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  • 651.
    Ahlqvist, Jan
    et al.
    Umeå University, Faculty of Medicine, Department of Odontology.
    Isberg, A M
    Umeå University, Faculty of Medicine, Department of Odontology.
    Bone demarcation of the temporomandibular joint. Validity of clinical assessment of bone thickness by means of CT.1998In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 39, no 6, p. 649-55Article in journal (Refereed)
    Abstract [en]

    PURPOSE: To study the CT depiction of bone demarcations in the temporomandibular joint, using conventional window level and window width; and to evaluate observer performance in estimating bone thickness in these images.

    MATERIAL AND METHODS: Seven joint specimens were imaged by CT and then cryosectioned. The measurements of bone wall thickness in the images were compared to the true bone thickness at each cutting level. In addition, 4 experienced radiologists estimated the thickness of the bone walls in the images.

    RESULTS: The relative difference between the CT reproduction and the true bone thickness was small for bone walls thicker than 2 mm. This difference increased with the decrease in bone thickness and the increase in the inclination of the bone wall from the perpendicular to the image plane. Bone walls thinner than 1 mm were reproduced as considerably thicker than their true thickness. This resulted in a clinical overestimation of bone thickness.

    CONCLUSION: Both the CT representation and the interpretation of bone demarcation in the temporomandibular joint may constitute a problem. Partial volume averaging effects can result in an overestimation of bone dimensions amounting to 200% for thin bones. The central white zone in images of thin bone walls obtained with the parameters described here could serve as an indicator that could help to reduce the risk of overestimating bone thickness.

  • 652.
    Ahlqvist, Jan
    et al.
    Umeå University, Faculty of Medicine, Department of Odontology.
    Isberg, Annika
    Umeå University, Faculty of Medicine, Department of Odontology.
    Validity of computed tomography in imaging thin walls of the temporal bone1999In: Dento-Maxillo-Facial Radiology, ISSN 0250-832X, E-ISSN 1476-542X, Vol. 28, no 1, p. 13-19Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: To evaluate the validity of computed tomography (CT) for reproduction of the bone margins of the temporomandibular joint (TMJ).

    METHODS: Seven TMJ specimens were examined with a CT and then cryosectioned. The bone separating the TMJ from the middle cranial fossa, middle ear and external auditory canal was measured as the full width at half maximum (FWHM). Measurements were compared with the true thickness of the bone wall.

    RESULTS: There was good agreement when the bone walls were thicker than 1 mm: accuracy was influenced only by the angle of the bone wall to the scanning plane. Conversely, bone walls thinner than 1 mm were reproduced with a magnification that increased with decreasing bone thickness. The difference increased further as the inclination of the bone wall became greater.

    CONCLUSION: Measurements performed at FWHM are reliable within +/- 10% for bone walls more than approximately 1 mm thick which form an angle of less than 35 degrees to the perpendicular of the scanning plane. For bone walls thinner than 1 mm and for those thicker than 1 mm with an inclination exceeding approximately 35 degrees, partial volume effects result in a progressively increasing magnification of bone thickness.

  • 653. Ahlqvist, Jan
    et al.
    Legrell, Per Erik
    A technique for the accurate administration of corticosteroids in the temporomandibular joint.1993In: Dento-Maxillo-Facial Radiology, ISSN 0250-832X, E-ISSN 1476-542X, Vol. 22, no 4, p. 211-3Article in journal (Refereed)
    Abstract [en]

    A new technique for intra-articular injection of a corticosteroid in the temporomandibular joint (TMJ) is presented. The corticosteroid is mixed with contrast medium and the administration visualized and controlled using fluoroscopy. When superior and inferior joint spaces have been filled and the soft tissues of the joint have been identified in the fluoroscopic image, additional corticosteroid can be administered to selected sites within the TMJ.

  • 654.
    Ahlqvist, Jenny
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies, Environmental Archaeology Lab.
    Miljöarkeologi i Umeå stads hamn och slagfältsarkeologi på Krutbrånet: Två fallstudier inom historisk arkeologi i Umeås 1800-tal2014Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This master thesis deals with two case studies in environmental archaeology and battlefield archaeology focusing on two major events in the late history of the Swedish coastal town Umeå and its nearby village Sävar. Established in the early 1600's, Umeå was known for its export of timber and import of cereals. The town has suffered from numerous fires, the fire in 1888 being the most devastating. Few written records of the town remain from before the 1900's. The latest war in Sweden's history is documented in historical sources and took place at Krutbrånet, Sävar where the Swedish troops suffered defeat against the russian forces in 1809. The old port in Umeå has not been previously excavated archaeologically and only a small part of the battlefield area at Krutbrånet has been surveyed. Neither of the sites have yet been protected sites under Swedish heritage conservation act. The purpose of these two case studies is to present new research results from these two sites.In the first case study, archaeobotany and soil chemistry methods were used to analyse soil samples from undisturbed cultural layers in a construction trench at the old port of Umeå. A thick burnt layer consisted of charcoal, oats and weeds, suggesting storage and possibly intended as food for horses. Oat and pea were radiocarbon dated to most likely late 1800's which places the burned layer with oats to the big city fire in 1888. The area could have intact cultural layers that are important to investigate for understanding the  unknown history of Umeås old port.The basis for the second case study is the material evidence of lead musket bullets found during a small field survey at Krutbrånet, conducted in 2010. The bullets were studied using X-ray Fluorescence together with spatial analysis to determine if troop nationality could be possible to distinguish based on composition, characteristics and spatial positions. The results revealed bullets  in varied sizes and composed of lead but also alloys of copper, antimony and tin that appear in mixed quantities spread in all the studied areas of the battlefield. Field surveys of uninvestigated areas at Krutbrånet are needed to understand the context of the studied material and of troop formations. Further studies could also be isotope analyses to determine the origins of the oats and bullets. 

  • 655.
    Ahlqvist, Jenny
    et al.
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies, Environmental Archaeology Lab.
    Eriksson, Samuel
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies, Environmental Archaeology Lab.
    Östman, Sofi
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies, Environmental Archaeology Lab.
    Engelmark, Roger
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies, Environmental Archaeology Lab.
    Makrofossil- och markkemisk analys av prover från Tanum Raä 1885, Tanum sn, Bohuslän2016Report (Other academic)
  • 656.
    Ahlqvist, Jenny
    et al.
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies, Environmental Archaeology Lab.
    Wallin, Jan-Erik
    Östman, Sofi
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies, Environmental Archaeology Lab.
    Olsson, Fredrik
    Miljöarkeologiska analyser av prover från Drognes 196/270 ID114281, Nes kommune, Akershus, Norge2018Report (Other academic)
  • 657.
    Ahlqvist, Jenny
    et al.
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies, Environmental Archaeology Lab.
    Östman, Sofi
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies, Environmental Archaeology Lab.
    Eriksson, Samuel
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies, Environmental Archaeology Lab.
    Eriksson, Mats
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies, Environmental Archaeology Lab.
    Linderholm, Johan
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies, Environmental Archaeology Lab.
    Miljöarkeologiska analyser av prover från huslämningar i Dobbeltspor Dilling, ID 216874, Rygge kommune, Østfold, Norge2018Report (Other academic)
  • 658.
    Ahlqvist, Magnus
    Umeå University, Faculty of Social Sciences, Basic training programme for Police Officers.
    Polishundverksamheten i Skellefteå2008Independent thesis Basic level (professional degree), 5 credits / 7,5 HE creditsStudent thesis
    Abstract [sv]

    Den svenska polisen har stor användning av hundar i det operativa polisarbetet. Hundar används bland annat för att eftersöka försvunna personer, spåra gärningsmän, skingra folkmassor, uppleta bevisföremål, söka narkotika och mycket mer. Polishundar brukar delas in i kategorierna ÖVS-hundar (övervakningshundar), specialsökhundar och kombihundar. De regionala myndigheterna bestämmer själva hur hundverksamhen ska vara utformad i länet. Den här rapporten tar sikte på att beskriva hur polishundsverksamheten ser ut i Skellefteå. Under våren 2007 skedde en omstrukturering av hundverksamheten i Västerbotten. Myndigheten bestämde att det inte längre skulle finnas någon egen ÖVS-hund i Skellefteå. Det bestämdes även att det i Skellefteå skulle startas upp ett nytt projekt med att utbilda en brottsplatsundersökningshund. För att få en bild av varför omstruktureringarna genomfördes har intervjuer hållits med personer som är insatta i frågan. Rapporten visar att omstruktureringen främst berodde på svårigheter att hitta kompetent personal som kunde utbilda polishundarna i Skellefteå. Vidare visar rapporten på ekonomiska motiv bakom omstruktureringen.

