same accuracy as topologies based on whole-genome sequences.

  • 627.
    Ahlkvist, Emilia
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies.
    Samkönade äktenskaps vara eller icke vara inom Svenska kyrkan.: En argumentationsanalys av debattartiklar från Kyrkans tidning och Dagens Nyheter.2014Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    I Samkönade äktenskaps vara eller icke vara inom Svenska kyrkan utförs en argumentationsanalys, baserad på hermeneutiks metod och kvalitativ textanalys, av debattartiklar som behandlat frågan som Svenska kyrkan ska behålla vigselrätten efter att svenska staten har gjort äktenskapsbalken könsneutral. Alla undersökta debattartiklar är publicerade mellan 2008-12-11 och 2009-10-31 i Kyrkans tidning och Dagens Nyheter. I resultatanalysen framgår det att både ja- och nej-sidan använder sig av ungefär samma typer av argument men med olika vinklingar och tolkningar. Nej-sidan använder sig dock mer av ett toleransperspektiv än ja-sidan. I ja-sidans argumenterande kan man hitta en underliggande normkritik av heteronormativiteten.

  • 628.
    Ahlkvist, Emilia
    et al.
    Umeå University, Faculty of Science and Technology, Department of Science and Mathematics Education.
    Jones, Elina
    Umeå University, Faculty of Science and Technology, Department of Science and Mathematics Education.
    Bedömningspraxis och utmaningar: En kvalitativ intervjustudie om gymnasielärares bedömningspraxis2015Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Utifrån ett yrkesetiskt och läroplansteoretiskt perspektiv syftar undersökningen till att genom intervjuer undersöka betygspraxis och möjliga utmaningar relaterade till betyg och bedömning. Detta i syfte att belysa vilka utmaningar lärare kan konfronteras med i bedömnings- och betygssituationer i ämnen och kurser som inte har nationella prov, och vilka handlingsmöjligheter lärarna har i sådana situationer utifrån satta ramar i styrdokument.  Vi har använt semistrukturerade kvalitativa intervjuer som datainsamlingsmetod med ett hermeneutiskt synsätt på tolkning. Resultatet visar att det som anses svårt i betygssättningssituationer skiljer sig från lärare till lärare men gemensamt för alla är att de önskar mer tid med kollegor för sambedömning och diskussion. Om denna önskan uppfylls bör även likvärdigheten förbättras. Påtryckningar från andra än läraren angående betygssättning är vanligast från elever men det ses inte som något negativt av lärarna. Påtryckningar från rektor angående krav på ökad måluppfyllelse har tolkats olika av tre lärare, varav två anser att lärare måste stå tillsammans för att försöka motstå dessa påtryckningar. Vanligt är att lärare ställs inför situationer där de måste ställa yrkesinterna normer mot allmänetiska normer och detta blir ibland en faktor som påverkar lärarnas betygssättningsprocess. Generellt kan vi se att våra informanter inte tycker det är ett problem att den så kallade “räddningsplankan” de nationella proven inte finns med.

  • 629.
    Ahlkvist, Johan
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Formic and Levulinic Acid from Cellulose via Heterogeneous Catalysis2014Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The chemical industry of today is under increased pressure to develop novel green materials, bio-fuels as well as sustainable chemicals for the chemical industry. Indeed, the endeavour is to move towards more eco-friendly cost efficient production processes and technologies and chemical transformation of renewables has a central role considering the future sustainable supply of chemicals and energy needed for societies. In the Nordic countries, the importance of pulping and paper industry has been particularly pronounced and the declining European demand on these products as a result of our digitalizing world has forced the industry to look at alternative sources of revenue and profitability. In this thesis, the production of levulinic and formic acid from biomass and macromolecules has been studied. Further, the optimum reaction conditions as well as the influence of the catalyst and biomass type were also discussed.

