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  • 1. Beldowski, Jacek
    et al.
    Klusek, Zygmunt
    Szubska, Marta
    Turja, Raisa
    Bulczak, Anna I.
    Rak, Daniel
    Brenner, Matthias
    Lang, Thomas
    Kotwicki, Lech
    Grzelak, Katarzyna
    Jakacki, Jaromir
    Fricke, Nicolai
    Ostin, Anders
    Olsson, Ulf
    Fabisiak, Jacek
    Garnaga, Galina
    Nyholm, Jenny Rattfelt
    Majewski, Piotr
    Broeg, Katja
    Soderstrom, Martin
    Vanninen, Paula
    Popiel, Stanislaw
    Nawala, Jakub
    Lehtonen, Kari
    Berglind, Rune
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Europeiska CBRNE-centret.
    Schmidt, Beata
    Chemical Munitions Search & Assessment-An evaluation of the dumped munitions problem in the Baltic Sea2016Inngår i: Deep-sea research. Part II, Topical studies in oceanography, ISSN 0967-0645, E-ISSN 1879-0100, Vol. 128, 85-95 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Chemical Munitions Search & Assessment (CHEMSEA) project has performed studies on chemical weapon (CW) detection, sediment pollution and spreading as well as biological effects of chemical warfare agents (CWAs) dumped in the Baltic Sea. Results suggest that munitions containing CWAs are more scattered on the seafloor than suspected, and previously undocumented dumpsite was discovered in Gdansk Deep. Pollution of sediments with CWA degradation products was local and close to the detected objects; however the pollution range was larger than predicted with theoretical models. Bottom currents observed in the dumpsites were strong enough for sediment re-suspension, and contributed to the transport of polluted sediments. Diversity and density of the faunal communities were poor at the dumping sites in comparison to the reference area, although the direct effects of CWA on benthos organisms were difficult to determine due to hypoxic or even anoxic conditions near the bottom. Equally, the low oxygen might have affected the biological effects assessed in cod and caged blue mussels. Nonetheless, both species showed significantly elevated molecular and cellular level responses at contaminated sites compared to reference sites.

  • 2.
    Berg, Lotta
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Niemiec, Moritz S.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Qian, Weixing
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Andersson, C. David
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Wittung-Stafshede, Pernilla
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Ekström, Fredrik
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen. Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Europeiska CBRNE-centret.
    Linusson, Anna
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Similar but Different: Thermodynamic and Structural Characterization of a Pair of Enantiomers Binding to Acetylcholinesterase2012Inngår i: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 51, nr 51, 12716-12720 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Take a closer look: Unexpectedly, a pair of enantiomeric ligands proved to have similar binding affinities for acetylcholinesterase. Further studies indicated that the enantiomers exhibit different thermodynamic profiles. Analyses of the noncovalent interactions in the protein-ligand complexes revealed that these differences are partly due to nonclassical hydrogen bonds between the ligands and aromatic side chains of the protein.

  • 3.
    Berglind, Rune
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Europeiska CBRNE-centret.
    Leffler, Per
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Sjöström, Michael
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Interactions between pH, potassium, calcium, bromide, and phenol and their effects on the bioluminescence of Vibrio fischeri2010Inngår i: Journal of Toxicology and Environmental Health, ISSN 1528-7394, E-ISSN 1087-2620, Vol. 73, nr 16, 1102-1112 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Little attention has been paid to how the light produced by the bacterium Vibrio fischeri in the Microtox assay is dependent on the concentration of essential ions such as sodium and potassium, and whether the concentrations of these ions affect the sensitivity of the test system to toxic chemicals. Five selected factors, pH, potassium (K(+)), calcium (Ca(2+)), bromide (Br(-)), and phenol (Phe), were simultaneously varied over a set of systematically planned experiments according to a D-optimal design that supported the estimation of a model with linear, quadratic, and two-factor interatcions of the studied factors. The bacterial light production represented by the gamma values in the Microtox assay for the 24 selected combinations of factors was measured at 5 and 15 min. The gamma values varied from negative to positive values greater than 1, indicating stimulation and inhibition of bacterial light production, respectively. The relationship between the gamma values and the factor settings was investigated with multiple linear regression. After 5 min of exposure, the light production was significantly affected by linear and quadratic terms for K(+), pH, and Phe and an interaction between pH and Phe. The situation was more complex after 15 min of exposure, since in addition significant interactions were found for K x Phe and Ca x pH. The tolerance of V. fischeri to Phe was enhanced by increasing the K and Ca concentrations. Data indicate that the ion composition and pH of the sample, as well as the diluents, need to be considered when the toxicity of salts, water samples, and extracts of sediments and soils are tested using commercially certified toxicity test kits.

