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  • 1.
    Abdullah, Sara Alawi
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Lång respektive fördröjd provtransport ger försämrad blodprovskvalitet2013Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 2.
    Abdulleteef, Lina
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Förekomst av humant papillomvirus i tonsillcancer i norra regionen i Sverige 2000-20122013Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • 3.
    Abrahamsson, Karolina
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Detektion av herpesvirus i hjärnvävnad med q-PCR: Utvärdering av KAPA Express Extract kit och KAPA PROBE FORCE q-PCR kit2016Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 4.
    Akula, Ilona
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Hjärtfunktion vid ärftlig transtyretin-amyloidos: Jämförelse av hjärtfrekvensvariabilitet och ekokardiografi mellan två amyloidfibrilltyper2015Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 5.
    Al Rabiey, Ahmed
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Detektion av aktin i paraffinsnitt från human vävnad2015Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 6.
    Albertsson, Jakob
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science. Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
    Effekt av förbehandling vid detektion av muterat superoxiddismutas-1 protein: Immunohistokemisk detektion av SOD1 aggregat hos G93A transgena möss2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
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  • 7.
    Ali, Jalal
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Fluorescerande Chlamydia trachomatis-mCherry för analys av nya antimikrobiella substanser2016Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 8.
    Ally Lalloo, Arshad
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Mapping the Role of ATP Binding and Hydrolysis of ClpB Domain in Francisella tularensis2017Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 9.
    Almeros, Isak
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Bindning av Adenovirus typ 40 till kommensala grampositiva och gramnegativa bakterier2013Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 10.
    Alverup, Josefin
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Förekomst av bakterier i hudstrukturer med sjukdomen Hidradenitis suppurativa: propionibacterium acnes, Propionibacterium granulosum och Staphylococcus species detektion med immunofluorescens2013Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • 11.
    Anderson, Filippa
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Förändrat uttryck av Epidermal Growth Factor Receptors ligander i androgenoberoende prostata-cancer2012Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
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  • 12.
    Andersson, Paulina
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Autolog adsorptionsteknik hos nytransfunderad patient med autoantikroppar – en experimentell metodutvärdering.2018Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 13.
    Andersson, Simon
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Binding of Norovirus-Like Particles to Integrin Expressing CHO Cells2017Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 14.
    Andersson, Viktor
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Vänsterkammarfunktion hos cancerpatienter som erhållit hjärttoxisk behandling: Intraobservatörvariabilitet för systoliska funktionsmått utvärderad med ekokardiografi2018Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 15.
    Arabi, Thyba
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science. Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Cajal cellernas roll i mag-tarm komplikationer hos patienter med transtyretin amyloidos2017Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 16.
    Arnqvist, Jennifer
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science. Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
    Optimering av lymfocytfraktionering med AutoMACS Pro för biobankning av hematologiska maligniteter2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
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  • 17.
    Aspelin, Jesper
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Anrikning med Illumina Nextera XT sekvenseringsbibliotek2017Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 18.
    Augustsson Sjögren, Daniel
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Characterisation of aptamers selected for binding to Yersinia pestis virulence protein LcrV2011Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
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  • 19.
    Baroshki, Rojan
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Mykofenolsyra och AUC-beräkning för organtransplanterade patienter2015Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 20.
    Baudin, Maria
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Ökad trombopoes och perifer trombocytaktivering i Hantavirus-infekterade patienter2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
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  • 21.
    Berg, Johanna
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Visualisering av mikroorganismer i hårfolliklar från patienter med follikulit2012Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
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  • 22.
    Berg, Mari
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science. Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Clinical Bacteriology.
    Utvärdering av Sysmex UF-5000 för snabb antibiotikaresistens­bestämning av bakterier2018Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 23.
    Berggren, Kevin
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Metodvalidering av IGF-1 med ECLIA på Cobas e601 system2019Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 24.
    Bergqvist, Simon
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science. Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.
    Preanalytisk stabilitet för 25(OH)-vitamin D i koagulerat blod och serum2019Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 25.
    Bixo, Mi
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Detektion av alloantikroppar hos nyligt transfunderade DAT-positiva patienter: Utvärdering med en experimentell in vitro modell2018Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 26. Björquist, P
    et al.
    Brohlin, Maria
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Ehnebom, J
    Ericsson, M
    Kristiansen, C
    Pohl, G
    Deinum, J
    Plasminogen activator inhibitor type-1 interacts exclusively with the proteinase domain of tissue plasminogen activator.1994In: Biochimica et Biophysica Acta, ISSN 0006-3002, E-ISSN 1878-2434, Vol. 1209, no 2, p. 191-202Article in journal (Refereed)
    Abstract [en]