    Nordic sulphite and sulphate (Kraft) cellulose originating from two Nordic pulp mills were used as raw materials in the catalytic synthesis of green platform chemicals, levulinic and formic acids, respectively. The catalyst of choice used in this study was a macro-porous, cationic ion-exchange resin, Amberlyst 70, for which the optimal reaction conditions leading to best yields were determined. Cellulose from Nordic pulp mills were used as raw materials in the catalytic one-pot synthesis of ‘green’ levulinic and formic acid. The kinetic experiments were performed in a temperature range of 150–200 °C and an initial substrate concentration regime ranging from 0.7 to 6.0 wt %. It was concluded that the most important parameters in the one-pot hydrolysis of biomass were the reaction temperature, initial reactant concentration, acid type as well as the raw material applied. The reaction route includes dehydration of glucose to hydroxymethylfurfural as well as its further rehydration to formic and levulinic acids. The theoretical maximum yield can hardly be obtained due to formation of humins. For this system, maximum yields of 59 mol % and 68 mol % were obtained for formic and levulinic acid, respectively. The maximum yields were separately obtained in a straight-forward conversion system only containing cellulose, water and the heterogeneous catalyst. These yields were achieved at a reaction temperature of 180 °C and an initial cellulose intake of 0.7 wt % and belong to the upper range for solid catalysts so far presented in the literature.

    The reaction network of the various chemical species involved was investigated and a simple mechanistic approach involving first order reaction kinetics was developed. The concept introduces a one-pot procedure providing a feasible route to green platform chemicals obtained via conversion of coniferous soft wood pulp to levulinic and formic acids, respectively. The model was able to describe the behaviour of the system in a satisfactory manner (degree of explanation 97.8 %). Since the solid catalyst proved to exhibit good mechanical strength under the experimental conditions applied here and a one-pot procedure providing a route to green platform chemicals was developed. A simplified reaction network of the various chemical species involved was investigated and a mechanistic approach involving first order reaction kinetics was developed.

  • 630.
    Ahlkvist, Johan
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Ajaikumar, Samikannu
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Larsson, William
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Mikkola, Jyri-Pekka
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    One-pot catalytic conversion of Nordic pulp media into green platform chemicals2013In: Applied Catalysis A: General, ISSN 0926-860X, E-ISSN 1873-3875, Vol. 454, p. 21-29Article in journal (Refereed)
    Abstract [en]

    In this paper, both sulphite and sulphate (Kraft) cellulose from Nordic pulp mills were used as raw materials in the catalytic one-pot synthesis of green platform chemicals, levulinic and formic acids, respectively. The catalyst of choice was a macro-porous, cationic ion-exchange resin, Amberlyst 70. The optimal reaction conditions were determined and the influence of various gas atmospheres was investigated. The maximum yields of 53% formic acid and 57% of levulinic acid were separately obtained in a straight-forward conversion system only containing cellulose, water and the heterogeneous catalyst. The concept introduces a one-pot procedure providing a feasible route to green platform chemicals obtained via conversion of coniferous soft wood pulp to levulinic and formic acids, respectively.

  • 631.
    Ahlkvist, Johan
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Mäki-Arvela, Päivi
    Åbo Akademi.
    Mikkola, Jyri-Pekka
    Umeå University, Faculty of Science and Technology, Department of Chemistry. Åbo Akademi University, Process Chemistry Centre, Åbo Akademi University, Industrial Chemistry & Reaction Engineering., Finland.
    Macro-molecules as a source of levulinic acid2014In: International Review of Chemical Engineering, ISSN 2035-1755, Vol. 16, no 1, p. 44-58Article in journal (Refereed)
    Abstract [en]

    The production of levulinic acid from biomass and macromolecules has been reviewed. It was concluded that the most important parameters in the one-pot hydrolysis of biomass, also including dehydration of glucose to hydroxymethylfurfural as well as its further rehydration to formic and levulinic acids, respectively, are the reaction temperature, initial reactant concentration, acid type as well as the raw material applied. The theoretical maximum yield can hardly be obtained due to formation of humins. Further, the optimum reaction conditions as well as the influence of the catalyst and biomass type are also discussed.