  • 659.
    Ahlqvist, Malin
    et al.
    Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Business Administration.
    Makslahti, Sanna
    Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Business Administration.
    Varumärkesbyggande inom hotellbranschen: En studie av tre hotell i Norrbotten2014Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Resandet i Europa prognostiseras att öka med 2,3 procent varje år fram till år 2030. Den svenska turismnäringen tros ha stora möjligheter att ta del av ökningen. De norrbottniska lokaltidningarna har under det senaste året rapporterat om nyetableringar inom hotell- och restaurangbranschen. Eftersom både konkurrensen och gästnätterna ökar i Norrbotten ligger större vikt vid att erbjuda rätt koncept till rätt pris.

    Vi ser att starka ledare som Steve Jobs hos Apple och Dave Horton hos Hilton Hotels & Resorts har visat på starkt engagemang, gediget arbete och målmedvetenhet. De har också vågat ta risker samtidigt som de varit lyhörda gentemot marknaden. Med anledning av ökad konkurrens och fler valmöjligheter blir det desto viktigare med starka varumärken.

    Utifrån denna bakgrund har vi utformat frågeställningen ”Hur förmedlas ett hotells varumärke till medarbetare samt hur arbetar hotellet med policys och riktlinjer för att stärka sitt varumärke?” med syftet att ta reda på vad som finns bakom företagens policys och implementeringen av dessa. Vi ville även se till medarbetarnas utbildning och vilka instruktioner de erhöll för att arbeta efter företagets värderingar och för varumärkets främjande. Vi hade även förhoppningar om att öka vår förståelse för uppbyggandet av varumärken inom hotellbranschen, samt att fördjupa våra kunskaper både teoretiskt och praktiskt.

    Vår teoretiska referensram skapades utifrån Aakers teori kring ett varumärkes beståndsdelar, Robles och Leyvas studie om kund- och varumärkeslojalitet i hotellbranschen, kommunikation av varumärket genom employer branding, McClellands motivationsteori samt Chen et als. studie om frontpersonals agerande på hotell. Utifrån teorierna har vi skapat ett intervjuunderlag med tre centrala teman; varumärke, kundsegment och kundlojalitet samt varumärket och medarbetarnas motivation.

    Vid intervjutillfället besökte vi tre hotell i Norrbotten där vi höll åtta personliga intervjuer med individer från olika befattningar. Detta resulterade i att vi kunde se både ledarens roll och varumärkesbyggandet från flera olika synvinklar.

    Det visade sig att varumärkesbyggandet hade mindre fokus än väntat och att hotellen indirekt arbetade med det genom frontpersonal och kvalitet samt att ett stort fokus ligger på personalen och deras bemötande mot gäst. Lojalitet visade sig vara av större vikt. Den visades både mot samhälle och gäst via kundservice genom tillgänglighet och lyhördhet för gästens behov. Alla hotellen innehar ett miljötänk, men det är inget som de marknadsför utåt. Det är på uppgång att marknadsföra sig som arbetsgivare via sociala medier. Arbetsgivarna lägger vikt på medarbetare med inre motivation och den övervägande motivatorn visade sig vara mötet med människor.

    Slutligen gav vi rekommendationer om en ökad miljömarknadsföring samt användandet av sociala medier. Vi ansåg också att ett mer utformat arbete kring lojalitetspolicys kan gynna organisationerna samt att det är viktigt att hålla liv i gemenskapen på arbetsplatsen.

  • 660.
    Ahlqvist, Stina
    Umeå University, Faculty of Science and Technology, Umeå School of Architecture.
    Charging the Void: (Perception Odd Logic)2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    As a concern for how new city developments invest in commercial

    public space of economic activity rather than cultural activity and

    inclusion, part of a global trend and also the case of Umeå’s ambition

    to reach the population growth of 200 000 inhabitants by the year of

    2050. The question to be asked in this regard is what kind of effect

    does this produce on the way we as local inhabitants can take control

    and be part of the creation of our own living environment? Or are

    we just victims of a life consumed by slow decay due to the capital

    dominance?

    In relation to this main concern, the project has been developing

    through the aspect of acknowledging inferior space and abandoned

    objects as a method and typology to analyze alternative ways to

    perceive the city off based the logic of clear function and use, but in

    terms of human interaction and subjective perception of space. The

    point of departure and important key element for this development

    derived from the early stages of research and influential work by

    Robert Smithson’s Monuments of Passaic New Jersey, (1967) with

    a main quote on the description of Smithson’s work and the term of

    monuments, here defined by Ann Reynolds as: “how something plot

    out and charge a space with meaning”

    Learning from memory traces of an abandoned set of futures evoked

    the idea and strive towards creating space not tied to a specific

    use or function, but as a collaboration and juxtaposition between

    form and the viewer’s experience. In add to an understanding of a

    presence which ties together the past and the present as an indirect

    translation of the developed concept for contemporary Ruins, as the

    perception of void. The ruins association to object defined through

    the observer became a guideline towards the aim of designing nonhierarchical

    space, free of us and interpreted by the visitor within the

    city scape.

    Based on this foundation this thesis aims to examine the possibilities

    of architectural structures which can encourage and create conditions

    for new cultural and social meetings. The abstract concept of space

    and deliberate openness to interpretation can allow the visitor to

    take co-authorship of their own living environment based on their

    personal understanding and imagination of that space. The action

    is by deliberate disjunction between form and viewer’s experience

    forced by a superimposition plan as a design strategy for redeveloping

    the current Döbelns Park into a new culture park in the city context

    of Umeå, Västerbotten, Sweden. Fragments of the park will in add

    create a system of integrated monumental sculpture scapes, as a

    network of in-between small scale interventions adapting to specific

    site conditions together with implemented greenery. To secure areas

    within the city scape with access to greenery and social interactive

    meeting points, part of the Urban strategy.

  • 661.
    Ahlqvist, Therese
    Umeå University, Faculty of Social Sciences, Department of Political Science.
    EMU & de demokratiska argumenten2000Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 662.
    Ahlqvist, Therese
    Umeå University, Faculty of Social Sciences, Department of Political Science.
    Högre utbildning och globalisering2001Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
  • 663.
    Ahlqvist, Tobias
    Umeå University, Faculty of Social Sciences, Department of Political Science.
    Kina i Afrika: Motiv, strategier och konsekvenser?2011Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 664. Ahlqvist-Rastad, Jane
    et al.
    Albertsson, Maria
    Bergh, Jonas
    Birgegård, Gunnar
    Johansson, Peter
    Jonsson, Bertil
    Kjellén, Elisabeth
    Påhlman, Sven
    Zackrisson, Björn
    Umeå University, Faculty of Medicine, Radiation Sciences, Oncology.
    Österborg, Anders
    Erythropoietin therapy and cancer related anaemia: updated Swedish recommendations.2007In: Med Oncol, ISSN 1357-0560, Vol. 24, no 3, p. 267-272Article in journal (Refereed)
  • 665. Ahlroth Pind, C.
    et al.
    Gunnbjörnsdottír, M.
    Bjerg, A.
    Järvholm, Bengt
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine.
    Lundbäck, B.
    Malinovschi, A.
    Middelveld, R.
    Nilsson Sommar, Johan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine.
    Norbäck, D.
    Janson, C.
    Patient-reported signs of dampness at home may be a risk factor for chronic rhinosinusitis: a cross-sectional study2017In: Clinical and Experimental Allergy, ISSN 0954-7894, E-ISSN 1365-2222, Vol. 47, no 11, p. 1383-1389Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: An association between dampness at home and respiratory conditions has been convincingly demonstrated in children. Fewer studies have been performed in adults, and data are lacking for chronic rhinosinusitis (CRS). With a prevalence of 10.9% in Europe, CRS imposes a significant burden on quality of life, as well as economy.