    Two different techniques have been used to study the complex formation of recombinant human plasminogen activator inhibitor type-1, PAI-1, with either recombinant human two-chain tissue plasminogen activator, tc tPA (EC 3.4.21.68), or the tPA deletion variants tc K2P, containing the kringle 2 domain and the proteinase domain, and P, containing only the proteinase domain. The same value for Kon, 2.10(7) M-1s-1 for binding of PAI-1 was found for the three tPA forms by direct detection of the complex formation in real time by surface plasmon resonance, BIAcore, or indirectly by monitoring the time course of the inhibition of tPA using the chromogenic substrate N-methylsulfonyl-D-Phe-Gly-Arg-4-pNA-acetate. Apparently, no conformational change is involved in the rate-limiting step, since the kon value was found to be independent of the temperature from 20 to 35 degrees C. By the BIAcore technique, it was found that the complex between PAI-1 and tPA covalently coupled to the surface, was stable at 25 degrees C, since no dissociation was seen in buffer. However, extended treatment with 1 M NH4OH destroyed the complex with t 1/2 = 5 h. The same kon values and complex composition were found by measuring either the binding of tPA to PAI-1 captured on the monoclonal antibody MAI-11 or the binding of PAI-1 to tPA captured on the monoclonal antibody 2:2 B10. Quantification of the complex composition between PAI-1 captured on the monoclonal antibody MAI-11 with either tPA, K2P or P gave a one-to-one ratio with the fraction of active PAI-1, consistent with the results from SDS-PAGE and the specific activity of PAI-1. The complexes of the three tPA forms with PAI-1 captured on a large surface of MAI-11 dissociated more rapidly from MAI-11, with the same apparent koff, kdis, = 2.10(-3) s-1, compared with 0.7-10(-3) s-1 for the dissociation of PAI-1 alone. In consistance, the Kd, calculated from the direct determination of the kon and koff for the association of different form of PAI-1 to a small surface of MAI-11, was found to be higher for PAI-1 in complex with tPA than for free active PAI-1. Apparently, upon complex formation, a change is induced in PAI-1 at the binding epitope for MAI-11.(ABSTRACT TRUNCATED AT 400 WORDS)

  • 27.
    Block, Emma
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    En jämförande neurografisk studie: Hur mätparametrar för utvärdering av neurofysiologisk sjukdom påverkas vid olika vinklar på armbågen2019Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 28.
    Blom, Amanda
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    HSP90- och IAP-inhibitor motverkar cisplatinresistens i lungcancerceller2013Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • 29.
    Blomdahl, Karin
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Könsskillnader i progress av hjärtengagemang hos patienter med ärftlig transthyretinamyloidos: En studie över tid2015Independent thesis Basic level (professional degree), 180 HE creditsStudent thesis
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  • 30.
    Boklund, Kajsa
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science. Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.
    Jämförelse av citratkoncentration i koagulationsprovtagningsrör: Jämförelse av citratkoncentrationerna 3,8 % och 3,2 % i koagulationsprovtagningsrör och dess effekter på analysresultat i samband med rörposttransport2014Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 31.
    Boldrup, Linda
    et al.
    Umeå University, Faculty of Medicine, Medical Biosciences, Pathology.
    Coates, Philip J
    Hedberg, Ylva
    Umeå University, Faculty of Medicine, Medical Biosciences, Pathology. Umeå University, Faculty of Medicine, Clinical Microbiology, Biomedical Laboratory Science.
    Sjöström, Björn
    Umeå University, Faculty of Medicine, Clinical Sciences, Otorhinolaryngology.
    Dahlqvist, Åke
    Umeå University, Faculty of Medicine, Clinical Sciences, Otorhinolaryngology.
    Nylander, Karin
    Umeå University, Faculty of Medicine, Medical Biosciences, Pathology.
    Expression of p63, COX-2, EGFR and beta-catenin in smokers and patients with squamous cell carcinoma of the head and neck reveal variations in non-neoplastic tissue and no obvious changes in smokers.2005In: International Journal of Oncology, ISSN 1019-6439, Vol. 27, no 6, p. 1661-1667Article in journal (Refereed)
    Abstract [en]