  • 632.
    Ahlkvist, Johan
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Samikannu, Ajaikumar
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Larsson, William
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Wärnå, Johan
    Umeå University, Faculty of Science and Technology, Department of Chemistry. Laboratory of Industrial Chemistry and Reaction Engineering, Process Chemistry Centre, Åbo Akademi University, Åbo, Finland.
    Salmi, Tapio
    Laboratory of Industrial Chemistry and Reaction Engineering, Process Chemistry Centre, Åbo Akademi University, Åbo, Finland.
    Mikkola, Jyri-Pekka
    Umeå University, Faculty of Science and Technology, Department of Chemistry. Laboratory of Industrial Chemistry and Reaction Engineering, Process Chemistry Centre, Åbo Akademi University, Åbo, Finland.
    Reaction Network upon One-pot Catalytic Conversion of Pulp2013In: / [ed] Sauro Pierucci, Jiří J. Klemeš, AIDIC - associazione italiana di ingegneria chimica, 2013, Vol. 32, p. 649-654Conference paper (Refereed)
    Abstract [en]

    Nordic sulphite and sulphate (Kraft) cellulose originating from Nordic pulp mills were used as raw materials in the catalytic synthesis of green platform chemicals, levulinic and formic acids, respectively. The catalyst of choice used in this study was a macro-porous, cationic ion-exchange resin Amberlyst 70 for which the optimal reaction conditions leading to best yields were determined. For this system, maximum yields of 53 mol-% and 57 mol-% were obtained for formic and levulinic acid, respectively. The reaction network of the various chemical species involved was investigated and a simple mechanistic approach involving first order reaction kinetics was developed. The prototype model was able to describe the behaviour of the system in a satisfactory manner.

  • 633.
    Ahlkvist, Johan
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Samikannu, Ajaikumar
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Mikkola, Jyri-Pekka
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Catalytic conversion of lignocellulosic materials2010Conference paper (Other academic)
  • 634.
    Ahlkvist, Johan
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Wärnå, Johan
    Åbo Akademi.
    Salmi, Tapio
    Åbo Akademi.
    Mikkola, Jyri-Pekka
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Experimental and Kinetic Modelling Studies upon Conversion of Nordic Pulp into Levulinic AcidManuscript (preprint) (Other academic)
    Abstract [en]

    In this paper, sulphite cellulose from a Swedish pulp mill was applied as the raw material upon catalytic, one-pot synthesis of green platform chemicals – levulinic and formic acids. Cationic ion-exchange resin, Amberlyst 70, was the catalyst of choice and the optimal reaction conditions leading to best yields were determined. The kinetic experiments were performed in a temperature range of 180–200 °C and an initial substrate concentration regime ranging from 0.7 to 6.0 wt %. For this system, maximum theoretical yields of around 59 mol % and 68 mol % were obtained for formic and levulinic acid, respectively. These yields were achieved at a reaction temperature of 180 °C and an initial cellulose intake of 0.7 wt %. A simplified reaction network of the various chemical species involved was investigated and a mechanistic approach involving first order reaction kinetics was developed. The model was able to describe the behaviour of the system in a satisfactory manner (degree of explanation 97.8 %). Since the solid catalyst proved to exhibit good mechanical strength under the experimental conditions applied here, the concept introduces a one-pot procedure providing a route to green platform chemicals from coniferous soft wood pulp to produce levulinic and formic acids, respectively.