    OBJECTIVE: Our aim was to study CRS and other respiratory conditions in relation to dampness at home in a representative sample of adults.

    METHODS: The Swedish GA(2) LEN questionnaire was answered by 26 577 adults (16-75 years) and included questions on respiratory symptoms, smoking, education and environmental exposure. CRS was defined according to the EP(3) OS criteria. Dampness was defined as reporting water damage, floor dampness or visible moulds in the home during the last 12 months. The dampness score was ranked from 0 to 3, counting the number of signs of dampness reported.

    RESULTS: Dampness at home was reported by 11.3% and was independently related to respiratory conditions after adjustment for demographic and socio-economic factors and smoking: CRS odds ratio (OR) 1.71; allergic rhinitis OR 1.24; current asthma OR 1.21; wheeze OR 1.37; nocturnal dyspnoea OR 1.80; nocturnal coughing OR 1.34; and chronic bronchitis OR 1.64. The risk of CRS and most of the other respiratory conditions was further elevated in subjects reporting multiple signs of dampness.

    CONCLUSIONS AND CLINICAL RELEVANCE: This study demonstrated an independent association between dampness at home and CRS in adults. The high burden of this and the other respiratory conditions studied is a strong argument in favour of countering indoor dampness by improving building standards.

  • 666.
    Ahlskog, Stina
    et al.
    Umeå University, Faculty of Social Sciences, Department of Sociology.
    Karlsson, Elisabeth
    Umeå University, Faculty of Social Sciences, Department of Sociology.
    HBT-arbete utifrån likabehandlingspolicy: Första och andra linjens chefers möjligheter för och föreställningar kring arbetet med HBT-frågor på Skellefteå kommun2014Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    HBT-frågor är idag en alltmer omtalad fråga i den samhälleliga debatten. Sedan diskrimineringslagstiftningen ändrades år 2009 har organisationer ett alltmer omfattande ansvar att arbeta för att motverka diskriminering i alla dess former. Då Skellefteå kommun har fattat beslut om att öka sitt invånarantal till 80 000 invånare år 2030 görs stora insatser föratt se till att alla människor har samma förutsättningar att leva och verka i kommunen.Uppdraget var därför att undersöka första och andra linjens chefers möjligheter att utifrån den befintliga likabehandlingspolicyn arbeta med HBT-frågor. Studien baseras på 12 intervjuer med första- och andra linjens chefer på en kvinnodominerad och en mansdominerad arbetsplats inom kommunen. Resultatet visar att cheferna upplever en begränsning i hur de kan använda sig av likabehandlingspolicyn i sitt dagliga arbete. Dokumentet ses mer som spelregler snarare än något som konkret kan användas praktiskt. Den mest framträdande föreställningen kring HBT-frågor bland cheferna på de arbetsplatser som undersökts var att det inte fanns någon problematik med diskriminering inom deras verksamhetsområde. Därför fanns en föreställning bland några av cheferna att något förebyggande arbete med dessa frågorinte behövdes. Det går att utläsa vissa skillnader mellan kvinnodominerade och mansdominerade arbetsplatser i hur man arbetar med HBT-frågor samt de föreställningar som finns kring hur dessa frågor talas om på arbetsplatserna. Cheferna på de kvinnodominerade arbetsplatserna var mer benägna att bedriva ett proaktivt likabehandlingsarbete än cheferna påde mansdominerade arbetsplatserna. Ingen bedriver dock ett specifikt arbete med HBT-frågori dagsläget.

  • 667. Ahlsson, Anders
    et al.
    Jideus, Lena
    Albage, Anders
    Kallner, Goran
    Holmgren, Anders
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.
    Boano, Gabriella
    Hermansson, Ulf
    Kimblad, Per-Ola
    Schersten, Henrik
    Sjogren, Johan
    Stahle, Elisabeth
    Aberg, Bengt
    Berglin, Eva
    A Swedish consensus on the surgical treatment of concomitant atrial fibrillation2012In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 46, no 4, p. 212-218Article, review/survey (Refereed)
    Abstract [en]

    Atrial fibrillation (AF) is a common arrhythmia among patients scheduled for open heart surgery and is associated with increased morbidity and mortality. According to international guidelines, symptomatic and selected asymptomatic patients should be offered concomitant surgical AF ablation in conjunction with valvular or coronary surgery. The gold standard in AF surgery is the Cox Maze III ("cut-and-sew") procedure, with surgical incisions in both atria according to a specified pattern, in order to prevent AF reentry circuits from developing. Over 90% of patients treated with the Cox Maze III procedure are free of AF after 1 year. Recent developments in ablation technology have introduced several energy sources capable of creating nonconducting atrial wall lesions. In addition, simplified lesion patterns have been suggested, but results with these techniques have been unsatisfactory. There is a clear need for standardization in AF surgery. The Swedish Arrhythmia Surgery Group, represented by surgeons from all Swedish units for cardiothoracic surgery, has therefore reached a consensus on surgical treatment of concomitant AF. This consensus emphasizes adherence to the lesion pattern in the Cox Maze III procedure and the use of biatrial lesions in nonparoxysmal AF.

  • 668.
    Ahlstrand, Johannes
    et al.
    Umeå University, Faculty of Social Sciences, Department of Social Work.
    Svedberg, Josefin
    Umeå University, Faculty of Social Sciences, Department of Social Work.
    Kuratorers tankar om relationens betydelse i samtalsbehandling2014Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Det övergripande syftet med denna kandidatuppsats är att utforska hur professionella hjälpare inom psykiatrin i Norrland etablerar och upprätthåller hjälpande relationer samt vilken syn de har på betydelsen av relationen för behandlingens utfall. I studien intervjuades fyra kuratorer som var anställda på psykiatriska kliniken i Norrland, varav två kvinnor och två män som representerade olika mottagningar. Det insamlade materialet analyserades med hjälp av en hermeneutisk metod och strukturerades upp med hjälp av kvalitativ innehållsanalys. I resultatet framkom det att intervjupersonerna såg relationen som väldigt viktig, både för att få till stånd en behandling men också för att upprätthålla en pågående behandling. Relationen i sig ansågs vara en bärare av hjälpen såväl som en hjälp i sig. Vi fann också att relationskompetens är en nödvändighet för att en behandling ska fungera. Begrepp som lyftes var autenticitet, att behandlaren är genuin, vågar visa känslor och reaktioner gentemot patienten. Ännu en faktor som särskilt påtalades var vikten av att som behandlare ha ett icke-dömande förhållningssätt gentemot patienten och se denne på ett realistiskt vis, vilket innebär att behandlaren ser patienten för den person den är.