    Squamous cell carcinoma of the head and neck (SCCHN), the 6th most common malignancy in the world, is associated with smoking and has a low 5-year survival rate. Various changes have been described at different stages of SCCHN tumour development, including overexpression of p63, a protein important for development of normal epidermal structures. p63 has been suggested to activate beta-catenin, and nuclear accumulation of beta-catenin is an important event in many cancers. Elevated COX-2 activity and overexpression of EGFR protein has been shown in a variety of human cancers, including SCCHN. An important question for the pathogenesis of SCCHN is when the genetic changes take place during the natural course of the disease, and whether they appear in clinically normal oral mucosa to predispose tumour development. We mapped the expression of p63, COX-2, EGFR, beta-catenin, and PP2A in oral mucosa from smokers/non-smokers and from patients with SCCHN. We also considered if changes occurring in tumours are present in the clinically normal tissue adjacent to the tumour. No direct influence of heavy smoking on the levels of the proteins studied could be seen. Tumours and clinically normal non-neoplastic tissue from SCCHN patients showed increased expression of COX-2 and PP2A. Interestingly, non-neoplastic tissue adjacent to SCCHN also showed increased beta-catenin, although this was not seen in tumours. The data support the notion that pre-existing alterations in clinically normal epithelium exist in patients with SCCHN and could be important for the pathogenesis of the disease and for local recurrences.

  • 32.
    Borgstedt, Håkan
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Överföring av Yersinia pseudotuberculosis effektorproteinet YopE till HeLa-celler, mer än en mekanism?2012Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
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  • 33.
    Boström, Emelie
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Validering av kolonn för analys av alkoholer och glykoler med gaskromatografi: Jämförelse av två kolonner samt fortsatt validering för klinisk tillämpning2018Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 34.
    Boström, Markus
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Utvärdering av 16S rRNA PCR vid mikrobiologisk diagnostik av misstänkt ortopedisk implantat infektioner2016Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 35.
    Braml, Johanna
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science. Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
    Lactoferricin Mediated Infection of Adenovirus 52019Independent thesis Basic level (degree of Bachelor), 20 credits / 30 HE creditsStudent thesis
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  • 36.
    Brandt, Sandra
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Genexpressionsförändringar i fettväv hos individer med typ 2-diabetes efter intervention med paleolitisk kost i kombination med eller utan fysisk aktivitet2019Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 37.
    Bravo, Mayra
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Genetisk kartläggning av mygg: Artbestämning av mygg genom barcoding2011Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
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  • 38.
    Brinck, Kajsa
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Ultraljuds effekt på bakterier: Studie av ultraljuds effekt på bakterier vid olika temperaturer och frekvenser av ultraljud.2011Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
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  • 39.
    Broberg, Annette
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science. Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.
    Betydelse av provtagningsrör för faktorer i fibrinolysen2014Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 40.
    Brohlin, Maria
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Kelk, Peyman
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
    Wiberg, Mikael
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy. Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Hand Surgery.
    Kingham, Paul J.
    Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
    Effects of a defined xeno-free medium on the growth and neurotrophic and angiogenic properties of human adult stem cells2017In: Cytotherapy, ISSN 1465-3249, E-ISSN 1477-2566, Vol. 19, no 5, p. 629-639Article in journal (Refereed)
    Abstract [en]

    Background. The growth properties and neurotrophic and angiogenic effects of human mesenchymal stromal cells (MSCs) cultured in a defined xeno-free, serum-free medium (MesenCult-XF) were investigated. Methods. Human MSCs from adipose tissue (ASCs) and bone marrow (BMSCs) were cultured in Minimum Essential Medium-alpha (alpha-MEM) containing fetal calf serum or in MesenCult-XF. Proliferation was measured over 10 passages and the colony-forming unit (CFU) assay and expression of cluster of differentiation (CD) surface markers were determined. Neurite outgrowth and angiogenic activity of the MSCs were determined. Results. At early passage, both ASCs and BMSCs showed better proliferation in MesenCult-XF compared with standard a-MEM containing serum. However, CFUs were significantly lower in MesenCult-XF. ASCs cultured in MesenCult-XF continued to expand at faster rates than cells grown in serum. BMSCs showed morphological changes at late passage in MesenCult-XF and stained positive for senescence beta-galactosidase activity. Expression levels of CD73 and CD90 were similar in both cell types under the various culture conditions but CD105 was significantly reduced at passage 10 in MesenCult-XF. In vitro stimulation of the cells enhanced the expression of brain derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF-A) and angiopoietin-1. Stimulated ASCs grown in MesenCult-XF evoked the longest neurite outgrowth in a neuron co-culture model. Stimulated BMSCs grown in MesenCult-XF produced the most extensive network of capillary-like tube structures in an in vitro angiogenesis assay. Conclusions. ASCs and BMSCs exhibit high levels of neurotrophic and angiogenic activity when grown in the defined serum free medium indicating their suitability for treatment of various neurological conditions. However, long-term expansion in MesenCult-XF might be restricted to ASCs.