  • 635.
    Ahlkvist, Johan
    et al.
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Wärnå, Johan
    Umeå University, Faculty of Science and Technology, Department of Chemistry. Laboratory of Industrial Chemistry and Reaction Engineering, Process Chemistry Centre, Åbo Akademi University,Turku, Finland.
    Salmi, Tapio
    Mikkola, Jyri-Pekka
    Umeå University, Faculty of Science and Technology, Department of Chemistry. Laboratory of Industrial Chemistry and Reaction Engineering, Process Chemistry Centre, Åbo Akademi University,Turku, Finland.
    Heterogeneously catalyzed conversion of nordic pulp to levulinic and formic acids2016In: Reaction Kinetics, Mechanisms and Catalysis, ISSN 1878-5190, E-ISSN 1878-5204, Vol. 119, no 2, p. 415-427Article in journal (Refereed)
    Abstract [en]

    Herein, one-pot conversion of cellulose to platform chemicals, formic and levulinic acids was demonstrated. The catalyst selected was an affordable, acidic ion-exchange resin, Amberlyst 70, whereas the cellulose used was sulfite cellulose delivered by a Swedish pulp mill. Furthermore, in an attempt to better understand the complex hydrolysis network of the polysaccharide, kinetic experiments were carried out to pinpoint the optimal reaction conditions with an initial substrate concentration of 0.7–6.0 wt% and a temperature range of 180–200 °C. Higher temperatures could not be used due to the limitations in the thermal stability of the catalyst. Overall, maximum theoretical yields of 59 and 68 mol% were obtained for formic and levulinic acid, respectively. The parameters allowing for the best performance were reaction temperature of 180 °C and initial cellulose concentration of 0.7 wt%. After studying the behavior of the system, a simplified reaction network in line with a mechanistic approach was developed and found to follow first order reaction kinetics. A satisfactory fit of the model to the experimental data was achieved (97.8 % degree of explanation). The catalyst chosen exhibited good mechanical strength under the experimental conditions and thus, a route providing green platform chemicals from soft wood pulp from coniferous trees (mixture of Scots Pine and Norway Spruce) was demonstrated.

  • 636.
    Ahlkvist, Pontus
    et al.
    Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Business Administration.
    Lagerlöf, Marcus
    Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Business Administration.
    Auditor-client Communication: A qualitative study on the effects of auditor tenure, feedback, and dissemination of communication2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Communication between auditors and their clients is a big part of the audit engagement. It is therefore contradictory that communication within audit engagements is an underresearched area. More research is needed to understand how it functions and what affects it. By exploring this area, both auditors and their clients will understand each other better which can improve their relationship. The little research which does exist in the area has focused on audit quality, with communication as one element of audit quality. This thesis expands on this by investigating communication between auditors and audited companies, more specifically we look at the effects of three factors: auditor tenure, feedback from the auditor, and dissemination of communication. These factors have been identified by using a deductive approach. This lead to the formulation of the following research question: How do the factors feedback, dissemination of communication, and auditor tenure affect the communication between external auditors and an audited company’s team? There are rules and guidelines available for the auditor on how to communicate with those in charge of governance of the audited company, such as managers. There are however no rules or guidelines regarding how to communicate with the personnel at lower levels. This lead to the purpose of the thesis being expanded to also investigate the differences in opinions between employees and managers. To answer the research question, a qualitative study has been conducted with the help of semi-structured interviews with staff members of audited companies in various industries located in Umeå, Sweden. An exploratory approach has therefore been utilized. The interviews were transcribed and analyzed using discourse analysis where patterns in the language were identified.The findings from the interviews indicate that auditor tenure and feedback from the auditor have significant effects on the communication between auditors and their clients. The particular effects of these factors were identified as well as differences between managers and employees. Dissemination of communication does not seem to have a very large impact on the communication in an auditing engagement, although the internal dissemination was found to be an issue.

  • 637.
    Ahlm, Clas
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Distribution of puumala virus in Sweden1997Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Puumala virus, belonging to the genus hantavirus, is the causative agent of nephropathia epidemica (NE), a relatively mild form of hemorrhagic fever with renal syndrome. Puumala virus occurs endemically in Central and Northern Europe and Western Russia. In Sweden, NE is reported from the northern and central parts but virtually not at all from the southern part of the country. The bank vole (Clethrionomys glareolus) is the main reservoir of Puumala virus and humans are infected by inhalation of aerosolized animal secreta. In northern Sweden, the density of the bank vole population varies cyclically in intervals of 3-4 years and the incidence of NE shows a covariation.