  • 4.
    Franzén, Oscar
    et al.
    Umeå universitet, Teknisk-naturvetenskaplig fakultet, Europeiska CBRNE-centret.
    Lindstein, Daniel
    Umeå universitet, Teknisk-naturvetenskaplig fakultet, Ekologi, miljö och geovetenskap.
    Förutsättningar för inplantering av fisk i svenska insjöar: med Hissjön som exempel2009Independent thesis Advanced level (degree of Master (One Year)), 20 poäng / 30 hpOppgave
  • 5.
    Gunnarsson, David
    et al.
    Umeå universitet, Teknisk-naturvetenskaplig fakultet, Molekylärbiologi (Teknisk-naturvetenskaplig fakultet).
    Leffler, Per
    Umeå universitet, Teknisk-naturvetenskaplig fakultet, Europeiska CBRNE-centret.
    Ekwurtzel, Emelie
    Martinsson, Gunilla
    Liu, Kui
    Umeå universitet, Medicinsk fakultet, Medicinsk kemi och biofysik.
    Selstam, Gunnar
    Umeå universitet, Medicinsk fakultet, Molekylärbiologi (Medicinska fakulteten).
    Mono-(2-ethylhexyl) phthalate stimulates basal steroidogenesis by a cAMP-independent mechanism in mouse gonadal cells of both sexes2008Inngår i: Reproduction, ISSN 1470-1626, Vol. 135, nr 5, 693-703 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Phthalates are widely used as plasticizers in a number of daily-life products. In this study, we investigated the influence of mono-(2-ethylhexyl) phthalate (MEHP), the active metabolite of the frequently used plasticizer di-(2-ethylhexyl) phthalate (DEHP), on gonadal steroidogenesis in vitro. MEHP (25–100 µM) stimulated basal steroid synthesis in a concentration-dependent manner in immortalized mouse Leydig tumor cells (MLTC-1). The stimulatory effect was also detected in KK-1 granulosa tumor cells. MEHP exposure did not influence cAMP or StAR protein levels and induced a gene expression profile of key steroidogenic proteins different from the one induced by human chorionic gonadotropin (hCG). Simultaneous treatment with MEHP and a p450scc inhibitor (aminoglutethimide) indicated that MEHP exerts its main stimulatory effect prior to pregnenolone formation. MEHP (10–100 µM) up-regulated hormone-sensitive lipase and 3-hydroxy-3-methylglutaryl coenzyme A reductase, suggesting that MEHP increases the amount of cholesterol available for steroidogenesis. Our data suggest that MEHP, besides its known inhibitory effect on hCG action, can directly stimulate gonadal steroidogenesis in both sexes through a cAMP- and StAR-independent mechanism. The anti-steroidogenic effect of DEHP has been proposed to cause developmental disorders such as hypospadias and cryptorchidism, whereas a stimulation of steroid synthesis may prematurely initiate the onset of puberty and theoretically affect the hypothalamic–pituitary–gonadal axis.

  • 6. Nyberg, Ann Göransson
    et al.
    Stricklin, Daniela
    Sellström, Åke
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Europeiska CBRNE-centret.
    Mass casualties and health care following the release of toxic chemicals or radioactive material-contribution of modern biotechnology2011Inngår i: International Journal of Environmental Research and Public Health, ISSN 1661-7827, E-ISSN 1660-4601, Vol. 8, nr 12, 4521-4549 s.Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Catastrophic chemical or radiological events can cause thousands of casualties. Such disasters require triage procedures to identify the development of health consequences requiring medical intervention. Our objective is to analyze recent advancements in biotechnology for triage in mass emergency situations. In addition to identifying persons "at risk" of developing health problems, these technologies can aid in securing the unaffected or "worried well". We also highlight the need for public/private partnerships to engage in some of the underpinning sciences, such as patho-physiological mechanisms of chemical and radiological hazards, and for the necessary investment in the development of rapid assessment tools through identification of biochemical, molecular, and genetic biomarkers to predict health effects. For chemical agents, biomarkers of neurotoxicity, lung damage, and clinical and epidemiological databases are needed to assess acute and chronic effects of exposures. For radiological exposures, development of rapid, sensitive biomarkers using advanced biotechnologies are needed to sort exposed persons at risk of life-threatening effects from persons with long-term risk or no risk. The final implementation of rapid and portable diagnostics tools suitable for emergency care providers to guide triage and medical countermeasures use will need public support, since commercial incentives are lacking.