  • 669.
    Ahlstrand, Marika
    Umeå University, Faculty of Social Sciences, Department of applied educational science.
    Digitala Med(ie)borgare: En intervjustudie rörande verksamma fritidslärares förhållnings- och arbetssätt med digitala verktyg och sociala medier2017Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Syftet med studien var att synliggöra och identifiera hur verksamma fritidslärare förhåller sig till samt arbetar med digitala verktyg och sociala medier. Vidare så var syftet även att synliggöra vilka effekter som fritidslärarna anser att dessa verktyg och medier kan ha på elevernas lärande.  Den metod som använts till studien har varit forskningsintervjuer, detta för att ta reda på hur det valda ämnet, digitala verktyg och sociala medier, tolkas och förstås utifrån de intervjuades egna perspektiv. Studien bygger på intervjuer gjorda på fem fritidshem med fem olika fritidslärare.

     

    Det resultat som framkommit har varit att de flesta av de intervjuade fritidslärarna har ställt sig positivt till digitala verktyg och sociala medier inom den pedagogiska verksamheten. De anser att elevernas sociala kompetens utvecklas, att eleverna inkluderas i varandras lärande samt att lärandet blir roligare via dessa verktyg och medier. Men det har även nämnts vissa negativa effekter av dessa digitala verktyg och sociala medier. Att eleverna kan bli exkluderade från övriga elevgruppen om hen inte har tillgång till dessa verktyg och medier. En fritidslärare nämnde även att dessa verktyg och medier kan framkalla negativt beteende, främst hos pojkar i form av bråk och slagsmål.

  • 670.
    Ahlstrand, Samuel
    Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
    Partiformning vid intern materialförsörjning och layoutanpassning av lager: En fallstudie vid GE Healthcare Umeå av två-binge, supermarkets ochmaterialspindlar2014Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    GE Healthcare (GEHC) Umeå har vid sin implementering av Lean genomfört förändringar i lagerstrukturen som är i behov av bättre anpassning. GEHC Umeås nya lagerstruktur innebär öppna supermarkets med förändrade försörjningsrutiner från lager till produktion. Ett två-binge system har implementeras där signalbehållare med material fylls av lageransvariga materialspindlar.

    Det första identifierade problemet och forskningsfrågan utgör två-bingarnas kvantiteter som bestämmer mängden artiklar vid monteringsstationerna. Dessa behöver ses över och en rutin för bestämmande av kvantitet behöver etableras. Som den andra, och oberoende forskningsfrågan, har antalet supermarkets (lager) och dessmaterialspindlar identifieras som är många till antalet och utspridda med begränsad samordning.

    Ett tidigare examensarbete, litteraturstudier, intervjuer samt egna observationer på plats har används för att beskriva nuläget genom både kvalitativa och kvantitativa metoder. På grund av bristen på liknande problem i litteraturen har externa partiformningsmetoder och lagerstyrning används och komplimenterats med simulering för två-binge systemet som del i besvarandet av den första frågeställningen. För den andra frågeställningen har delar ur förenklad systematisk lokalplanläggning används där bland annat olika centraliseringsgrader undersökts med simulering av materialtransporter vid olika artikelplaceringar.

    Idag sätts kvantiteten efter prognoserat användande utifrån personliga erfarenheter. Samordningen mellan materialspindlarna är bristande och nyttjandegraden upplevs ojämn samtidigt som godsmottagningen skulle gynnas av ökad kapacitet. Standardiserade processer i materialhanteringen saknas och produktionsgrupperna har skilda arbetssätt som antaskunna gynnas av en centralisering där gemensamma rutiner lättare kan etableras.

    De historiska transaktionerna visar att det finns utrymme för förbättringar då vissa artiklar genererar långa transportsträckor på grund lagerplats i förhållande till var de används iproduktionen. De nya binge-kvantiteterna från partiformningsmetoderna EOQ, m-EOQ och Kanbanformeln har testats i simulering av påfyllning och materialåtgång via en implementation i Excel VBA.

    Kanbanformeln uppvisar högsta servicenivån 90 %, för lägsta totalkostnaden och minskad kapitalbindning. Kanbankvantiteterna minskar den totala kostnaden med 20 %. Antalet påfyllningar skulle öka med 7 % och antalet artiklar i produktion minskar med 59%. För layoutanpassningen har även simulering av olika orderplock och artikelplaceringen genomförts. Resultatet visar att en centraliseringsgrad är möjlig med en liten ökning avmaterialtransporterna. Det framgår även att artiklar som plockas väldigt sällan är beräknade att ta upp 89 hyllställage av totalt 230 stycken och bör ses över. Detta tillsammans med kravspecifikationen från analys-delen har hjälpt för att generera olika koncept.

    GEHC Umeå bör använda Kanbanformeln i framtiden för bestämmande av kvantiteten i bingarna. Vissa anpassningar för gemensamma artiklar i Comm-lagret och artiklar utan historiska efterfrågan bör ske. För layouten bör GEHC Umeå först och främst flytta artiklarsom idag bidrar med onödiga transporter. På längre sikt bör en ökad grad centralisering avlagren vara möjlig med hänsyn till fördelar vid samordning och informell spridning av arbetsrutiner. Materialspindlarna bör underlätta för godsmottagningen, delta i bristrapportering samt förbättringsarbetet. Utöver detta bör möjligheter till ökat samarbetet mellan materialplaneringen, produktionsplaneringen och materialspindlarna undersökas

  • 671. Ahlstrand, Tuuli
    et al.
    Kovesjoki, Laura
    Maula, Terhi
    Oscarsson, Jan
    Umeå University, Faculty of Medicine, Department of Odontology.
    Ihalin, Riikka
    Aggregatibacter actinomycetemcomitans LPS binds human interleukin-82019In: Journal of Oral Microbiology, ISSN 2000-2297, E-ISSN 2000-2297, Vol. 11, no 1Article in journal (Refereed)
    Abstract [en]

    Various gram-negative species sequester host cytokines using outer membrane proteins or surface modulation by sulfated polysaccharides. An outer membrane lipoprotein (BilRI) of the periodontal pathogen Aggregatibacter actinomycetemcomitans binds several cytokines, including interleukin (IL)-8. Because IL-8 is positively charged at physiological pH, we aimed to determine whether IL-8 interacts with negatively charged lipopolysaccharide (LPS). Binding was investigated using electrophoretic mobility shift assays and microwell-based time-resolved fluorometric immunoassay. LPS from each tested strain of A. actinomycetemcomitans (N = 13), Pseudomonas aeruginosa (N = 1) and Escherichia coli (N = 1) bound IL-8. The K-d value of the A. actinomycetemcomitans LPS-IL-8 interaction varied between 1.2-17 mu M irrespective of the serotype and the amount of phosphorus in LPS and was significantly lower than that of the BilRI-IL-8 interaction. Moreover, IL-8 interacted with whole A. actinomycetemcomitans cells and outer membrane vesicles. Hence, LPS might be involved in binding of IL-8 to the outer membrane of A. actinomycetemcomitans. This raises an interesting question regarding whether other gram-negative periodontal pathogens use LPS for IL-8 sequestering in vivo.