  • 41.
    Brolin, Ida
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Inverkan av apolipoprotein E4 vid HSV1-infektion av GMK- och SH-SY5Y-celler2019Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 42.
    Burvall Engman, Amanda
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Förändring av temperaturtrösklar vid kvantitativ sensorisk testning: Med avseende på stimuleringshastighet och interstimulusintervall2019Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 43.
    Burén, Victoria
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Riskbedömning gällande humant papilloma virus (HPV) kontamination: Undersökning av den analysprocess från provtagning, cytologisk utstryk på glas till amplifiering av DNA som bidrar till diagnos av cervixcancer2014Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 44.
    Bylund, Olof
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Lokal validering av GLI 2012: En retrospektiv studie om referensvärden för spirometri vid klinisk fysiologi i Umeå2016Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 45.
    Bäckström, Michelle
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    IgE-förekomst i lymfoida och endokrina organ: jämförelse mellan NOD-och B6-möss2013Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • 46. Cheng, X F
    et al.
    Brohlin, Maria
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Pohl, G
    Bäck, O
    Wallén, P
    Binding of tissue plasminogen activator to endothelial cells. The effect on functional properties. Localization of a ligand in the B-chain of tPA.1995In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 77, no 2, p. 149-64Article in journal (Refereed)
    Abstract [en]

    The binding of 125I-labelled tissue plasminogen activator (tPA), the tPA A- or B-chain to endothelial cells (EC) were studied in suspensions of cultured human umbilical vein EC (HUVEC) or immortalized microvascular EC (HMEC). By determinations of the concentration-dependent binding it was shown that both the A-chain and the B-chain, which were isolated after partial reduction of two-chain tPA, contain ligands for binding to EC. The affinity for the B-chain was much higher than for the A-chain according to Scatchard analysis (Kd 24 and 515 nM, respectively), whereas the number of binding sites was higher for the A-chain than for the B-chain (Bmax 8 x 10(5) and 1.2 x 10(5), respectively). There were no cross interactions between the A- and B-chains and their binding sites. The binding of tPA to EC induced an almost 100-fold increase of the activation rate when compared to the same amount of enzyme in free solution, which in contrast to the fibrin-induced stimulation was not inhibited by antibodies against fibrin. The enzymatic activity of the B-chain was much less affected by the association to the cells. Both tPA and the tPA B-chain were largely protected against inhibition by an excess plasminogen activator type-1 (PAI-1) when bound to EC, whereas the same amount of free tPA was totally inactivated. The competition studies strongly indicated that an N-terminal segment in the B-chain, AKHRRSPGER, may be the ligand part of the B-chain. It is interesting to note that this polypeptide segment also participates in a binding site for PAI-1, necessary for effective inhibition. This implies a possible competition between PAI-1 and a tPA-receptor for binding of tPA. High molecular weight urokinase had no quenching effect on the binding of the B-chain to EC.

  • 47.
    Chitheer, Athir
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science. Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
    Generation of a Chimeric HAdV-5/56 Virus2018Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 48.
    Claesson, Thomas
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Bärextrakts effekt på trombocytfunktion: Nyuppsatt metod med helblodsaggregometri2013Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • 49.
    Curiche, Natalia
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Visualization of Propionibacterium acnes in Patients Diagnosed with Acne Vulgaris. - Propionibacterium acnes Detected with Immuno­fluorescence and Fluorescence in situ Hybridization.2011Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
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  • 50.
    Dahlberg, Ida
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Biomedical Laboratory Science.
    Förekomsten av Propionibacterium acnes är låg hos patienter med Rosacea: En studie av sambandet mellan Propionibacterium acnes och Rosacea med immunofluorescens2011Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
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Output format
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  • asciidoc
  • rtf