  • 7.
    Plamboeck, Agneta H.
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Europeiska CBRNE-centret.
    Stöven, Svenja
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Europeiska CBRNE-centret.
    Davidson, Raquel Duarte
    Fykse, Else-Marie
    Griffiths, Mark
    Nieuwenhuizen, Maarten
    Rivier, Cedric
    van der Schans, Marcel
    Laboratory analysis of CBRN-substances: Stakeholder networks as clue to higher CBRN resilience in Europe2016Inngår i: TrAC. Trends in analytical chemistry, ISSN 0165-9936, E-ISSN 1879-3142, Vol. 85, nr Part B, 2-9 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The threat of terrorists using CBRN agents continues to pose a risk of mass casualties and severe disruption of societal functions in Europe. Standardisation of crisis management activities is one important step towards effective national and international interoperability and increased resilience. Understanding which CBRN agents are involved in an incident is vital for appropriate response measures. We applied a system's view on the process of CBRN sample analysis and see three discrete applications; Immediate incident response, Forensics, Post incident monitoring. Together with laboratory experts and policy makers from across Europe we identified needs for quality assurance measures in these three areas. Here, we suggest various harmonisation activities that can facilitate interoperability between all stakeholders concerned with CBRN sample analysis. Foremost, we recommend purpose-oriented laboratory networks, but also minimum performance requirements for First Responders' detection and sampling capabilities, best practices for sample transport and documentation.

  • 8.
    Plamboeck, Agneta
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Europeiska CBRNE-centret.
    Sahovic, Dzenan
    Umeå universitet, Samhällsvetenskapliga fakulteten, Statsvetenskapliga institutionen. Europeiska CBRNE-centret, European CBRNE Center.
    Karlsson Bazarschi, Johanna
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Europeiska CBRNE-centret.
    Enhancing First Responder CBRN Capabilities2015Inngår i: ABC. Casopis urgentne medicine (Journal of Emergency Medicine), ISSN 1451-1053, Vol. 15, nr 2, 60-65 s.Artikkel i tidsskrift (Annet vitenskapelig)
  • 9.
    Sahovic, Dzenan
    et al.
    Umeå universitet, Samhällsvetenskapliga fakulteten, Statsvetenskapliga institutionen. European CBRNE Center.
    Engberg, Jan
    Umeå universitet, Samhällsvetenskapliga fakulteten, Statsvetenskapliga institutionen.
    Van Hemert, Dianne
    TNO Defence, Safety and Security.
    Nyström, Rebecca
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Europeiska CBRNE-centret.
    Lindgren, Karin
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Europeiska CBRNE-centret.
    Comparative Mapping of Legal and Political Contexts of Different EU Countries: PRACTICE project deliverable 8.22013Rapport (Annet vitenskapelig)
  • 10.
    Sellström, Åke
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Europeiska CBRNE-centret.
    Plamboeck, Agneta
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Europeiska CBRNE-centret.
    Sigsworth, Andrew
    Police National CBRN Center .
    Deegan, Andrew
    Police National CBRN Center .
    Brinek, Josef
    SUJCHBO.
    Kralik, Lukas
    SUJCHBO.
    Becker, Anne
    Robert Koch-institute.
    Gebert, Susanne
    Robert Koch-institute.
    Norrhem, Bo
    Lindholmen Science Park.
    Rydberg, Gunilla
    Lindholmen Science Park.
    Sommade, Christian
    HCFDC.
    Dhermain, Joel
    DGA Maitrise NRBC.
    Jacquelard, Christophe
    Cilas.
    Goebel, Johann
    EADS.
    Tunemalm, Anna-Karin
    FOI.
    Bucht, Göran
    FOI.
    Nexon, Elisande
    Foundation Pour la recherche strategique.
    Di Camillo, Federica
    Istituto affari internazionali.
    Miranda, Valérie
    Istituto affari internazionali.
    Riti, Emidio
    Selex Galileo.
    George, Marc
    UCL.
    Menning, Dennis
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Europeiska CBRNE-centret.
    Final Report of CBRNEmap: A better preparedness and response for European citizens facing CBRNE Threats2011Rapport (Annet (populærvitenskap, debatt, mm))
    Abstract [en]