  • 672. Ahlstrand, Tuuli
    et al.
    Tuominen, Heidi
    Beklen, Arzu
    Torittu, Annamari
    Oscarsson, Jan
    Umeå University, Faculty of Medicine, Department of Odontology.
    Sormunen, Raija
    Pöllänen, Marja T.
    Permi, Perttu
    Ihalin, Riikka
    A novel intrinsically disordered outer membrane lipoprotein of Aggregatibacter actinomycetemcomitans binds various cytokines and plays a role in biofilm response to interleukin-1β and interleukin-82017In: Virulence, ISSN 2150-5594, E-ISSN 2150-5608, Vol. 8, no 2, p. 115-134Article in journal (Refereed)
    Abstract [en]

    Intrinsically disordered proteins (IDPs) do not have a well-defined and stable 3-dimensional fold. Some IDPs can function as either transient or permanent binders of other proteins and may interact with an array of ligands by adopting different conformations. A novel outer membrane lipoprotein, bacterial interleukin receptor I (BilRI) of the opportunistic oral pathogen Aggregatibacter actinomycetemcomitans binds a key gatekeeper proinflammatory cytokine interleukin (IL)-1β. Because the amino acid sequence of the novel lipoprotein resembles that of fibrinogen binder A of Haemophilus ducreyi, BilRI could have the potential to bind other proteins, such as host matrix proteins. However, from the tested host matrix proteins, BilRI interacted with neither collagen nor fibrinogen. Instead, the recombinant non-lipidated BilRI, which was intrinsically disordered, bound various pro/anti-inflammatory cytokines, such as IL-8, tumor necrosis factor (TNF)-α, interferon (IFN)-γ and IL-10. Moreover, BilRI played a role in the in vitro sensing of IL-1β and IL-8 because low concentrations of cytokines did not decrease the amount of extracellular DNA in the matrix of bilRI− mutant biofilm as they did in the matrix of wild-type biofilm when the biofilms were exposed to recombinant cytokines for 22 hours. BilRI played a role in the internalization of IL-1β in the gingival model system but did not affect either IL-8 or IL-6 uptake. However, bilRI deletion did not entirely prevent IL-1β internalization, and the binding of cytokines to BilRI was relatively weak. Thus, BilRI might sequester cytokines on the surface of A. actinomycetemcomitans to facilitate the internalization process in low local cytokine concentrations.

  • 673.
    Ahlström, Angelica
    Umeå University, Faculty of Social Sciences, Department of Law.
    Plan-och bygglagen i ljuset av en oväntad befolkningsökning - Hur tryggas de sociala rättigheterna?2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • 674.
    Ahlström, Björn
    Umeå University, Faculty of Social Sciences, Department of Sociology.
    Bullying and social objectives: A study of prerequisites for success in Swedish schools2009Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis examines the relationship between organizations structure, culture and leadership. The specific organization that has been studied is Swedish secondary schools. The Swedish schools have a divided task, first to develop the students academic skills and secondly to develop the students socially and civically. This thesis has its interest on the schools social environment with special interest focused on questions regarding bullying and insulting behaviour. The data that has been used consists of interviews and questionnaires with students, teachers and principals in 24 Swedish schools that have been studied in a larger study. This work is a part of a project called Structure, Culture and Leadership – prerequisites for successful schools?.  The 24 schools that took part in the SCL study were divided in to four different groups depending on how well they are succeeding in reaching the social and academic objectives formulated in the steering documents. The main result show that principals that succeed to align structure and culture in relation to both the social and academic objectives are the ones that can be perceived as successful. It is these schools that have the lowest level of bullying and the highest grades. The principal takes social responsibility and takes questions in relation to bullying and insulting behaviour seriously. By doing that the principal can communicate the seriousness of the topic in order to develop awareness within the organization and a preventive work can therefore be possible. In schools that work with the students’ ability to be participative seems to develop the students both socially and academically.

  • 675.
    Ahlström, Björn
    Umeå University, Faculty of Social Sciences, Centre for Principal Development.
    Med hänsyn till både tid och rum: systematiskt kvalitetsarbete i fyra dimensioner2018In: Att leda skolor med stöd i forskning: exempel, analyser och utmaningar / [ed] Niclas Rönnström & Olof Johansson, Stockholm: Natur och kultur, 2018, 1, p. 297-322Chapter in book (Refereed)
  • 676.
    Ahlström, Björn
    Umeå University, Faculty of Social Sciences, Centre for Principal Development.
    Mobbning i svensk forskning2014In: Framgångsriks skolor: mer om struktur, kultur, ledarskap / [ed] Jonas Höög & Olof Johansson, Lund: Studentlitteratur AB, 2014, p. 217-233Chapter in book (Refereed)
  • 677.
    Ahlström, Björn
    Umeå University, Faculty of Social Sciences, Department of Sociology.
    Mobbning och skolans sociala mål2011In: Struktur, kultur och ledarskap: Förutsättningar för framgångsrika skolor / [ed] Jonas Höög, Olof Johansson, Lund: Studentlitteratur , 2011, 1, p. 153-174Chapter in book (Other academic)
  • 678.
    Ahlström, Björn
    Umeå University, Faculty of Social Sciences, Centre for Principal Development.
    Rektorers syn på mobbning: eller "Vi är som alla andra"2014In: Framgångsrika skolor: mer om struktur, kultur, ledarskap / [ed] Jonas Höög & Olof Johansson, Lund: Studentlitteratur AB, 2014, p. 197-216Chapter in book (Refereed)
  • 679.
    Ahlström, Björn
    Umeå University, Faculty of Social Sciences, Centre for Principal Development.
    Rektors ansvar: Att ta ställning?2014In: Skolledare i mötet mellan nationella mål och lokal policy / [ed] Elisabet Nihlfors & Olof Johansson, Malmö: Gleerups Utbildning AB, 2014, p. 179-191Chapter in book (Refereed)
  • 680.
    Ahlström, Björn
    Umeå University, Faculty of Social Sciences, Department of Sociology.
    Student participation and school success: A study about participation, grades and bullying among 9th grade students in Sweden2010In: Education Inquiry, ISSN 2000-4508, Vol. 1, no 2, p. 97-115Article in journal (Refereed)
    Abstract [en]

    In the Swedish school law and curriculum it is stated that students shall be participative in their work. They should work in a participative manner and the pedagogical idea is that influence and participation has multiple benefits for the students’ development. In this article the relationship between student participation and school success is examined. By using a theoretically based participation index eight schools were chosen to be closer examined. Success was measured by the schools grades and the level of perceived bullying among the students. Student participation seems to have beneficial effects on the students’ academic and social development. In schools that have higher level of student participation the grades were higher and the level of perceived bullying among the students was lower than schools with a lower level of participation.

  • 681.
    Ahlström, Björn
    Umeå University, Faculty of Social Sciences, Department of Sociology.
    "We are no different": Swedish Principals views on their SchoolsIn: Power and education, ISSN 1757-7438Article in journal (Refereed)
    Abstract [en]

    This article focuses on principals and their leadership and this is related to perceived level of bullying among the students. Eight schools were chosen in this study, the four schools with the lowest amount and the four schools with the highest amount of students that perceived that bullying occurred at their school. At these schools interviews made with the principals where analysed. One specific question where analysed where the principals answered if they had any bullying at their school. The conclusion is that schools that seem to have a high level of bullying have principals that give two types of responses, one that mitigates the problem by responding that the level of bullying is at a “normal” level or just like “any other school”. The second response is a one of denial where the principals responds with a “no problem”-response that indicates that it does not occur bullying at their school. The schools that have a low level of bullying on the other hand have principals that acknowledge that it occurs. Schools that have a high level of bullying have principals that do not acknowledge that. On schools with a low level of bullying the principals perceives the level of bullying as problem and acknowledge its existence.

  • 682.
    Ahlström, Björn
    et al.
    Umeå University, Faculty of Social Sciences, Department of Sociology. Umeå University, Faculty of Social Sciences, Centre for Principal Development.
    Höög, Jonas
    Umeå University, Faculty of Social Sciences, Department of Sociology. Umeå University, Faculty of Social Sciences, Centre for Principal Development.
    Measuring the social and civic objectives of schools2010In: School leadership: international perspectives / [ed] Stephan Huber, Bern: Peter Lang Publishing Group, 2010, p. 19-37Chapter in book (Other academic)
    Abstract [en]

    This study is part of a Swedish project "Structure, Culture, Leadership – prerequisites for successful schools?" The study presents a tool for the analysis of school outcomes. How can social and civic objectives be measured and what differences between schools can be found when it comes to achieving these objectives? The aim is to assess the pupils' development through a questionnaire based on the curriculum in areas like: democratic values, communication, respect for human differences, self-consciousness, responsibility, critical evaluation, creativity. The study is conducted among 2128 pupils in 24 secondary schools in 12 municipalities. Results show that it is possible to develop an instrument based on the Swedish steering documents. It's also obvious that school differences can be assessed with the Social and Civic Objectives Scale (SCOS) Using the SCOS instrument helps us to broaden the definition of a "successful school" by incorporating academic as well as social and civic objectives.