    The prevalence of serum antibodies to hantaviruses in northern Sweden was studied in a stratified and randomly selected adult population sample comprising 1538 subjects. As expected, the prevalence increased with age. There was no difference between men and women, which was unexpected based on a male:female ratio of > 2:1 in clinical reports. By use of an immunofiuorescent assay, a seroprevalence of 5.4% and by a newly developed enzyme-linked immunosorbent assay (ELISA) with recombinant Puumala virus nucleocapsid protein as antigen, a prevalence of 8.9% was recorded. This is about or more than ten times higher than what would be calculated from clinical reports.

    By use of the ELISA, an occupational risk of acquisition of Puumala virus infection was demonstrated. Serum samples from 910 farmers and 663 referent subjects living in various rural parts of Sweden were tested. Among farmers from the Puumala virus-endemic northern and central parts of the country, the seroprevalence (12.9%) was higher (p=0.01) than in referents (6.8%). In the southern part of Sweden, only 2/459 persons had antibodies. Only a limited number of children with NE had been previously reported. In a separate study, 32 children with Puumala virus infection were identified and the clinical picture of NE in children was found to be similar to that of adult cases.

    Variations in the prevalence of Puumala virus in the bank vole population within an endemic region are not well known. Here, a higher mean rodent density and a higher prevalence of Puumala virus-specific serum antibodies were recorded in the vicinity of households afflicted with NE than in rural control areas. The data indicated that the risk of exposure locally within an endemic region may vary widely and tentatively suggested that a threshold density of bank voles might be necessary to achieve before effective spread of Puumala virus within the rodent population may occur.

    There is no firm evidence of the occurrence of Puumala virus among wild living animals other than rodents. A study of Swedish moose, an animal which is ecologically well characterized, was performed. Convincing evidence of past Puumala virus infection was found in 5/260 moose originating from Puumala virus-endemic areas but in none of 167 animals from nonendemic areas. Based on the low seroprevalence recorded, moose seemed to serve as endstage hosts rather than being active parts of the enzootic circle of transmission.

    In conclusion, the present investigations confirmed that the exposure to Puumala virus is geographically well restricted in Sweden. Seroprevalence studies indicated that only a minor proportion of individuals infected with Puumala virus are clinically reported, with a bias in favour of men. NE was confirmed to occur in children, with a clinical picture similar to that of adults. An occupational risk was defined for acquisition of Puumala virus infection. Studies in rodents suggested that there may be wide local variations within a limited area in the risk of exposure to Puumala virus. The studies validated the usefulness of a newly developed ELISA based on recombinant nucleocapsid peptides of hantaviruses and finally, methodological progress was reached when Puumala virus was, for the first time, successfully isolated from a Scandinavian patient.

  • 638.
    Ahlm, Clas
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Norrländska infektionssjukdomar2011In: Infektionssjukdomar: Epidemiologi, klinik, terapi / [ed] Ivarsson-Norrby, Sundbyberg: Säve förlag , 2011, 5Chapter in book (Other academic)
  • 639.
    Ahlm, Clas
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Alexeyev, O A
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
    Elgh, Fredrik
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
    Aava, Birgitta
    Wadell, Göran
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
    Tärnvik, Arne
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Juto, Per
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
    Palo, T
    High prevalence of hantavirus antibodies in bank voles (Clethrionomys glareolus) captured in the vicinity of households afflicted with nephropathia epidemica.1997In: American Journal of Tropical Medicine and Hygiene, ISSN 0002-9637, E-ISSN 1476-1645, Vol. 56, no 6, p. 674-8Article in journal (Refereed)
    Abstract [en]