    CBRNEmap was a pre-study to the upcoming CBRNE technology demonstrator. Accordingly, considerable efforts were used to describe the feasibility and to sort out a number of basic requirements of the contemplated demonstrator object. This report deals with two areas deemed important when constructing a civilian CBRNE system of systems, its limitations and some suggested specifications: A useful CBRNE system of systems will improve and connect important societal functions vital before, during and after a CBRNE accident and/or attack. CBRNEmap identifies three clusters of activities as the most important when making our society resilient to CBRNE. These are, the cluster of activities making up the response function, the cluster of activities defining the function to protect identified targets and the cluster of societal investments enabling Europe to become more resilient. As examples and as a source of inspiration the three societal functions described above (response, protect and enabling) were used to discuss the CBRNE technology demonstrator. The demonstrator objects were populated by technologies and thereafter discussed with respect to choice of scenarios, choice of parameters to be used for its validation and with respect to its market value. Based on its conclusions, its working process and its interaction with external partners CBRNEmap recommends that:

    The use of Integrated Project Teams will be given priority when evaluating the upcoming demonstrator objects.

    The European Commission does everything possible to ensure that the results of previous “EU project” get integrated into the upcoming demonstrator object.

    Appropriate limitations and projections are made to the CBRNE system of systems perspective, in order to produce a CBRNE demonstrator serving the societal functions responsible or operational active.

    Considerable efforts are given to validating the improvements and/or added value of the demonstrator object.

    The cluster of societal investment we refer to as the enabler is further investigated in a future SSA.

  • 11.
    Stöven, Svenja
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Europeiska CBRNE-centret.
    Bäcklund, Anna
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Europeiska CBRNE-centret.
    Sahovic, Dzenan
    Umeå universitet, Samhällsvetenskapliga fakulteten, Statsvetenskapliga institutionen.
    Ethics Issues Management Workshop: PRACTICE project deliverable 1.32013Rapport (Annet vitenskapelig)
  • 12.
    Vonkavaara, Malin
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Klinisk bakteriologi.
    Pavel, Shaikh Terkis Islam
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Klinisk bakteriologi.
    Hölzl, Kathrin
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Klinisk bakteriologi.
    Nordfelth, Roland
    Umeå universitet, Medicinska fakulteten, Institutionen för molekylärbiologi (Medicinska fakulteten).
    Sjöstedt, Anders
    Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Klinisk bakteriologi. Umeå universitet, Medicinska fakulteten, Molekylär Infektionsmedicin, Sverige (MIMS).
    Stöven, Svenja
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Europeiska CBRNE-centret.
    Francisella is sensitive to insect antimicrobial peptides2013Inngår i: Journal of Innate Immunity, ISSN 1662-811X, E-ISSN 1662-8128, Vol. 5, nr 1, 50-59 s.Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Francisella tularensis causes the zoonotic disease tularemia. Arthropod vectors are important transmission routes for the disease, although it is not known how Francisella survives the efficient arthropod immune response. Here, we used Drosophila melanogaster as a model host for Francisella infections and investigated whether the bacteria are resistant to insect humoral immune responses, in particular to the antimicrobial peptides (AMPs) secreted into the insect hemolymph. Moreover, we asked to which extent such resistance might depend on LPS structure and surface characteristics of the bacteria. We analyzed F. novicida mutant strains in genes, directly or indirectly involved in specific steps of LPS biosynthesis, for virulence in wildtype and Relish E20 immune deficient flies, and tested selected mutants for sensitivity to AMPs in vitro. We demonstrate that Francisella is sensitive to specific fly AMPs, i.e. Attacin, Cecropin, Drosocin and Drosomycin. Furthermore, six bacterial genes, kpsF, manB, lpxF, slt, tolA and pal, were found to be required for resistance to Relish-dependent immune responses, illustrating the importance of structural details of Francisella lipid A and Kdo core for interactions with AMPs. Interestingly, a more negative surface charge and lack of O-antigen did not render mutant bacteria more sensitive to cationic AMPs and attenuated virulence in flies.

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