  • 683.
    Ahlström, Hanna
    et al.
    Umeå University, Faculty of Medicine, Department of Nursing.
    Sjöstedt, Pamela
    Umeå University, Faculty of Medicine, Department of Nursing.
    Den äldre människans bästa vän: En litteraturstudie om vårdhundens positiva effekter på personer med demenssjukdom2014Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Bakgrund: Många personer med demenssjukdom bor på särskilda boenden. Vårdmiljön på de särskilda boendena består både av fysiska och psykosociala faktorer, vilka påverkar hälsan. Demenssjukdom är ett kroniskt tillstånd som kan orsaka flera olika symtom. Beteendemässiga och psykiska symtom vid demenssjukdom (BPSD) är vanligt förekommande och har en negativ påverkan på livskvalitén hos personer med demenssjukdom samt personer i deras närhet. BPSD behandlas oftast med läkemedel, men det finns flera kompletterande icke- farmakologiska behandlingsmetoder och djurassisterad intervention är en av dem. Inom vården har djur visat sig ha flera positiva effekter på hälsan. Hundar är det djur som används mest och finns inom exempelvis hospice, rehabilitering och demensvård.  Syfte: Syftet var att belysa positiva effekter av att använda vårdhundar inom demensvård på särskilt boende. Metod: En litteraturstudie där resultatet baserats på nio kvantitativa studier. Först genomfördes systematiska sökningar i olika databaser med utvalda sökord. Därefter granskades, analyserades och sammanställdes de valda studierna. Resultat: Sammanställningen resulterade i fyra huvudkategorier; påverkan på BPSD, påverkan på kognition, påverkan på livskvalité samt påverkan på läkemedelsanvändning. Djurassisterad intervention kan minska BPSD, förbättra orienteringsförmågan, ökad social interaktion och förbättra livskvalitén hos personer med demenssjukdom. Inom läkemedelsanvändningen sågs inga skillnader. Konklusion: Litteraturstudiens slutsats är att vårdhundar kan ha flera positiva effekter på personer med demenssjukdom. Det krävs mer forskning om interventionens utformning och om dess potentiella förmåga att komplettera eller ersätta läkemedelsanvändning.   

  • 684.
    Ahlström, Ingela
    Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
    A study of viral co-infection amongst children suffering from malar2013Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • 685.
    Ahlström, Johannes
    et al.
    Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Business Administration.
    Ficeková, Michaela
    Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Business Administration.
    The relationship between current financial slack resources and future CSR performance.: A quantitative study of public companies in the Nordic Markets2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Companies are expected to be good corporate citizens and fulfil expectations of both shareholders and stakeholders. Depending on their corporate objectives, companies undertake different CSR activities using their preferred financial resources. The relationship between these two notions is interesting to investigate in the Nordic context since companies in this geographical area are the global leaders in sustainability. We formulate the following research question as:

    What is the relationship between financial slack and the CSR performance in Nordic countries?

    As such, the purpose of this thesis is to investigate the underpinnings of whether companies choose to allocate their financial slack resources towards improving performance of CSR, or so called value creation. Doing so, we investigate the relationship between financial slack resources and CSR score.

    In adopting a regulatory position on the development of society, we conduct our research in accordance with the functionalist research paradigm, namely through commitment to the objectivist ontic and positivist epistemic research philosophies. We answer the research question using the deductive approach. Our research design is framed with an explanatory purpose relying on archival strategy to perform a quantitative study.

    The theoretical underpinnings for analysis comes in the form of legitimacy theory, the institutional differences hypothesis, Resource-based theory, slack resources theory, stakeholder and shareholder theory. We use multiple linear regressions to analyse cross-sectional data for the period between 2005 and 2015 collected from Thomson Reuters DataStream.

    Our result indicates that the relationship between financial slack and CSR performance in the following year is mixed with both positive and negative relationships being present. Our most important finding is a pattern indicating that during the year 2008 the relationship changed from being positive to negative. This implies that the more funds a company has at its discretion, the less likely it is for them to invest it in developing their CSR performance the following year. This could have severe negative implications on shareholders, stakeholders and society.

  • 686.
    Ahlström, Jonas
    Umeå University, Faculty of Social Sciences, Department of Political Science.
    Målstyrning i Migrationsverket: ur två perspektiv2007Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 687.
    Ahlström, Katarina
    et al.
    Anesthesia and Intensive Care Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Biber, Björn
    Anesthesia and Intensive Care Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Åberg, Anna-Maja
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology.
    Abrahamsson, Pernilla
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology.
    Johansson, Göran
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology.
    Ronquist, Gunnar
    Department of Medical Chemistry, Uppsala University, Uppsala, Sweden.
    Waldenström, Anders
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Cardiology.
    Haney, Michael F.
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology.
    Exogenous carbon monoxide does not affect cell membrane energy availability assessed by sarcolemmal calcium fluxes during myocardial ischaemia-reperfusion in the pig2011In: European Journal of Anaesthesiology, ISSN 0265-0215, E-ISSN 1365-2346, Vol. 28, no 5, p. 356-362Article in journal (Refereed)
    Abstract [en]

    Carbon monoxide is thought to be cytoprotective and may hold therapeutic promise for mitigating ischaemic injury. The purpose of this study was to test low-dose carbon monoxide for protective effects in a porcine model of acute myocardial ischaemia and reperfusion.In acute open-thorax experiments in anaesthetised pigs, pretreatment with low-dose carbon monoxide (5% increase in carboxyhaemoglobin) was conducted for 120 min before localised ischaemia (45 min) and reperfusion (60 min) was performed using a coronary snare. Metabolic and injury markers were collected by microdialysis sampling in the ventricular wall. Recovery of radio-marked calcium delivered locally by microperfusate was measured to assess carbon monoxide treatment effects during ischaemia/reperfusion on the intracellular calcium pool.Coronary occlusion and ischaemia/reperfusion were analysed for 16 animals (eight in each group). Changes in glucose, lactate and pyruvate from the ischaemic area were observed during ischaemia and reperfusion interventions, though there was no difference between carbon monoxide-treated and control groups during ischaemia or reperfusion. Similar results were observed for glycerol and microdialysate Ca recovery.These findings show that a relatively low and clinically relevant dose of carbon monoxide did not seem to provide acute protection as indicated by metabolic, energy-related and injury markers in a porcine myocardial ischaemia/reperfusion experimental model. We conclude that protective effects of carbon monoxide related to ischaemia/reperfusion either require higher doses of carbon monoxide or occur later after reperfusion than the immediate time frame studied here. More study is needed to characterise the mechanism and time frame of carbon monoxide-related cytoprotection.