    Puumala virus, the causative agent of nephropathia epidemica (NE), occurs endemically in Europe and is spread mainly by the bank vole (Clethrionomys glareolus). In the vicinity of each of four households afflicted with NE, we studied rodents with regard to population density and prevalence of Puumala virus-specific antibodies. For each case area, a control area was randomly selected 10 km away, without regard to the presence of human settlement. During 6,000 trap nights, 328 rodents were caught, of which 299 were C. glareolus. The mean rodent densities of case and control areas were 6.6 and 3.7 animals per 100 trap nights (P < 0.001). The prevalence of serum antibodies was 15.9% in case areas compared with 5.6% in control areas (P < 0.05). In three of the case areas, where NE had occurred 3-10 weeks before trapping, the rodent density and seroprevalence were much higher than in the fourth area, where NE occurred 38 weeks before trapping. In conclusion, C. glareolus seropositive for Puumala virus occurred more frequently near households afflicted with NE than in control areas 10 km away.

  • 640.
    Ahlm, Clas
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Axelsson, I
    Jansson, B
    [Maternal health care must improve its tracing of hepatitis B virus carriers].1990In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 87, no 37, p. 2865-6Article in journal (Refereed)
  • 641.
    Ahlm, Clas
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Eliasson, Mats
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Vapalahti, O.
    University of Helsinki and Helsinki University Central Hospital Laboratory, Finland.
    Evander, Magnus
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
    Seroprevalence of Sindbis virus and associated risk factors in northern Sweden2014In: Epidemiology and Infection, ISSN 0950-2688, E-ISSN 1469-4409, Vol. 142, no 7, p. 1559-1565Article in journal (Refereed)
    Abstract [en]

    Mosquito-borne Sindbis virus (SINV) cause disease characterized by rash, fever and arthritis which often leads to long-lasting arthralgia. To determine the seroprevalence of SINV and associated risk factors in northern Sweden, a randomly selected population aged between 25 and 74 years were invited to join the MONICA study. Serum from 1611 samples were analysed for specific IgG antibodies. Overall, 2·9% had IgG against SINV. More men (3·7%) than women (2·0%) were SINV seropositive (P = 0·047) and it was more common in subjects with a lower educational level (P = 0·013) and living in small, rural communities (P < 0·001). Seropositivity was associated with higher waist circumference (P = 0·1), elevated diastolic blood pressure (P = 0·037), and history of a previous stroke (P = 0·011). In a multiple logistic regression analysis, adjusting for known risk factors for stroke, seropositivity for SINV was an independent predictor of having had a stroke (odds ratio 4·3, 95% confidence interval 1·4–13·0,P = 0·011).

  • 642.
    Ahlm, Clas
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Herlitz, H
    Säll, C
    Eriksson, C
    Settergren, B
    [Is vole fever (nephropathia epidemica) spreading in the south of Sweden?].1992In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 89, no 40, p. 3275-Article in journal (Refereed)
  • 643.
    Ahlm, Clas
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Juto, Per
    Settergren, Bo
    [Nephropathia epidemica--a current disease in Norrland].1990In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 87, no 43, p. 3521-2, 3527Article in journal (Refereed)
  • 644.
    Ahlm, Clas
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Juto, Per
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
    Stegmayr, Birgitta
    Settergren, Bo
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Wadell, Göran
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
    Tärnvik, Arne
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Elgh, Fredrik
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
    Prevalence of serum antibodies to hantaviruses in northern Sweden as measured by recombinant nucleocapsid proteins.1997In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, E-ISSN 1651-1980, Vol. 29, no 4, p. 349-54Article in journal (Refereed)
    Abstract [en]

    An enzyme-linked immunosorbent assay (ELISA) based on recombinant nucleocapsid protein (rN delta) (aa 1-117) of Hantaan, Seoul, Dobrava, Sin Nombre and Puumala hantaviruses was used to determine the prevalence of antibodies among randomized and stratified individuals from northern Sweden. In total, 137/1533 individuals (8.9%) had specific serum IgG antibodies to Puumala virus, the only hantavirus known to occur in the region. The prevalence of antibodies to Puumala virus (8.9%) was determined to be higher than previously reported (5.4%) in the same serum material, by use of immunofluorescence assay. As expected, sera reactive to Puumala virus rN delta did frequently cross-react with Sin Nombre virus protein. Unexpectedly, 21/1533 (1.4%) individuals recognized the Sin Nombre virus rN delta exclusively. Another 8 subjects showed reactivity in the ELISA to Hantaan, Seoul, or Dobrava virus-derived rN delta but not Puumala virus or Sin Nombre virus rN delta. The present demonstration in some individuals of antibodies specifically recognizing the Sin Nombre, Dobrava, Hantaan and Seoul virus protein justifies an awareness of the possibility that hantaviruses antigenically different from Puumala virus might occur in the region.

  • 645.
    Ahlm, Clas
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Linderholm, Mats
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Juto, Per
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
    Stegmayr, Birgitta
    Settergren, Bo
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Prevalence of serum IgG antibodies to Puumala virus (haemorrhagic fever with renal syndrome) in northern Sweden.1994In: Epidemiology and Infection, ISSN 0950-2688, E-ISSN 1469-4409, Vol. 113, no 1, p. 129-36Article in journal (Refereed)
    Abstract [en]

    A stratified and randomly-selected population sample was identified in 1990 in order to study the seroprevalence of nephropathia epidemica (haemorrhagic fever with renal syndrome) in Northern Sweden. Sera from 1538 subjects (750 men, 788 women), 25-64 years of age, were analysed for the presence of Puumala virus (PUV) specific-IgG by the indirect immunofluorescence antibody test. Specific IgG was detected in sera from 83 subjects (5.4%). Men and women had similar seroprevalence rates. The highest seroprevalences were found in subjects 55 years or older (8.0%) and among farmers and forestry workers (15.9%). The geographic distribution of seropositive individuals was uneven and there were significantly more seropositive persons in rural than in urban areas (P < 0.05).

  • 646.
    Ahlm, Clas
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Lindén, Christina
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Ophthalmology.
    Linderholm, M
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Alexeyev, O A
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
    Billheden, J
    Elgh, Fredrik
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
    Fagerlund, M
    Zetterlund, B
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neurophysiology.
    Settergren, B
    Central nervous system and ophthalmic involvement in nephropathia epidemica (European type of haemorrhagic fever with renal syndrome)1998In: Journal of Infection, ISSN 0163-4453, E-ISSN 1532-2742, Vol. 36, no 2, p. 149-155Article in journal (Refereed)
    Abstract [en]

    Central nervous system (CNS) - related symptoms occur in haemorrhagic fever with renal syndrome (HFRS). To study the CNS and ophthalmic involvement in nephropathia epidemica (NE), the European type of HFRS, we included 26 patients in a prospective study. Most common CNS-related symptoms were headache (96%), insomnia (83%), vertigo (79%), nausea (79%), and vomiting (71%). Ophthalmic symptoms were reported by 82% of patients; 41% had photophobia and 50% had impaired vision. A transient loss of vision was recorded in one patient, who also had a generalized seizure. Minor white matter lesions were found in about half of the patients investigated with brain magnetic resonance imaging (MRI). Electroencephalography (EEG) showed severe alterations in only one patient, and slight and reversible patterns in another two patients. Neopterin, interleukin-6 and interferon-gamma levels in the cerebrospinal fluid (CSF) were elevated, which may indicate immune activation. However, we found no evidence of intrathecal NE virus replication. We conclude that CNS-related symptoms are common in NE, and transient ophthalmic involvement can be demonstrated in about half of the patients.