  • 688.
    Ahlström, Katarina
    et al.
    Anestesi, Sahlgrenska akademin, Göteborgs universitet.
    Biber, Björn
    Anestesi, Sahlgrenska akademin, Göteborgs universitet.
    Åberg, Annamaja
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology.
    Waldenström, Anders
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Cardiology.
    Ronquist, Gunnar
    Abrahamsson, Pernilla
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology.
    Strandén, Per
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology.
    Johansson, Göran
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology.
    Haney, Michael
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology.
    Metabolic responses in ischemic myocardium after inhalation of carbon monoxide2009In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 53, no 8, p. 1036-1042Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: To clarify the mechanisms of carbon monoxide (CO) tissue-protective effects, we studied energy metabolism in an animal model of acute coronary occlusion and pre-treatment with CO. METHODS: In anesthetized pigs, a coronary snare and microdialysis probes were placed. CO (carboxyhemoglobin 5%) was inhaled for 200 min in test animals, followed by 40 min of coronary occlusion. Microdialysate was analyzed for lactate and glucose, and myocardial tissue samples were analyzed for adenosine tri-phosphate, adenosine di-phosphate, and adenosine mono-phosphate. RESULTS: Lactate during coronary occlusion was approximately half as high in CO pre-treated animals and glucose levels decreased to a much lesser degree during ischemia. Energy charge was no different between groups. CONCLUSIONS: CO in the low-doses tested in this model results in a more favorable energy metabolic condition in that glycolysis is decreased in spite of maintained energy charge. Further work is warranted to clarify the possible mechanistic role of energy metabolism for CO protection.

  • 689.
    Ahlström, Nathalie
    et al.
    Umeå University, Faculty of Social Sciences, Department of Social Work.
    Häggström, Elin
    Umeå University, Faculty of Social Sciences, Department of Social Work.
    Kvinnors levda erfarenheter av sexualiserat våld: En kvalitativ studie av texter från #metoo med fokus på utrymme, ansvar & motstånd2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Den här studien undersöker hur kvinnor i text skildrar sina levda erfarenheter av sexualiserat våld i samband med me too-rörelsen med inriktning på vilket utrymme det sexualiserade våldet får, hur ansvaret beskrivs för utövandet av det samt motstånd gentemot det. Valet av studieområde har uppkommit utifrån att vi uppfattat en stor kunskapslucka gällande forskning om kvinnors egna skriftliga återberättelser om levda erfarenheter av sexualiserat våld. Studiens fokus på utrymme, ansvar och motstånd grundar sig i att Isdal (2017) anser att synliggörande av sexualiserat våld är en av den viktigaste komponenten i bekämpandet av det. Coates och Wade (2007) menar att ansvar för våld i stor utsträckning beskrivs på ett tvetydigt sätt och att offrets motstånd ofta döljs.

     

    Genom riktad och summerande innehållsanalys samt abduktiv ansats har texterna studerats. Resultaten visar att det sexualiserade våldet i genomsnitt ges 50 % av utrymmet i texterna, och att det verbala sexualiserade våldet är mest förekommande. Två typer av berättarstilar avseende hur skribenterna beskriver sina levda erfarenheter har noterats. I den första berättarstilen innehåller texterna längre beskrivningar kring bakgrund och följder av det sexualiserade våldet, medan den andra berättarstilen ger den levda erfarenheten av sexualiserat våldet en stor plats i texten i förhållande till övrigt innehåll.

     

    Gällande ansvaret för det sexualiserade våldet förmedlar texterna direkt och indirekt att det både ligger på skribenterna, på personen som beskrivs som förövare samt på utomstående. Detta görs bland annat genom skribenternas sätta att beskriva det sexualiserade våldet på ett ensidigt eller ömsesidigt sätt. I regel tillskriver skribenterna personen som beskrivs som förövare subjektsposition, medan de själva ibland framställs som objekt och ibland som subjekt.

                                                                                              

    Motstånd mot det sexualiserade våldet skildras i 94 % av de analyserade texterna i form av fysiskt, psykiskt, intellektuellt och/eller spirituellt motstånd. De olika typerna av motstånd benämns 353 gånger, där det fysiska motståndet är mest förekommande. Trots detta innehåller många av texterna uttryck av att skribenten inte anser sig ha gjort motstånd.

     

    Samtliga texter synliggör mäns sexualiserade våld mot kvinnor. Skribenterna säger ifrån genom att dela med sig av sina levda erfarenheter och synliggör på så sätt sexualiserat våld.

  • 690.
    Ahlström, Stina
    et al.
    Rehabilitation Unit, Luleå Primary Health Care, Luleå, Sweden.
    Bernspång, Birgitta
    Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Occupational Therapy.
    Occupational  performance of persons who have suffered a stroke: a follow-up study2003In: Scandinavian Journal of Occupational Therapy, ISSN 1103-8128, E-ISSN 1651-2014, Vol. 10, no 2, p. 88-94Article in journal (Refereed)
    Abstract [en]

    The main purpose of this study was to describe the progress made in terms of occupational performance during a two-year period by persons who had suffered a stroke and had been discharged to their home after their initial hospital stay. The population of the study consisted of 49 persons, 30 men and 19 women, with a mean age of 69 years. The Assessment of Motor and Process Skills (AMPS) was used to assess their occupational performance. Of the whole population at discharge, 66% showed increased effort and 29% showed decreased efficiency and independency. The results also showed that the persons who had decreased the most in their efficiency dropped out from the study. Twenty-nine persons participated in the study for 2 years. The best ADL ability was seen in the population at 3 months after discharge. A decrease was seen at 18 months after discharge in AMPS ADL process ability and at 24 months in AMPS ADL motor ability. The results suggest that persons who have suffered a stroke and live in their homes maintain their AMPS ADL ability performance for 1.5 to 2 years. A low AMPS ADL process ability measure in persons who have suffered a stroke signifies a reduced possibility of living at home.

  • 691.
    Ahlsén, Ingrid
    et al.
    Umeå University, Faculty of Social Sciences, Department of Informatics.
    Hartelius, Anna
    Umeå University, Faculty of Social Sciences, Department of Informatics.
    Nytta eller nöje – en fallstudie av Iggesunds Bruks intranät.1999Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 692. Ahl-Waris, Eva
    et al.
    Nordlund, Christer
    Umeå University, Faculty of Arts, Department of historical, philosophical and religious studies.
    Om tillkomsten och användningen av en fornlämningsplats: arkeologibruk kring Kökars franciskankonvent2014In: Historisk Tidskrift för Finland, ISSN 0046-7596, E-ISSN 2343-2888, Vol. 99, no 2, p. 147-190Article in journal (Refereed)
  • 693. Ahlén Bergman, Emma
    et al.
    Hartana, Ciputra Adijaya
    Johansson, Markus
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Urology and Andrology. Department of Urology, Sundsvall Hospital, Sundsvall, Sweden..
    Linton, Ludvig B
    Berglund, Sofia
    Hyllienmark, Martin
    Lundgren, Christian
    Holmström, Benny
    Palmqvist, Karin
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Urology and Andrology. Department of Surgery, Urology Section, Östersund County Hospital, Östersund, Sweden.
    Hansson, Johan
    Alamdari, Farhood
    Huge, Ylva
    Aljabery, Firas
    Riklund, Katrine
    Winerdal, Malin E
    Krantz, David
    Zirakzadeh, Ali A .
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Urology and Andrology. Unit of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
    Marits, Per
    Sjöholm, Louise K
    Sherif, Amir
    Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Urology and Andrology. Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology.
    Winqvist, Ola
    Increased CD4+ T cell lineage commitment determined by CpG methylation correlates with better prognosis in urinary bladder cancer patients.2018In: Clinical Epigenetics, E-ISSN 1868-7083, Vol. 10, article id 102Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Urinary bladder cancer is a common malignancy worldwide. Environmental factors and chronic inflammation are correlated with the disease risk. Diagnosis is performed by transurethral resection of the bladder, and patients with muscle invasive disease preferably proceed to radical cystectomy, with or without neoadjuvant chemotherapy. The anti-tumour immune responses, known to be initiated in the tumour and draining lymph nodes, may play a major role in future treatment strategies. Thus, increasing the knowledge of tumour-associated immunological processes is important. Activated CD4+ T cells differentiate into four main separate lineages: Th1, Th2, Th17 and Treg, and they are recognized by their effector molecules IFN-γ, IL-13, IL-17A, and the transcription factor Foxp3, respectively. We have previously demonstrated signature CpG sites predictive for lineage commitment of these four major CD4+ T cell lineages. Here, we investigate the lineage commitment specifically in tumour, lymph nodes and blood and relate them to the disease stage and response to neoadjuvant chemotherapy.

    RESULTS: Blood, tumour and regional lymph nodes were obtained from patients at time of transurethral resection of the bladder and at radical cystectomy. Tumour-infiltrating CD4+ lymphocytes were significantly hypomethylated in all four investigated lineage loci compared to CD4+ lymphocytes in lymph nodes and blood (lymph nodes vs tumour-infiltrating lymphocytes: IFNG -4229 bp p < 0.0001, IL13 -11 bp p < 0.05, IL17A -122 bp p < 0.01 and FOXP3 -77 bp p > 0.05). Examination of individual lymph nodes displayed different methylation signatures, suggesting possible correlation with future survival. More advanced post-cystectomy tumour stages correlated significantly with increased methylation at the IFNG -4229 bp locus. Patients with complete response to neoadjuvant chemotherapy displayed significant hypomethylation in CD4+ T cells for all four investigated loci, most prominently in IFNG p < 0.0001. Neoadjuvant chemotherapy seemed to result in a relocation of Th1-committed CD4+ T cells from blood, presumably to the tumour, indicated by shifts in the methylation patterns, whereas no such shifts were seen for lineages corresponding to IL13, IL17A and FOXP3.

    CONCLUSION: Increased lineage commitment in CD4+ T cells, as determined by demethylation in predictive CpG sites, is associated with lower post-cystectomy tumour stage, complete response to neoadjuvant chemotherapy and overall better outcome, suggesting epigenetic profiling of CD4+ T cell lineages as a useful readout for clinical staging.

  • 694.
    Ahlénius, Anna
    Umeå University, Faculty of Social Sciences, Department of Law.
    Otillåten betalning av skuld: En jämförelse mellan återvinningsbestämmelserna och otillbörligt gynnande av borgenär2013Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
  • 695.
    Ahlénius, Caroline
    Umeå University, Umeå School of Education (USE). Umeå University, Faculty of Social Sciences, Department of applied educational science.
    Familjen börjar i förskolan: Föräldrars perspektiv på problematiska inskolningar2011Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Syftet för denna kvalitativa studie var att utveckla förståelse för föräldrars perspektiv på deras barns förskolestart och vad som då kan vara problematiskt. Syftet var också att bidra med kunskaper om önskvärda handlingsmönster hos pedagoger vid förskolestarten. Studien genomfördes på internet där tio respondenter hittades på ett internetforum för föräldrar. Föräldrarnas inlägg insamlades och därtill genomfördes en e-postenkätundersökning som jag formulerat för denna studie. Några aspekter som visade sig vara viktiga för alla tillfrågade föräldrar var tillgången till information i förhand, möjligheter till inflytande över inskolningsarbetet, samt en fungerande kommunikation mellan pedagoger och föräldrar. I samtliga undersökta fall av problematiska inskolningar uppstod med eller mindre uttalade konflikter kring när och hur föräldern skulle lämna barnet och hur man skulle tolka barnets gråt.

  • 696.
    Ahmad, Bayar
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Apotekverksamhetens regler i Holland: – skillnader och likheter mellan Sverige och Holland2014Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • 697.
    Ahmad, Bayar
    Umeå University, Faculty of Science and Technology, Department of Chemistry.
    Apotekverksamhetens regler i Holland – skillnader och likheter mellan Sverige och Holland2014Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • 698.
    Ahmad, Farooq
    et al.
    Umeå University, Faculty of Science and Technology, Department of Computing Science.
    Lindgren, Helena
    Umeå University, Faculty of Science and Technology, Department of Computing Science.
    Selection of foundational ontology for collaborative knowledge modeling in healthcare domain2010In: Artificial intelligence: methodology, systems, and applications / [ed] Dicheva, Darina; Dochev, Danail, Springer Berlin/Heidelberg, 2010, p. 261-262Conference paper (Refereed)
    Abstract [en]

    Ontology design is an important process for structuring knowledge to be reused in different projects in the health domain. In this paper, we describe an ontology design for the collaborative knowledge building system ACKTUS to be used for developing personalized knowledge applications for different domains. Different foundational ontologies were compared with respect to selected criteria considered vital for the project, such as modularity and descriptiveness.

  • 699.
    Ahmad, Iftikhar
    Umeå University, Faculty of Science and Technology, Plant Physiology.
    Screening for mutants with delayed leaf senescence in Arabidopsis2009Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Senescence is the last stage of development in plants. During foliar senescence, theleaves experience changes in metabolism, cell structures and gene expression. In thisprocess the limiting nutrients of leaves are relocated from senescing organs to thedeveloping leaves, fruits and buds. The genetic screening to identify senescence mutantsis of utmost importance both for scientific research and for future biotechnology becausethe stay green mutants could increase crop yields.In our experimental setup, the senescence was induced by darkening the individual leavesof Arabidopsis thaliana plants with “mittens” for six days. We have screened 1064Arabidopsis plants for the mutants with delayed senescence phenotypes (stay-green,light-green and slightly light green plants) by measuring chlorophyll content, proteincontent and change in protein levels of the rubisco LSU, COXII, GS1 and GS2 duringdark induced senescence. After senescence induction, the wild type plants had showntypical yellowing and drying of leaves coupled with chlorophyll and protein degradation,while the foliar senescence progresses more slowly in selected stay green mutants. Theselected stay green mutants (19/29, 19/1043 and 19/531) delayed the degradation ofchlorophyll and protein contents even after 6 days of dark treatment. Furthermore, theretention of chloroplast and mitochondrial protein (rubisco LSU and GS2, and COXIIrespectively) and their higher chlorophyll contents may suggest that 19/29, 19/531and19/1043 plants may maintain their photosynthetic and respiratory activities. Thesemutants delay the functional leaf senescence and could be candidates for functional staygreen mutants for upcoming experiments.

  • 700.
    Ahmad, Irfan
    et al.
    Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet; Department of Allied Health Sciences, University of Health Sciences.
    Cimdins, Annika
    Beske, Timo
    Römling, Ute
    Detailed analysis of c-di-GMP mediated regulation of csgD expression in Salmonella typhimurium2017In: BMC Microbiology, ISSN 1471-2180, E-ISSN 1471-2180, Vol. 17, article id 27Article in journal (Refereed)
    Abstract [en]

    Background: The secondary messenger cyclic di-GMP promotes biofilm formation by up regulating the expression of csgD, encoding the major regulator of rdar biofilm formation in Salmonella typhimurium. The GGDEF/EAL domain proteins regulate the c-di-GMP turnover. There are twenty-two GGDEF/EAL domain proteins in the genome of S. typhimurium. In this study, we dissect the role of individual GGDEF/EAL proteins for csgD expression and rdar biofilm development. Results: Among twelve GGDEF domains, two proteins upregulate and among fifteen EAL domains, four proteins down regulate csgD expression. We identified two additional GGDEF proteins required to promote optimal csgD expression. With the exception of the EAL domain of STM1703, solely, diguanylate cyclase and phosphodiesterase activities are required to regulate csgD mediated rdar biofilm formation. Identification of corresponding phosphodiesterases and diguanylate cyclases interacting in the csgD regulatory network indicates various levels of regulation by c-di-GMP. The phosphodiesterase STM1703 represses transcription of csgD via a distinct promoter upstream region. Conclusion: The enzymatic activity and the protein scaffold of GGDEF/EAL domain proteins regulate csgD expression. Thereby, c-di-GMP adjusts csgD expression at multiple levels presumably using a multitude of input signals.

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