  • 647.
    Ahlm, Clas
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Lundberg, Sonia
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Fessé, Kerstin
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Wiström, Johan
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Health problems and self-medication among Swedish travellers.1994In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, E-ISSN 1651-1980, Vol. 26, no 6, p. 711-7Article in journal (Refereed)
    Abstract [en]

    500 consecutive travellers seeking pre-travel health advice were issued a questionnaire before leaving Sweden to continuously record health problems and use of medication during travel. Of 442 subjects who turned in assessable questionnaires (232 male and 210 female, mean age 37 years), 81% travelled to areas at high risk for the acquisition of diarrhea. The mean duration of travel was 4 weeks. During travel 218 (49% at 95% CI 44.3 to 53.7%) of the travellers experienced some illness and 61 (14%) had symptoms of more than one illness. The mean duration of illness was 4.5 days, and 65 subjects (30% of ill travellers) were confined to bed for a mean duration of 2 days. The incidence of illness was significantly (p < 0.01) higher among travellers to high risk than to low risk areas (55% vs 26%), among young travellers than among elderly (65% vs 33%), and among those going on adventure tours compared with recreational tourists (74% vs 41%). Diarrhea was reported by 36% (95% CI 31.6 to 40.5%), and respiratory tract infection by 21% (95% CI 17.2 to 24.8%). Self-medication with one or several drugs was initiated by 163 (75%) travellers experiencing illness during travel. Thus, every second Swedish traveller to tropical and subtropical areas experienced some kind of travel-related, often incapacitating, health problem.

  • 648.
    Ahlm, Clas
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Olsen, Björn
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Koskinen, Lars Ove
    Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Neurosurgery.
    Monsen, Tor
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Clinical Bacteriology.
    Brain abscess caused by methicillin-resistant Staphylococcus aureus2000In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, E-ISSN 1651-1980, Vol. 32, no 5, p. 562-563Article in journal (Refereed)
    Abstract [en]

    A Swedish tourist was admitted to a Cuban hospital due to epileptic seizures caused by brain tumors. Upon return to Sweden and admission to our hospital, methicillin-resistant Staphylococcus aureus (MRSA) was isolated. He was later considered to be free of MRSA but then developed a brain abscess from which MRSA was isolated.

  • 649.
    Ahlm, Clas
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Settergren, Bo
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Gothefors, Leif
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
    Juto, Per
    Nephropathia epidemica (hemorrhagic fever with renal syndrome) in children: clinical characteristics.1994In: The Pediatric Infectious Disease Journal, ISSN 0891-3668, E-ISSN 1532-0987, Vol. 13, no 1, p. 45-9Article in journal (Refereed)
    Abstract [en]

    The clinical characteristics of serologically verified nephropathia epidemica, the Scandinavian form of hemorrhagic fever with renal syndrome, were studied in Swedish children who were < 15 years of age. In 1990 to 1992, 14 cases were prospectively followed. A retrospective survey during 1984 to 1990 disclosed another 18 cases. Among the 32 cases (20 boys, 12 girls, 3 to 15 years of age; median age, 11 years), the most common symptoms were fever (100%), headache (100%), abdominal pain (93%), vomiting (91%) and back pain (76%). Laboratory findings included elevated serum creatinine concentration (19 of 28) and thrombocytopenia (7 of 22). Urinalysis showed proteinuria (31 of 31 patients) and hematuria (24 of 30). Six children had mild hemorrhagic manifestations (epistaxis, metrorrhagia, and petechiae). No severe complications occurred. The clinical symptoms of children with nephropathia epidemica seem to be similar to those found among adult nephropathia epidemica cases.

  • 650.
    Ahlm, Clas
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Thelin, Anders
    Elgh, Fredrik
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
    Juto, Per
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
    Stiernström, E L
    Holmberg, S
    Tärnvik, Arne
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
    Prevalence of antibodies specific to Puumala virus among farmers in Sweden1998In: Scandinavian Journal of Work, Environment and Health, ISSN 0355-3140, E-ISSN 1795-990X, Vol. 24, no 2, p. 104-108Article in journal (Refereed)
    Abstract [en]

    Serological evidence confirmed that the exposure of humans to Puumala virus is firmly restricted to the northern and central parts of Sweden. In addition the evidence indicated that, in this region, farming is associated with an increased risk of contracting hantavirus infection.

10111213141516 601 - 650 of 87918
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